The Early Promise of TBRI Implementation in Schools

The program known as Trust Based Relational Intervention® (TBRI®) began as an exploration into the detrimental behaviors of foster and adopted children placed in homes with unsuspecting caregivers who assumed their living environment would result in positive results rather than fear based emotions and behaviors. The researchers at the Karyn Purvis Institute of Child Development (KPICD) at Texas Christian University held summer camps for adopted children and through that work developed an intervention to meet the needs of children who had experienced trauma. KPICD identifies these young people as “children from hard places” (Purvis & Cross, 2005). Copeland et al (2007) reported that an estimated 68% of children in the United States have experienced some sort of trauma. This astounding statistic holds great meaning for teachers and administrators, because these children from hard places routinely manifest aggressive and undesired behaviors due to an altering of their physiology. The literature on TBRI® at this point mostly has chronicled success with families, group homes and summer camps (McKenzie, Purvis, & Cross, 2014; Howard, Parris, Neilson, Lusk, Bush, Purvis & Cross, 2014; Purvis & Cross, 2006). TBRI® has only recently been implemented in school settings. This report provides an overview of the impacts of trauma, trauma related work in schools, and the four articles published to this point related to the use of TBRI® in schools

Ovarian Teratoma Masquerading as a CSF Pseudocyst in a Female with a Ventriculoperitoneal Shunt

Background. In today's fast-paced and high-acuity emergency departments, clinicians are often compelled to triage cases so rapidly that a differential diagnosis consistent with the history and physical examination is not comprehensive. Case Report. This case report describes the unexpected finding of a cystic ovarian neoplasm in a young female with an abdominal mass and a ventriculoperitoneal shunt, initially diagnosed as a cerebrospinal fluid pseudocyst. We use this case to illustrate that the astute clinician must always synthesize a diagnosis from all data sources and not to rely on initial radiographic evaluations. Conclusions. This remarkable case demonstrates that all differential diagnoses must be entertained in order to rapidly and accurately diagnose a patient with a cystic abdominal mass

Neurenteric cyst at the dorsal craniocervical junction in a child: Case report

Neurenteric cysts, also known as enterogenous cysts, are uncommon, benign, congenital lesions that usually occur in the posterior mediastinum but can be seen at any level of the neuraxis. Here, we report a pediatric patient with a neurenteric cyst in the dorsal craniocervical junction as the only third reported pediatric case in the literature in this rare location, and describe the clinical course and pathologic findings with a review of the literature on this rare entity

Observed bodies generate object-based spatial codes

Contemporary studies of spatial and social cognition frequently use human figures as stimuli. The interpretation of such studies may be complicated by spatial compatibility effects that emerge when researchers employ spatial responses, and participants spontaneously code spatial relationships about an observed body. Yet, the nature of these spatial codes – whether they are location- or object-based, and coded from the perspective of the observer or the figure – has not been determined. Here, we investigated this issue by exploring spatial compatibility effects arising for objects held by a visually presented whole-bodied schematic human figure. In three experiments, participants responded to the colour of the object held in the figure’s left or right hand, using left or right key presses. Left-right compatibility effects were found relative to the participant’s egocentric perspective, rather than the figure’s. These effects occurred even when the figure was rotated by 90 degrees to the left or to the right, and the coloured objects were aligned with the participant’s midline. These findings are consistent with spontaneous spatial coding from the participant’s perspective and relative to the normal upright orientation of the body. This evidence for object-based spatial coding implies that the domain general cognitive mechanisms that result in spatial compatibility effects may contribute to certain spatial perspective-taking and social cognition phenomena

Reduction of hexavalent chromium by fasted and fed human gastric fluid. II. Ex vivo gastric reduction modeling

AbstractTo extend previous models of hexavalent chromium [Cr(VI)] reduction by gastric fluid (GF), ex vivo experiments were conducted to address data gaps and limitations identified with respect to (1) GF dilution in the model; (2) reduction of Cr(VI) in fed human GF samples; (3) the number of Cr(VI) reduction pools present in human GF under fed, fasted, and proton pump inhibitor (PPI)-use conditions; and (4) an appropriate form for the pH-dependence of Cr(VI) reduction rate constants. Rates and capacities of Cr(VI) reduction were characterized in gastric contents from fed and fasted volunteers, and from fasted pre-operative patients treated with PPIs. Reduction capacities were first estimated over a 4-h reduction period. Once reduction capacity was established, a dual-spike approach was used in speciated isotope dilution mass spectrometry analyses to characterize the concentration-dependence of the 2nd order reduction rate constants. These data, when combined with previously collected data, were well described by a three-pool model (pool 1 = fast reaction with low capacity; pool 2 = slow reaction with higher capacity; pool 3 = very slow reaction with higher capacity) using pH-dependent rate constants characterized by a piecewise, log-linear relationship. These data indicate that human gastric samples, like those collected from rats and mice, contain multiple pools of reducing agents, and low concentrations of Cr(VI) (<0.7 mg/L) are reduced more rapidly than high concentrations. The data and revised modeling results herein provide improved characterization of Cr(VI) gastric reduction kinetics, critical for Cr(VI) pharmacokinetic modeling and human health risk assessment

Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.

Ulcerative colitis is a chronic inflammatory disease of the colon that presents as diarrhea and gastrointestinal bleeding. We performed a genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry. In an analysis that controlled for gender and population structure, ulcerative colitis loci attaining genome-wide significance and subsequent replication in two independent populations were identified on chromosomes 1p36 (rs6426833, combined P = 5.1 x 10(-13), combined odds ratio OR = 0.73) and 12q15 (rs1558744, combined P = 2.5 x 10(-12), combined OR = 1.35). In addition, combined genome-wide significant evidence for association was found in a region spanning BTNL2 to HLA-DQB1 on chromosome 6p21 (rs2395185, combined P = 1.0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29)

First confirmed ultra-compact dwarf galaxy in the NGC 5044 group

Context. Ultra-compact dwarfs (UCDs) are stellar systems displaying colours and metallicities between those of globular clusters (GCs) and early-type dwarf galaxies, as well as sizes of Reff . 100 pc and luminosities in the range −13.5 < MV < −11 mag. Although their origin is still subject of debate, the most popular scenarios suggest that they are massive star clusters or the nuclei of tidally stripped dwarf galaxies. Aims. NGC 5044 is the central massive elliptical galaxy of the NGC 5044 group. Its GC/UCD system is completely unexplored. Methods. In Gemini+GMOS deep images of several fields around NGC 5044 and in spectroscopic multi-object data of one of these fields, we detected an unresolved source with g′ ∼ 20.6 mag, compatible with being an UCD. Its radial velocity was obtained with FXCOR and the penalized pixel-fitting (pPXF) code. To study its stellar population content, we measured the Lick/IDS indices and compared them with predictions of single stellar population models, and we used the full spectral fitting technique. Results. The spectroscopic analysis of the UCD revealed a radial velocity that agrees with the velocity of the elliptical galaxy NGC 5044. From the Lick/IDS indices, we have obtained a luminosity-weighted age and metallicity of 11.7 +1.4 −1.2 Gyr and [Z/H] = −0.79 ± 0.04 dex, respectively, as well as [α/Fe] = 0.30 ± 0.06. From the full spectral fitting technique, we measured a lower age (8.52 Gyr) and a similar total metallicity ([Z/H] = −0.86 dex). Conclusions. Our results indicate that NGC 5044-UCD1 is most likely an extreme GC (MV ∼ −12.5 mag) belonging to the GC system of the elliptical galaxy NGC 5044

Lessons learned from pre-clinical testing of xenogeneic decellularized esophagi in a rabbit model

Summary Decellularization of esophagi from several species for tissue engineering is well described, but successful implantation in animal models of esophageal replacement has been challenging. The purpose of this study was to assess feasibility and applicability of esophageal replacement using decellularized porcine esophageal scaffolds in a new pre-clinical model. Following surgical replacement in rabbits with a vascularizing muscle flap, we observed successful anastomoses of decellularized scaffolds, cues of early neovascularization, and prevention of luminal collapse by the use of biodegradable stents. However, despite the success of the surgical procedure, the long-term survival was limited by the fragility of the animal model. Our results indicate that transplantation of a decellularized porcine scaffold is possible and vascular flaps may be useful to provide a vascular supply, but long-term outcomes require further pre-clinical testing in a different large animal model