1,232 research outputs found
Searches for Physics Beyond the Standard Model at Colliders
All experimental measurements of particle physics today are beautifully
described by the Standard Model. However, there are good reasons to believe
that new physics may be just around the corner at the TeV energy scale. This
energy range is currently probed by the Tevatron and HERA accelerators and
selected results of searches for physics beyond the Standard Model are
presented here. No signals for new physics have been found and limits are
placed on the allowed parameter space for a variety of different particles.Comment: Proceedings for 2007 Europhysics Conference on High Energy Physics,
Manchester, July 200
The MAGNOLIA Trial: Zanubrutinib, a Next-Generation Bruton Tyrosine Kinase Inhibitor, Demonstrates Safety and Efficacy in Relapsed/Refractory Marginal Zone Lymphoma
Purpose: Marginal zone lymphoma (MZL) is an uncommon non-Hodgkin lymphoma with malignant cells that exhibit a consistent dependency on B-cell receptor signaling. We evaluated the efficacy and safety of zanubrutinib, a next-generation selective Bruton tyrosine kinase inhibitor, in patients with relapsed/ refractory (R/R) MZL. Patients and Methods: Patients with R/R MZL were enrolled in the phase II MAGNOLIA (BGB-3111-214) study. The primary endpoint was overall response rate (ORR) as determined by an independent review committee (IRC) based on the Lugano 2014 classification. Results: Sixty-eight patients were enrolled. After a median follow-up of 15.7 months (range, 1.6 to 21.9 months), the IRCassessed ORR was 68.2% and complete response (CR) was 25.8%. The ORR by investigator assessment was 74.2%, and the CR rate was 25.8%. The median duration of response (DOR) and median progression-free survival (PFS) by independent review was not reached. The IRC-assessed DOR rate at 12 months was 93.0%, and IRC-assessed PFS rate was 82.5% at both 12 and 15 months. Treatment was well tolerated with the majority of adverse events (AE) being grade 1 or 2. The most common AEs were diarrhea (22.1%), contusion (20.6%), and constipation (14.7%). Atrial fibrillation/flutter was reported in 2 patients; 1 patient had grade 3 hypertension. No patient experienced major hemorrhage. In total, 4 patients discontinued treatment due to AEs, none of which were considered treatment-related by the investigators. Conclusions: Zanubrutinib demonstrated highORRand CR rate with durable disease control and a favorable safety profile in patients with R/R MZL. _2021 The Authors; Published by the American Association for Cancer Research
Bigger, Better, Faster, More at the LHC
Multijet plus missing energy searches provide universal coverage for theories
that have new colored particles that decay into a dark matter candidate and
jets. These signals appear at the LHC further out on the missing energy tail
than two-to-two scattering indicates. The simplicity of the searches at the LHC
contrasts sharply with the Tevatron where more elaborate searches are necessary
to separate signal from background. The searches presented in this article
effectively distinguish signal from background for any theory where the LSP is
a daughter or granddaughter of the pair-produced colored parent particle
without ever having to consider missing energies less than 400 GeV.Comment: 26 pages, 8 Figures. Minor textual changes, typos fixed and
references adde
Where the Sidewalk Ends: Jets and Missing Energy Search Strategies for the 7 TeV LHC
This work explores the potential reach of the 7 TeV LHC to new colored states
in the context of simplified models and addresses the issue of which search
regions are necessary to cover an extensive set of event topologies and
kinematic regimes. This article demonstrates that if searches are designed to
focus on specific regions of phase space, then new physics may be missed if it
lies in unexpected corners. Simple multiregion search strategies can be
designed to cover all of kinematic possibilities. A set of benchmark models are
created that cover the qualitatively different signatures and a benchmark
multiregion search strategy is presented that covers these models.Comment: 30 pages, 8 Figures, 3 Tables. Version accepted at JHEP. Minor
changes. Added figur
Search for the Higgs boson in events with missing transverse energy and b quark jets produced in proton-antiproton collisions at s**(1/2)=1.96 TeV
We search for the standard model Higgs boson produced in association with an
electroweak vector boson in events with no identified charged leptons, large
imbalance in transverse momentum, and two jets where at least one contains a
secondary vertex consistent with the decay of b hadrons. We use ~1 fb-1
integrated luminosity of proton-antiproton collisions at s**(1/2)=1.96 TeV
recorded by the CDF II experiment at the Tevatron. We find 268 (16) single
(double) b-tagged candidate events, where 248 +/- 43 (14.4 +/- 2.7) are
expected from standard model background processes. We place 95% confidence
level upper limits on the Higgs boson production cross section for several
Higgs boson masses ranging from 110 GeV/c2 to 140 GeV/c2. For a mass of 115
GeV/c2 the observed (expected) limit is 20.4 (14.2) times the standard model
prediction.Comment: 8 pages, 2 figures, submitted to Phys. Rev. Let
Prototype ATLAS IBL Modules using the FE-I4A Front-End Readout Chip
The ATLAS Collaboration will upgrade its semiconductor pixel tracking
detector with a new Insertable B-layer (IBL) between the existing pixel
detector and the vacuum pipe of the Large Hadron Collider. The extreme
operating conditions at this location have necessitated the development of new
radiation hard pixel sensor technologies and a new front-end readout chip,
called the FE-I4. Planar pixel sensors and 3D pixel sensors have been
investigated to equip this new pixel layer, and prototype modules using the
FE-I4A have been fabricated and characterized using 120 GeV pions at the CERN
SPS and 4 GeV positrons at DESY, before and after module irradiation. Beam test
results are presented, including charge collection efficiency, tracking
efficiency and charge sharing.Comment: 45 pages, 30 figures, submitted to JINS
Observation and Mass Measurement of the Baryon
We report the observation and measurement of the mass of the bottom, strange
baryon through the decay chain , where
, , and .
Evidence for observation is based on a signal whose probability of arising from
the estimated background is 6.6 x 10^{-15}, or 7.7 Gaussian standard
deviations. The mass is measured to be (stat.) (syst.) MeV/.Comment: Minor text changes for the second version. Accepted by Phys. Rev.
Let
Search for New Particles Leading to Z+jets Final States in Collisions at TeV
We present the results of a search for new particles that lead to a \Z boson
plus jets in collisions at TeV using the Collider
Detector at Fermilab (CDF II). A data sample with a luminosity of 1.06 \ifb\
collected using \Z boson decays to and is used. We describe a
completely data-based method to predict the dominant background from
standard-model \Z+jet events. This method can be similarly applied to other
analyses requiring background predictions in multi-jet environments, as shown
when validating the method by predicting the background from +jets in \ttbar
production. No significant excess above the background prediction is observed,
and a limit is set using a fourth generation quark model to quantify the
acceptance. Assuming and using a leading-order
calculation of the cross section, quark masses below 268 \gev/c^2
are excluded at 95% confidence level.Comment: To be submitted to PR
First Measurement of the W Boson Mass in Run II of the Tevatron
We present a measurement of the W boson mass using 200/pb of data collected
in pbar p collisions at sqrt(s) = 1.96 TeV by the CDF II detector at Run II of
the Fermilab Tevatron. With a sample of 63964 W -> e nu candidates and 51128 W
-> mu nu candidates, we measure M_W = (80413 +- 34 (stat) +- 34 (syst) = 80413
+- 48) MeV/c^2. This is the most precise single measurement of the W boson mass
to date.Comment: published version in PR
Search for Third Generation Vector Leptoquarks in p anti-p Collisions at sqrt(s) = 1.96 TeV
We describe a search for a third generation vector leptoquark (VLQ3) that
decays to a b quark and tau lepton using the CDF II detector and 322 pb^(-1) of
integrated luminosity from the Fermilab Tevatron. Vector leptoquarks have been
proposed in many extensions of the standard model (SM). Observing a number of
events in agreement with SM expectations, assuming Yang-Mills (minimal)
couplings, we obtain the most stringent upper limit on the VLQ3 pair production
cross section of 344 fb (493 fb) and lower limit on the VLQ3 mass of 317
GeV/c^2 (251 GeV/c^2) at 95% C.L.Comment: 7 pages, 2 figures, submitted to PR
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