Competencias legales de los psicólogos clínicos.

Se analizan y estudian las competencias legales de los psicólogos clínicos en la red de servicios públicos de salud mental; derivadas de la aprobación del Decreto de la Especialidad de Psicología Clínica. El análisis se enmarca dentro de un modelo de atención comunitario apoyado en el trabajo del equipo interdisciplinario

Competencias legales de los psicólogos clínicos.

Se analizan y estudian las competencias legales de los psicólogos clínicos en la red de servicios públicos de salud mental; derivadas de la aprobación del Decreto de la Especialidad de Psicología Clínica. El análisis se enmarca dentro de un modelo de atención comunitario apoyado en el trabajo del equipo interdisciplinario

Priorities in Cardio-Oncology Basic and Translational Science

Despite improvements in cancer survival, cancer therapy–related cardiovascular toxicity has risen to become a prominent clinical challenge. This has led to the growth of the burgeoning field of cardio-oncology, which aims to advance the cardiovascular health of cancer patients and survivors, through actionable and translatable science. In these Global Cardio-Oncology Symposium 2023 scientific symposium proceedings, we present a focused review on the mechanisms that contribute to common cardiovascular toxicities discussed at this meeting, the ongoing international collaborative efforts to improve patient outcomes, and the bidirectional challenges of translating basic research to clinical care. We acknowledge that there are many additional therapies that are of significance but were not topics of discussion at this symposium. We hope that through this symposium-based review we can highlight the knowledge gaps and clinical priorities to inform the design of future studies that aim to prevent and mitigate cardiovascular disease in cancer patients and survivors.</p

Evaluation of transparent 20L polyproylene buckets for household solar water disinfection (SODIS) of drinking water in resource-poor environments.

Solar water disinfection (SODIS) is an appropriate technology for treating drinking water in developing communities, as it is effective, low- or zero-cost, easy to use. The WHO recognises SODIS as an appropriate intervention to provide drinking water after manmade or natural disasters. Nevertheless, uptake is low due partially to the burden of using small volume polyethylene terephthalate (PET) bottles (1.5-2 L). A major challenge is to develop a low cost transparent container for disinfecting larger volumes of water. This study examines the capability of transparent polypropylene (PP) buckets of 5 and 20 litres volume, as SODIS containers using three waterborne pathogen indicator organisms: E. coli, MS2-phage and Cryptosporidium parvum oocysts

Microbiological evaluation of 5 L- And 20 L-transparent polypropylene buckets for solar water disinfection (SODIS)

Background: Solar water disinfection (SODIS) is an appropriate technology for household treatment of drinking water in low-to-middle-income communities, as it is effective, low cost and easy to use. Nevertheless, uptake is low due partially to the burden of using small volume polyethylene terephthalate bottles (1.5-2 L). A major challenge is to develop a low-cost transparent container for disinfecting larger volumes of water. (2) Methods: This study examines the capability of transparent polypropylene (PP) buckets of 5 L- and 20 L- volume as SODIS containers using three waterborne pathogen indicators: Escherichia coli, MS2-phage and Cryptosporidium parvum. (3) Results: Similar inactivation kinetics were observed under natural sunlight for the inactivation of all three organisms in well water using 5 L- and 20 L-buckets compared to 1.5 L-polyethylene-terephthalate (PET) bottles. The PP materials were exposed to natural and accelerated solar ageing (ISO-16474). UV transmission of the 20 L-buckets remained stable and with physical integrity even after the longest ageing periods (9 months or 900 h of natural or artificial solar UV exposure, respectively). The 5 L-buckets were physically degraded and lost significant UV-transmission, due to the thinner wall compared to the 20 L-bucket. (4) Conclusion: This work demonstrates that the 20 L SODIS bucket technology produces excellent bacterial, viral and protozoan inactivation and is obtained using a simple transparent polypropylene bucket fabricated locally at very low cost ($2.90 USD per unit). The increased bucket volume of 20 L allows for a ten-fold increase in treatment batch volume and can thus more easily provide for the drinking water requirements of most households. The use of buckets in households across low to middle income countries is an already accepted practice

Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis

Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk associated with RA.Methods: The frequencies of monocyte subpopulations in the peripheral blood of 140 RA patients and 145 healthy donors (HDs) included in the PRECISESADS study were determined by flow cytometry. A second cohort of 50 RA patients and 30 HDs was included, of which CD14+ and CD16+ monocyte subpopulations were isolated using immuno-magnetic selection. Their transcriptomic profiles (mRNA and microRNA), proinflammatory patterns and activated pathways were evaluated and related to clinical features and CV risk. Mechanistic in vitro analyses were further performed.Results: CD14++CD16+ intermediate monocytes were extended in both cohorts of RA patients. Their increased frequency was associated with the positivity for autoantibodies, disease duration, inflammation, endothelial dysfunction and the presence of atheroma plaques, as well as with the CV risk score. CD14+ and CD16+ monocyte subsets showed distinctive and specific mRNA and microRNA profiles, along with specific intracellular signaling activation, indicating different functionalities. Moreover, that specific molecular profiles were interrelated and associated to atherosclerosis development and increased CV risk in RA patients. In vitro, RA serum promoted differentiation of CD14+CD16− to CD14++CD16+ monocytes. Co-culture with RA-isolated monocyte subsets induced differential activation of endothelial cells.Conclusions: Our overall data suggest that the generation of inflammatory monocytes is associated to the autoimmune/inflammatory response that mediates RA. These monocyte subsets, -which display specific and distinctive molecular signatures- might promote endothelial dysfunction and in turn, the progression of atherosclerosis through a finely regulated process driving CVD development in RA

Meeting daily drinking water needs for communities in Sub-Saharan Africa using solar reactors for harvested rainwater

Two large reactors designed for solar water disinfection (SODIS) of harvested rainwater (HRW) were built and tested in Spain (controlled conditions) and Uganda (field testing). Both reactors use V-trough aluminium mirrors and UV-transparent poly(methyl-methacrylate) (PMMA) photo-reactor tubes of diameters, 100 mm and 200 mm, for treating 90L and 140L per batch, respectively. No differences in terms of treatment performances were obtained between both solar reactors. Complete disinfection of synthetic HRW spiked with a consortium of waterborne pathogens (E. coli, S. enteritidis, E. faecalis and MS2 coliphage) was achieved under natural sunlight, obtaining > 5-log reduction values (LRV) of all bacteria for a maximum solar UVA dose of 270 kJ/m2 or 120 min of solar exposure. A 5-LRV for MS2 virus was also achieved with a maximum of up to 620 kJ/m2 of UVA dose or 300 min of solar exposure. Accelerated and natural aging of the UV-transparent PMMA material were also investigated, showing that the material is highly transparent in the UVB (from 7 to 75 %) and UVA (87 %) and photostable, with no significant change in UVB&A transmittance for 9 months under extreme conditions of solar radiation, humidity and temperature. Results for the reactors in the field, in two rural primary schools in Uganda over 1 year, demonstrated excellent performances with complete reductions of the bacterial load in natural HRW to undetectable levels of E. coli, E. faecalis and Total coliforms (4 LRV were also attained. An analysis of cost, materials selection and solar resources needed has been carried out to determine the affordability and feasibility of this technology. The results of this analysis demonstrated the potential capability of the 140L solar V-trough reactor for treating HRW, with an estimated cost of €0.0012 per liter

Detection of alpha and betacoronaviruses in multiple Iberian bat species

Bat coronaviruses (CoV) are putative precursors of the severe acute respiratory syndrome (SARS) CoV and other CoV that crossed the species barrier from zoonotic reservoirs into the human population. To determine the presence and distribution of CoV in Iberian bats, 576 individuals of 26 different bat species were captured in 13 locations in Spain. We report for the first time the presence of 14 coronaviruses in 9 Iberian bat species. Phylogenetic analysis of a conserved CoV genome region (RdRp gene) shows a wide diversity and distribution of alpha and betacoronavirus in Spain. Interestingly, although some of these viruses are related to other European BatCoV, or to Asian CoV, some of the viruses found in Spain cluster in new groups of α and β CoV.Peer reviewe