Designed and emergent tectonics: resituating architectural knowledge

Architecture is usually defined through intent while cities come into being out of multiple human actions over a long period of time. This seems to trap us between a view of architecture as authored object, and a view of the city as authorless, evolutionary process. The debate about the autonomous and the contingent object thus, goes back to the separation of architecture from its skill base in craft and building practice that took place in the Renaissance. This separation also includes the operations through which buildings and cities are produced by designers, clients, users, regulatory codes, markets and infrastructures. The resurgence in the debate on the competing claims of autonomy and contingency testifies that since the Renaissance we have failed to develop theories and techniques that address the relationship between authored architecture and authorless contexts. As a result, coupled with commercial forces, recent advancements in digital technology and complexity theory claim architecture and the city as self-organization, dismantling architecture and depriving it from relevance in shaping social capital. If in the Renaissance, architecture was separated from the city, which was the relationship between the ways in which a city was built and the urban fabric? How can we better understand the relationship between the architectural project and the processes that configure the urban structure in which it is situated? This paper argues that for architecture to reclaim its scope as a social discipline it needs to theorise its relationship with the social, the political and the economic processes of its context

The Anatomy of Knowledge: Quantitative and Qualitative Analysis of the Evolution of Ideas in Space Syntax Conference Articles (1997-2017)

Since its inception in the 1970s, space syntax has matured into a theory and a method comprising a set of recurring theoretical and analytical concepts, as well as new ones emerging through the years. How can we trace the evolution of the field through language? How can we analyse the development of ideas in space syntax research? What can we learn from this evolution about knowledge creation in this area? Recognising that language is central to the development of ideas in any field, this paper uses automated text-analyses, focusing more specifically on all papers published in the space syntax symposia proceedings from 1997 to 2017. The purpose is to trace the trajectory of ideas as they were elaborated, used and perhaps changed in the collective work of authors researching within this field in different parts of the world. Firstly, we identify concepts and technical terminology in the field through a combined quantitative and qualitative text analysis. Secondly, we statistically assess the use of these terms, revealing patterns and trends in the evolution of knowledge in space syntax. Thirdly, we compare patterns between established concepts and categories that stabilise over time with concepts emerging more recently. The results from our analysis of networks of concept relationships suggest that: (i) concepts and terms evolve in dependent trajectories; (ii) ideas have evolutionary developments, with some emerging and gaining growing attention, while others showing clear signs of stability, and others losing centrality over time, including networks of what can be termed as ‘canonical’ concepts. We have also identified (iii) an overall decline in the use of early space syntax concepts rooted in social theory and anthropology; (iv) a trend of decreasing conceptual novelty over time; (v) traces of increasing influence by other fields; and finally (vi) signs of a clear ‘technological turn’ in the field

Understanding the City as a Whole: An Integrative Analysis of Rio de Janeiro and its Informal Settlements

Informal settlements are an increasing global phenomenon. Since the mid-century Rio de Janeiro went through a series of paradigmatic changes, trying to cope with this phenomenon. The scope of these interventions ranged from entire eradications of these settlements in the 1960s to present in situ programmes of infrastructural upgrades. Up to now favelas are seen as independent parts of the city, spatial manifestations of urban poverty and intra-urban inequality in the need to be solved. Even recent attempts to integrate favelas socially and spatially with the city failed to remove the physical and conceptual boundaries between the formal and the informal. Underlying these approaches is the perception of those areas as something different, rather than an integral element of the complex urban system. Trying to overcome the fragmentation of the city this study combines formal and informal parts into an integrated model of the whole city. Following a syntactical analysis using GIS mapping and space syntax, this study explores the morphology of favelas in the context of metropolitan Rio throughout different scales and in relation to their topographic location. 60 different local areas are then selected and compared against each other according to their configurational characteristics. The analytic results highlight the affordances and constrains of informal and formal structures. Understanding the particularities of those two differently perceived systems and the ways in which they interact with each other can inform future analysis and policymaking

The triterpene echinocystic acid and its 3-O-glucoside derivative are revealed as potent and selective glucocorticoid receptor agonists

Glucocorticoids are steroid hormones widely used to control many inflammatory conditions. These effects are primarily attributed to glucocorticoid receptor transrepressional activities but with concomitant receptor transactivation associated with considerable side effects. Accordingly, there is an immediate need for selective glucocorticoid receptor agonists able to dissociate transactivation from transrepression. Triterpenoids have structural similarities with glucocorticoids and exhibit anti-inflammatory and apoptotic activities via mechanisms that are not well-defined. In this study, we examined whether echinocystic acid and its 3-O-glucoside derivative act, at least in part, through the regulation of glucocorticoid receptor and whether they can constitute selective receptor activators. We showed that echinocystic acid and its glucoside induced glucocorticoid receptor nuclear translocation by 75% and 55%. They suppressed the nuclear factor-kappa beta transcriptional activity by 20% and 70%, respectively, whereas they have no glucocorticoid receptor transactivation capability and stimulatory effect on the expression of the phosphoenolopyruvate carboxykinase target gene in HeLa cells. Interestingly, their suppressive effect is diminished in glucocorticoid receptor low level COS-7 cells, verifying the receptor involvement in this process. Induced fit docking calculations predicted favorable binding in the ligand binding domain and structural characteristics which can be considered consistent with the experimental observations. Further, glucocorticoids exert apoptotic activities; we have demonstrated here that the echinocystic acids in combination with the synthetic glucocorticoid, dexamethasone, induce apoptosis. Taken together, our results indicate that echinocystic acids are potent glucocorticoid receptor regulators with selective transrepressional activities (dissociated from transactivation), highlighting the potential of echinocystic acid derivatives as more promising treatments for inflammatory conditions

SpaceGates Academy: teaching science communication and outreach of astronomy, planetary and space science to physics students

Science Communication and Societ

Sometimes Sperm Whales (Physeter macrocephalus) Cannot Find Their Way Back to the High Seas: A Multidisciplinary Study on a Mass Stranding

BACKGROUND: Mass strandings of sperm whales (Physeter macrocephalus) remain peculiar and rather unexplained events, which rarely occur in the Mediterranean Sea. Solar cycles and related changes in the geomagnetic field, variations in water temperature and weather conditions, coast geographical features and human activities have been proposed as possible causes. In December 2009, a pod of seven male sperm whales stranded along the Adriatic coast of Southern Italy. This is the sixth instance from 1555 in this basin. METHODOLOGY/PRINCIPAL FINDINGS: Complete necropsies were performed on three whales whose bodies were in good condition, carrying out on sampled tissues histopathology, virology, bacteriology, parasitology, and screening of veins looking for gas emboli. Furthermore, samples for age determination, genetic studies, gastric content evaluation, stable isotopes and toxicology were taken from all the seven specimens. The animals were part of the same group and determined by genetic and photo-identification to be part of the Mediterranean population. Causes of death did not include biological agents, or the "gas and fat embolic syndrome", associated with direct sonar exposure. Environmental pollutant tissue concentrations were relatively high, in particular organochlorinated xenobiotics. Gastric content and morphologic tissue examinations showed a prolonged starvation, which likely caused, at its turn, the mobilization of lipophilic contaminants from the adipose tissue. Chemical compounds subsequently entered the blood circulation and may have impaired immune and nervous functions. CONCLUSIONS/SIGNIFICANCE: A multi-factorial cause underlying this sperm whales' mass stranding is proposed herein based upon the results of postmortem investigations as well as of the detailed analyses of the geographical and historical background. The seven sperm whales took the same "wrong way" into the Adriatic Sea, a potentially dangerous trap for Mediterranean sperm whales. Seismic surveys should be also regarded as potential co-factors, even if no evidence of direct impact has been detected

Sensing the ocean biological carbon pump from space: A review of capabilities, concepts, research gaps and future developments

The element carbon plays a central role in climate and life on Earth. It is capable of moving among the geosphere, cryosphere, atmosphere, biosphere and hydrosphere. This flow of carbon is referred to as the Earth’s carbon cycle. It is also intimately linked to the cycling of other elements and compounds. The ocean plays a fundamental role in Earth’s carbon cycle, helping to regulate atmospheric CO2 concentration. The ocean biological carbon pump (OBCP), defined as a set of processes that transfer organic carbon from the surface to the deep ocean, is at the heart of the ocean carbon cycle. Monitoring the OBCP is critical to understanding how the Earth’s carbon cycle is changing. At present, satellite remote sensing is the only tool available for viewing the entire surface ocean at high temporal and spatial scales. In this paper, we review methods for monitoring the OBCP with a focus on satellites. We begin by providing an overview of the OBCP, defining and describing the pools of carbon in the ocean, and the processes controlling fluxes of carbon between the pools, from the surface to the deep ocean, and among ocean, land and atmosphere. We then examine how field measurements, from ship and autonomous platforms, complement satellite observations, provide validation points for satellite products and lead to a more complete view of the OBCP than would be possible from satellite observations alone. A thorough analysis is then provided on methods used for monitoring the OBCP from satellite platforms, covering current capabilities, concepts and gaps, and the requirement for uncertainties in satellite products. We finish by discussing the potential for producing a satellite-based carbon budget for the oceans, the advantages of integrating satellite-based observations with ecosystem models and field measurements, and future opportunities in space, all with a view towards bringing satellite observations into the limelight of ocean carbon research

Ocean carbon from space: Current status and priorities for the next decade

This is the final version. Available on open access from Elsevier via the DOI in this recordData availability: Data for Fig. 1a were generated from a free Scopus (https://www.scopus.com/) search of the terms "Ocean carbon satellite" (using All fields) in March 2022. Data from Fig. 1b and 1c were generated from the workshop registration and are available within the figure (participation number, geographical representation and gender split).The ocean plays a central role in modulating the Earth’s carbon cycle. Monitoring how the ocean carbon cycle is changing is fundamental to managing climate change. Satellite remote sensing is currently our best tool for viewing the ocean surface globally and systematically, at high spatial and temporal resolutions, and the past few decades have seen an exponential growth in studies utilising satellite data for ocean carbon research. Satellite-based observations must be combined with in-situ observations and models, to obtain a comprehensive view of ocean carbon pools and fluxes. To help prioritise future research in this area, a workshop was organised that assembled leading experts working on the topic, from around the world, including remote-sensing scientists, field scientists and modellers, with the goal to articulate a collective view of the current status of ocean carbon research, identify gaps in knowledge, and formulate a scientific roadmap for the next decade, with an emphasis on evaluating where satellite remote sensing may contribute. A total of 449 scientists and stakeholders participated (with balanced gender representation), from North and South America, Europe, Asia, Africa, and Oceania. Sessions targeted both inorganic and organic pools of carbon in the ocean, in both dissolved and particulate form, as well as major fluxes of carbon between reservoirs (e.g., primary production) and at interfaces (e.g., air-sea and land–ocean). Extreme events, blue carbon and carbon budgeting were also key topics discussed. Emerging priorities identified include: expanding the networks and quality of in-situ observations; improved satellite retrievals; improved uncertainty quantification; improved understanding of vertical distributions; integration with models; improved techniques to bridge spatial and temporal scales of the different data sources; and improved fundamental understanding of the ocean carbon cycle, and of the interactions among pools of carbon and light. We also report on priorities for the specific pools and fluxes studied, and highlight issues and concerns that arose during discussions, such as the need to consider the environmental impact of satellites or space activities; the role satellites can play in monitoring ocean carbon dioxide removal approaches; economic valuation of the satellite based information; to consider how satellites can contribute to monitoring cycles of other important climatically-relevant compounds and elements; to promote diversity and inclusivity in ocean carbon research; to bring together communities working on different aspects of planetary carbon; maximising use of international bodies; to follow an open science approach; to explore new and innovative ways to remotely monitor ocean carbon; and to harness quantum computing. Overall, this paper provides a comprehensive scientific roadmap for the next decade on how satellite remote sensing could help monitor the ocean carbon cycle, and its links to the other domains, such as terrestrial and atmosphere.European Space AgencySimons FoundationUK National Centre for Earth Observation (NCEO)UKRIAtlantic Meridional Transect ProgrammeSwiss National Science Foundatio