Production of food-grade microcarriers based on by-products from the food industry to facilitate the expansion of bovine skeletal muscle satellite cells for cultured meat production

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Forced quantitative randomized response model: a new device

Sensitive variable, Randomized response model, Forced questions,

Effects of cardiac resynchronisation therapy in patients with heart failure having a narrow QRS Complex enrolled in PROSPECT

International audienceINTRODUCTION: Current guidelines recommend cardiac resynchronisation therapy (CRT) in patients with severe symptomatic heart failure, depressed left ventricular (LV) systolic function and a wide QRS complex (>or=120 ms). However, patients with heart failure having a narrow QRS complex might also benefit from CRT. DESIGN SETTING PATIENTS INTERVENTIONS: During the Predictors of Response to Cardiac Resynchronisation Therapy (PROSPECT) trial, 41 patients were enrolled in a 'narrow' QRS sub-study. These patients had a QRS complex <130 ms, but documented evidence of mechanical dyssynchrony by any of seven pre-defined echocardiographic measures. RESULTS: After 6 months of CRT, 26 (63.4%) patients showed improvement according to the Clinical Composite Score, 4 (9.8%) remained unchanged and 11 (26.8%) worsened. In patients with paired data, the 6-min walking distance increased from 334+/-118 m to 382+/-128 m, (p=0.003) and quality-of-life score improved from 44.2+/-19.7 to 26.8+/-20.2 (p<0.0001). Furthermore, there was a significant decrease in LV end-systolic diameter (from 59+/-9 to 55+/-12 mm, p=0.002) and in LV end-diastolic diameter (from 67+/-9 to 63+/-11 mm, p=0.007). CONCLUSION: The results suggest that CRT may have a beneficial effect in heart failure patients with a narrow QRS complex and mechanical dyssynchrony as assessed by echocardiography. The majority of patients improved on clinical symptoms, and there was an evident reduction in LV diameters. Larger studies are needed to clearly define selection criteria for CRT in patients with a narrow QRS complex

Excitation energy dependence of prompt fission γ\gamma-ray emission from 241Pu∗^{241}\mathrm{Pu}{}^{*}

International audiencePrompt fission γ rays (PFGs) resulting from the Pu240(d,pf) reaction have been measured as a function of fissioning nucleus excitation energy Ex at the Oslo Cyclotron Laboratory. We study the average total PFG multiplicity per fission, the average total PFG energy released per fission, and the average PFG energy. No significant changes in these characteristics are observed over the range 5.75<Ex<8.25 MeV. The physical implications of this result are discussed. The experimental results are compared to simulations conducted using the computational fission model FREYA. We find that FREYA reproduces the experimental PFG characteristics within 8% deviation across the Ex range studied. Previous excitation energy-dependent PFG measurements conducted below the second-chance fission threshold have large uncertainties, but are generally in agreement with our results within a 2σ confidence interval. However, both a published parametrization of the PFG energy dependence and the most recent PFG evaluation included in ENDF/B-VIII.0 were found to poorly describe the PFG excitation-energy dependence observed in this and previous experiments

The study of prompt fission <i>γ</i> rays at the Oslo Cyclotron Laboratory

International audienceThe study of prompt fission γ rays (PFGs) is crucial for understanding the energy and angular momentum distribution in fission, and over the last decade there has been an revived interest in this aspect of fission. We present the new experimental setup at the Oslo Cyclotron Laboratory for detecting PFGs resulting from charged particle-induced fission. Additionally, PFGs from the reaction 240 Pu(d,pf) were measured in April 2018, and the fission gated proton-γ coincidence spectrum is shown. In order to explore the dependence of the PFG emission on the excitation energy and angular momentum of the compound nucleus, we plan several experiments where charged particle reactions are used to induce fission in various plutonium isotopes. The final results will be compared to predictions made by the Fission Reaction Event Yield Algorithm (FREYA) in an upcoming publication, to benchmark the current modelling of both the PFGs and the fission process

The multidimensional randomized response design: Estimating different aspects of the same sensitive behavior

The conventional randomized response design is unidimensional in the sense that it measures a single dimension of a sensitive attribute, like its prevalence, frequency, magnitude, or duration. This paper introduces a multidimensional design characterized by categorical questions that each measure a different aspect of the same sensitive attribute. The benefits of the multidimensional design are (i) a substantial gain in power and efficiency, and the potential to (ii) evaluate the goodness-of-fit of the model, and (iii) test hypotheses about evasive response biases in case of a misfit. The method is illustrated for a two-dimensional design measuring both the prevalence and the magnitude of social security fraud