Pengaruh Relaksasi Otot Progresif Terhadap Penurunan Tingkat Kecemasan pada Pasien Pre Operasi Di Ruang Wijaya Kusuma Rsud Dr. R Soeprapto Cepu

Kecemasan merupakan respon adaptif yang normal terhadap stress karena pembedahan. Rasacemas biasanya timbul pada tahap preoperatif ketika pasien mengantisipasi pembedahannya.Untuk mengurangi kecemasan dapat diatasi dengan menggunakan tehnik relaksasi, salahsatunya adalah dengan relaksasi otot progresif.Tujuan umum dalam penelitian ini adalah untuk mengetahui pengaruh relaksasi otot progresifterhadap penurunan tingkat kecemasan pada pasien preoperasi di Ruang Wijaya Kusuma RSUDDr. R Soeprapto Cepu.Penelitian ini dilakukan pada tanggal 13 Januari-13 Februari 2014. Jenis penelitian denganmenggunakan Quasi-Experimentone group pre test post test design. Teknik sampling yangdigunakan adalah purposive sampling dengan sampel sejumlah 25 responden.Penelitimenggunakan lembar observasi untuk relaksasi otot progresif. Sedangkan pengukuran tingkatkecemasan menggunakan skala HARS (Hamilton Anxienty Rating Scale).Hasil uji Marginal Homogenity didapatkan nilai p 0,000 (<0,05) yang berarti ada pengaruhrelaksasi otot progresif terhadap penurunan tingkat kecemasan pada pasien preoperasi di RuangWijaya Kusuma RSUD Dr. R Soeprapto Cepu, Sehingga disarankan pasien diharapkan mampumelakukannya sendiri dalam pelaksanaan relaksasi otot progresif untuk mengatasi kecemasanyang muncul sewaktu-waktu saat akan dilakukan tindakan operasi

Studi Farmakovigilans Penggunaan Obat Antiretriviral di Puskesmas Semarang

The increase in cases of the HIV epidemic in Indonesia at the end of 2009 continued to increase, it is estimated that around 332.200 people are living with HIV. This figure has almost doubled from 2005 as many as 170.000 people living with HIV. Provision of extensive anti-retroviral therapy (ART) also result in mutations of the HIV virus that can lead to resistance. The purpose of this study was to determine the description and incidence of unwanted drug reactions in patients who were prescribed antiretroviral drugs and to assess the quality of life of patients who had received anti-retroviral drug prescriptions at the public health center. This type of research is a descriptive observational study, data collection was carried out retrospectively on patients who received herbal medicine at the public health center. The sampling technique in this study was quota sampling with a research instrument in the form of ROTD interview sheets taken from the Naranjo algorithm. The results showed that the use of antiretroviral drugs (ARVs) would cause unwanted drug reactions such as nausea, vomiting, dizziness (vertigo) which were categorized as possibilities and possibilities. &nbsp; &nbsp; &nbsp; &nbsp;Kasus epidemi HIV di Indonesia pada tahun 2015 jumlah penderita yang terinfeksi HIV sebanyak 30.935 jiwa hingga tahun 2019 meningkat sebanyak 50.282 kasus baru. Pemberian Anti Retroviral Therapy (ART) memiliki dampak interaksi dan efek samping obat dalam jangka waktu yang lama. Meningkatnya efek samping obat dipengaruhi adanya perubahan mitokondria yang mengalami disfungsi serebrovaskular dan metabolism obat yang besar oleh enzim golongan sitokrom P450. Tujuan Penelitian yaitu untuk mengetahui gambaran dan kejadian reaksi obat yang tidak diinginkan pada pasien yang diberikan resep obat antiretroviral di puskesmas. Jenis penelitian ini merupakan penelitian observasional deskriptif, pengambilan data dilakukan secara prospektif pada pasien yang menerima obat HIV di Puskesmas. Populasi penelitian ini berjumlah 10 pasien yang telah memenuhi kriteria inklusi dan ekslusi. Teknik pengambilan sampel dalam penelitian ini adalah quota sampling dengan instrumen penelitian berupa lembar wawancara ROTD yang diambil dari algoritma Naranjo. Hasil penelitian menunjukkan bahwa penggunaan obat antiretroviral (ARV) dapat menimbulkan reaksi obat yang tidak diinginkan (ROTD) seperti mual, muntah, pusing (vertigo) pada 10 pasien dan masuk kategori probable sebesar 70% dan possible sebesar 30%. &nbsp; Kata kunci: Farmakovigilans, Antiretroviral (ARV), Reaksi obat yang tidak diinginkan (ROTD) &nbsp; &nbsp; &nbsp

Pendampingan Program Farkom (Farmakology and Complementary Therapy) Untuk Pasien dan Keluarga Penderita Kanker Payudara

Breast cancer patients need to get palliative care to improve their quality of life. Family existence becomes an important role for breast cancer sufferers to fulfill physical and psychological health. Palliative care can be given to patients in the form of complementary and pharmacological therapy (FARKOM). FARKOM's community service program aims to improve family knowledge and abilities in the care of family members with breast cancer and support for taking medication control. The target of this community service activity is to involve five families with breast cancer members in the Bandarharjo Village. The methods of this activity include lectures on the Farkom program (Pharmacology and complementary therapy), demonstrations of progressive muscle relaxation techniques and how to make beetroot juice, simulations by grouping participants according to family members and practicing, then monitoring and evaluating related to the Farkom program. Based on the pre-test and post-test results after being given treatment, there was an increase in the percentage value, namely a 25% increase in progressive muscle relaxation exercises, herbal juice production increased 30% and monitor filling schedule for taking medication increased 30%. Thus, this mentoring activity can be said to be successful because it can increase the knowledge and ability of participants in participating in community service activities

ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE Xestospongia sp.

Plasmodium falciparum, the agent of malignant malaria, is one of mankind\u27s most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite\u27s rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 pg/mL. A compiled spectrum analysis, FTIR, 11-1-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as fiavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen. Plasmodium falciparum adalah parasit penyebab utama penyakit malaria, yang merupakan salah sate penyakit terparah di negara-negara tropis. Sayangnya, upaya pengembangan vaksin preventif atau abet remedial lainnya sedang menghadapi kendala besar karena cepatnya evolusi resistensi obat malaria. Berikut, kami ketengahkan hasil riset kali ini tentang uji aktivitas antimalaria dari spons laut Xestospongia sp. yang diekstraksi dengan menggunakan pelarut n-heksana. Hasil pengamatan menghasilkan lima fraksi. Hasil identifikasi menggunakan FT1R, \u27H-NMR dan GC-MS, menunjukkan bahwa fraksi keempat menghasilkan daya hambat tertinggi terhadap pertumbuhan P. falciparum 3D7 (IC50: 7.13 pg/mL). Dapat kami laporkan pula bahwa fraksi keempat terdeteksi mengandung senyawa metabofit sekunder, flavonoid dan triterpenoid. Terakhir, penelitian ini menghasilkan suatu struktur dugaan dengan basal ibuprofen

ISOLATION AND PRESENCE OF ANTIMALARIAL ACTIVITIES OF MARINE SPONGE <i>Xestospongia</i> sp.

Plasmodium falciparum, the agent of malignant malaria, is one of mankind's most severe scourges, mainly in the tropic world. Efforts to develop preventive vaccines or remedial drugs are handicapped by the parasite's rapid evolution of drug resistance. Here, we presented an advance work on examination of antimalarial component from marine life of Xestospongia sp., the study is based on hexane extraction method. The premier result, we obtained five fractions. Among these five fractions, the fourth has the most potent inhibitory against the growth of P. falciparum 3D7 with an IC50: 7.13 µg/mL. A compiled spectrum analysis, FTIR, 1H-NMR and GC-MS, revealed that the fourth fraction consisted abundantly of two secondary metabolites such as flavonoids and triterpenoids. Finally, our results suggest a plausible structure rooted to the base of ibuprofen

Impact on Medical Education and the Medical Student’s Attitude, Practice, Mental Health, After One Year of the Covid-19 Pandemic in Indonesia

Introduction: The COVID-19 pandemic has caused disruptions in educational institutions across the country, prompting medical schools to adopt online learning systems. This study aims to determine impact on medical education and the medical student’s attitude, practice, mental health after 1 year of the Covid-19 pandemic in Indonesia. Methods: This study utilized a cross-sectional design. An online questionnaire was distributed digitally to 49 medical schools in Indonesia from February–May 2021. A total of 7,949 medical students participated in this study. Sampling was carried out based on a purposive technique whose inclusion criteria were active college students. This research used questionnaires distributed in online version among 49 medical faculties that belong to The Association of Indonesian Private Medical Faculty. Instruments included demographic database, medical education status, experience with medical tele-education, ownership types of electronic devices, availability of technologies, programs of education methods, career plans, attitudes toward pandemic, and the mental health of respondents. Univariate and bivariate statistical analysis was conducted to determine the association of variables. All statistical analyses using (IBM) SPSS version 22.0. Results: Most of the respondents were female (69.4%), the mean age was 20.9 � 2.1 years. More than half of the respondents (58.7%) reported that they have adequate skills in using digital devices. Most of them (74%) agreed that e-learning can be implemented in Indonesia. The infrastructure aspects that require attention are Internet access and the type of supporting devices. The pandemic also has an impact on the sustainability of the education program. It was found that 28.1% were experiencing financial problems, 2.1% postponed their education due to this problems. The delay of the education process was 32.6% and 47.5% delays in the clinical education phase. Around 4% student being sick, self-isolation and taking care sick family. the pandemic was found to affect students’ interests and future career plans (34%). The majority of students (52.2%) are concerned that the pandemic will limit their opportunities to become specialists. Nearly 40% of respondents expressed anxiety symptoms about a variety of issues for several days. About a third of respondents feel sad, depressed, and hopeless for a few days. Results: Most of the respondents were female (69.4%), the mean age was 20.9 � 2.1 years. More than half of the respondents (58.7%) reported that they have adequate skills in using digital devices. Most of them (74%) agreed that e-learning can be implemented in Indonesia. The infrastructure aspects that require attention are Internet access and the type of supporting devices. The pandemic also has an impact on the sustainability of the education program. It was found that 28.1% were experiencing financial problems, 2.1% postponed their education due to this problems. The delay of the education process was 32.6% and 47.5% delays in the clinical education phase. Around 4% student being sick, self-isolation and taking care sick family. the pandemic was found to affect students’ interests and future career plans (34%). The majority of students (52.2%) are concerned that the pandemic will limit their opportunities to become specialists. Nearly 40% of respondents expressed anxiety symptoms about a variety of issues for several days. About a third of respondents feel sad, depressed, and hopeless for a few days. Conclusion: The infrastructure and competency of its users are required for E-learning to be successful. The majority of medical students believe that e-learning can be adopted in Indonesia and that their capacity to use electronic devices is good. However, access to the internet remains a problem. On the other side, the pandemic has disrupted the education process and mental health, with fears of being infected with SARSCoV- 2, the loss of opportunities to apply for specialty training, and the potential for increased financial difficulties among medical students. Our findings can be used to assess the current educational process in medical schools and maximize e-learning as an alternative means of preparing doctors for the future. Keywords: COVID-19, e-learning, Indonesia, medical education, student

PENGARUH EKSTRAK ETANOLIK BUAH PARIJOTO (Medinilla speciosa Blume) TERHADAP KADAR GULA DARAH DAN FUNGSI SEKSUAL TIKUS JANTAN GALUR WISTAR MODEL DIABETES MELLITUS KRONIK

ABSTRACTChronic diabetes mellitus is a disease of increased blood glucose levels in a long time so that it can affect sexual function such as damage spermatogenesis and aphrodisiac function. Parijoto has flavonoid content. This study aimed to determine the effect of ethanolic extract of parijoto (Medinilla speciosa Blume) fruit in blood glucose level and the sexual function in alloxan-induced diabetic male rats. The design of the study was post test only control group design, 25 male wistar rats aged 2 months with BB 100-200 gram divided into 5 groups. Group 1 (normal control), group 2 (negative control) induced alloxan 100mg / kgBB, groups 3, 4, and 5 were alloxan induced and administered EEBP at doses of 100 mg / kgBW, 250 mg / kgBW, and 500 mg / kgBW. Alloxan-induced rats were left for 4 weeks to achieve chronic DM. Data analysis of blood glucose level and spermatozoa quality using one way anova followed by LSD post hoc. While aphrodisiac of introducing and climbing using one way anova continued by LSD and coitus using kruskal wallis. The results showed that there were significant differences between negative control with normal group, III, IV, and V. The effect of ethanolic extract of parijoto fruit on blood glucose level and sexual function in alloxan-induced diabetic male rats showed no difference between treatment group of 100 mg / kgBW with negative group, and there were significant differences between treatment group of 250 mg / kgBW and 500 mg / kgBW with negative group. Ethanolic extract of parijoto fruit at dose 250 mg / kgBB and 500 mg / kgBB decrease blood glucose level, improve and increase sexual function in alloxan-induced diabetic male rats

Penjualan kredit sepeda motor Honda pada event (Februari-Maret) PT. FIF Bandar Lampung 2009 [Laporan Akhir]

Bibl. 41v, 41 hlm. : il. 28 cm. -- Lamp. (7 lembar

Pengaruh Relaksasi Otot Progresif Terhadap Penurunan Tingkat Kecemasan pada Pasien Pre Operasi Di Ruang Wijaya Kusuma Rsud Dr. R Soeprapto Cepu

Kecemasan merupakan respon adaptif yang normal terhadap stress karena pembedahan. Rasacemas biasanya timbul pada tahap preoperatif ketika pasien mengantisipasi pembedahannya.Untuk mengurangi kecemasan dapat diatasi dengan menggunakan tehnik relaksasi, salahsatunya adalah dengan relaksasi otot progresif.Tujuan umum dalam penelitian ini adalah untuk mengetahui pengaruh relaksasi otot progresifterhadap penurunan tingkat kecemasan pada pasien preoperasi di Ruang Wijaya Kusuma RSUDDr. R Soeprapto Cepu.Penelitian ini dilakukan pada tanggal 13 Januari-13 Februari 2014. Jenis penelitian denganmenggunakan Quasi-Experimentone group pre test post test design. Teknik sampling yangdigunakan adalah purposive sampling dengan sampel sejumlah 25 responden.Penelitimenggunakan lembar observasi untuk relaksasi otot progresif. Sedangkan pengukuran tingkatkecemasan menggunakan skala HARS (Hamilton Anxienty Rating Scale).Hasil uji Marginal Homogenity didapatkan nilai p 0,000

EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN PNEUMONIA DI RSUP Dr. SARDJITO YOGYAKARTA (STUDI KASUS PASIEN RAWAT INAP PADA PERIODE FEBRUARI � MEI 2013)

Pneumonia is an infection in the bronchial and alveolar edge that can be caused by various pathogens such as bacteria, fungi, viruses and parasites. Most of the treatment of pneumonia carried antibotik treatment with empirical approach, using antibiotics that have a broad spectrum with the aim that the selected antibiotic can fight a number of possible causes of infectious pathogens. Though unwitting use of broad-spectrum antibiotics are not controlled very possibly create unwanted problems such as the emergence of drug side effects and the potential for resistance. This study is an observational analytic, where the data required and collected prospectively for pneumonia in hospitalized patients in internal medicine wards Hospital Dr. Sardjito Yogyakarta from February - May 2013. Effectiveness of antibiotics against pneumonia patients based on observations of the development of the patient's clinical response using objective and subjective parameters. Results showed that antibiotic therapy in patients hospitalized pneumonia in Hospital Dr, Sardjito Yogyakarta experienced clinical improvement or recovery based on information out of the hospital as much as 72.4% and as much as 58.6% of pneumonia patients received therapy according to the standard therapy of pneumonia