A study of real-time computer graphic display technology for aeronautical applications

Hardware, algorithms and software for real-time raster graphics were designed and implemented

Determinants of OSS revenue model choices

The open source software movement is traditionally not affiliated to profit-oriented business behaviour. However, commercial activity has become increasingly common, and, business models have institutionalized in the field of open source software. The aim of this research paper is to explore the determinants of profitable revenue models for businesses based on open source software. Therefore, the study focuses on analysing different revenue options of open source software businesses as a part of more comprehensive open source software (OSS) business models. We explore other business model elements as the potential determinants of firm-level revenue model choices. This study draws on a qualitative research approach on the issue through two analytical business cases – MySQL and Red Hat – both of which illustrate the complexity and heterogeneity of solutions and options in the field of OSS. Thus, we analyse the business models of the selected case companies and identify the underlying endogenous elements, i.e. offerings, resources and relationships within them. Finally, we discuss the managerial implications derived from the cases to describe how these business model elements affect the development of successful revenue models in the field of open source software

Combining total and differential somatic cell count to better assess the association of udder health status with milk yield, composition and coagulation properties in cattle

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Älykkäät keräys- ja kuljetusratkaisut osana tulevaisuuden jätehuoltopalveluja

Tiivistelmä. Ennusteiden mukaan jätteiden määrä tulee kasvamaan tulevaisuudessa. Suomessa jätteiden määrän kasvu on ollut nopeampaa kuin bruttokansantuotteen kasvu. Se on huolestuttavaa. Tämän työn tavoitteena on tutustua Suomessa käytössä oleviin älykkäisiin ratkaisuihin, niiden toimintaan sekä vaikutuksiin jätehuollossa. Tämä työ on kirjallisuuskatsaus, jossa perehdytään neljään älykkääseen ratkaisuun tapauskohtaisesti. Tuloksien perusteella älykkäitä ratkaisuja pystyttäisiin hyödyntämään jätehuollossa. Hyödynnettävyyden laajuus ja helppous vaihtelevat tapauksien välillä.Smart collection and transport solutions as part of the waste management services of the future. Abstract. According to predictions, the amount of waste will increase in the future. In Finland, the growth of the amount of waste has been faster than the growth of the gross domestic product. It is alarming. The goal of this thesis is to get to know the intelligent solutions for waste management used in Finland, their operation, and effects. This thesis is a literature review, where four innovative solutions are oriented case by case. Based on the results, intelligent solutions could be used in waste management. The extent and ease of usability varies between cases

Drought response of modern and old oat lines in greenhouse and long-term field trials

Peer reviewe

The in vitro effects of resistin on the innate immune signaling pathway in isolated human subcutaneous adipocytes

Context: Obesity-associated inflammation is a contributory factor in the pathogenesis of type 2 diabetes mellitus (T2DM); the mechanisms underlying the progression to T2DM are unclear. The adipokine resistin has demonstrated pro-inflammatory properties in relation to obesity and T2DM. Objective: To characterize resistin expression in human obesity and address the role of resistin in the innate immune pathway. Furthermore, examine the influence of lipopolysaccharide, recombinant human resistin (rhResistin), insulin and rosiglitazone in human adipocytes. Finally, analyze the effect of rhResistin on the expression of components of the NF-κB pathway and insulin signaling cascade. Methods: Abdominal subcutaneous adipose tissue was obtained from patients undergoing elective liposuction surgery (n = 35, aged: 36-49 yr; BMI: 26.5 ± 5.9 kg/m2). Isolated adipocytes were cultured with rhResistin (10-50 ng/ml). The level of cytokine secretion from isolated adipocytes was examined by ELISA. The effect of rhResistin on protein expression of components of the innate immune pathway was examined by Western blot. Results: In-vitro studies demonstrated that antigenic stimuli increase resistin secretion (P < 0.001) from isolated adipocytes. Pro-inflammatory cytokine levels were increased in response to rhResistin (P < 0.001); this was attenuated by rosiglitazone (P < 0.01). When examining components of the innate immune pathway, rhResistin stimulated Toll-like receptor-2 protein expression. Similarly, mediators of the insulin signaling pathway, phosphospecific JNK1 and JNK2, were upregulated in response to rhResistin. Conclusion: Resistin may participate in more than one mechanism to influence pro-inflammatory cytokine release from human adipocytes; potentially via the integration of NF-κB and JNK signaling pathways

Calculus and heat flow in metric measure spaces and applications to spaces with Ricci bounds from below

This paper is devoted to a deeper understanding of the heat flow and to the refinement of calculus tools on metric measure spaces (X,d,m). Our main results are: - A general study of the relations between the Hopf-Lax semigroup and Hamilton-Jacobi equation in metric spaces (X,d). - The equivalence of the heat flow in L^2(X,m) generated by a suitable Dirichlet energy and the Wasserstein gradient flow of the relative entropy functional in the space of probability measures P(X). - The proof of density in energy of Lipschitz functions in the Sobolev space W^{1,2}(X,d,m). - A fine and very general analysis of the differentiability properties of a large class of Kantorovich potentials, in connection with the optimal transport problem. Our results apply in particular to spaces satisfying Ricci curvature bounds in the sense of Lott & Villani [30] and Sturm [39,40], and require neither the doubling property nor the validity of the local Poincar\'e inequality.Comment: Minor typos corrected and many small improvements added. Lemma 2.4, Lemma 2.10, Prop. 5.7, Rem. 5.8, Thm. 6.3 added. Rem. 4.7, Prop. 4.8, Prop. 4.15 and Thm 4.16 augmented/reenforced. Proof of Thm. 4.16 and Lemma 9.6 simplified. Thm. 8.6 corrected. A simpler axiomatization of weak gradients, still equivalent to all other ones, has been propose

Resistin-Like Molecule-β Inhibits SGLT-1 Activity and Enhances GLUT2-Dependent Jejunal Glucose Transport

International audienceOBJECTIVE: An increased expression of RELM-beta (resistin-like molecule-beta), a gut-derived hormone, is observed in animal models of insulin resistance/obesity and intestinal inflammation. Intestinal sugar absorption is modulated by dietary environment and hormones/cytokines. The aim of this study was to investigate the effect of RELM-beta on intestinal glucose absorption. RESEARCH DESIGN AND METHODS: Oral glucose tolerance test was performed in mice and rats in the presence and the absence of RELM-beta. The RELM-beta action on glucose transport in rat jejunal sacs, everted rings, and mucosal strips was explored as well as downstream kinases modulating SGLT-1 and GLUT2 glucose transporters. RESULTS: Oral glucose tolerance test carried out in rodents showed that oral administration of RELM-beta increased glycemia. Studies in rat jejunal tissue indicated that mucosal RELM-beta promoted absorption of glucose from the gut lumen. RELM-beta had no effect on paracellular mannitol transport, suggesting a transporter-mediated transcellular mechanism. In studies with jejunal mucosa mounted in Ussing chamber, luminal RELM-beta inhibited SGLT-1 activity in line with a diminished SGLT-1 abundance in brush border membranes (BBMs). Further, the potentiating effect of RELM-beta on jejunal glucose uptake was associated with an increased abundance of GLUT2 at BBMs. The effects of RELM-beta were associated with an increased amount of protein kinase C betaII in BBMs and an increased phosphorylation of AMP-activated protein kinase (AMPK). CONCLUSIONS: The regulation of SGLT-1 and GLUT2 by RELM-beta expands the role of gut hormones in short-term AMPK/protein kinase C mediated control of energy balance