A Chip Off The Old Block!

A 35 year old male presented 9 months after sustaining a penetrating injury to the neck with a false aneurysm of the common carotid artery (CCA). At exploration, a 5mm piece of granite was embedded in the posterior wall of the CCA with overlying endothelialisation. He was treated with segmental resection and an interposition vein graft. Apart from the risk of foreign body embolisation at the time of the original presentation, it seems remarkable that the patient did not suffer a stroke due to embolism of thrombus that one would normally have expected to form on the highly thrombogenic stone surface

Fluvial organic carbon flux from an eroding peatland catchment, southern Pennines, UK

This study investigates for the first time the relative importance of dissolved organic carbon (DOC) and particulate organic carbon (POC) in the fluvial carbon flux from an actively eroding peatland catchment in the southern Pennines, UK. Event scale variability in DOC and POC was examined and the annual flux of fluvial organic carbon was estimated for the catchment. At the event scale, both DOC and POC were found to increase with discharge, with event based POC export accounting for 95% of flux in only 8% of the time. On an annual cycle, exports of 35.14 t organic carbon (OC) are estimated from the catchment, which represents an areal value of 92.47 g C m<sup>−2</sup> a<sup>−1</sup>. POC was the most significant form of organic carbon export, accounting for 80% of the estimated flux. This suggests that more research is required on both the fate of POC and the rates of POC export in eroding peatland catchments

Fluvial organic carbon flux from an eroding peatland catchment, southern Pennines, UK

International audienceThis study investigates for the first time the relative importance of dissolved organic carbon (DOC) and particulate organic carbon (POC) in the fluvial carbon flux from an actively eroding peatland catchment in the southern Pennines, UK. Event scale variability in DOC and POC was examined and the annual flux of fluvial organic carbon was estimated for the catchment. At the event scale, both DOC and POC were found to increase with discharge, with event based POC export accounting for 95% of flux in only 8% of the time. On an annual cycle, 40.8 t organic carbon (OC) is exported from the catchment, which represents an areal value of 107 gC m?2 a?1. POC was the most significant form of organic carbon export, accounting for ~82% of the estimated flux. This suggests that more research is required on both the fate of POC and the rates of POC export in eroding peatland catchments

Spatial variability of nitrate concentration in lakes in Snowdonia, North Wales, UK

International audienceAt a regional scale, high nitrate (NO3?) concentrations in upland surface waters generally occur in tandem with high nitrogen (N) deposition levels. However, significant differences in the patterns of surface water NO3? concentration have been observed within areas of similar N deposition yet relatively few studies have been undertaken which examine within-region variation of NO3? concentrations. A study of 76 lakes in Snowdonia, north Wales, an area of high deposition and sensitive catchments, was undertaken to assess variation in surface water NO3? concentration across a 20 x 20 km grid square and to identify catchments vulnerable to NO3? leaching. Nitrate concentrations vary considerably, particularly during winter when values range from 0.7 to 70 ?eq l-1. Although retention by vegetation and soil microbes in summer reduces the amount of NO3? reaching the lakes, 37 % of sites are characterised by NO3? concentrations greater then 4 ?eq l-1. The elevated concentrations occurring in summer suggests that N breakthrough has occurred. By examining the ratio of NO3? to total strong acid anions, it is shown that NO3? contributes significantly to freshwater acidity, particularly during the winter. Redundancy analysis shows that NO3? leaching is greatest, both in winter and summer, in catchments with high proportions of bare rock where soil and vegetation cover is limited. Nitrogen cycling in these catchments, generally at higher altitudes, may no longer be governed by seasonal biological controls. They are likely to be saturated with respect to nitrogen (i.e. incapable of further N retention) as a result of the elevated deposition levels in the area. The contribution of NO3? to acidity is also greatest at these sites. In winter, significant positive relationships are also evident between NO3? concentration and soil pH and coniferous woodland. The study demonstrates the importance of catchment factors in modifying the relationship between N deposition and N leaching in upland catchments

A new architecture for DNA-templated synthesis in which abasic sites protect reactants from degradation

The synthesis of artificial sequence-defined polymers that match and extend the functionality of proteins is an important goal in materials science. One way of achieving this is to program a sequence of chemical reactions between precursor building blocks by means of attached oligonucleotide adapters. However, hydrolysis of the reactive building blocks has so far limited the length and yield of product that can be obtained using DNA-templated reactions. Here, we report an architecture for DNA-templated synthesis in which reactants are tethered at internal abasic sites on opposite strands of a DNA duplex. We show that an abasic site within a DNA duplex can protect a nearby thioester from degradation, significantly increasing the yield of a DNA-templated reaction. This protective effect has the potential to overcome the challenges associated with programmable sequence-controlled synthesis of long non-natural polymers by extending the lifetime of the reactive building blocks

A New Architecture for DNA‐Templated Synthesis in Which Abasic Sites Protect Reactants from Degradation

The synthesis of artificial sequence‐defined polymers that match and extend the functionality of proteins is an important goal in materials science. One way of achieving this is to program a sequence of chemical reactions between precursor building blocks by means of attached oligonucleotide adapters. However, hydrolysis of the reactive building blocks has so far limited the length and yield of product that can be obtained using DNA‐templated reactions. Here, we report an architecture for DNA‐templated synthesis in which reactants are tethered at internal abasic sites on opposite strands of a DNA duplex. We show that an abasic site within a DNA duplex can protect a nearby thioester from degradation, significantly increasing the yield of a DNA‐templated reaction. This protective effect has the potential to overcome the challenges associated with programmable, sequence‐controlled synthesis of long non‐natural polymers by extending the lifetime of the reactive building blocks