Maturandum

IMAGO: revista de emblemática y cultura visual ha logrado dar recientemente un gran salto en la clasificación circ, hoy por hoy el sistema de clasificación de revistas más importante de España, en donde hemos sido evaluados y clasificados en la posición B.También esto repercute sobre la colección de «Anejos» de la revista, que recientemente ha publicado dos monografías.Lo puede «emblematizar» todo aquel emblema de Alciato cuyo mote reza: Maturandum, y que la edición italiana (Lyon, 1549) le daba un sentido muy claro: Che le buone deliberationi si debbono mettere in opera à tempo, sentido que también asumía la traducción española del mismo editor y año: Que todo se deue hazer con sazon. Evidentemente, van a cumplirse casi diez años desde que se aprobó la creación de la revista por la Asamblea General de la SEE (Gandía, octubre de 2007). El primer número correspondió a 2009, y vamos ya por el octavo.

Moderation of the Big Five Personality Factors on the Relationship between being Mobbed at Work and Physical Health Complaints and Absenteeism

Achtergrond. Pesterijen op het werk zijn wijdverspreid en kunnen zeer negatieve gevolgen hebben, zowel voor het slachtoffer als voor de organisatie waarvoor het slachtoffer werkt. Doel. Het doel van dit onderzoek is meer inzicht te verwerven in de modererende invloed van de Big Five persoonlijkheidsfactoren, op de relatie tussen gepest worden op het werk en lichamelijke gezondheidsklachten en ziekteverzuim. Deelnemers, procedure en onderzoeksontwerp. Er is gebruik gemaakt van cross-sectioneel e-mail vragenlijstonderzoek. De onderzoekspopulatie bestaat uit 18 tot 65-jarige medewerkers van Vlaamse overheidsinstellingen. Voor het werven van de respondenten wordt gebruik gemaakt van een selecte steekproef van overheidsinstellingen op basis van vrijwillige reactie. In totaal hebben 11 van de 470 benaderde overheidsinstellingen (2.3%) deelgenomen aan dit onderzoek. Van de 2650 benaderde medewerkers hebben 1085 medewerkers (41%) de vragenlijst online of schriftelijk ingevuld. Meetinstrumenten. Pesterijen zijn gemeten met de Negative Acts Questionnaire (NAQ, Einarsen & Raknes, 1997), de Big Five persoonlijkheidsfactoren met de NEO-Five Factor Inventory (NEO-FFI, Costa & McCrea, 1992), lichamelijke gezondheidsklachten met de Vragenlijst Onderzoek Ervaren Gezondheid (VOEG, Joosten & Drop, 1987) en ziekteverzuim met één item uit de Vragenlijst Organisatiestress-D (VOS-D, Bergers, Marcelissen & De Wolff, 1986). Resultaten. Er is een positief verband tussen de mate van werkgerelateerde pesterijen en lichamelijke gezondheidsklachten van gepesten. Naarmate werknemers vaker werkgerelateerd worden gepest, ervaren zij meer lichamelijke gezondheidsklachten. De Big Five persoonlijkheidsfactoren modereren deze relatie niet. Verder is er een positief verband tussen de mate van persoonsgerelateerde pesterijen en het ziekteverzuim van gepesten. Naarmate werknemers vaker persoonsgerelateerd worden gepest, neemt het aantal verzuimdagen toe. Enkel de persoonlijkheidsfactor openheid modereert deze relatie. Deze relatie is tegengesteld aan de verwachting sterker voor werknemers die hoog scoren op openheid. Conclusie. Pesterijen op het werk hebben een negatieve invloed op zowel de lichamelijke gezondheid als het ziekteverzuim van gepesten. De invloed van Big Five persoonlijkheidsfactoren op beide relaties is echter minder groot dan in dit onderzoek verwacht werd

Newsletter new technologies and innovation policy. January 1985. 35.

Title changed to Innovation and technology transfer Newsletter in 198

A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells.

Signalling through gap junctions contributes to control insulin secretion and, thus, blood glucose levels. Gap junctions of the insulin-producing β-cells are made of connexin 36 (Cx36), which is encoded by the GJD2 gene. Cx36-null mice feature alterations mimicking those observed in type 2 diabetes (T2D). GJD2 is also expressed in neurons, which share a number of common features with pancreatic β-cells. Given that a synonymous exonic single nucleotide polymorphism of human Cx36 (SNP rs3743123) associates with altered function of central neurons in a subset of epileptic patients, we investigated whether this SNP also caused alterations of β-cell function. Transfection of rs3743123 cDNA in connexin-lacking HeLa cells resulted in altered formation of gap junction plaques and cell coupling, as compared to those induced by wild type (WT) GJD2 cDNA. Transgenic mice expressing the very same cDNAs under an insulin promoter revealed that SNP rs3743123 expression consistently lead to a post-natal reduction of islet Cx36 levels and β-cell survival, resulting in hyperglycemia in selected lines. These changes were not observed in sex- and age-matched controls expressing WT hCx36. The variant GJD2 only marginally associated to heterogeneous populations of diabetic patients. The data document that a silent polymorphism of GJD2 is associated with altered β-cell function, presumably contributing to T2D pathogenesis

Versatile Graded-Index Multi-Mode Fiber for High Capacity Single-and Multi-Mode Optical Home Network

International audienceA graded-index multi-mode fiber has been optimized to sustain a single excited mode when coupled with a standard single-mode fiber at 1310/1550nm while offering large effective modal bandwidth at 850nm under VCSEL excitations. Modeling and experimental results are presented

Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians

Copyright: Copyright 2008 Elsevier B.V., All rights reserved.The associations of the adiponectin (APM1) gene with parameters of the metabolic syndrome are inconsistent. We performed a systematic investigation based on fine-mapped single nucleotide polymorphisms (SNPs) highlighting the genetic architecture and their role in modulating adiponectin plasma concentrations in a particularly healthy population of 1,727 Caucasians avoiding secondary effects from disease processes. Genotyping 53 SNPs (average spacing of 0.7 kb) in the APM1 gene region in 81 Caucasians revealed a two-block linkage disequilibrium (LD) structure and enabled comprehensive tag SNP selection. We found particularly strong associations with adiponectin concentrations for 11 of the 15 tag SNPs in the 1,727 subjects (five P values <0.0001). Haplotype analysis provided a thorough differentiation of adiponectin concentrations with 9 of 17 haplotypes showing significant associations (three P values <0.0001). No significant association was found for any SNP with the parameters of the metabolic syndrome. We observed a two-block LD structure of APM1 pointing toward at least two independent association signals, one including the promoter SNPs and a second spanning the relevant exons. Our data on a large number of healthy subjects suggest a clear modulation of adiponectin concentrations by variants of APM1, which are not merely a concomitant effect in the course of type 2 diabetes or coronary artery disease.publishersversionPeer reviewe

Medicine in words and numbers: a cross-sectional survey comparing probability assessment scales

Contains fulltext : 56355.pdf ( ) (Open Access)Background / In the complex domain of medical decision making, reasoning under uncertainty can benefit from supporting tools. Automated decision support tools often build upon mathematical models, such as Bayesian networks. These networks require probabilities which often have to be assessed by experts in the domain of application. Probability response scales can be used to support the assessment process. We compare assessments obtained with different types of response scale. Methods / General practitioners (GPs) gave assessments on and preferences for three different probability response scales: a numerical scale, a scale with only verbal labels, and a combined verbal-numerical scale we had designed ourselves. Standard analyses of variance were performed. Results / No differences in assessments over the three response scales were found. Preferences for type of scale differed: the less experienced GPs preferred the verbal scale, the most experienced preferred the numerical scale, with the groups in between having a preference for the combined verbal-numerical scale. Conclusion / We conclude that all three response scales are equally suitable for supporting probability assessment. The combined verbal-numerical scale is a good choice for aiding the process, since it offers numerical labels to those who prefer numbers and verbal labels to those who prefer words, and accommodates both more and less experienced professionals.8 p

Analysis of the impact of the SARS-CoV-2 infection on the pediatric population hospitalized during the pandemic in the Greater Paris University Hospitals

BackgroundThe clinical characteristics, disease progression and outcome in children affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection appear significantly milder compared to older individuals. Nevertheless, the trends in hospitalization and clinical characteristics in the pediatric population seem to be different over time across the different epidemic waves.ObjectiveOur aim was to understand the impact of the different COVID-19 variants in the pediatric population hospitalized in the Pediatric Departments of the Public Hospital in the Greater Paris area by the analysis performed with the Assistance Publique-Hopitaux de Paris (AP-HP) Health Data Warehouse.MethodsThis is a retrospective cohort study including 9,163 patients under 18 years of age, hospitalized from 1 March 2020 to 22 March 2022, in the Paris area, with confirmed infection by SARS-CoV-2. Three mutually exclusive groups with decreasing severity (Pediatric Inflammatory Multisystem Syndrome (PIMS), symptomatic infection, mild or asymptomatic infection) were defined and described regarding demography, medical history, complication of the SARS-CoV-2 infection, and treatment during admission. Temporal evolution was described by defining three successive waves (March–September 2020, October 2020–October 2021, and November 2021–March 2022) corresponding to the emergence of the successive variants.ResultsIn the study period, 9,163 pediatric patients with SARS-CoV-2 infection were hospitalized in 21 AP-HP hospitals. The number of patients with SARS-CoV-2 infection increased over time for each wave of the pandemic (the mean number of patients per month during the first wave was 332, 322 during the 2nd, and 595 during the third wave). In the medical history, the most associated concomitant disease was chronic respiratory disease. Patients hospitalized during the third wave presented a higher incidence of pulmonary involvement (10.2% compared to 7% and 6.5% during the first and second waves, respectively). The highest incidence of PIMS was observed during the first and second waves (4.2% in the first and second waves compared to 2.3% in the 3rd wave).DiscussionThis analysis highlighted the high incidence of hospitalized children in the Greater Paris Area during the third wave of SARS-CoV-2 pandemic corresponding to the Omicron Covid-19 variant, which is probably an expression of a concomitant SARS-CoV-2, while a decreased incidence of PIMS complication was observed during the same period