921 research outputs found
Integral equation method for the electromagnetic wave propagation in stratified anisotropic dielectric-magnetic materials
We investigate the propagation of electromagnetic waves in stratified
anisotropic dielectric-magnetic materials using the integral equation method
(IEM). Based on the superposition principle, we use Hertz vector formulations
of radiated fields to study the interaction of wave with matter. We derive in a
new way the dispersion relation, Snell's law and reflection/transmission
coefficients by self-consistent analyses. Moreover, we find two new forms of
the generalized extinction theorem. Applying the IEM, we investigate the wave
propagation through a slab and disclose the underlying physics which are
further verified by numerical simulations. The results lead to a unified
framework of the IEM for the propagation of wave incident either from a medium
or vacuum in stratified dielectric-magnetic materials.Comment: 14pages, 3figure
The 3D Structure of N132D in the LMC: A Late-Stage Young Supernova Remnant
We have used the Wide Field Spectrograph (WiFeS) on the 2.3m telescope at
Siding Spring Observatory to map the [O III] 5007{\AA} dynamics of the young
oxygen-rich supernova remnant N132D in the Large Magellanic Cloud. From the
resultant data cube, we have been able to reconstruct the full 3D structure of
the system of [O III] filaments. The majority of the ejecta form a ring of
~12pc in diameter inclined at an angle of 25 degrees to the line of sight. We
conclude that SNR N132D is approaching the end of the reverse shock phase
before entering the fully thermalized Sedov phase of evolution. We speculate
that the ring of oxygen-rich material comes from ejecta in the equatorial plane
of a bipolar explosion, and that the overall shape of the SNR is strongly
influenced by the pre-supernova mass loss from the progenitor star. We find
tantalizing evidence of a polar jet associated with a very fast oxygen-rich
knot, and clear evidence that the central star has interacted with one or more
dense clouds in the surrounding ISM.Comment: Accepted for Publication in Astrophysics & Space Science, 18pp, 8
figure
Experimental Implementation of the Quantum Random-Walk Algorithm
The quantum random walk is a possible approach to construct new quantum
algorithms. Several groups have investigated the quantum random walk and
experimental schemes were proposed. In this paper we present the experimental
implementation of the quantum random walk algorithm on a nuclear magnetic
resonance quantum computer. We observe that the quantum walk is in sharp
contrast to its classical counterpart. In particular, the properties of the
quantum walk strongly depends on the quantum entanglement.Comment: 5 pages, 4 figures, published versio
New Quantum Theory of Laser Cooling Mechanisms
In this paper, we study the laser cooling mechanisms with a new quantum
theory approach by applying a new Schrodinger equation, which can describe a
particle in conservative and non-conservative force field. With the new theory,
we prove the atom in laser field can be cooled, and give the atom cooling
temperature, which is accordance with experiment result. Otherwise, we give new
prediction that the atom cooling temperature is directly proportional to the
atom vibration frequency. By calculation, we find they are: .Comment: arXiv admin note: text overlap with arXiv:physics/0601097,
arXiv:0710.5078, arXiv:0707.2280 by other authors without attributio
Interference-induced gain in Autler-Townes doublet of a V-type atom in a cavity
We study the Autler-Townes spectrum of a V-type atom coupled to a
single-mode, frequency-tunable cavity field at finite termperature, with a
pre-selected polarization in the bad cavity limit, and show that, when the mean
number of thermal photons and the excited sublevel splitting is very
large (the same order as the cavity linewidth), the probe gain may occur at
either sideband of the doublet, depending on the cavity frequency, due to the
cavity-induced interference.Comment: Minor changes are mad
Charmless hadronic decays and new physics effects in the general two-Higgs doublet models
Based on the low-energy effective Hamiltonian with the generalized
factorization, we calculate the new physics contributions to the branching
ratios of the two-body charmless hadronic decays of and mesons
induced by the new gluonic and electroweak charged-Higgs penguin diagrams in
the general two-Higgs doublet models (models I, II and III). Within the
considered parameter space, we find that: (a) the new physics effects from new
gluonic penguin diagrams strongly dominate over those from the new -
and - penguin diagrams; (b) in models I and II, new physics contributions
to most studied B meson decay channels are rather small in size: from -15% to
20%; (c) in model III, however, the new physics enhancements to the
penguin-dominated decay modes can be significant, , and
therefore are measurable in forthcoming high precision B experiments; (d) the
new physics enhancements to ratios {\cal B}(B \to K \etap) are significant in
model III, , and hence provide a simple and plausible new
physics interpretation for the observed unexpectedly large B \to K \etap
decay rates; (e) the theoretical predictions for and
in model III are still consistent with the data
within errors; (f) the significant new physics enhancements to the
branching ratios of and decays are helpful to improve the
agreement between the data and the theoretical predictions; (g) the theoretical
predictions of in the 2HDM's are generally
consistent with experimental measurements and upper limits ()Comment: 55 pages, Latex file, 17 PS and EPS figures. With minor corrections,
final version to be published in Phys.Rev. D. Repot-no: PKU-TH-2000-4
Coordination in multiagent systems and Laplacian spectra of digraphs
Constructing and studying distributed control systems requires the analysis
of the Laplacian spectra and the forest structure of directed graphs. In this
paper, we present some basic results of this analysis partially obtained by the
present authors. We also discuss the application of these results to
decentralized control and touch upon some problems of spectral graph theory.Comment: 15 pages, 2 figures, 40 references. To appear in Automation and
Remote Control, Vol.70, No.3, 200
Effect of CpG Depletion of Vector Genome on CD8+ T Cell Responses in AAV Gene Therapy
Adeno associated viral (AAV) vectors have emerged as a preferred platform for in vivo gene replacement therapy and represent one of the most promising strategies to treat monogenetic disorders such as hemophilia. However, immune responses to gene transfer have hampered human gene therapy in clinical trials. Over the past decade, it has become clear that innate immune recognition provides signals for the induction of antigen-specific responses against vector or transgene product. In particular, TLR9 recognition of the vector's DNA genome in plasmacytoid dendritic cells (pDCs) has been identified as a key factor. Data from clinical trials and pre-clinical studies implement CpG motifs in the vector genome as drivers of immune responses, especially of CD8+ T cell activation. Here, we demonstrate that cross-priming of AAV capsid-specific CD8+ T cells depends on XCR1+ dendritic cells (which are likely the main cross-presenting cell that cooperates with pDCs to activate CD8+ T cells) and can be minimized by the elimination of CpG motifs in the vector genome. Further, a CpG-depleted vector expressing human coagulation factor IX showed markedly reduced (albeit not entirely eliminated) CD8+ T cell infiltration upon intramuscular gene transfer in hemophilia B mice when compared to conventional CpG+ vector (comprised of native sequences), resulting in better preservation of transduced muscle fibers. Therefore, this deimmunization strategy is helpful in reducing the potential for CD8+ T cell responses to capsid or transgene product. However, CpG depletion had minimal effects on antibody responses against capsid or transgene product, which appear to be largely independent of CpG motifs
Human upper-airway respiratory airflow: In vivo comparison of computational fluid dynamics simulations and hyperpolarized 129Xe phase contrast MRI velocimetry
Computational fluid dynamics (CFD) simulations of respiratory airflow have the potential to change the clinical assessment of regional airway function in health and disease, in pulmonary medicine and otolaryngology. For example, in diseases where multiple sites of airway obstruction occur, such as obstructive sleep apnea (OSA), CFD simulations can identify which sites of obstruction contribute most to airway resistance and may therefore be candidate sites for airway surgery. The main barrier to clinical uptake of respiratory CFD to date has been the difficulty in validating CFD results against a clinical gold standard. Invasive instrumentation of the upper airway to measure respiratory airflow velocity or pressure can disrupt the airflow and alter the subject’s natural breathing patterns. Therefore, in this study, we instead propose phase contrast (PC) velocimetry magnetic resonance imaging (MRI) of inhaled hyperpolarized 129Xe gas as a non-invasive reference to which airflow velocities calculated via CFD can be compared. To that end, we performed subject-specific CFD simulations in airway models derived from 1H MRI, and using respiratory flowrate measurements acquired synchronously with MRI. Airflow velocity vectors calculated by CFD simulations were then qualitatively and quantitatively compared to velocity maps derived from PC velocimetry MRI of inhaled hyperpolarized 129Xe gas. The results show both techniques produce similar spatial distributions of high velocity regions in the anterior-posterior and foot-head directions, indicating good qualitative agreement. Statistically significant correlations and low Bland-Altman bias between the local velocity values produced by the two techniques indicates quantitative agreement. This preliminary in vivo comparison of respiratory airway CFD and PC MRI of hyperpolarized 129Xe gas demonstrates the feasibility of PC MRI as a technique to validate respiratory CFD and forms the basis for further comprehensive validation studies. This study is therefore a first step in the pathway towards clinical adoption of respiratory CFD
Global impacts of the 1980s regime shift
Despite evidence from a number of Earth systems that abrupt temporal changes known as regime shifts are important, their nature, scale and mechanisms remain poorly documented and understood. Applying principal component analysis, change-point analysis and a sequential t-test analysis of regime shifts to 72 time series, we confirm that the 1980s regime shift represented a major change in the Earth's biophysical systems from the upper atmosphere to the depths of the ocean and from the Arctic to the Antarctic, and occurred at slightly different times around the world. Using historical climate model simulations from the Coupled Model Intercomparison Project Phase 5 (CMIP5) and statistical modelling of historical temperatures, we then demonstrate that this event was triggered by rapid global warming from anthropogenic plus natural forcing, the latter associated with the recovery from the El Chichón volcanic eruption. The shift in temperature that occurred at this time is hypothesized as the main forcing for a cascade of abrupt environmental changes. Within the context of the last century or more, the 1980s event was unique in terms of its global scope and scale; our observed consequences imply that if unavoidable natural events such as major volcanic eruptions interact with anthropogenic warming unforeseen multiplier effects may occur
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