Gas Gain Measurements from a Negative Ion TPC X-ray Polarimeter

Gas-based time projection chambers (TPCs) have been shown to be highly sensitive X-ray polarimeters having excellent quantum efficiency while at the same time achieving large modulation factors. To observe polarization of the prompt X-ray emission of a Gamma-ray burst (GRB), a large area detector is needed. Diffusion of the electron cloud in a standard TPC could be prohibitive to measuring good modulation when the drift distance is large. Therefore, we propose using a negative ion TPC (NITPC) with Nitromethane (CH3NO2) as the electron capture agent. The diffusion of negative ions is reduced over that of electrons due to the thermal coupling of the negative ions to the surrounding gas. This allows for larger area detectors as the drift distance can be increased without degrading polarimeter modulation. Negative ions also travel ~200 times slower than electrons, allowing the readout electronics to operate slower, resulting in a reduction of instrument power. To optimize the NITPC design, we have measured gas gain with SciEnergy gas electron multipliers (GEMs) in single and double GEM configurations. Each setup was tested with different gas combinations, concentrations and pressures: P10 700 Torr, Ne+CO2 700 Torr at varying concentrations of CO2 and Ne+CO2+CH3NO2 700 Torr. We report gain as a function of total voltage, measured from top to bottom of the GEM stack, and as a function of drift field strength for the gas concentrations listed above. Examples of photoelectron tracks at 5.9 keV are also presented.Comment: 6 pages, 6 figures, accepted for publication in IEEE Trans Nucl Sc

Recent X-ray hybrid CMOS detector developments and measurements

The Penn State X-ray detector lab, in collaboration with Teledyne Imaging Sensors (TIS), have progressed their efforts to improve soft X-ray Hybrid CMOS detector (HCD) technology on multiple fronts. Having newly acquired a Teledyne cryogenic SIDECAR ASIC for use with HxRG devices, measurements were performed with an H2RG HCD and the cooled SIDECAR. We report new energy resolution and read noise measurements, which show a significant improvement over room temperature SIDECAR operation. Further, in order to meet the demands of future high-throughput and high spatial resolution X-ray observatories, detectors with fast readout and small pixel sizes are being developed. We report on characteristics of new X-ray HCDs with 12.5 micron pitch that include in-pixel CDS circuitry and crosstalk-eliminating CTIA amplifiers. In addition, PSU and TIS are developing a new large-scale array Speedster-EXD device. The original 64 x 64 pixel Speedster-EXD prototype used comparators in each pixel to enable event driven readout with order of magnitude higher effective readout rates, which will now be implemented in a 550 x 550 pixel device. Finally, the detector lab is involved in a sounding rocket mission that is slated to fly in 2018 with an off-plane reflection grating array and an H2RG X-ray HCD. We report on the planned detector configuration for this mission, which will increase the NASA technology readiness level of X-ray HCDs to TRL 9.Comment: 12 pages, 11 figures, appears in Proc. SPIE 2017. error in reported detector thickness, changed from 200 microns to 100 micron

Evidence for 1122 Hz X-Ray Burst Oscillations from the Neutron-Star X-Ray Transient XTE J1739-285

We report on millisecond variability from the X-ray transient XTE J1739-285. We detected six X-ray type I bursts and found evidence for oscillations at 1122 +/- 0.3 Hz in the brightest X-ray burst. Taking into consideration the power in the oscillations and the number of trials in the search, the detection is significant at the 99.96% confidence level. If the oscillations are confirmed, the oscillation frequency would suggest that XTE J1739-285 contains the fastest rotating neutron star yet found. We also found millisecond quasiperiodic oscillations in the persistent emission with frequencies ranging from 757 Hz to 862 Hz. Using the brightest burst, we derive an upper limit on the source distance of about 10.6 kpc.Comment: To appear in ApJL, 4 page

Deafferentiation-associated changes in afferent and efferent processes in the guinea pig cochlea and afferent regeneration with chronic intrascalar brain-derived neurotrophic factor and acidic fibroblast growth factor

Deafferentation of the auditory nerve from loss of sensory cells is associated with degeneration of nerve fibers and spiral ganglion neurons (SGN). SGN survival following deafferentation can be enhanced by application of neurotrophic factors (NTF), and NTF can induce the regrowth of SGN peripheral processes. Cochlear prostheses could provide targets for regrowth of afferent peripheral processes, enhancing neural integration of the implant, decreasing stimulation thresholds, and increasing specificity of stimulation. The present study analyzed distribution of afferent and efferent nerve fibers following deafness in guinea pigs using specific markers (parvalbumin for afferents, synaptophysin for efferent fibers) and the effect of brain derived neurotrophic factor (BDNF) in combination with acidic fibroblast growth factor (aFGF). Immediate treatment following deafness was compared with 3-week-delayed NTF treatment. Histology of the cochlea with immunohistochemical techniques allowed quantitative analysis of neuron and axonal changes. Effects of NTF were assessed at the light and electron microscopic levels. Chronic BDNF/aFGF resulted in a significantly increased number of afferent peripheral processes in both immediate- and delayed-treatment groups. Outgrowth of afferent nerve fibers into the scala tympani were observed, and SGN densities were found to be higher than in normal hearing animals. These new SGN might have developed from endogenous progenitor/stem cells, recently reported in human and mouse cochlea, under these experimental conditions of deafferentation-induced stress and NTF treatment. NTF treatment provided no enhanced maintenance of efferent fibers, although some synaptophysin-positive fibers were detected at atypical sites, suggesting some sprouting of efferent fibers. J. Comp. Neurol. 507:1602–1621, 2008. © 2008 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/58023/1/21619_ftp.pd

Glial cell line-derived neurotrophic factor and chronic electrical stimulation prevent VIII cranial nerve degeneration following denervation

As with other cranial nerves and many CNS neurons, primary auditory neurons degenerate as a consequence of loss of input from their target cells, the inner hair cells (IHCs). Electrical stimulation (ES) of spiral ganglion cells (SGCs) has been shown to enhance their survival. Glial cell line-derived neurotrophic factor (GDNF) has also been shown to increase survival of SGCs following IHC loss. In this study, the combined effects of the GDNF transgene delivered by adenoviral vectors (Ad- GDNF ) and ES were tested on SGCs after first eliminating the IHCs. Animal groups received Ad- GDNF or ES or both. Ad- GDNF was inoculated into the cochlea of guinea pigs after deafening, to overexpress human GDNF . ES-treated animals were implanted with a cochlear implant electrode and chronically stimulated. A third group of animals received both Ad- GDNF and ES (GDNF/ES). Electrically evoked auditory brainstem responses were recorded from ES-treated animals at the start and end of the stimulation period. Animals were sacrificed 43 days after deafening and their ears prepared for evaluation of IHC survival and SGC counts. Treated ears exhibited significantly greater SGC survival than nontreated ears. The GDNF/ES combination provided significantly better preservation of SGC density than either treatment alone. Insofar as ES parameters were optimized for maximal protection (saturated effect), the further augmentation of the protection by GDNF suggests that the mechanisms of GDNF- and ES-mediated SGC protection are, at least in part, independent. We suggest that GDNF/ES combined treatment in cochlear implant recipients will improve auditory perception. These findings may have implications for the prevention and treatment of other neurodegenerative processes. J. Comp. Neurol. 454:350–360, 2002. © 2002 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34465/1/10480_ftp.pd

Delayed neurotrophin treatment following deafness rescues spiral ganglion cells from death and promotes regrowth of auditory nerve peripheral processes: Effects of brain-derived neurotrophic factor and fibroblast growth factor

The extent to which neurotrophic factors are able to not only rescue the auditory nerve from deafferentation-induced degeneration but also promote process regrowth is of basic and clinical interest, as regrowth may enhance the therapeutic efficacy of cochlear prostheses. The use of neurotrophic factors is also relevant to interventions to promote regrowth and repair at other sites of nerve trauma. Therefore, auditory nerve survival and peripheral process regrowth were assessed in the guinea pig cochlea following chronic infusion of BDNF + FGF 1 into scala tympani, with treatment initiated 4 days, 3 weeks, or 6 weeks after deafferentation from deafening. Survival of auditory nerve somata (spiral ganglion neurons) was assessed from midmodiolar sections. Peripheral process regrowth was assessed using pan-Trk immunostaining to selectively label afferent fibers. Significantly enhanced survival was seen in each of the treatment groups compared to controls receiving artificial perilymph. A large increase in peripheral processes was found with BDNF + FGF 1 treatment after a 3-week delay compared to the artificial perilymph controls and a smaller enhancement after a 6-week delay. Neurotrophic factor treatment therefore has the potential to improve the benefits of cochlear implants by maintaining a larger excitable population of neurons and inducing neural regrowth. © 2007 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/56070/1/21320_ftp.pd