257 research outputs found
Hook-billed Kite, Chondrohierax uncinatus, southbound autumn migration in Belize and Mexico
The Hook-billed Kite (Chondrohierax uncinatus) is a specialized Neotropical raptor with a wide distribution that has received little research attention. The species is considered non-migratory across most of its distribution, but there are scattered records of Hook-billed Kite migration. The present research describes, for the first time, the largest southbound autumn migration of Hook-billed Kite in Belize and Mexico and evaluates the effects of environmental conditions on this phenomenon. Eight years of count data were collected in Belize and 25 years in Mexico. During a total of 3093.1 count hr from 2013-2020 in Belize, 39928 Hook-billed Kites were counted on their southbound autumn migration with a mean (±SE) annual count of 4991 ± 1083 kites/yr. In comparison, during a total of 42531 count hr from 1995-2019 at two count sites in Mexico, 3870 Hook-billed Kites were counted. The mean 95% seasonal passage window of Hook-billed Kites in Belize was 44.9 ± 2.5 d (n= 8) from 26 October to 9 December compared to 13 September to 11 November in Mexico. Precipitation on the breeding grounds had no influence on the timing or magnitude of the kite migration through Belize, whereas in Mexico, migration time occurred later as precipitation north of the count site increased. The present research provides critical ecological information, which can aid in identifying potential threats, conservation needs, and population status for Hook-billed Kites and other neotropical raptors
Effects of the reaction cavity on metastable optical excitation in ruthenium-sulfur dioxide complexes
We report photoexcited-state crystal structures for two new members of the
[Ru(SO_2)(NH_3)_4X]Y family: 1:X=H2O, Y=(+/-)-camphorsulfonate_2;
2:X=isonicotinamide, Y=tosylate_2. The excited states are metastable at 100 K,
with a photoconversion fraction of 11.1(7)% achieved in 1, and 22.1(10)% and
26.9(10)% at the two distinct sites in 2.We further show using solid-state
density-functional-theory calculations that the excited-state geometries
achieved are strongly influenced by the local crystal environment. This result
is relevant to attempts to rationally design related photoexcitation systems
for optical data-storage applications.Comment: 6 pages, 5 figure
Changing the Environment Based on Empowerment as Intrinsic Motivation
This is an open access article distributed under the Creative Commons Attribution License CC BY 3.0 which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.One aspect of intelligence is the ability to restructure your own environment so that the world you live in becomes more beneficial to you. In this paper we investigate how the information-theoretic measure of agent empowerment can provide a task-independent, intrinsic motivation to restructure the world. We show how changes in embodiment and in the environment change the resulting behaviour of the agent and the artefacts left in the world. For this purpose, we introduce an approximation of the established empowerment formalism based on sparse sampling, which is simpler and significantly faster to compute for deterministic dynamics. Sparse sampling also introduces a degree of randomness into the decision making process, which turns out to beneficial for some cases. We then utilize the measure to generate agent behaviour for different agent embodiments in a Minecraft-inspired three dimensional block world. The paradigmatic results demonstrate that empowerment can be used as a suitable generic intrinsic motivation to not only generate actions in given static environments, as shown in the past, but also to modify existing environmental conditions. In doing so, the emerging strategies to modify an agent’s environment turn out to be meaningful to the specific agent capabilities, i.e., de facto to its embodiment.Peer reviewedFinal Published versio
Evidence for Type Ia Supernova Diversity from Ultraviolet Observations with the Hubble Space Telescope
We present ultraviolet (UV) spectroscopy and photometry of four Type Ia
supernovae (SNe 2004dt, 2004ef, 2005M, and 2005cf) obtained with the UV prism
of the Advanced Camera for Surveys on the Hubble Space Telescope. This dataset
provides unique spectral time series down to 2000 Angstrom. Significant
diversity is seen in the near maximum-light spectra (~ 2000--3500 Angstrom) for
this small sample. The corresponding photometric data, together with archival
data from Swift Ultraviolet/Optical Telescope observations, provide further
evidence of increased dispersion in the UV emission with respect to the
optical. The peak luminosities measured in uvw1/F250W are found to correlate
with the B-band light-curve shape parameter dm15(B), but with much larger
scatter relative to the correlation in the broad-band B band (e.g., ~0.4 mag
versus ~0.2 mag for those with 0.8 < dm15 < 1.7 mag). SN 2004dt is found as an
outlier of this correlation (at > 3 sigma), being brighter than normal SNe Ia
such as SN 2005cf by ~0.9 mag and ~2.0 mag in the uvw1/F250W and uvm2/F220W
filters, respectively. We show that different progenitor metallicity or
line-expansion velocities alone cannot explain such a large discrepancy.
Viewing-angle effects, such as due to an asymmetric explosion, may have a
significant influence on the flux emitted in the UV region. Detailed modeling
is needed to disentangle and quantify the above effects.Comment: 17 pages, 13 figures, accepted by Ap
Diving into the vertical dimension of elasmobranch movement ecology
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
Diving into the vertical dimension of elasmobranch movement ecology
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
Diving into the vertical dimension of elasmobranch movement ecology
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
The Science Performance of JWST as Characterized in Commissioning
This paper characterizes the actual science performance of the James Webb
Space Telescope (JWST), as determined from the six month commissioning period.
We summarize the performance of the spacecraft, telescope, science instruments,
and ground system, with an emphasis on differences from pre-launch
expectations. Commissioning has made clear that JWST is fully capable of
achieving the discoveries for which it was built. Moreover, almost across the
board, the science performance of JWST is better than expected; in most cases,
JWST will go deeper faster than expected. The telescope and instrument suite
have demonstrated the sensitivity, stability, image quality, and spectral range
that are necessary to transform our understanding of the cosmos through
observations spanning from near-earth asteroids to the most distant galaxies.Comment: 5th version as accepted to PASP; 31 pages, 18 figures;
https://iopscience.iop.org/article/10.1088/1538-3873/acb29
Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia ®; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-κB localization and IκB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-κB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-κB and degradation of IκB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-κB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
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