Water place, water power

Thesis (M.Arch.)--Massachusetts Institute of Technology, Dept. of Architecture, 1980.MICROFICHE COPY AVAILABLE IN ARCHIVES AND ROTCH.Includes bibliographical references.by Philip O. Belanger.M.Arch

Technology and Information Fusion Needs to Address the Food, Energy, Water Systems (FEWS) Nexus Challenges

In response to the Food, Energy, Water Systems (FEWS) Nexus Challenge grant awarded by NSF, the team of investigators led by David Ebert, along with Christian Butzke, Melba Crawford, Phillip Owens, and Dimitrios Peroulis conducted a two-day workshop in Napa, California on November 5th and 6th, 2015. The workshop addressed the emerging issues in the food/energy/water systems throughout the diverse geography of the United States and over various crops and environmental conditions to better understand and model and ultimately devise a solution for the challenges to the FEWS nexus. One of the intended outcomes of the workshop was to generate a report that will chart the research challenges and opportunities for solving these challenges and have an impact on scientific fields including, sensing technology, hydrology, soil science, climate, data fusion, analysis, visualization, and data driven decision 2 making, as well as agricultural production, local and regional economies, sustainability and planning. The information contained in this post-workshop report serves as that foundation.In response to the Food, Energy, Water Systems (FEWS) Nexus Challenge grant awarded by NSF, the team of investigators led by David Ebert, along with Christian Butzke, Melba Crawford, Phillip Owens, and Dimitrios Peroulis conducted a two-day workshop in Napa, California on November 5th and 6th, 2015. The workshop addressed the emerging issues in the food/energy/water systems throughout the diverse geography of the United States and over various crops and environmental conditions to better understand and model and ultimately devise a solution for the challenges to the FEWS nexus. One of the intended outcomes of the workshop was to generate a report that will chart the research challenges and opportunities for solving these challenges and have an impact on scientific fields including, sensing technology, hydrology, soil science, climate, data fusion, analysis, visualization, and data driven decision 2 making, as well as agricultural production, local and regional economies, sustainability and planning. The information contained in this post-workshop report serves as that foundation

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

Table S1. Demographic and clinical features of human subjects used in this study. Figure S1. Aβ deposition in microvessels in AD patients and APPSw/0 mice. Figure S2. Biochemical analysis of Aβ42 aggregates. Figure S3. Cy3-Aβ42 cellular uptake in wild type mouse brain slices within 30 min. Figure S4. Pericyte coverages in Lrp1lox/lox and Lrp1lox/lox; Cspg4-Cre mice. Figure S5.. LRP1 and apoE suppression with siRNA. (DOCX 1454 kb

Subterranean Termites.

6 p

Thunderstorm occurrence at ten sites across Great Britain over 1884–1993

The UK Met Office's Daily Weather Reports (DWR) contain extensive logs of UK thunderstorm activity. To date, only a very small fraction of these data have been digitized as part of the MIDAS dataset, and exclusively after 1950. Using the recently‐scanned UK Met Office Monthly Weather Reports (MWR), which are based on a subset of the observations that form the DWR, we here provide digitized data and a summary of thunderdays from 10 long‐running British stations over the period 1884–1993. The data are presented ‘as is’, with no attempt to provide any corrections or calibration. For 4 of the 10 stations, thunderday observations were discontinued at various times between 1949 and 1964, and it is necessary to switch to a neighbouring station in order to continue the series. Approximately half the series exhibit sharp drops in thunderdays at various points between 1960 and 1990, although none are coincident with known station changes. Comparison with nearby MIDAS stations suggests the low thunderdays are the result of changes in observing practice, rather than genuine changes in thunderstorm occurrence. These potential data issues limit interpretation of the long‐term trends. However, it can nevertheless be concluded that none of the stations show the expected increase in thunderdays as a result of the rise in surface temperature over the 20th century. In order to provide more quantitative determination of the long‐term trends in thunderstorm occurrence, we advocate further digitization efforts to recover the data from the numerous stations in the MWRs, and subsequent analysis of the common signals across neighbouring stations

Матеріали інформаційно-методичного забезпечення дисципліни «Кримінальне правозастосування (Проблеми призначення покарань)»

В правовій державі кримінально-правовим засобам регулювання протидії злочинності відводиться ключова роль не тільки в сфері притягнення винних осіб до заслуженої відповідальності, а й у наданні правової допомоги громадя- нам та юридичним особам та забезпеченні їх правової безпеки, захисту прав і свобод потерпілих від злочинів особам, а також для того, щоб попередити в майбутньому можливість вчинення нових злочинів. Під час вивчення курсу «Кримінальне правозастосування (Проблеми при- значення покарань)» студенти отримують теоретичні знання і практичні навич- ки з організації діяльності по реалізації законодавчих приписів щодо криміна- льно-правової політики держави.Навчальна нормативна дисципліна «Кримінальне правозастосування (Проблеми призначення покарань)» передбачає опанування теорії, методології і методики застосування в практиці судів норм кримінального права України. Систематизований виклад положень навчальної дисципліни покликаний сфор- мувати практичні навички застосування норм кримінального права майбутніми юристами у правоохоронній діяльності

Prolonged and tunable residence time using reversible covalent kinase inhibitors.

Drugs with prolonged on-target residence times often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking. Here we made progress toward this elusive goal by targeting a noncatalytic cysteine in Bruton's tyrosine kinase (BTK) with reversible covalent inhibitors. Using an inverted orientation of the cysteine-reactive cyanoacrylamide electrophile, we identified potent and selective BTK inhibitors that demonstrated biochemical residence times spanning from minutes to 7 d. An inverted cyanoacrylamide with prolonged residence time in vivo remained bound to BTK for more than 18 h after clearance from the circulation. The inverted cyanoacrylamide strategy was further used to discover fibroblast growth factor receptor (FGFR) kinase inhibitors with residence times of several days, demonstrating the generalizability of the approach. Targeting of noncatalytic cysteines with inverted cyanoacrylamides may serve as a broadly applicable platform that facilitates 'residence time by design', the ability to modulate and improve the duration of target engagement in vivo

Mars Tumbleweed: FY2003 Conceptual Design Assessment

NASA LaRC is studying concepts for a new type of Mars exploration vehicle that would be propelled by the wind. Known as the Mars Tumbleweed, it would derive mobility through use of the Martian surface winds. Tumbleweeds could conceivably travel greater distances, cover larger areas of the surface, and provide access to areas inaccessible by conventional vehicles. They would be lightweight and relatively inexpensive, allowing a multiple vehicle network to be deployed on a single mission. Tumbleweeds would be equipped with sensors for conducting science and serve as scouts searching broad areas to identify specific locations for follow-on investigation by other explorers. An extensive assessment of LaRC Tumbleweed concepts was conducted in FY03, including refinement of science mission scenarios, definition of supporting subsystems (structures, power, communications), testing in wind tunnels, and development of a dynamic simulation capability

Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: possible role of differential RhoA activity.

Coronary heart disease is the leading cause of morbidity in patients with type 2 diabetes mellitus (T2DM), frequently resulting in a requirement for coronary revascularization using the internal mammary artery (IMA) or saphenous vein (SV). Patency rates of SV grafts are inferior to IMA and further impaired by T2DM whilst IMA patencies appear similar in both populations. Smooth muscle cells (SMC) play a pivotal role in graft integration; we therefore examined the phenotype and proliferative function of IMA- and SV-SMC isolated from non-diabetic (ND) patients or those diagnosed with T2DM