Evaluating Alternate Motor Pathway Changes following a Stroke

Background: Stroke is the fifth cause of death in the United States. Not only is stroke a leading cause of death but it is also a leading cause of long-term disability in the United States. Long-term impairments after stroke include gait instability, upper limb paralysis, sensory deficits, pain, depression, and cognitive impairments. The most common impairment is motor paresis of the upper and lower limb. Rehabilitation remains the gold standard in addressing motor paresis with the goal of enabling subjects to regain independence and daily living skills. Strokes often impact the crossed lateral corticospinal tract, by damaging the tract or the neighboring pathways. The damage within these pathways results in motor deficits. Detailed understanding of changes to the corticospinal tract, major neuronal pathway providing voluntary motor function, after stroke has resulted in the use of targeted therapies to improve rehabilitation outcomes. Alternate motor pathways also give a significant role in stroke recovery. This may be because many of the pathways work independently or work together with the corticospinal tract to trigger motor and sensory function. The overall goal of the project was to evaluate neurodegeneration and neuroregeneration in alternate motor pathways in patients who have suffered an acute ischemic stroke. Methods: Within this study 30 subjects who have suffered an acute stroke and 10 healthy control patients will be enrolled into the study. We will conduct motor function exams and collect neuroimages at two, twelve, and twenty-four weeks after the initial stroke event in each subject. Ten healthy age-matched controls will also be enrolled for a single MRI collection visit. We collected T1-weighted magnetic resonance images (MRI) and diffusion weighted imaging (DWI). When analyzing the images we used DSI studio to shade in our regions of interest. FSL was utilized to extract integrity of evaluated tracts. Results: We observed neuroanatomical differences at the level of the cerebral peduncle and posterior limb of internal capsule in both the affected (stroke-side) and unaffected hemispheres of the brain. Our preliminary data suggests that immediately after a stroke event, minimal changes are noted that become more dramatic over time. Conclusions: Our results suggest that alternate motor pathways undergo dynamic changes post-stroke. Our pilot work has found that while the corticospinal tract remains a critical component in recovery, other pathways may also be impacted post-stroke in a time dependent manner. Future work will evaluate advanced neurite imaging modalities, like NODDI, to evaluate microstructural property changes post-stroke

A discursive psychology analysis of emotional support for men with colorectal cancer

Recent research into both masculinity and health, and the provision of social support for people with cancer has focussed upon the variations that may underlie broad assumptions about masculine health behaviour. The research reported here pursues this interest in variation by addressing the discursive properties of talk about emotional support, by men with colorectal cancer - an understudied group in the social support and cancer literature. Semi-structured interviews were conducted with eight men with colorectal cancer, and the transcripts analysed using an intensive discursive psychology approach. From this analysis two contrasting approaches to this group of men’s framing of emotional support in the context of cancer are described. First, talk about cancer was positioned as incompatible with preferred masculine identities. Second, social contact that affirms personal relationships was given value, subject to constraints arising from discourses concerning appropriate emotional expression. These results are discussed with reference to both the extant research literature on masculinity and health, and their clinical implications, particularly the advice on social support given to older male cancer patients, their families and friends

Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund’s adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats

Background: Intraplantar administration of complete Freund's adjuvant (CFA) and formalin are two noxious stimuli commonly used to produce sustained pain-related behaviors in rodents for research on neurobiology and treatment of pain. One clinically relevant manifestation of pain is depression of behavior and mood. This study compared effects of intraplantar CFA and formalin on depression of positively reinforced operant behavior in an assay of intracranial self-stimulation (ICSS) in rats. Effects of CFA and formalin on other physiological and behavioral measures, and opioid effects on formalin-induced depression of ICSS, were also examined. Results: There were four main findings. First, consistent with previous studies, both CFA and formalin produced similar paw swelling and mechanical hypersensitivity. Second, CFA produced weak and transient depression of ICSS, whereas formalin produced a more robust and sustained depression of ICSS that lasted at least 14 days. Third, formalin-induced depression of ICSS was reversed by morphine doses that did not significantly alter ICSS in saline-treated rats, suggesting that formalin effects on ICSS can be interpreted as an example of pain-related and analgesic-reversible depression of behavior. Finally, formalin-induced depression of ICSS was not associated with changes in central biomarkers for activation of endogenous kappa opioid systems, which have been implicated in depressive-like states in rodents, nor was it blocked by the kappa antagonist norbinaltorphimine. Conclusions: These results suggest differential efficacy of sustained pain stimuli to depress brain reward function in rats as assessed with ICSS. Formalin-induced depression of ICSS does not appear to engage brain kappa opioid systems. Electronic supplementary material The online version of this article (doi:10.1186/1744-8069-10-62) contains supplementary material, which is available to authorized users

Discovery of a Young L Dwarf Binary, SDSS J224953.47+004404.6AB

We report discovery of a young 0.32" L dwarf binary, SDSS J2249+0044AB, found as the result of a Keck LGSAO imaging survey of young field brown dwarfs. Weak K, Na, and FeH features as well as strong VO absorption in the integrated-light J-band spectrum indicate a young age for the system. From spatially resolved K-band spectra we determine spectral types of L3 and L5 for components A and B, respectively. SDSS J2249+0044A is spectrally very similar to G196-3B, an L3 companion to a young M2.5 field dwarf. Thus, we adopt 100 Myr (the age estimate of the G196-3 system) as the age of SDSS J2249+0044AB, but ages of 12-790 Myr are possible. By comparison to G196-3B, we estimate a distance to SDSS J2249+0044AB of 54 +- 16 pc and infer a projected separation of 17 +- 5 AU for the binary. Comparison of the luminosities to evolutionary models at an age of 100 Myr yields masses of 0.029 and 0.022 Msun for SDSS J2249+0044A and B, respectively. Over the possible ages of the system (12-790 Myr), the mass of SDSS J2249+0044A could range from 0.011 to 0.070 Msun and the mass of SDSS J2249+0044B could range from 0.009 to 0.065 Msun. Evolutionary models predict that either component could be burning deuterium, which could result in a mass ratio as low as 0.4, or alternatively, a reversal in the luminosities of the binary. We find a likely proper motion companion, GSC 00568-01752, which lies 48.9" away (2600 AU) and has SDSS+2MASS colors consistent with an early M dwarf. The photometric distance to GSC 00568-01752 is 53 +- 15 pc, in agreement with our distance estimate for SDSS J2249+0044AB. The space motion of SDSS J2249+0044AB shows no obvious coincidence with known young moving groups. The unusually red near-IR colors, young age, and low masses of the binary make it an important template for studying planetary-mass objects found by direct imaging surveys.Comment: revised, accepted versio

Dark Matter Direct Detection with Non-Maxwellian Velocity Structure

The velocity distribution function of dark matter particles is expected to show significant departures from a Maxwell-Boltzmann distribution. This can have profound effects on the predicted dark matter - nucleon scattering rates in direct detection experiments, especially for dark matter models in which the scattering is sensitive to the high velocity tail of the distribution, such as inelastic dark matter (iDM) or light (few GeV) dark matter (LDM), and for experiments that require high energy recoil events, such as many directionally sensitive experiments. Here we determine the velocity distribution functions from two of the highest resolution numerical simulations of Galactic dark matter structure (Via Lactea II and GHALO), and study the effects for these scenarios. For directional detection, we find that the observed departures from Maxwell-Boltzmann increase the contrast of the signal and change the typical direction of incoming DM particles. For iDM, the expected signals at direct detection experiments are changed dramatically: the annual modulation can be enhanced by more than a factor two, and the relative rates of DAMA compared to CDMS can change by an order of magnitude, while those compared to CRESST can change by a factor of two. The spectrum of the signal can also change dramatically, with many features arising due to substructure. For LDM the spectral effects are smaller, but changes do arise that improve the compatibility with existing experiments. We find that the phase of the modulation can depend upon energy, which would help discriminate against background should it be found.Comment: 34 pages, 16 figures, submitted to JCAP. Tables of g(v_min), the integral of f(v)/v from v_min to infinity, derived from our simulations, are available for download at http://astro.berkeley.edu/~mqk/dmdd

A Survey for Circumstellar Disks Around Young Substellar Objects

(Abridged) We have completed the first systematic survey for disks around spectroscopically identified young brown dwarfs and very low mass stars. We have obtained L'-band (3.8 um) imaging for 38 very cool objects in IC 348 and Taurus. Our targets span spectral types from M6 to M9.5 (~100 to ~15 Mjup). Using the objects' measured spectral types and extinctions, we find that most of our sample (77%+/-15%) possess intrinsic IR excesses, indicative of disks. Because the excesses are modest, conventional analyses using only IR colors would have missed most of the sources with excesses. The observed IR excesses are correlated with Halpha emission, consistent with a common accretion disk origin. The excesses can be explained by disk reprocessing of starlight alone; the implied accretion rates are at least an order of magnitude below typical values for classical T Tauri stars. The observed distribution of IR excesses suggests the presence of inner disk holes. The disk frequency appears to be independent of the mass and age. In the same star-forming regions, disks around brown dwarfs are at least as long-lived (~3 Myr) as disks around the T Tauri stars. Altogether, the frequency and properties of young circumstellar disks appear to be similar from the stellar regime down to the substellar and planetary-mass regime. This provides prima facie evidence of a common origin for most stars and brown dwarfs.Comment: ApJ, in press, 28 pages. Minor change to the online, abridged version of the abstract. No change to the actual pape

Evolution of the Chandra CCD Spectra of SNR 1987A: Probing the Reflected-Shock Picture

We continue to explore the validity of the reflected shock structure (RSS) picture in SNR 1987A that was proposed in our previous analyses of the X-ray emission from this object. We used an improved version of our RSS model in a global analysis of 14 CCD spectra from the monitoring program with Chandra. In the framework of the RSS picture, we are able to match both the expansion velocity curve deduced from the analysis of the X-ray images and light curve. Using a simplified analysis, we also show that the X-rays and the non-thermal radio emission may originate from the same shock structure (the blast wave). We believe that using the RSS model in the analysis of grating data from the Chandra monitoring program of SNR 1987A that cover a long enough time interval, will allow us to build a more realistic physical picture and model of SNR 1987A.Comment: 14 pages, 1 Table, 8 figures, accepted for publication in MNRA

Microwave plasma-activated chemical vapour deposition of nitrogen-doped diamond, II:CH₄/N₂/H₂ plasmas

[Image: see text] We report a combined experimental and modeling study of microwave-activated dilute CH(4)/N(2)/H(2) plasmas, as used for chemical vapor deposition (CVD) of diamond, under very similar conditions to previous studies of CH(4)/H(2), CH(4)/H(2)/Ar, and N(2)/H(2) gas mixtures. Using cavity ring-down spectroscopy, absolute column densities of CH(X, v = 0), CN(X, v = 0), and NH(X, v = 0) radicals in the hot plasma have been determined as functions of height, z, source gas mixing ratio, total gas pressure, p, and input power, P. Optical emission spectroscopy has been used to investigate, with respect to the same variables, the relative number densities of electronically excited species, namely, H atoms, CH, C(2), CN, and NH radicals and triplet N(2) molecules. The measurements have been reproduced and rationalized from first-principles by 2-D (r, z) coupled kinetic and transport modeling, and comparison between experiment and simulation has afforded a detailed understanding of C/N/H plasma-chemical reactivity and variations with process conditions and with location within the reactor. The experimentally validated simulations have been extended to much lower N(2) input fractions and higher microwave powers than were probed experimentally, providing predictions for the gas-phase chemistry adjacent to the diamond surface and its variation across a wide range of conditions employed in practical diamond-growing CVD processes. The strongly bound N(2) molecule is very resistant to dissociation at the input MW powers and pressures prevailing in typical diamond CVD reactors, but its chemical reactivity is boosted through energy pooling in its lowest-lying (metastable) triplet state and subsequent reactions with H atoms. For a CH(4) input mole fraction of 4%, with N(2) present at 1–6000 ppm, at pressure p = 150 Torr, and with applied microwave power P = 1.5 kW, the near-substrate gas-phase N atom concentration, [N](ns), scales linearly with the N(2) input mole fraction and exceeds the concentrations [NH](ns), [NH(2)](ns), and [CN](ns) of other reactive nitrogen-containing species by up to an order of magnitude. The ratio [N](ns)/[CH(3)](ns) scales proportionally with (but is 10(2)–10(3) times smaller than) the ratio of the N(2) to CH(4) input mole fractions for the given values of p and P, but [N](ns)/[CN](ns) decreases (and thus the potential importance of CN in contributing to N-doped diamond growth increases) as p and P increase. Possible insights regarding the well-documented effects of trace N(2) additions on the growth rates and morphologies of diamond films formed by CVD using MW-activated CH(4)/H(2) gas mixtures are briefly considered

Multi-frequency Radio Measurements of SN 1987A over 22 Years

We present extensive observations of the radio emission from the remnant of SN 1987A made with the Australia Telescope Compact Array (ATCA), since the first detection of the remnant in 1990. The radio emission has evolved in time providing unique information on the interaction of the supernova shock with the circumstellar medium. We particularly focus on the monitoring observations at 1.4, 2.4, 4.8 and 8.6 GHz, which have been made at intervals of 4-6 weeks. The flux density data show that the remnant brightness is now increasing exponentially, while the radio spectrum is flattening. The current spectral index value of -0.68 represents an 18+/-3% increase over the last 8 years. The exponential trend in the flux is also found in the ATCA imaging observations at 9 GHz, which have been made since 1992, approximately twice a year, as well as in the 843 MHz data set from the Molonglo Observatory Synthesis Telescope from 1987 to March 2007. Comparisons with data at different wavelengths (X-ray, H\alpha) are made. The rich data set that has been assembled in the last 22 years forms a basis for a better understanding of the evolution of the supernova remnant.Comment: 37 pages, 11 figures, accepted by Ap

Thrombosis Is Reduced by Inhibition of COX-1, but Unaffected by Inhibition of COX-2, in an Acute Model of Platelet Activation in the Mouse

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