Lip rounding in Amoy and Mandarin high vowels: maximum dispersion, or adequate separation

There are two hypotheses about the relationship between phonological contrasts and phonetic feature scales. Some phoneticians propose that values are chosen so that contrasting phonemes are maximally separated, e.g., Lilijencrants and Lindblom, 1972, while others claim that they need only to be adequately separated, e.g., Maddieson, 1977. This paper tests the competing hypotheses by comparing lip position in Mandarin [i], [y], [u] with that of Amoy [i] and [u]. According to adequate separation, the lip spreadness/roundness of Mandarin will be more extreme than that of Amoy, since there are three high vowels in Mandarin but only two in Amoy. According to the maximum dispersion hypothesis, the degree of roundness should be the same in both languages. Amoy and Mandarin data were collected from three bilingual speakers. The results support the Adequate Separation Theory. This paper also tests Wood's (1986) claim that in a language with two high rounded vowels, /u/ and /y/, /u/ is more rounded than /y/. The result shows that this claim is not necessarily true

The vehicle emissions and performance monitoring system: analysis of tailpipe emissions and vehicle performance

This paper describes tailpipe emission results generated by the Vehicle Performance and Emissions Monitoring system (VPEMS). VPEMS integrates on-board emissions and vehicle/driver performance measurements with positioning and communications technologies, to transmit a coherent spatio-temporally referenced dataset to a central base station in near real time. These results focus on relationships between tailpipe emissions of CO, CO2, NOx and speed and acceleration. Emissions produced by different driving modes are also presented. Results are generally as one would expect, showing variation between vehicle speed, vehicle acceleration and emissions. Data is based upon a test run in central London on urban streets with speeds not exceeding about 65 km/h. The results presented demonstrate the capabilities of the system. Various issues remain with regard to validation of the data and expansion of the system capability to obtain additional vehicle performance data

Time series analysis of local authority policy interventions on highway works durations

Highway works are highly inconvenient and disruptive for society. Accordingly, four highway policy interventions were investigated in Derby, England for potential corresponding reductions in highway works durations. Time series analysis tested the durational impacts on Highway Authority (HA) and utility industry led works. Modelling results demonstrated that a highway works management Permit Scheme (chargeable) reduced utility works durations by 5.4%; (727 work days annually). Conversely, three conflated interventions comprising: the Permit Scheme (cost-free to HAs), JCB Pothole Master deployment, and the construction direct labour organisation (DLO), did not make any statistically significant difference on HA works durations; however, introducing an automated works order management system (WOMS) reduced HA works duration by 34% (6519 work days annually). Key findings are that chargeable Permit Scheme charges can create impetus for change as demonstrated by the utility industry. Furthermore, WOMS revealed that back office efficiency can lead to on-site efficiency in works execution

Overcoming the barriers to implementing urban road user charging schemes

Urban road user charging offers the potential to achieve significant improvements in urban transport, but is notoriously difficult to implement. Cities need guidance on the range of factors to be considered in planning and implementing such schemes. This paper summarises the results of a 3 year programme which has collated evidence on the issues of most concern to cities. A state of the art report has provided evidence on 14 themes, ranging from objectives and design to implementation and evaluation. A set of 16 case studies has reviewed experience in design and implementation across Europe. The paper summarises their findings, provides references to more detailed information, presents the resulting policy recommendations to European, national and local government, and outlines the areas in which further research is needed

Case Report A Rapidly Enlarging Squamous Inclusion Cyst in an Axillary Lymph Node following Core Needle Biopsy

A 73-year-old woman was found to have a 1.7 cm axillary mass, for which a core needle biopsy was performed. The specimen revealed fragmented squamous epithelium surrounded by lymphoid tissue consistent with a squamous inclusion cyst in a lymph node, but a metastatic squamous cell carcinoma could not be excluded. Within one month, the lesion enlarged to 5 cm and was excised. Touch preparation cytology during intraoperative consultation displayed numerous single and sheets of atypical epithelioid cells with enlarged nuclei and occasional mitoses, suggesting a carcinoma. However, multinucleated giant cells and neutrophils in the background indicated reactive changes. We interpreted the touch preparation as atypical and recommended conservative surgical management. Permanent sections revealed a ruptured squamous inclusion cyst in a lymph node with extensive reactive changes. Retrospectively, the atypical epithelioid cells on touch preparation corresponded to reactive histiocytes. This is the first case report of a rapidly enlarging ruptured squamous inclusion cyst in an axillary lymph node following core needle biopsy. Our case demonstrates the diagnostic challenges related to a ruptured squamous inclusion cyst and serves to inform the readers to consider this lesion in the differential diagnosis for similar situations

Visual Analysis of Uncertainty in Trajectories

Mining trajectory datasets has many important applications. Real trajectory data often involve uncertainty due to inadequate sampling rates and measurement errors. For some trajectories, their precise positions cannot be recovered and the exact routes that vehicles traveled cannot be accurately reconstructed. In this paper, we investigate the uncertainty problem in trajectory data and present a visual analytics system to reveal, analyze, and solve the uncertainties associated with trajectory samples. We first propose two novel visual encoding schemes called the road map analyzer and the uncertainty lens for discovering road map errors and visually analyzing the uncertainty in trajectory data respectively. Then, we conduct three case studies to discover the map errors, to address the ambiguity problem in map-matching, and to reconstruct the trajectories with historical data. These case studies demonstrate the capability and effectiveness of our system. ? 2014 Springer International Publishing.EI

Expedient synthesis of an atypical oxazolidinone compound library

In order to address the current downturn in the drug discovery pipeline, initiatives are being undertaken to synthesise screening libraries of sp3-rich, low molecular weight compounds. As part of the European Lead Factory initiative, the synthesis and derivatisation of a simple hexahydrooxazolo[5,4-c]pyridin-2(1H)-one bicyclic carbamate has been achieved. The synthetic route employed involved a telescoped hetero-Diels-Alder/[2,3]-sigmatropic rearrangement/cyclisation sequence to deliver the desired core scaffold containing two points for further diversification. When applied, this synthesis was found to be robust and scalable which allowed the production of a 155 compound library