A multiple replica approach to simulate reactive trajectories

A method to generate reactive trajectories, namely equilibrium trajectories leaving a metastable state and ending in another one is proposed. The algorithm is based on simulating in parallel many copies of the system, and selecting the replicas which have reached the highest values along a chosen one-dimensional reaction coordinate. This reaction coordinate does not need to precisely describe all the metastabilities of the system for the method to give reliable results. An extension of the algorithm to compute transition times from one metastable state to another one is also presented. We demonstrate the interest of the method on two simple cases: a one-dimensional two-well potential and a two-dimensional potential exhibiting two channels to pass from one metastable state to another one

Domain Dynamics of Magnetic Films with Perpendicular Anisotropy

We study the magnetic properties of nanoscale magnetic films with large perpendicular anisotropy comparing polarization microscopy measurements on Co_28Pt_72 alloy samples based on the magneto-optical Kerr effect with Monte Carlo simulations of a corresponding micromagnetic model. We focus on the understanding of the dynamics especially the temperature and field dependence of the magnetisation reversal process. The experimental and simulational results for hysteresis, the reversal mechanism, domain configurations during the reversal, and the time dependence of the magnetisation are in very good qualitative agreement. The results for the field and temperature dependence of the domain wall velocity suggest that for thin films the hysteresis can be described as a depinning transition of the domain walls rounded by thermal activation for finite temperatures.Comment: 7 pages Latex, Postscript figures included, accepted for publication in Phys.Rev.B, also availible at: http://www.thp.Uni-Duisburg.DE/Publikationen/Publist_Us_R.htm

Strain-induced magma degassing: insights from simple-shear experiments on bubble bearing melts

International audienceExperiments have been performed to determine the effect of deformation on degassing of bubble-bearing melts. Cylindrical specimens of phonolitic composition, initial water content of 1.5 wt.% and 2 vol.% bubbles, have been deformed in simple-shear (torsional configuration) in an internally heated Paterson-type pressure vessel at temperatures of 798-848 K, 100-180 MPa confining pressure and different final strains. Micro-structural analyses of the samples before and after deformation have been performed in two and three dimensions using optical microscopy, a nanotomography machine and synchrotron tomography. The water content of the glasses before and after deformation has been measured using Fourier Transform Infrared Spectroscopy (FTIR). In samples strained up to a total of γ ∼ 2 the bubbles record accurately the total strain, whereas at higher strains (γ ∼ 10) the bubbles become very flattened and elongate in the direction of shear. The residual water content of the glasses remains constant up to a strain of γ ∼ 2 and then decreases to about 0.2 wt.% at γ ∼ 10. Results show that strain enhances bubble coalescence and degassing even at low bubble volume-fractions. Noticeably, deformation produced a strongly water under-saturated melt. This suggests that degassing may occur at great depths in the volcanic conduit and may force the magma to become super-cooled early during ascent to the Earth's surface potentially contributing to the genesis of obsidian

Low-frequency radio emission in the massive galaxy cluster MACS J0717.5 + 3745

International audienceTo investigate the nonthermal emission mechanism and their interaction during cluster mergers, we analyze multiple low-frequency radio data for the X-ray luminous massive galaxy cluster MACS J0717.5 + 3745, located at z = 0.5548. Large-scale structure-formation models in the Universe suggest that galaxy clusters grow via constant accretion of gas and the merger of galaxy groups and smaller clusters. Low-frequency radio observations trace these mergers in the form of relics and halos. The dual frequency observations were performed on MACS J0717.5 + 3745 to investigate the spectral index pattern of the nonthermal emission and its interaction within the intracluster medium (ICM), during merger process. Methods: Continuum observations were carried out using GMRT at 0.235 and 0.61 GHz on MACS J0717.5 + 3745 and archival data from the VLA (0.074 and 1.42 GHz) and WSRT (0.325 GHz) was used to complement the results. Furthermore, to explore the thermal and nonthermal interactions within the ICM and the morphological distribution, Chandra X-ray and HST data were used. Results: A highly complex nonthermal radio emission distribution is seen in the cluster at very low frequencies, with a global spectral index α0.2350.61˜-1.17±0.37. We have detected a giant radio halo within the cluster system with a linear size of 1.58 Mpc and a "Chair-shaped" filament structure between the merging subclusters of linear size 853 kpc at 0.235 GHz. This is the most powerful halo ever observed with P1.4 = 9.88 × 1025 WHz-1 and an equipartition magnetic field estimate of ~6.49 μG. The bright filament structure is well located in the central merging region of subclusters with enhanced temperature, as shown by Chandra and HST data analysis, further indicating the formation of this structure due to shock waves encountered within the ICM during the merger events

The FFAG R&D and medical application project RACCAM

JACoW web site http://accelconf.web.cern.ch/AccelConf/e06/Pre-Press/WEPCH161.pdf WEPCH161International audienceThe RACCAM project (Recherche en ACCelerateurs et Applications Medicales) has recently obtained fundings, extending over three years (2006-2008), from the French National Research Agency (ANR). RACCAM is a tripartite collaboration, involving (i) the CNRS Laboratory IN2P3/LPSC, (ii) the French magnet industrial SIGMAPHI, and (iii) the nuclear medecine Departement of Grenoble Hospital. The project concerns fixed field alternating gradient accelerator (FFAG) research on the one hand, and on the other hand their application as hadrontherapy and biology research machines. RACCAM's goal is three-fold, (i) participate to the on-going international collaborations in the field of FFAGs and recent concepts of "non-scaling" FFAGs, with frames for instance, the Neutrino Factory (NuFact) and the EMMA project of an electron model of a muon FFAG accelerator, (ii) design, build and experiment a prototype of an FFAG magnet proper to fulfil the requirements of rapid cycling acceleration, (iii) develop the concepts, and show the feasibility, of the application of such FFAG beams to hadrontherapy and to biology research

Production of Extrachromosomal MicroDNAs Is Linked to Mismatch Repair Pathways and Transcriptional Activity

SummaryMicroDNAs are <400-base extrachromosomal circles found in mammalian cells. Tens of thousands of microDNAs have been found in all tissue types, including sperm. MicroDNAs arise preferentially from areas with high gene density, GC content, and exon density from promoters with activating chromatin modifications and in sperm from the 5′-UTR of full-length LINE-1 elements, but are depleted from lamin-associated heterochromatin. Analysis of microDNAs from a set of human cancer cell lines revealed lineage-specific patterns of microDNA origins. A survey of microDNAs from chicken cells defective in various DNA repair proteins reveals that homologous recombination and non-homologous end joining repair pathways are not required for microDNA production. Deletion of the MSH3 DNA mismatch repair protein results in a significant decrease in microDNA abundance, specifically from non-CpG genomic regions. Thus, microDNAs arise as part of normal cellular physiology—either from DNA breaks associated with RNA metabolism or from replication slippage followed by mismatch repair

GMRT observations of the Ophiuchus galaxy cluster

VLA observations at 1477 MHz revealed the presence of a radio mini-halo surrounding the faint central point-like radio source in the Ophiuchus cluster of galaxies. In this work we present a study of the radio emission from this cluster of galaxies at lower radio frequencies. We observed the Ophiuchus cluster at 153, 240, and 614 MHz with the GMRT. The mini-halo is clearly detected at 153 and 240 MHz while it is not detected at 610 MHz. The most prominent feature at low frequencies is a patch of diffuse steep spectrum emission located at about 5' south-east from the cluster center. By combining these images with that at 1477 MHz, we derived the spectral index of the mini-halo. Globally, the mini-halo has a low-frequency spectral index of alpha_240^153 ~1.4 +/- 0.3 and an high-frequency spectral index of alpha_1477^240 ~ 1.60 +/- 0.05. Moreover, we measure a systematic increase of the high-frequency spectral index with radius: the azimuthal radial average of alpha_1477^240 increases from about 1.3, at the cluster center, up to about 2.0 in the mini-halo outskirts. The observed radio spectral index is in agreement with that obtained by modeling the non-thermal hard X-ray emission in this cluster of galaxies. We assume that the X-ray component arises from inverse Compton scattering between the photons of the cosmic microwave background and a population of non-thermal electrons which are isotropically distributed and whose energy spectrum is a power law with index p. We derive that the electrons energy spectrum should extend from a minimum Lorentz factor of gamma_min < 700 up to a maximum Lorentz factor of gamma_max =3.8 x 10^4 with an index p=3.8 +/- 0.4. The volume-averaged strength for a completely disordered intra-cluster magnetic field is B_V ~0.3 +/- 0.1 micro-G.Comment: 14 pages, 8 figures, accepted for publication in Astronomy and Astrophysics. For a version with high-quality figures see http://erg.ca.astro.it/preprints/ophi_2010

LOFAR MSSS: The Scaling Relation between AGN Cavity Power and Radio Luminosity at Low Radio Frequencies

This article has been accepted for publication in a forthcoming issue of Astronomy & Astrophysics. Reproduced with permission from Astronomy & Astrophysics. © 2018 ESO.We present a new analysis of the widely used relation between cavity power and radio luminosity in clusters of galaxies with evidence for strong AGN feedback. We study the correlation at low radio frequencies using two new surveys - the First Alternative Data Release of the TIFR GMRT Sky Survey (TGSS ADR1) at 148 MHz and LOFAR's first all-sky survey, the Multifrequency Snapshot Sky Survey (MSSS) at 140 MHz. We find a scaling relation $P_{\rm cav} \propto L_{148}^{\beta}$, with a logarithmic slope of $\beta = 0.51 \pm 0.14$, which is in good agreement with previous results based on data at 327 MHz. The large scatter present in this correlation confirms the conclusion reached at higher frequencies that the total radio luminosity at a single frequency is a poor predictor of the total jet power. We show that including measurements at 148 MHz alone is insufficient to reliably compute the bolometric radio luminosity and reduce the scatter in the correlation. For a subset of four well-resolved sources, we examine the detected extended structures at low frequencies and compare with the morphology known from higher frequency images and Chandra X-ray maps. In Perseus we discuss details in the structures of the radio mini-halo, while in the 2A 0335+096 cluster we observe new diffuse emission associated with multiple X-ray cavities and likely originating from past activity. For A2199 and MS 0735.6+7421, we confirm that the observed low-frequency radio lobes are confined to the extents known from higher frequencies. This new low-frequency analysis highlights the fact that existing cavity power to radio luminosity relations are based on a relatively narrow range of AGN outburst ages. We discuss how the correlation could be extended using low frequency data from the LOFAR Two-metre Sky Survey (LoTSS) in combination with future, complementary deeper X-ray observations.Peer reviewe