From winery by-product to healthy product: bioavailability, redox signaling and oxidative stress modulation by wine pomace product

The wine pomace is the main winery by-products that suppose an economic and environmental problem and their use as a functional ingredient are being increasingly recognized as a good and inexpensive source of bioactive compounds. In this sense, it is known the potential health properties of wine pomace products in the prevention of disorders associated with oxidative stress and inflammation such as endothelial dysfunction, hypertension, hyperglycemia, diabetes, obesity. Those effects are due to the bioactive compounds of wine pomace and the mechanisms concern especially modulation of antioxidant/prooxidant activity, improvement of nitric oxide bioavailability, reduction of pro-inflammatory cytokines and modulation of antioxidant/inflammatory signal pathways. This review mainly summarizes the mechanisms of wine pomace products as modulators of oxidative status involved in cell pathologies as well as their potential therapeutic use for cardiovascular diseases. For this purpose, the review provides an overview of the findings related to the wine pomace bioactive compounds profile, their bioavailability and the action mechanisms for maintaining the redox cell balance involved in health benefits. The review suggests an important role for wine pomace product in cardiovascular diseases prevention and their regular food intake may attenuate the development and progression of comorbidities associated with cardiovascular diseases.The authors thank the financial support of the Spain Ministry of Science, Innovation and Universities (Ref. PGC2018-097113-B-I00)

Using Automated Reasoning Tools in GeoGebra in the Teaching and Learning of Proving in Geometry

ABSTRACT: This document introduces, describes and exemplifies the technical features of some recently implemented automated reasoning tools in the dynamic mathematics software GeoGebra. The new tools are based on symbolic computation algorithms, allowing the automatic and rigorous proving and discovery of theorems on constructed geometric figures. Some examples of the use in the classroom of such commands are provided, including one describing how intuitive handling of GeoGebra automated reasoning tools may result in unexpected outputs. In all cases the emphasis is made in the potential utility of these tools as a guiding stick to foster student activities (exploration, reasoning) in the learning of elementary geometry. Moreover, a collection of appendices describing other, more sophisticated, low-level GeoGebra tools (Prove, ProveDetails), as well as instructions on how to obtain the translation of GeoGebra commands into other languages, and details about debugging, are included.Work partially supported by the grant MTM2017-88796-P from the Spanish MINECO and the ERDF (European Regional Development Fund)

Effect of a Diet Supplemented with α-Tocopherol and β-Carotene on ATP and Antioxidant Levels after Hepatic Ischemia-Reperfusion

Ischemia-reperfusion injury associated with liver transplantation remains a serious complication in clinical practice. In the present study the effect of intake of α-tocopherol or β-carotene to limit liver injury by oxidative stress in ischemia and reperfusion was explored. Wistar rats were fed with diets enriched with α-tocopherol (20 mg/day) or β-carotene (3 mg/day) for 21 days. After 21 days, their livers were subjected to 15 and 30 min of ischemia and afterwards were reperfused for 60 min. The recovery of levels of ATP during reperfusion was better in the group of rats whose diets were supplemented with α-tocopherol or β-carotene than in the group control. The supplementation of the diet induced changes in the profile of enzymatic antioxidants. The supplementation with α-tocopherol and β-carotene resulted in a decreased of superoxide dismutase during the ischemia and a recovery was observed after reperfusion. Not changes were observed for the enzymes catalase and glutathione peroxidase and glutathione but their values were higher to those of the group control. In conclusion, the supplementation with α-tocopherol and β-carotene improve the antioxidant and energetic state of liver after ischemia and reperfusion injury

Time harmonic and static crack problems in 3-D transversely isotropic bodies

Boundary Elements XXVI, ISBN 1-85312-708-6Three dimensional crack problems in transversely isotropic solids under static and time harmonic dynamic loading conditions are studied in this paper using a mixed BE approach. Hypersingular and strongly singular kernels appearing in the formulation are regularized prior to any discretization. Two different crack geometries are studied. Stress Intensity Factors are computed from the crack opening displacements at quarter-point quadratic elements. The results obtained in this paper show a good agreement with other results. The number of elements required is rather small.Ministerio de Ciencia y Tecnología DPI2000-1217-C02-01Ministerio de Ciencia y Tecnología DPI2001-2377-C02-0

Estudio numérico de grietas en sólidos 3-D transversalmente isótropos

XVI Congreso Nacional de Ingeniería Mecánica, celebrado en León en 2004En este artículo se presentan resultados de problemas de Mecánica de la Fractura dinámica armónica en materiales transversalmente isótropos. Estos resultados han sido obtenidos mediante la aplicación de la formulación mixta del Método de los Elementos de Contorno desarrollada por los autores. Dicha formulación permite que tan solo sea necesario discretizar la superficie de la grieta y el contorno externo del problema. La formulación se valida mediante la comparación de algunos resultados con los obtenidos por otros autores. Posteriormente se resuelven otros problemas de gran interés pero más complicados para los que no existe solución previa conocida por los autoresResults for severa! problems of time harmonic Fracture Mechanics in transversely isotropic solids are presented in this paper. A Mixed Boundary Element Formulation developed by the authors has been used in order to obtain these results. Only the crack surface and the externa! boundary need to be discretized. Results obtained for sorne simple problems are compared with those obtained by other authors. Then, other interesting and more complex problems, for which no previous results are known by the authors, are solved.Ministerio de Ciencia y Tecnología DPI2000-12l 7-C02-0lMinisterio de Ciencia y Tecnología DPI2001-2377-C02-0

Análisis de los errores cometidos al resolver un límite en exámenes de PAU

La clasificación de errores supone una fuente de información muy útil para el profesorado, y permite diagnosticar las deficiencias que se hayan producido en el proceso de enseñanzaaprendizaje. Los análisis a gran escala permiten detectar comportamientos generalizados en grandes poblaciones de estudiantes. En este trabajo se lleva a cabo el análisis de los errores cometidos en la resolución de un ejercicio en las pruebas de acceso a la Universidad de Oviedo (PAU), en España. El trabajo se ha centrado en el manejo del lenguaje y procedimientos matemáticos, por lo cual se ha seleccionado un ejercicio presentando en un contexto meramente matemático, que consistía en la resolución de un límite. Para analizar la tipología de errores se ha utilizado la clasificación realizada por Radatz (1979). Tras un primer pilotaje para calibrar la clasificación inicial, se analizaron un total de 616 exámenes, la totalidad de los que realizaron la opción de examen de PAU en la que se incluía este ejercicio. En el 71% de ellos se cometió algún tipo de error, siendo (con mucha diferencia) el más frecuente, el debido a un aprendizaje deficiente de hechos, destrezas y conceptos previos

Enunciados ni ciertos ni falsos en razonamiento automático en geometría

ABSTRACT: We investigate and generalize to an extended framework the notion of true on components labeled by Zhou, Wang and Sun in their paper "Automated Reducible Geometric Theorem Proving and Discovery by Gröbner Basis Method", J. Automat. Reasoning 59 (3), 331-344, 2017. A new, simple criterion is presented for a statement to be simultaneously not generally true and not generally false (i.e. true on components), and its performance is exemplified through the implementation of this test in the dynamic geometry program GeoGebra. This extended abstract is based on a recent work by the authors.Partially supported by the Spanish Research Project MTM2017-88796-P Computación simbólica: nuevos retos en álgebra y geometría y sus aplicaciones

Beneficial Effects of Olive Oil Enriched with Lycopene on the Plasma Antioxidant and Anti-Inflammatory Profile of Hypercholesterolemic Patients

Olive oil and lycopene are foods that have potent antioxidant activity. The objective was to determine the effects of consumption of olive oil enriched with lycopene on oxidative stress biomarkers in hypercholesterolemic subjects. We examined the effects of oil enriched with lycopene extract daily intake during 1 month on plasma antioxidant capacity, lipids profile (triacylgycerols, total cholesterol, cHDL; cLDL, ox-LDL), biomarkers of oxidative stress, and inflammatory markers related with atherosclerosis risk (C-reactive protein (CRP), IL-6; sDC4L) in subjects hypercholesteremics (cholesterol > 220 mg/dL). In the group consuming olive oil-lycopene, significant increases (p < 0.05) in the levels of plasma lycopene concentration (0.146 ± 0.03 versus 0.202 ± 0.04 (µmol/L)), α-carotene (0.166 ± 0.064 versus 0.238 ± 0.07) and in β-carotene (0.493 ± 0.187 versus 0.713 ± 0.221) were observed. These results are linked with the increases of plasma antioxidants and decreases biomarkers of oxidative stress (carbonyl groups, malondialdehyde and 8-hydroxy-deoxiguanosine) observed in hypercholesterolemic group. In relation to lipid profile, a significant decrease was observed in the levels of ox-LDL (781 ± 302 versus 494 ± 200), remaining unchanged the levels of TG, cholesterol, HDL and LDL-c. Regarding inflammatory biomarkers, the levels of CRP and IL-6 decreased significantly. The positive results obtained in this study support the use of olive oil enriched with lycopene to reduce the risk of coronary disease

Cytotoxicity study of bakery product melanoidins on intestinal and endothelial cell lines

Melanoidins contribute to organoleptic properties of processed foods and exert benefits in health. The aim of this study was to isolate and characterize melanoidins from baked products (common bread, soft bread and biscuits), evaluate their cytotoxicity and determine their suitability as functional additives. Extraction yield, spectrophotometric characteristics, colorimetric properties, antioxidant capacity, and cytotoxicity of melanoidins were assessed. Among the studied products, soft bread had the highest extraction throughput. Melanoidins from biscuit showed the highest antioxidant capacity, closely followed by those of soft bread. Melanoidins did not exert cytotoxic effects on Caco-2 and HUVEC cells (viability was >80%). Nevertheless, incubation of HUVEC cells with melanoidins from common bread and biscuit slightly decreased viability, whereas gastrointestinal digestion of such melanoidins softened the decrease in cell viability. This study point to soft bread as a safe and efficient source of melanoidins, that could be potentially used in the future as functional ingredient.Autonomous Government of Castilla y León and FEDER (JCyL/FEDER) BU243P1

Radiovisiografía : nueva alternativa diagnóstica en odontoestomatología

Para el diagnóstico de diversas patologías odontológicas, la exploración de tejidos blandos y duros debe ser rigurosa. En muchas ocasiones, además de las técnicas de inspección, palpación, percusión y auscultación podemos servirnos de métodos complementarios como sondaje, aspiración, citología, biopsia, cultivos y para el diagnóstico por imagen nos valdremos de la radiología simple y de contraste. Actualmente podemos disponer de un nuevo método llamado Visiorradiología, que nos proporciona una serie de ventajas frente a la radiología convencional. En este trabajo se presenta un estudio comparativo entre la radiología simple y la visiorradiología en base al estudio de diversas piezas dentales, concluyéndose con los mejores resultados y posibilidades de la segunda con respecto a la primera en cuanto a rapidez, tratamiento de imágenes así como la posibilidad de almacenamiento en soporte magnético y control visual mediante impresora para el dueño de los animales.To diagnose some odontologic pathologies, the soft and tough tissues exploration must be strict. Sometimes, we can use complementary methods like sounding, aspiration, citology, biopsy, cultures and image diagnosis using ordinary and contrast radiology; in addition to the following techniques: examination, palpation, percution and auscultation. Actually we can have available a new method provide us advantages against the conventional radiology. In this study we present a comparative study between the simple radiology and the visiorradiology according to some tooth studies. We demonstrate that visiorradiology is beíter for the speed, images quality as well as the storing possibility . in magnetic supports and visual control trough the printer for the owner