Prospects for intranasal drug delivery systems with Ginkgo biloba in the treatment of cerebral circulatory disorders

Purpose: To analyze the range of currently available nasal medicines, and to study extant information on the use of Ginkgo biloba herbal complexes for the treatment of cerebral circulatory disorders of different etiologies. The study dwelt on the features and prospects of intranasal drug administration. Currently, intranasal administration is used primarily for the treatment of local symptoms. However, it has a much higher potential: the mucous membrane of the nasal cavity offers an opportunity for noninvasive treatment using systemic administration. Methods: The study involved the analysis of materials from information-retrieval systems, library databases, patent databases, and scientific information repositories such as e-Library. PubMed, Scopus, Google Scholar, as well as materials from the websites of manufacturers of herbal medicinal products and other herbal substances. Results: Herbal medicinal products have great potential in terms of intranasal administration. This is especially true of herbal medicines obtained through extraction of leaves of Ginkgo biloba, which have a broad spectrum of action, i.e., anti-aggregatory, venotonic, nootropic, anti-hypoxic, antioxidant, antiinflammatory, membrane-stabilizing, and capillary-protective effects. The range of Ginkgo biloba-based medicines calls for expansion, and this testifies to a good potential of these products in terms of further research and use. The analysis of literature and technical information showed the existence of a wide range of nasal medicines currently in use. However, only few drugs are used for the treatment of cerebrovascular diseases. Furthermore, there are no herbal medicines among these drugs, despite obvious advantages of herbal products such as ease of use, high bioavailability, and systemic action potential. Conclusion: The current status of research on nasal dosage forms of Ginkgo biloba herbal complexes warrants further development involving biopharmaceutical and pharmacological studies

Measurement of W Polarisation at LEP

The three different helicity states of W bosons produced in the reaction e+ e- -> W+ W- -> l nu q q~ at LEP are studied using leptonic and hadronic W decays. Data at centre-of-mass energies \sqrt s = 183-209 GeV are used to measure the polarisation of W bosons, and its dependence on the W boson production angle. The fraction of longitudinally polarised W bosons is measured to be 0.218 \pm 0.027 \pm 0.016 where the first uncertainty is statistical and the second systematic, in agreement with the Standard Model expectation

Measurement of W Polarisation at LEP

The three different helicity states of W bosons produced in the reaction e+ e- -> W+ W- -> l nu q q~ at LEP are studied using leptonic and hadronic W decays. Data at centre-of-mass energies \sqrt s = 183-209 GeV are used to measure the polarisation of W bosons, and its dependence on the W boson production angle. The fraction of longitudinally polarised W bosons is measured to be 0.218 \pm 0.027 \pm 0.016 where the first uncertainty is statistical and the second systematic, in agreement with the Standard Model expectation

Study of the e+e- -> Ze+e- process at LEP

The cross section of the process e+e- -> Ze+e is measured with 0.7fb^-1 of data collected with the L3 detector at LEP. Decays of the Z boson into quarks and muons are considered at centre-of-mass energies ranging from 183GeV up to 209GeV. The measurements are found to agree with Standard Model predictions, achieving a precision of about 10% for the hadronic channel

Lambda and Sigma0 Pair Production in Two-Photon Collisions at LEP

Strange baryon pair production in two-photon collisions is studied with the L3 detector at LEP. The analysis is based on data collected at e+e- centre-of-mass energies from 91 GeV to 208 GeV, corresponding to an integrated luminosity of 844 pb-1. The processes gamma gamma -> Lambda Anti-lambda and gamma gamma -> Sigma0 Anti-sigma0 are identified. Their cross sections as a function of the gamma gamma centre-of-mass energy are measured and results are compared to predictions of the quark-diquark model

Search for a Higgs Boson Decaying to Weak Boson Pairs at LEP

A Higgs particle produced in association with a Z boson and decaying into weak boson pairs is searched for in 336.4 1/pb of data collected by the L3 experiment at LEP at centre-of-mass energies from 200 to 209 GeV. Limits on the branching fraction of the Higgs boson decay into two weak bosons as a function of the Higgs mass are derived. These results are combined with the L3 search for a Higgs boson decaying to photon pairs. A Higgs produced with a Standard Model e+e- --> Zh cross section and decaying only into electroweak boson pairs is excluded at 95% CL for a mass below 107 GeV

Bose-Einstein Correlations of Neutral and Charged Pions in Hadronic Z Decays

Bose-Einstein correlations of both neutral and like-sign charged pion pairs are measured in a sample of 2 million hadronic Z decays collected with the L3 detector at LEP. The analysis is performed in the four-momentum difference range 300 MeV < Q < 2 GeV. The radius of the neutral pion source is found to be smaller than that of charged pions. This result is in qualitative agreement with the string fragmentation model

Measurement of the W+W-gamma Cross Section and Direct Limits on Anomalous Quartic Gauge Boson Couplings at LEP

The process e+e- -> W+W-gamma is analysed using the data collected with the L3 detector at LEP at a centre-of-mass energy of 188.6GeV, corresponding to an integrated luminosity of 176.8pb^-1. Based on a sample of 42 selected W+W- candidates containing an isolated hard photon, the W+W-gamma cross section, defined within phase-space cuts, is measured to be: sigma_WWgamma = 290 +/- 80 +/- 16 fb, consistent with the Standard Model expectation. Including the process e+e- -> nu nu gamma gamma, limits are derived on anomalous contributions to the Standard Model quartic vertices W+W- gamma gamma and W+W-Z gamma at 95% CL: -0.043 GeV^-2 < a_0/Lambda^2 < 0.043 GeV^-2 0.08 GeV^-2 < a_c/Lambda^2 < 0.13 GeV^-2 0.41 GeV^-2 < a_n/Lambda^2 < 0.37 GeV^-2

Inclusive Charged Hadron Production in Two-Photon Collisions at LEP

Inclusive charged hadron production, e+e- -> e+e- h+- X, is studied using 414 pb-1 of data collected at LEP with the L3 detector at centre-of-mass energies between 189 and 202 GeV. Single particle inclusive differential cross sections are measured as a function of the particle transverse momentum, pt, and pseudo-rapidity, eta. For p_t < 1.5 GeV, the data are well described by an exponential, typical of soft hadronic processes. For higher pt, the onset of perturbative QCD processes is observed. The pi+- production cross section for pt > 5 GeV is much higher than the NLO QCD predictions

Production of Single W Bosons at \sqrt{s}=189 GeV and Measurement of WWgamma Gauge Couplings

Single W boson production in electron-positron collisions is studied with the L3 detector at LEP. The data sample collected at a centre-of-mass energy of \sqrt{s} = 188.7GeV corresponds to an integrated luminosity of 176.4pb^-1. Events with a single energetic lepton or two acoplanar hadronic jets are selected. Within phase-space cuts, the total cross-section is measured to be 0.53 +/- 0.12 +/- 0.03 pb, consistent with the Standard Model expectation. Including our single W boson results obtained at lower \sqrt{s}, the WWgamma gauge couplings kappa_gamma and lambda_gamma are determined to be kappa_gamma = 0.93 +/- 0.16 +/- 0.09 and lambda_gamma = -0.31 +0.68 -0.19 +/- 0.13