Relation between convective rainfall properties and antecedent soil moisture heterogeneity conditions in North Africa

Recent observational studies have demonstrated the relevance of soil moisture heterogeneity and the associated thermally-induced circulation on deep convection and rainfall triggering. However, whether this dynamical mechanism further influences rainfall propertiessuch as rain volume or timinghas yet to be confirmed by observational data. Here, we analyze 10 years of satellite-based sub-daily soil moisture and precipitation records and explore the potential of strong spatial gradients in morning soil moisture to influence the properties of afternoon rainfall in the North African region, at the 100-km scale. We find that the convective rain systems that form over locally drier soils and anomalously strong soil moisture gradients have a tendency to initiate earlier in the afternoon; they also yield lower volumes of rain, weaker intensity and lower spatial variability. The strongest sensitivity to antecedent soil conditions is identified for the timing of the rain onset; it is found to be correlated with the magnitude of the soil moisture gradient. Further analysis shows that the early initiation of rainfall over dry soils and strong surface gradients yet requires the presence of a very moist boundary layer on that day. Our findings agree well with the expected effects of thermally-induced circulation on rainfall properties suggested by theoretical studies and point to the potential of locally drier and heterogeneous soils to influence convective rainfall development. The systematic nature of the identified effect of soil moisture state on the onset time of rainstorms in the region is of particular relevance and may help foster research on rainfall predictability

A Novel C1q Domain-Containing Protein Isolated from the Mollusk Modiolus kurilensis Recognizing Glycans Enriched with Acidic Galactans and Mannans

C1q domain-containing (C1qDC) proteins are a group of biopolymers involved in immune response as pattern recognition receptors (PRRs) in a lectin-like manner. A new protein MkC1qDC from the hemolymph plasma of Modiolus kurilensis bivalve mollusk widespread in the Northwest Pacific was purified. The isolation procedure included ammonium sulfate precipitation followed by affinity chromatography on pectin-Sepharose. The full-length MkC1qDC sequence was assembled using de novo mass-spectrometry peptide sequencing complemented with N-terminal Edman’s degradation, and included 176 amino acid residues with molecular mass of 19 kDa displaying high homology to bivalve C1qDC proteins. MkC1qDC demonstrated antibacterial properties against Gram-negative and Gram-positive strains. MkC1qDC binds to a number of saccharides in Ca(2+)-dependent manner which characterized by structural meta-similarity in acidic group enrichment of galactose and mannose derivatives incorporated in diversified molecular species of glycans. Alginate, κ-carrageenan, fucoidan, and pectin were found to be highly effective inhibitors of MkC1qDC activity. Yeast mannan, lipopolysaccharide (LPS), peptidoglycan (PGN) and mucin showed an inhibitory effect at concentrations three orders of magnitude greater than for the most effective saccharides. MkC1qDC localized to the mussel hemal system and interstitial compartment. Intriguingly, MkC1qDC was found to suppress proliferation of human adenocarcinoma HeLa cells in a dose-dependent manner, indicating to the biomedical potential of MkC1qDC protein

The origins and spread of domestic horses from the Western Eurasian steppes

This is the final version. Available on open access from Nature Research via the DOI in this recordData availability: All collapsed and paired-end sequence data for samples sequenced in this study are available in compressed fastq format through the European Nucleotide Archive under accession number PRJEB44430, together with rescaled and trimmed bam sequence alignments against both the nuclear and mitochondrial horse reference genomes. Previously published ancient data used in this study are available under accession numbers PRJEB7537, PRJEB10098, PRJEB10854, PRJEB22390 and PRJEB31613, and detailed in Supplementary Table 1. The genomes of ten modern horses, publicly available, were also accessed as indicated in their corresponding original publications57,61,85-87.NOTE: see the published version available via the DOI in this record for the full list of authorsDomestication of horses fundamentally transformed long-range mobility and warfare. However, modern domesticated breeds do not descend from the earliest domestic horse lineage associated with archaeological evidence of bridling, milking and corralling at Botai, Central Asia around 3500 BC. Other longstanding candidate regions for horse domestication, such as Iberia and Anatolia, have also recently been challenged. Thus, the genetic, geographic and temporal origins of modern domestic horses have remained unknown. Here we pinpoint the Western Eurasian steppes, especially the lower Volga-Don region, as the homeland of modern domestic horses. Furthermore, we map the population changes accompanying domestication from 273 ancient horse genomes. This reveals that modern domestic horses ultimately replaced almost all other local populations as they expanded rapidly across Eurasia from about 2000 BC, synchronously with equestrian material culture, including Sintashta spoke-wheeled chariots. We find that equestrianism involved strong selection for critical locomotor and behavioural adaptations at the GSDMC and ZFPM1 genes. Our results reject the commonly held association between horseback riding and the massive expansion of Yamnaya steppe pastoralists into Europe around 3000 BC driving the spread of Indo-European languages. This contrasts with the scenario in Asia where Indo-Iranian languages, chariots and horses spread together, following the early second millennium BC Sintashta culture

Regional co-variability of spatial and temporal soil moisture-precipitation coupling in North Africa : An observational perspective

The magnitude and sign of soil moisture-precipitation coupling (SMPC) is investigated using a probability-based approach and 10 years of daily microwave satellite data across North Africa at a 1° horizontal scale. Specifically, the co-existence and co-variability of spatial (i.e. using soil moisture gradients) and temporal (i.e. using soil moisture anomaly) soil moisture effects on afternoon rainfall is explored. The analysis shows that in the semi-arid environment of the Sahel, the negative spatial and the negative temporal coupling relationships do not only co-exist, but are also dependent on one another. Hence, if afternoon rain falls over temporally drier soils, it is likely to be surrounded by a wetter environment. Two regions are identified as SMPC "hot spots". These are the south-western part of the domain (7-15° N, 10° W-7° E), with the most robust negative SMPC signal, and the South Sudanese region (5-13° N, 24-34° E). The sign and significance of the coupling in the latter region is found to be largely modulated by the presence of wetlands and is susceptible to the number of long-lived propagating convective systems. The presence of wetlands and an irrigated land area is found to account for about 30 % of strong and significant spatial SMPC in the North African domain. This study provides the first insight into regional variability of SMPC in North Africa, and supports the potential relevance of mechanisms associated with enhanced sensible heat flux and mesoscale variability in surface soil moisture for deep convection development.</p

Relation between convective rainfall properties and antecedent soil moisture heterogeneity conditions in North Africa

Recent observational studies have demonstrated the relevance of soil moisture heterogeneity and the associated thermally-induced circulation on deep convection and rainfall triggering. However, whether this dynamical mechanism further influences rainfall properties-such as rain volume or timing-has yet to be confirmed by observational data. Here, we analyze 10 years of satellite-based sub-daily soil moisture and precipitation records and explore the potential of strong spatial gradients in morning soil moisture to influence the properties of afternoon rainfall in the North African region, at the 100-km scale. We find that the convective rain systems that form over locally drier soils and anomalously strong soil moisture gradients have a tendency to initiate earlier in the afternoon; they also yield lower volumes of rain, weaker intensity and lower spatial variability. The strongest sensitivity to antecedent soil conditions is identified for the timing of the rain onset; it is found to be correlated with the magnitude of the soil moisture gradient. Further analysis shows that the early initiation of rainfall over dry soils and strong surface gradients yet requires the presence of a very moist boundary layer on that day. Our findings agree well with the expected effects of thermally-induced circulation on rainfall properties suggested by theoretical studies and point to the potential of locally drier and heterogeneous soils to influence convective rainfall development. The systematic nature of the identified effect of soil moisture state on the onset time of rainstorms in the region is of particular relevance and may help foster research on rainfall predictability.</p

The “Angiogenic Switch” and Functional Resources in Cyclic Sports Athletes

Regular physical activity in cyclic sports can influence the so-called “angiogenic switch”, which is considered as an imbalance between proangiogenic and anti-angiogenic molecules. Disruption of the synthesis of angiogenic molecules can be caused by local changes in tissues under the influence of excessive physical exertion and its consequences, such as chronic oxidative stress and associated hypoxia, metabolic acidosis, sports injuries, etc. A review of publications on signaling pathways that activate and inhibit angiogenesis in skeletal muscles, myocardium, lung, and nervous tissue under the influence of intense physical activity in cyclic sports. Materials: We searched PubMed, SCOPUS, Web of Science, Google Scholar, Clinical keys, and e-LIBRARY databases for full-text articles published from 2000 to 2020, using keywords and their combinations. Results: An important aspect of adaptation to training loads in cyclic sports is an increase in the number of capillaries in muscle fibers, which improves the metabolism of skeletal muscles and myocardium, as well as nervous and lung tissue. Recent studies have shown that myocardial endothelial cells not only respond to hemodynamic forces and paracrine signals from neighboring cells, but also take an active part in heart remodeling processes, stimulating the growth and contractility of cardiomyocytes or the production of extracellular matrix proteins in myofibroblasts. As myocardial vascularization plays a central role in the transition from adaptive heart hypertrophy to heart failure, further study of the signaling mechanisms involved in the regulation of angiogenesis in the myocardium is important in sports practice. The study of the “angiogenic switch” problem in the cerebrovascular and cardiovascular systems allows us to claim that the formation of new vessels is mediated by a complex interaction of all growth factors. Although the lungs are one of the limiting systems of the body in cyclic sports, their response to high-intensity loads and other environmental stresses is often overlooked. Airway epithelial cells are the predominant source of several growth factors throughout lung organogenesis and appear to be critical for normal alveolarization, rapid alveolar proliferation, and normal vascular development. There are many controversial questions about the role of growth factors in the physiology and pathology of the lungs. The presented review has demonstrated that when doing sports, it is necessary to give a careful consideration to the possible positive and negative effects of growth factors on muscles, myocardium, lung tissue, and brain. Primarily, the “angiogenic switch” is important in aerobic sports (long distance running). Conclusions: Angiogenesis is a physiological process of the formation of new blood capillaries, which play an important role in the functioning of skeletal muscles, myocardium, lung, and nervous tissue in athletes. Violation of the “angiogenic switch” as a balance between proangiogenic and anti-angiogenic molecules can lead to a decrease in the functional resources of the nervous, musculoskeletal, cardiovascular, and respiratory systems in athletes and, as a consequence, to a decrease in sports performance