336 research outputs found
Holographic Coulomb Branch Flows with N=1 Supersymmetry
We obtain a large, new class of N=1 supersymmetric holographic flow
backgrounds with U(1)^3 symmetry. These solutions correspond to flows toward
the Coulomb branch of the non-trivial N=1 supersymmetric fixed point. The
massless (complex) chiral fields are allowed to develop vevs that are
independent of their two phase angles, and this corresponds to allowing the
brane to spread with arbitrary, U(1)^2 invariant, radial distributions in each
of these directions. Our solutions are "almost Calabi-Yau:" The metric is
hermitian with respect to an integrable complex structure, but is not Kahler.
The "modulus squared" of the holomorphic (3,0)-form is the volume form, and the
complete solution is characterized by a function that must satisfy a single
partial differential equation that is closely related to the Calabi-Yau
condition. The deformation from a standard Calabi-Yau background is driven by a
non-trivial, non-normalizable 3-form flux dual to a fermion mass that reduces
the supersymmetry to N=1. This flux also induces dielectric polarization of the
D3-branes into D5-branes.Comment: 22 pages; harvmac. Typos corrected;small improvements in presentatio
A harmonic family of dielectric flow solutions with maximal supersymmetry
We construct a new harmonic family: dielectric flow solutions with maximal
supersymmetry in eleven-dimensional supergravity. These solutions are
asymptotically AdS_4 x S^7, while in the infra-red the M2 branes are
dielectrically polarized into M5 branes. These solutions are holographically
dual to vacua of the mass deformed theory on M2 branes. They also provide an
interesting insight on the supergravity solutions sourced by giant gravitons,
allowing one to see how supergravity solves the giant graviton puzzle.Comment: 21 pages, LaTeX. reference adde
Boundary Action of N=2 Super-Liouville Theory
We derive a boundary action of N=2 super-Liouville theory which preserves
both N=2 supersymmetry and conformal symmetry by imposing explicitly and . The resulting boundary action shows a new duality
symmetry.Comment: 15 pages; One reference is adde
Hypoxia modulates platelet purinergic signalling pathways.
BACKGROUND: âHypoxia resulting from ascent to high-altitude or pathological states at sea level is known to increase platelet reactivity. Previous work from our group has suggested that this may be adenosine diphosphate (ADP)-specific. Given the clinical importance of drugs targeting ADP pathways, research into the impact of hypoxia on platelet ADP pathways is highly important.
METHODS: âOptimul aggregometry was performed on plasma from 29 lowland residents ascending to 4,700 m, allowing systematic assessment of platelet reactivity in response to several platelet agonists. Aggregometry was also performed in response to ADP in the presence of inhibitors of the two main ADP receptors, P2Y1 and P2Y12 (MRS2500 and cangrelor, respectively). Phosphorylation of vasodilator-stimulated phosphoprotein (VASP), a key determinant of platelet aggregation, was analysed using the VASPFix assay.
RESULTS: âHypobaric hypoxia significantly reduced the ability of a fixed concentration of cangrelor to inhibit ADP-induced aggregation and increased basal VASP phosphorylation. However, in the absence of P2Y receptor inhibitors, we did not find evidence of increased platelet sensitivity to any of the agonists tested and found reduced sensitivity to thrombin receptor-activating peptide-6 amide.
CONCLUSION: âOur results provide evidence of increased P2Y1 receptor activity at high altitude and suggest down-regulation of the P2Y12 pathway through increased VASP phosphorylation. These changes in ADP pathway activity are of potential therapeutic significance to high-altitude sojourners and hypoxic sea level patients prescribed platelet inhibitors and warrant further investigation
Measuring Black Hole Spin using X-ray Reflection Spectroscopy
I review the current status of X-ray reflection (a.k.a. broad iron line)
based black hole spin measurements. This is a powerful technique that allows us
to measure robust black hole spins across the mass range, from the stellar-mass
black holes in X-ray binaries to the supermassive black holes in active
galactic nuclei. After describing the basic assumptions of this approach, I lay
out the detailed methodology focusing on "best practices" that have been found
necessary to obtain robust results. Reflecting my own biases, this review is
slanted towards a discussion of supermassive black hole (SMBH) spin in active
galactic nuclei (AGN). Pulling together all of the available XMM-Newton and
Suzaku results from the literature that satisfy objective quality control
criteria, it is clear that a large fraction of SMBHs are rapidly-spinning,
although there are tentative hints of a more slowly spinning population at high
(M>5*10^7Msun) and low (M<2*10^6Msun) mass. I also engage in a brief review of
the spins of stellar-mass black holes in X-ray binaries. In general,
reflection-based and continuum-fitting based spin measures are in agreement,
although there remain two objects (GROJ1655-40 and 4U1543-475) for which that
is not true. I end this review by discussing the exciting frontier of
relativistic reverberation, particularly the discovery of broad iron line
reverberation in XMM-Newton data for the Seyfert galaxies NGC4151, NGC7314 and
MCG-5-23-16. As well as confirming the basic paradigm of relativistic disk
reflection, this detection of reverberation demonstrates that future large-area
X-ray observatories such as LOFT will make tremendous progress in studies of
strong gravity using relativistic reverberation in AGN.Comment: 19 pages. To appear in proceedings of the ISSI-Bern workshop on "The
Physics of Accretion onto Black Holes" (8-12 Oct 2012). Revised version adds
a missing source to Table 1 and Fig.6 (IRAS13224-3809) and corrects the
referencing of the discovery of soft lags in 1H0707-495 (which were in fact
first reported in Fabian et al. 2009
On the accretion disc properties in eclipsing dwarf nova EM Cyg
In this paper we analyzed the behavior of the unusual dwarf nova EM Cyg using
the data obtained in April-October, 2007 in Vyhorlat observatory (Slovak
Republic) and in September, 2006 in Crimean Astrophysical Observatory
(Ukraine). During our observations EM Cyg has shown outbursts in every 15-40
days. Because on the light curves of EM Cyg the partial eclipse of an accretion
disc is observed we applied the eclipse mapping technique to reconstruct the
temperature distribution in eclipsed parts of the disc. Calculations of the
accretion rate in the system were made for the quiescent and the outburst
states of activity for different distances.Comment: 6 pages, 3 figures, accepted in Astrophysics and Space Scienc
Genetic, abiotic and social influences on sex differentiation in cichlid fishes and the evolution of sequential hermaphroditism
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73799/1/j.1467-2979.2005.00184.x.pd
New record of Clypeasterophilus stebbingi (Rathbun, 1918) (Decapoda: Brachyura: Pinnotheridae) from the east coast of Nicaragua
Creative methods: problematics for inquiry and pedagogy in health and social care
This article provides an overview of initial discussions emerging from the Creative Methods Network, an informal organisation concerned with the use of the creative arts in research, teaching and practice in health and social care. Key issues are presented and contextualised with regard to the current conditions in which health and social care research and education is practised. Our own discussions have come to question the seeming dominance of governance within professional education programmes in which there is a primary focus on developing technical skill and capacity. Such governance often extends itself to the measurement of the implementation of these technical skills and this is set against concerns about the absence of creativity and the humanities in the educational programmes of caring for human beings. Consequently, the article reflects a view that the use of the creative arts and humanities in the education of the human caring professions is being eroded away in favour of technical-rational reasoning. It is argued that this then presents an important problem manifested in an emphasis on established and quantifiable knowledge transfer which inhibits other forms of knowledge generation. For the purposes of this discussion we have viewed this problem through the lenses offered by Foucault and Bourdieu
Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory
Data from the Pierre Auger Observatory are analyzed to search for
anisotropies near the direction of the Galactic Centre at EeV energies. The
exposure of the surface array in this part of the sky is already significantly
larger than that of the fore-runner experiments. Our results do not support
previous findings of localized excesses in the AGASA and SUGAR data. We set an
upper bound on a point-like flux of cosmic rays arriving from the Galactic
Centre which excludes several scenarios predicting sources of EeV neutrons from
Sagittarius . Also the events detected simultaneously by the surface and
fluorescence detectors (the `hybrid' data set), which have better pointing
accuracy but are less numerous than those of the surface array alone, do not
show any significant localized excess from this direction.Comment: Matches published versio
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