4,627 research outputs found
Cavitation of Electrons Bubbles in Liquid Helium Below saturation Pressure
We have used a Hartree-type electron-helium potential together with a density
functional description of liquid He and He to study the explosion of
electron bubbles submitted to a negative pressure. The critical pressure at
which bubbles explode has been determined as a function of temperature. It has
been found that this critical pressure is very close to the pressure at which
liquid helium becomes globally unstable in the presence of electrons. It is
shown that at high temperatures the capillary model overestimates the critical
pressures. We have checked that a commonly used and rather simple
electron-helium interaction yields results very similar to those obtained using
the more accurate Hartree-type interaction. We have estimated that the
crossover temperature for thermal to quantum nucleation of electron bubbles is
very low, of the order of 6 mK for He.Comment: 22 pages, 9 figure
On Validating an Astrophysical Simulation Code
We present a case study of validating an astrophysical simulation code. Our
study focuses on validating FLASH, a parallel, adaptive-mesh hydrodynamics code
for studying the compressible, reactive flows found in many astrophysical
environments. We describe the astrophysics problems of interest and the
challenges associated with simulating these problems. We describe methodology
and discuss solutions to difficulties encountered in verification and
validation. We describe verification tests regularly administered to the code,
present the results of new verification tests, and outline a method for testing
general equations of state. We present the results of two validation tests in
which we compared simulations to experimental data. The first is of a
laser-driven shock propagating through a multi-layer target, a configuration
subject to both Rayleigh-Taylor and Richtmyer-Meshkov instabilities. The second
test is a classic Rayleigh-Taylor instability, where a heavy fluid is supported
against the force of gravity by a light fluid. Our simulations of the
multi-layer target experiments showed good agreement with the experimental
results, but our simulations of the Rayleigh-Taylor instability did not agree
well with the experimental results. We discuss our findings and present results
of additional simulations undertaken to further investigate the Rayleigh-Taylor
instability.Comment: 76 pages, 26 figures (3 color), Accepted for publication in the ApJ
A Single Nucleotide Polymorphism in the RASGRF2 Gene Is Associated with Alcoholic Liver Cirrhosis in Men
Background
Genetic polymorphisms in the RAS gene family are associated with different diseases, which may include alcohol-related disorders. Previous studies showed an association of the allelic variant rs26907 in RASGRF2 gene with higher alcohol intake. Additionally, the rs61764370 polymorphism in the KRAS gene is located in a binding site for the let-7 micro-RNA family, which is potentially involved in alcohol-induced inflammation. Therefore, this study was designed to explore the association between these two polymorphisms and susceptibility to alcoholism or alcoholic liver disease (ALD).
Methods
We enrolled 301 male alcoholic patients and 156 healthy male volunteers in this study. Polymorphisms were genotyped by using TaqMan® PCR assays for allelic discrimination. Allelic and genotypic frequencies were compared between the two groups. Logistic regression analysis was performed to analyze the inheritance model.
Results
The A allele of the RASGRF2 polymorphism (rs26907) was significantly more prevalent among alcoholic patients with cirrhosis (23.2%) compared to alcoholic patients without ALD (14.2%). This difference remained significant in the group of patients with alcohol dependence (28.8% vs. 14.3%) but not in those with alcohol abuse (15.1% vs. 14.4%). Multivariable logistic regression analysis showed that the A allele of this polymorphism (AA or GA genotype) was associated with alcoholic cirrhosis both in the total group of alcoholics (odds ratio [OR]: 2.33, 95% confidence interval [CI]: 1.32–4.11; P = 0.002) and in the group of patients with alcohol dependence (OR: 3.1, 95% CI: 1.50–6.20; P = 0.001). Allelic distributions of the KRAS polymorphism (rs61764370) did not differ between the groups.
Conclusions
To our knowledge, this genetic association study represents the first to show an association of the RASGRF2 G>A (rs26907) polymorphism with ALD in men, particularly in the subgroup of patients with AD. The findings suggest the potential relevance of the RAS gene family in alcoholism and ALD
Anatomy of the Soft-Photon Approximation in Hadron-Hadron Bremsstrahlung
A modified Low procedure for constructing soft-photon amplitudes has been
used to derive two general soft-photon amplitudes, a two-s-two-t special
amplitude and a two-u-two-t special amplitude
, where s, t and u are the Mandelstam variables.
depends only on the elastic T-matrix evaluated at four sets
of (s,t) fixed by the requirement that the amplitude be free of derivatives
(T/s and /or T/). Likewise
depends only on the elastic T-matrix evaluated at four sets
of (u,t). In deriving these amplitudes, we impose the condition that
and reduce to and
, respectively, their tree level approximations. The
amplitude represents photon emission from a sum of
one-particle t-channel exchange diagrams and one-particle s-channel exchange
diagrams, while the amplitude represents photon
emission from a sum of one-particle t-channel exchange diagrams and
one-particle u-channel exchange diagrams. The precise expressions for
and are determined by using the
radiation decomposition identities of Brodsky and Brown. We point out that it
is theoretically impossible to describe all bremsstrahlung processes by using
only a single class of soft-photon amplitudes. At least two different classes
are required: the amplitudes which depend on s and t or the amplitudes which
depend on u and t. When resonance effects are important, the amplitude
, not , should be used. For processes with
strong u-channel exchange effects, the amplitude should be
the first choice.Comment: 49 pages report # LA-UR-92-270
The wheat ω-gliadin genes: structure and EST analysis
A survey and analysis is made of all available ω-gliadin DNA sequences including ω-gliadin genes within a large genomic clone, previously reported gene sequences, and ESTs identified from the large wheat EST collection. A contiguous portion of the Gli-B3 locus is shown to contain two apparently active ω-gliadin genes, two pseudogenes, and four fragments of the 3′ portion of ω-gliadin sequences. Comparison of ω-gliadin sequences allows a phylogenetic picture of their relationships and genomes of origin. Results show three groupings of ω-gliadin active gene sequences assigned to each of the three hexaploid wheat genomes, and a fourth group thus far consisting of pseudogenes assigned to the A-genome. Analysis of ω-gliadin ESTs allows reconstruction of two full-length model sequences encoding the AREL- and ARQL-type proteins from the Gli-A3 and Gli-D3 loci, respectively. There is no DNA evidence of multiple active genes from these two loci. In contrast, ESTs allow identification of at least three to four distinct active genes at the Gli-B3 locus of some cultivars. Additional results include more information on the position of cysteines in some ω-gliadin genes and discussion of problems in studying the ω-gliadin gene family
The "Ram Effect": A "Non-Classical" Mechanism for Inducing LH Surges in Sheep
During spring sheep do not normally ovulate but exposure to a ram can induce ovulation. In some ewes an LH surge is induced immediately after exposure to a ram thus raising questions about the control of this precocious LH surge. Our first aim was to determine the plasma concentrations of oestradiol (E2) E2 in anoestrous ewes before and after the "ram effect" in ewes that had a "precocious" LH surge (starting within 6 hours), a "normal" surge (between 6 and 28h) and "late» surge (not detected by 56h). In another experiment we tested if a small increase in circulating E2 could induce an LH surge in anoestrus ewes. The concentration of E2 significantly was not different at the time of ram introduction among ewes with the three types of LH surge. "Precocious" LH surges were not preceded by a large increase in E2 unlike "normal" surges and small elevations of circulating E2 alone were unable to induce LH surges. These results show that the "precocious" LH surge was not the result of E2 positive feedback. Our second aim was to test if noradrenaline (NA) is involved in the LH response to the "ram effect". Using double labelling for Fos and tyrosine hydroxylase (TH) we showed that exposure of anoestrous ewes to a ram induced a higher density of cells positive for both in the A1 nucleus and the Locus Coeruleus complex compared to unstimulated controls. Finally, the administration by retrodialysis into the preoptic area, of NA increased the proportion of ewes with an LH response to ram odor whereas treatment with the α1 antagonist Prazosin decreased the LH pulse frequency and amplitude induced by a sexually active ram. Collectively these results suggest that in anoestrous ewes NA is involved in ram-induced LH secretion as observed in other induced ovulators
Preparation of amino-substituted indenes and 1,4-dihydronaphthalenes using a one-pot multireaction approach: total synthesis of oxybenzo[c]phenanthridine alkaloids
Allylic trichloroacetimidates bearing a 2-vinyl or 2-allylaryl group have been designed as substrates for a one-pot, two-step multi-bond-forming process leading to the general preparation of aminoindenes and amino-substituted 1,4-dihydronaphthalenes. The synthetic utility of the privileged structures formed from this one-pot process was demonstrated with the total synthesis of four oxybenzo[c]phenanthridine alkaloids, oxychelerythrine, oxysanguinarine, oxynitidine, and oxyavicine. An intramolecular biaryl Heck coupling reaction, catalyzed using the Hermann–Beller palladacycle was used to effect the key step during the synthesis of the natural products
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