Homogeneous nucleation of a non-critical phase near a continuous phase transition

Homogeneous nucleation of a new phase near a second, continuous, transition, is considered. The continuous transition is in the metastable region associated with the first-order phase transition, one of whose coexisting phases is nucleating. Mean-field calculations show that as the continuous transition is approached, the size of the nucleus varies as the response function of the order parameter of the continuous transition. This response function diverges at the continuous transition, as does the temperature derivative of the free energy barrier to nucleation. This rapid drop of the barrier as the continuous transition is approached means that the continuous transition acts to reduce the barrier to nucleation at the first-order transition. This may be useful in the crystallisation of globular proteins.Comment: 6 pages, 1 figur

Jet angular correlation in vector-boson fusion processes at hadron colliders

Higgs boson and massive-graviton productions in association with two jets via vector-boson fusion (VBF) processes and their decays into a vector-boson pair at hadron colliders are studied. They include scalar and tensor boson production processes via weak-boson fusion in quark-quark collisions, gluon fusion in quark-quark, quark-gluon and gluon-gluon collisions, as well as their decays into a pair of weak bosons or virtual gluons which subsequently decay into $\ell\bar\ell$, $q\bar q$ or $gg$. We give the helicity amplitudes explicitly for all the VBF subprocesses, and show that the VBF amplitudes dominate the exact matrix elements not only for the weak-boson fusion processes but also for all the gluon fusion processes when appropriate selection cuts are applied, such as a large rapidity separation between two jets and a slicing cut for the transverse momenta of the jets. We also show that our off-shell vector-boson current amplitudes reduce to the standard quark and gluon splitting amplitudes with appropriate gluon-polarization phases in the collinear limit. Nontrivial azimuthal angle correlations of the jets in the production and in the decay of massive spin-0 and -2 bosons are manifestly expressed as the quantum interference among different helicity states of the intermediate vector-bosons. Those correlations reflect the spin and the CP nature of the Higgs bosons and the massive gravitons.Comment: 47 pages, 7 figures, 10 tables; references added, version to appear in JHE

Kinematical Limits on Higgs Boson Production via Gluon Fusion in Association with Jets

In this paper, we analyze the high-energy limits for Higgs boson plus two jet production. We consider two high-energy limits, corresponding to two different kinematic regions: a) the Higgs boson is centrally located in rapidity between the two jets, and very far from either jet; b) the Higgs boson is close to one jet in rapidity, and both of these are very far from the other jet. In both cases the amplitudes factorize into impact factors or coefficient functions connected by gluons exchanged in the t channel. Accordingly, we compute the coefficient function for the production of a Higgs boson from two off-shell gluons, and the impact factors for the production of a Higgs boson in association with a gluon or a quark jet. We include the full top quark mass dependence and compare this with the result obtained in the large top-mass limit.Comment: 35 pages, 6 figure

Measurement of the B0-anti-B0-Oscillation Frequency with Inclusive Dilepton Events

The $B^0$-$\bar B^0$ oscillation frequency has been measured with a sample of 23 million \B\bar B pairs collected with the BABAR detector at the PEP-II asymmetric B Factory at SLAC. In this sample, we select events in which both B mesons decay semileptonically and use the charge of the leptons to identify the flavor of each B meson. A simultaneous fit to the decay time difference distributions for opposite- and same-sign dilepton events gives $\Delta m_d = 0.493 \pm 0.012{(stat)}\pm 0.009{(syst)}$ ps$^{-1}$.Comment: 7 pages, 1 figure, submitted to Physical Review Letter

Comparative Analysis of Calcineurin Inhibitor-Based Methotrexate and Mycophenolate Mofetil-Containing Regimens for Prevention of Graft-versus-Host Disease after Reduced-Intensity Conditioning Allogeneic Transplantation

The combination of a calcineurin inhibitor (CNI) such as tacrolimus (TAC) or cyclosporine (CYSP) with methotrexate (MTX) or with mycophenolate mofetil (MMF) has been commonly used for graft-versus-host disease (GVHD) prophylaxis after reduced-intensity conditioning (RIC) allogeneic hematopoietic cell transplantation (alloHCT), but there are limited data comparing efficacy of the 2 regimens. We evaluated 1564 adult patients who underwent RIC alloHCT for acute myelogenous leukemia (AML) and acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), and myelodysplastic syndrome (MDS) from 2000 to 2013 using HLA-identical sibling (matched related donor [MRD]) or unrelated donor (URD) peripheral blood graft and received CYSP or TAC with MTX or MMF for GVHD prophylaxis. Primary outcomes of the study were acute and chronic GVHD and overall survival (OS). The study divided the patient population into 4 cohorts based on regimen: MMF-TAC, MMF-CYSP, MTX-TAC, and MTX-CYSP. In the URD group, MMF-CYSP was associated with increased risk of grade II to IV acute GVHD (relative risk [RR], 1.78; P <.001) and grade III to IV acute GVHD (RR, 1.93; P =.006) compared with MTX-TAC. In the URD group, use of MMF-TAC (versus MTX-TAC) lead to higher nonrelapse mortality. (hazard ratio, 1.48; P =.008). In either group, no there was no difference in chronic GVHD, disease-free survival, and OS among the GVHD prophylaxis regimens. For RIC alloHCT using MRD, there are no differences in outcomes based on GVHD prophylaxis. However, with URD RIC alloHCT, MMF-CYSP was inferior to MTX-based regimens for acute GVHD prevention, but all the regimens were equivalent in terms of chronic GVHD and OS. Prospective studies, targeting URD recipients are needed to confirm these results

The transverse momentum dependence of quark fragmentation functions from cascade models

de Groot EH, Engels J. The transverse momentum dependence of quark fragmentation functions from cascade models. Zeitschrift für Physik, C : particles and fields. 1979;1(1):51-59.A covariant generalization of the one-dimensional cascade model for quark fragmentation functions is presented, so as to include the transverse momentum behaviour and the possibility to produce different particles at different vertices along the chain. In the scaling limit the exact solution is given, if the primordial function is of the type [alpha] –1·T([rho][tau]). For the more general case of factorizing primordial functions an analytic expression for the seagull effect is derived, which turns out to be independent of the functionT([rho][tau])

HLA-matched allogeneic stem cell transplantation improves outcome of higher risk myelodysplastic syndrome A prospective study on behalf of SFGM-TC and GFM

International audienceAllogeneic hematopoietic stem cell transplantation (HSCT) is considered the only a curative treatment in patients with higher risk myelodysplastic syndrome (MDS), although demethylating agents (DMA) have been reported to improve survival. The advantage of HSCT over other treatment comes from retrospective studies and the aim of the current study was to prospectively test this hypothesis, analyzing in particular patients from the pre-transplant period to avoid the selection bias of performing transplantation. This study was conducted to compare overall survival in MDS patients candidates to transplantation according to donor availability. The majority of patients (76%) received a treatment with DMA after registration, 69% had a human leukocyte antigen (HLA)-identical donor, 70% of whom were transplanted. Baseline patient and disease characteristics were similar according to donor availability. Four-year overall survival was significantly better in patients with an HLA matched donor (37%) compared to patients without donor (15%). There was also evidence that this overall survival advantage was because of transplantation. Mortality risk was decreased after transplantation but it became significant only after the second year post transplant, because of early transplant-related mortality. Our results appear to justify, in higher risk MDS, a transplantation approach in all potential candidates who have an HLA identical donor