Symmetry Breaking in Jetting

In the bubble-jet printing process, it has been observed that the drop that ultimately pinches off from the ink jet sometimes moves sideways rather than straight relative to the symmetry axis of the liquid jet. We examined various mechanisms that might lead to the deflection of the ink drop. In particular, we focused on whether the liquid filament that connects the lead drop to the nozzle is capable of supporting lateral waves which might propagate from the nozzle toward the lead drop and break the symmetry at pinch-off

Musical Collaboration in the Films of David O. Selznick, 1932-1957.

This dissertation investigates the collaborative process of film scoring as practiced in the films of David O. Selznick, a producer whose close attention to music distinguished him from Hollywood competitors. Drawing from extensive archival research, I examine the producer's memos, composers' scores, and various correspondences to trace streams of influence that shaped the musical rhetoric of Selznick's most significant films. Close study reveals that interpretive arguments concerning these films are best grounded in a thorough knowledge of the film scores' collaborative construction. Rather than depicting Selznick as a producer-auteur who merely imposed his ideas on composers, this dissertation views the scores from his films as sites of artistic contestation in which musical decisions made before, during, and after composition alternately reflect instances of negotiation and resistance. Selznick's collaboration with composers Miklós Rózsa, Max Steiner, Dimitri Tiomkin, and Franz Waxman forms the centerpiece of this study, with select scores receiving special emphasis. Analysis of _King Kong_ (1933), _The Young in Heart_ (1938), _Gone with the Wind_ (1939), and _Rebecca_ (1940) shows Selznick's growing involvement in the film scoring process and also highlights the savvy mediation of composers and music directors. Inspection of _Symphony of Six Million_ (1932), _Little Lord Fauntleroy_ (1936), and _Since You Went Away_ (1944) further reveals Selznick's indebtedness to musical practices of the silent cinema. The scores for _Spellbound_ (1945), _The Paradine Case_ (1947), and _Portrait of Jennie_ (1948) bear intricate collaborative tensions--often involving director Alfred Hitchcock--and receive a chapter each, allowing ample space to explore the aesthetic controversies surrounding each score's production, promotion, and reception. In these chapters theoretical concerns, such as the relationship between music, subjectivity, and gender, gain nuance when set against the backdrop of creative collaboration. By considering issues of authorship and artistic control, this dissertation demonstrates that the scores for Selznick's films convey a dense polyphony of ideas, revisions, and interpolations effected by composers, music editors, directors, and producer. Scrutiny of these scores and the process of their construction illuminates rarely glimpsed facets of film music production, encouraging the scholar to reconsider the social dynamics that constitute artistic collaboration in multimedia.Ph.D.Music: MusicologyUniversity of Michigan, Horace H. Rackham School of Graduate Studieshttp://deepblue.lib.umich.edu/bitstream/2027.42/75870/1/nplatte_1.pd

Multiple Application Propfan Study (MAPS): Advanced tactical transport

This study was conducted to ascertain potential benefits of a propfan propulsion system application to a blended wing/body military tactical transport. Based on a design cruise Mach no. of 0.75 for the design mission, the results indicate a significant advantage in various figures of merit for the propfan over those of a comparable technology turbofan. Although the propfan has a 1.6 percent greater takeoff gross weight, its life cycle cost is 5.3 percent smaller, partly because of a 27 percent smaller specific fuel consumption. When employed on alternate missions, the propfan configuration offers significantly improved flexibility and capability: an increase in sea level penetration distance of more than 100 percent, or in time-on-station of 24 percent, or in deployment payload of 38 percent

Recovering piecewise smooth functions from nonuniform Fourier measurements

In this paper, we consider the problem of reconstructing piecewise smooth functions to high accuracy from nonuniform samples of their Fourier transform. We use the framework of nonuniform generalized sampling (NUGS) to do this, and to ensure high accuracy we employ reconstruction spaces consisting of splines or (piecewise) polynomials. We analyze the relation between the dimension of the reconstruction space and the bandwidth of the nonuniform samples, and show that it is linear for splines and piecewise polynomials of fixed degree, and quadratic for piecewise polynomials of varying degree

Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells

Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key transcription factor regulating a plethora of detoxifying enzymes and antioxidant genes involved in drug metabolism and defence against oxidative stress. The glucocorticoid receptor (GR) is a ligand-induced transcription factor involved in the regulation of energy supply for metabolic needs to cope with various stressors. GR activity is controlled by glucocorticoids, which are synthesized in the adrenal glands and regenerated mainly in the liver from inactive cortisone by 11β-hydroxysteroid dehydrogenase-1 (11β-HSD1).; Using transfected HEK-293 cells and hepatic H4IIE cells we show that glucocorticoids, activated by 11β-HSD1 and acting through GR, suppress the Nrf2-dependent antioxidant response. The expression of the marker genes NQO1, HMOX1 and GST2A was suppressed upon treatment of 11β-HSD1 expressing cells with cortisone, an effect that was reversed by 11β-HSD1 inhibitors. Furthermore, our results demonstrate that elevated glucocorticoids lowered the ability of cells to detoxify H(2)O(2). Moreover, a comparison of gene expression in male and female rats revealed an opposite sexual dimorphism with an inverse relationship between 11β-HSD1 and Nrf2 target gene expression.; The results demonstrate a suppression of the cellular antioxidant defence capacity by glucocorticoids and suggest that elevated 11β-HSD1 activity may lead to impaired Nrf2-dependent antioxidant response. The gender-specific differences in hepatic expression levels of 11β-HSD1 and Nrf2 target genes and the impact of pharmacological inhibition of 11β-HSD1 on improving cellular capacity to cope with oxidative stress warrants further studies in vivo

Association of Type and Location of BRCA1 and BRCA2 Mutations With Risk of Breast and Ovarian Cancer (vol 313, pg 1347, 2015)

Heli Nevanlinna ja Kristiina Aittomäki ovat CIMBA Consortium -työryhmän jäseniä.IMPORTANCE Limited information about the relationship between specific mutations in BRCA1 or BRCA2 (BRCA1/2) and cancer risk exists. OBJECTIVE To identify mutation-specific cancer risks for carriers of BRCA1/2. DESIGN, SETTING, AND PARTICIPANTS Observational study of women who were ascertained between 1937 and 2011 (median, 1999) and found to carry disease-associated BRCA1 or BRCA2 mutations. The international sample comprised 19 581 carriers of BRCA1 mutations and 11 900 carriers of BRCA2 mutations from 55 centers in 33 countries on 6 continents. We estimated hazard ratios for breast and ovarian cancer based on mutation type, function, and nucleotide position. We also estimated RHR, the ratio of breast vs ovarian cancer hazard ratios. A value of RHR greater than 1 indicated elevated breast cancer risk; a value of RHR less than 1 indicated elevated ovarian cancer risk. EXPOSURES Mutations of BRCA1 or BRCA2. MAIN OUTCOMES AND MEASURES Breast and ovarian cancer risks. RESULTS Among BRCA1 mutation carriers, 9052 women (46%) were diagnosed with breast cancer, 2317(12%) with ovarian cancer, 1041 (5%) with breast and ovarian cancer, and 7171 (37%) without cancer. Among BRCA2 mutation carriers, 6180 women (52%) were diagnosed with breast cancer, 682(6%) with ovarian cancer, 272(2%) with breast and ovarian cancer, and 4766 (40%) without cancer. In BRCA1, we identified 3 breast cancer cluster regions (BCCRs) located at c.179 to c.505 (BCCR1; RHR = 1.46; 95% Cl, 1.22-1.74; P = 2 x 10(-6)), c.4328 to c.4945 (BCCR2; RH R = 1.34; 95% Cl, 1.01-1.78; P =.04), and c. 5261 to c.5563 (BCCR2', RHR = 1.38; 95% Cl, 1.22-1.55; P = 6 x 10(-9)). We also identified an ovarian cancer cluster region (OCCR) from c.1380 to c.4062 (approximately exon 11) with RHR = 0.62 (95% Cl, 0.56-0.70; P = 9 x 10(-17)). In BRCA2, we observed multiple BCCRs spanning c.1 to c.596 (BCCR1; RHR = 1.71; 95% Cl, 1.06-2.78; P =.03), c.772 to c.1806 (BCCRI; RHR = 1.63; 95% Cl, 1.10-2.40; P =.01), and c.7394 to c.8904 (BCCR2; RHR = 2.31; 95% Cl, 1.69-3.16; P =.00002). We also identified 3 OCCRs: the first (OCCR1) spanned c.3249 to c.5681 that was adjacent to c.5946delT (6174delT; RHR = 0.51; 95% Cl, 0.44-0.60; P = 6 x 10(-17)). The second OCCR spanned c.6645 to c.7471 (OCCR2; RHR = 0.57; 95% Cl, 0.41-0.80; P =.001). Mutations conferring nonsense-mediated decay were associated with differential breast or ovarian cancer risks and an earlier age of breast cancer diagnosis for both BRCA1 and BRCA2 mutation carriers. CONCLUSIONS AND RELEVANCE Breast and ovarian cancer risks varied by type and location of BRCA1/2 mutations. With appropriate validation, these data may have implications for risk assessment and cancer prevention decision making for carriers of BRCA1 and BRCA2 mutations.Peer reviewe