Exploring the tidal response to bathymetry evolution and present-day sea level rise in a channel–shoal environment

Intertidal flats and salt marshes in channel–shoal environments are at severe risk of drowning under sea level rise (SLR) ultimately ceasing their function of coastal defense. Earlier studies indicated that these environments can be resilient against moderate SLR as their mean height is believed to correlate with tidal amplitude and mean sea level. Recent morphological analyses in the German Wadden Sea on the northwestern European continental shelf contradicted this assumption as mean tidal flat accretion surpassed relative SLR, indicating that nonlinear feedback between SLR, coastal morphodynamics, and tidal dynamics played a role. We explored this relationship in the German Wadden Sea's channel–shoal environment by revisiting the sensitivity of tidal dynamics to observed SLR and coastal bathymetry evolution over one nodal cycle (1997 to 2015) with a numerical model. We found a proportional response of tidal high and low water to SLR when the bathymetry was kept constant. In contrast, coastal bathymetry evolution caused a spatially varying hydrodynamic reaction with both increases and decreases in patterns of tidal characteristics within a few kilometers. An explorative assessment of potential mechanisms suggested that energy dissipation declined near the coast, which we related to a decreasing tidal prism and declining tidal energy import. Our study stresses the fact that an accurate representation of coastal morphology in hindcasts, nowcasts, and ensembles for bathymetry evolution to assess the impact of SLR is needed when using numerical models.</p

Balancing scientific interests and the rights of participants in designing a recall by genotype study

Recall by genotype (RbG) studies aim to better understand the phenotypes that correspond to genetic variants of interest, by recruiting carriers of such variants for further phenotyping. RbG approaches pose major ethical and legal challenges related to the disclosure of possibly unwanted genetic information. The Cooperative Health Research in South Tyrol (CHRIS) study is a longitudinal cohort study based in South Tyrol, Italy. Demand has grown for CHRIS study participants to be enrolled in RbG studies, thus making the design of a suitable ethical framework a pressing need. We here report upon the design of a pilot RbG study conducted with CHRIS study participants. By reviewing the literature and by consulting relevant stakeholders (CHRIS participants, clinical geneticists, ethics board, GPs), we identified key ethical issues in RbG approaches (e.g. complexity of the context, communication of genetic results, measures to further protect participants). The design of the pilot was based on a feasibility assessment, the selection of a suitable test case within the ProtectMove Research Unit on reduced penetrance of hereditary movement disorders, and the development of appropriate recruitment and communication strategies. An empirical study was embedded in the pilot study with the aim of understanding participants’ views on RbG. Our experience with the pilot study in CHRIS allowed us to contribute to the development of best practices and policies for RbG studies by drawing recommendations: addressing the possibility of RbG in the original consent, implementing tailored communication strategies, engaging stakeholders, designing embedded empirical studies, and sharing research experiences and methodology

Whole-body vibration training induces hypertrophy of the human patellar tendon

I Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på onlinelibrary.wiley.com / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The definitive version is available at onlinelibrary.wiley.comAnimal studies suggest that regular exposure to whole-body vibration (WBV) induces an anabolic response in bone and tendon. However, the effects of this type of intervention on human tendon properties and its influence on the muscle-tendon unit function have never been investigated. The aim of this study was to investigate the effect of WBV training on the patellar tendon mechanical, material and morphological properties, the quadriceps muscle architecture and the knee extension torque–angle relationship. Fifty-five subjects were randomized into either a vibration, an active control, or an inactive control group. The active control subjects performed isometric squats on a vibration platform without vibration. Muscle and tendon properties were measured using ultrasonography and dynamometry. Vibration training induced an increase in proximal (6.3%) and mean (3.8%) tendon cross-sectional area, without any appreciable change in tendon stiffness and modulus or in muscle architectural parameters. Isometric torque at a knee angle of 90° increased in active controls (6.7%) only and the torque–angle relation remained globally unchanged in all groups. The present protocol did not appreciably alter knee extension torque production or the musculo-tendinous parameters underpinning this function. Nonetheless, this study shows for the first time that WBV elicits tendon hypertrophy in humans.Seksjon for fysisk prestasjonsevne / Department of Physical Performanc

An integrated marine data collection for the German Bight – Part 2: Tides, salinity, and waves (1996–2015)

Marine spatial planning requires reliable data for, e.g., the design of coastal structures, research, or sea level rise adaptation. This task is particularly ambiguous in the German Bight (North Sea, Europe) because a compromise must be found between economic interests and biodiversity since the environmental status is monitored closely by the European Union. For this reason, we have set up an open-access, integrated marine data collection for the period from 1996 to 2015. It provides bathymetry, surface sediments, tidal dynamics, salinity, and waves for the German Bight and is of interest to stakeholders in science, government, and the economy. This part of a two-part publication presents data from numerical hindcast simulations for sea surface elevation, depth-averaged current velocity, bottom shear stress, depth-averaged salinity, wave parameters, and wave spectra. As an improvement to existing data collections, our data represent the variability in the bathymetry by using annually updated model topographies. Moreover, we provide data at a high temporal and spatial resolution (Hagen et al., 2020b); i.e., numerical model results are gridded to 1000 m at 20 min intervals (https://doi.org/10.48437/02.2020.K2.7000.0004). Tidal characteristic values (Hagen et al., 2020a), such as tidal range or ebb current velocity, are computed based on numerical modeling results (https://doi.org/10.48437/02.2020.K2.7000.0003). Therefore, this integrated marine data collection supports the work of coastal stakeholders and scientists, which ranges from developing detailed coastal models to handling complex natural-habitat problems or designing coastal structures.</p

Effect of trauma on asylum seekers and refugees receiving a WHO psychological intervention: a mediation model

Background: Scalable psychological interventions such as the WHO’s Self-Help Plus (SH+) have been developed for clinical and non-clinical populations in need of psychological support. SH+ has been successfully implemented to prevent common mental disorders among asylum seekers and refugees who are growing in number due to increasing levels of forced migration. These populations are often exposed to multiple, severe sources of traumatisation, and evidence of the effect of such events on treatment is insufficient, especially for non-clinical populations. Objective: We aim to study the effect of potentially traumatic experiences (PTEs) and the mediating role of symptoms of posttraumatic stress disorder (PTSD) on the improvement following SH+. Method: Participants allocated to SH+ who received at least three sessions (N = 345) were extracted from two large, randomised, European prevention trials involving asylum seekers and refugees. Measures of distress, depression, functional impairment, and post-traumatic stress symptoms were administered at baseline and 6 months post-intervention, together with measures of well-being and quality of life. Adjusted models were constructed to examine the effect of PTEs on post-intervention improvement. The possible mediating role of PTSD symptoms in this relationship was then tested. Results: Increasing numbers of PTEs decreased the beneficial effect of SH+ for all measures. This relationship was mediated by symptoms of PTSD when analysing measures of well-being and quality of life. However, this did not apply for measures of mental health problems. Conclusions: Exposure to PTEs may largely reduce benefits from SH+. PTSD symptomatology plays a specific, mediating role on psychological well-being and quality of life of participants who experienced PTE. Healthcare professionals and researchers should consider the role of PTEs and PTSD symptoms in the treatment of migrants and refugees and explore possible feasible add-on solutions for cases exposed to multiple PTEs

Asymptotics for products of characteristic polynomials in classical β\beta-Ensembles

We study the local properties of eigenvalues for the Hermite (Gaussian), Laguerre (Chiral) and Jacobi $\beta$-ensembles of $N\times N$ random matrices. More specifically, we calculate scaling limits of the expectation value of products of characteristic polynomials as $N\to\infty$. In the bulk of the spectrum of each $\beta$-ensemble, the same scaling limit is found to be $e^{p_{1}}{}_1F_{1}$ whose exact expansion in terms of Jack polynomials is well known. The scaling limit at the soft edge of the spectrum for the Hermite and Laguerre $\beta$-ensembles is shown to be a multivariate Airy function, which is defined as a generalized Kontsevich integral. As corollaries, when $\beta$ is even, scaling limits of the $k$-point correlation functions for the three ensembles are obtained. The asymptotics of the multivariate Airy function for large and small arguments is also given. All the asymptotic results rely on a generalization of Watson's lemma and the steepest descent method for integrals of Selberg type.Comment: [v3] 35 pages; this is a revised and enlarged version of the article with new references, simplified demonstations, and improved presentation. To be published in Constructive Approximation 37 (2013