23 research outputs found
Retrospective evaluation of pre-surgical electroretinography results in a mixed-breed canine population presented for cataract removal surgery
Scrubs contamination, domestic laundry effect and workwear habits of clinical staff at a referral hospital
Relationship between magnetic resonance imaging findings and histological grade in spinal peripheral nerve sheath tumors in dogs
BackgroundPeripheral nerve sheath tumors (PNSTs) are a group of neoplasms originating from Schwann cells or pluripotent cell of the neural crest. Therapeutic options and prognosis are influenced by their degree of malignancy and location.Hypothesis/ObjectivesIdentify magnetic resonance imaging (MRI) features predictive of PNST histologic grade.AnimalsFortyâfour dogs with histopathological diagnosis of spinal PNSTs and previous MRI investigation.MethodsA multicenter retrospective study including cases with (a) histopathologic diagnosis of PNST and (b) MRI studies available for review. Histologic slides were reviewed and graded by a boardâcertified pathologist according to a modified French system (FNCLCC) for grading soft tissue sarcomas. The MRI studies were reviewed by 2 boardâcertified radiologists blinded to the grade of the tumor and the final decision on the imaging characteristics was reached by consensus. Relationships between tumor grade and histological and MRI findings were assessed using statistical analysis.ResultsFortyâfour cases met inclusion criteria; 16 patients were PNSTs Grade 1 (lowâgrade), 19 were PNSTs Grade 2 (mediumâgrade), and 9 were PNSTs Grade 3 (highâgrade). Large volume (Pâ=â.03) and severe peripheral contrast enhancement (Pâ=â.04) were significantly associated with high tumor grade. Degree of muscle atrophy, heterogeneous signal and tumor growth into the vertebral canal were not associated with grade.Conclusions and Clinical ImportanceGrade of malignancy was difficult to identify based on diagnostic imaging alone. However, some MRI features were predictive of highâgrade PNSTs including tumor size and peripheral contrast enhancement
Causes of thrombocytopenia in dogs in the United Kingdom: A retrospective study of 762 cases
Background: Thrombocytopenia is a common laboratory abnormality in dogs, and numerous diseases have been associated with its development. Estimates for the sensitivity and specificity of the degree of reduction of platelet concentration for the diagnosis of primary immuneâmediated thrombocytopenia (pITP) have not been reported. Objectives: To report the prevalence of different causes of thrombocytopenia in dogs in the United Kingdom and to investigate the utility of platelet concentration to differentiate causes of thrombocytopenia. Methods: Medical records of 762 dogs with thrombocytopenia presented to seven referral hospitals from January 2017 to December 2018 were retrospectively reviewed. Cases were assigned into the following categories: pITP, infectious diseases, neoplasia, inflammatory/other immuneâmediated disorders and miscellaneous causes. The prevalence of the different categories was estimated, and platelet concentrations were compared. Receiverâoperating characteristic (ROC) curves were used to investigate the utility of platelet concentration to differentiate between causes of thrombocytopenia. Results: The most common disease category associated with thrombocytopenia was neoplasia (27.3%), followed by miscellaneous causes (26.9%), pITP (18.8%), inflammatory/immuneâmediated disorders (14.4%) and infectious diseases (12.6%). Dogs with pITP had significantly lower platelet concentrations (median 8 Ă 109/L, range: 0â70 Ă 109/L) than dogs in the other four categories. Platelet concentration was useful for distinguishing pITP from other causes of thrombocytopenia (area under ROC curve = 0.89, 95% confidence interval 0.87, 0.92), with a platelet concentration â€12 Ă 109/L being 60% sensitive and 90% specific. Conclusions: Severe thrombocytopenia was highly specific for a diagnosis of pITP, which was more prevalent in this UK population of thrombocytopenic dogs compared with previous epidemiological studies. Conversely, the proportion of dogs with infectious diseases was lower than in previous reports from other locations
Public Roads as Places of Interspecies Conflict: A Study of Horse-Human Interactions on UK Roads and Impacts on Equine Exercise
Real or perceived traffic risk is a significant barrier to walking and cycling. To understand whether similar barriers influence equestrians, this study obtained exercise behaviours, road use and experiences of road-related incidents from UK equestrians (n = 6390) via an online questionnaire. Multivariable logistic regression models were used to identify factors associated with road use and experiencing a near-miss or injury-causing incident in the previous year. Content analysis identified themes around equestriansâ decisions not to use roads. Our results show that most equestrians (84%) use roads at least once weekly, and in the previous year, 67.7% had a near-miss and 6.1% an injury-causing incident. Road use differs regionally, with exercise type and off-road route availability. Road-using equestrians covered greater daily distances and were younger. However, younger equestrians were at higher risk of near-misses. Respondentsâ decisions not to use roads were based on individualised risk assessments arising from: the road itself, perceptions of other road users, the individual horse and the handlerâs own emotional management. Roads were perceived as extremely dangerous places with potentially high conflict risk. Injury-causing incidents were associated with increasing road-use anxiety or ceasing to use roads, the proximity of off-road routes, having a near-miss and type of road use. Targeted road-safety campaigns and improved off-road access would create safer equestrian spaces
Application of the Ridden Horse Pain Ethogram to Elite Dressage Horses Competing in World Cup Grand Prix Competitions
There is considerable debate about the social license to compete with horses and controversy about training methods for dressage horses. The objectives were to: 1. apply the Ridden Horse Pain Ethogram (RHpE) to dressage horses competing at elite Grand Prix level; 2. compare RHpE and judgesâ scores; and 3. document deviations in gaits from FĂ©dĂ©ration Equestre Internationale (FEI) guidelines. Video recordings of 147 competitors from nine World Cup competitions were assessed. Spearmanâs rank correlation coefficient tested the correlation between RHpE and judgesâ scores. The median RHpE score was 3 (IQR 1, 4; range 0, 7). There was a moderate negative correlation (Spearman rho â0.40, p < 0.001) between the RHpE scores and the judgesâ scores. Mouth open with separation of the teeth for â„10 s (68%), head behind vertical â„10° â„10 s (67%), an intense stare for â„5 s (30%) and repeated tail swishing (29%) were the most frequent RHpE behaviours. Deviations from FEI guidelines were most frequent in passage, piaffe, canter flying-changes, canter pirouettes and âhalt-immobility-rein back five steps-collected trotâ. In conclusion, most horses appeared to work comfortably for the majority of the test. Further investigation of the influence of a double bridle compared with a snaffle bridle on head position and mouth opening is merited
Public Roads as Places of Interspecies Conflict: A Study of Horse-Human Interactions on UK Roads and Impacts on Equine Exercise
Application of the Ridden Horse Pain Ethogram to 150 Horses with Musculoskeletal Pain before and after Diagnostic Anaesthesia
The Ridden Horse Pain Ethogram (RHpE) was developed to facilitate the recognition of musculoskeletal pain. The aim of this study was to document changes in RHpE scores before and after diagnostic anaesthesia was performed to alleviate pain ± when the saddle was changed. One hundred and fifty horses underwent ridden exercise as part of an investigation of poor performance. The RHpE was applied before and after the interventions. Fifty-two (34.7%) horses exhibited a bilaterally symmetrical short step length and/or restricted hindlimb impulsion and engagement. Fifty-three (35.3%) horses had episodic lameness; only forty-five (30.0%) horses were continuously lame. The median maximum lameness grade when ridden was 2/8 (interquartile range [IQR]: 0â3; range: 0â4). Fifty-six (37.3%) horses had an ill-fitting saddle, which was considered likely to influence performance. The median RHpE scores after the interventions (2/24 [IQR: 1â3, range: 0â12]) were significantly lower than before the interventions (9/24 [IQR: 8â11, range: 2â15]) (Wilcoxon signed-rank z = 10.6, p p = 0.262). It was concluded that the absence of overt lameness does not preclude primary musculoskeletal pain. Gait quality and performance can be improved by diagnostic anaesthesia, with substantial reductions in RHpE scores