Advanced modulation technology development for earth station demodulator applications. Coded modulation system development

A jointly optimized coded modulation system is described which was designed, built, and tested by COMSAT Laboratories for NASA LeRC which provides a bandwidth efficiency of 2 bits/s/Hz at an information rate of 160 Mbit/s. A high speed rate 8/9 encoder with a Viterbi decoder and an Octal PSK modem are used to achieve this. The BER performance is approximately 1 dB from the theoretically calculated value for this system at a BER of 5 E-7 under nominal conditions. The system operates in burst mode for downlink applications and tests have demonstrated very little degradation in performance with frequency and level offset. Unique word miss rate measurements were conducted which demonstrate reliable acquisition at low values of Eb/No. Codec self tests have verified the performance of this subsystem in a stand alone mode. The codec is capable of operation at a 200 Mbit/s information rate as demonstrated using a codec test set which introduces noise digitally. The measured performance is within 0.2 dB of the computer simulated predictions. A gate array implementation of the most time critical element of the high speed Viterbi decoder was completed. This gate array add-compare-select chip significantly reduces the power consumption and improves the manufacturability of the decoder. This chip has general application in the implementation of high speed Viterbi decoders

Results of an International Multidisciplinary Consultation on a New Criteria to Assess Acute Pancreatitis Severity: the “Determinant-Based Classification”

Context The Atlanta definition of acute pancreatitis (AP) severity are based on empiric description of occurrences that are merely associated with severity, so resulting in a suboptimal assessment. Objective To develop a new classification of AP severity on the basis of a sound conceptual framework, comprehensive review of published evidence, and worldwide consultation. Methods Invitation to contribute to the development of a new classification of AP severity was sent to all surgeons, gastroenterologists, internists, intensivists, and radiologists who are currently active in the field of clinical AP. A global web-based survey was conducted and a dedicated international symposium was organized to bring contributors from different disciplines together and discuss the concept and definitions. Results The new classification of AP severity is based on the actual local and systemic determinants of severity. The “local determinants” relates to whether there is (peri)pancreatic necrosis or not, and if present whether it is sterile or infected. The “systemic determinants” relates to whether there is organ failure or not, and if present whether it is transient or persistent. The presence of a determinant can modify the effect of another such that the presence of both infected (peri)pancreatic necrosis and persistent organ failure has a greater effect on severity than either alone. The derivation of a classification based on the above principles results in four categories of severity: “mild”, “moderate”, “severe”, and “critical”. Conclusion This classification is the result of a consultative process amongst pancreatologists from 49 countries. It provides a set of concise up-to-date definitions of all the main entities pertinent to classifying the severity of AP in clinical practice and research. This ensures that the “Determinant-Based Classification” can be used in a uniform manner through the world

Potentiale zur Integration von Elektrofahrzeugen in innerstädtischen Verkehrsstrukturen : Schlußbericht zum Forschungs- und Entwicklungsvorhaben FE-Nr. 70386/92 des Bundesministers für Verkehr, Bonn

Die vorliegende Studie untersucht, aufgrund umfangreicher Erfahrungen aus Praxistests, welche Energie in kWh/km bisher gebaute Elektrofahrzeuge mit unterschiedlichen Batterien bei unterschiedlichen Tagesfahrleistungen verbrauchen. Die für die Ladung der Traktionsbatterien notwendigen "Stromtankstellen", unterteilt in Haupt- und Nachladestellen, können auf der Basis der vorhandenen Technik installiert werden, wobei Normungen durchgeführt und Genehmigungsverfahren vereinfacht werden sollten. Hauptladestellen werden hauptsächlich Steckdosen in Garagen und privaten Parkanlagen sein, die mit geringen Kosten installierbar sind. Durch den Ersatz von Fahrzeugen mit konventionellem Otto- und Dieselantrieb durch Elektrofahrzeuge läßt sich der verkehrsbedingte CO2-Ausstoß mindern, wenn die CO2-Emissionen bei der Bereitstellung des elektrischen Stroms geringer sind als die mit der Nutzung fossiler Treibstoffe verbundenen Emissionen. Eine Minderung der CO2-Emissionen bei der Stromemerzeugung kann insbesondere durch die Nutzung von CO2-freien Energieträgern erreicht werden. Das Forschungsvorhaben zeigt, daß Elektrofahrzeuge kaufbar sind, die Infrastruktur für ihre Energieversorgung mit der heutigen Technik geschaffen und die Energie für 2 Mio. Elektrofahrzeuge von dem heutigen Kraftwerkspark - vor allem während der Nacht - zur Verfügung gestellt werden kann

Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent.

The evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. In this study, we traced the recent origins and global spread of a multidrug-resistant, community-associated Staphylococcus aureus lineage from the Indian subcontinent, the Bengal Bay clone (ST772). We generated whole-genome sequence data of 340 isolates from 14 countries, including the first isolates from Bangladesh and India, to reconstruct the evolutionary history and genomic epidemiology of the lineage. Our data show that the clone emerged on the Indian subcontinent in the early 1960s and disseminated rapidly in the 1990s. Short-term outbreaks in community and health care settings occurred following intercontinental transmission, typically associated with travel and family contacts on the subcontinent, but ongoing endemic transmission was uncommon. Acquisition of a multidrug resistance integrated plasmid was instrumental in the emergence of a single dominant and globally disseminated clade in the early 1990s. Phenotypic data on biofilm, growth, and toxicity point to antimicrobial resistance as the driving force in the evolution of ST772. The Bengal Bay clone therefore combines the multidrug resistance of traditional health care-associated clones with the epidemiological transmission of community-associated methicillin-resistant S. aureus (MRSA). Our study demonstrates the importance of whole-genome sequencing for tracking the evolution of emerging and resistant pathogens. It provides a critical framework for ongoing surveillance of the clone on the Indian subcontinent and elsewhere.IMPORTANCE The Bengal Bay clone (ST772) is a community-associated and multidrug-resistant Staphylococcus aureus lineage first isolated from Bangladesh and India in 2004. In this study, we showed that the Bengal Bay clone emerged from a virulent progenitor circulating on the Indian subcontinent. Its subsequent global transmission was associated with travel or family contact in the region. ST772 progressively acquired specific resistance elements at limited cost to its fitness and continues to be exported globally, resulting in small-scale community and health care outbreaks. The Bengal Bay clone therefore combines the virulence potential and epidemiology of community-associated clones with the multidrug resistance of health care-associated S. aureus lineages. This study demonstrates the importance of whole-genome sequencing for the surveillance of highly antibiotic-resistant pathogens, which may emerge in the community setting of regions with poor antibiotic stewardship and rapidly spread into hospitals and communities across the world

Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent

The evolution and global transmission of antimicrobial resistance have been well documented for Gram-negative bacteria and health care-associated epidemic pathogens, often emerging from regions with heavy antimicrobial use. However, the degree to which similar processes occur with Gram-positive bacteria in the community setting is less well understood. In this study, we traced the recent origins and global spread of a multidrug-resistant, community-associated Staphylococcus aureus lineage from the Indian subcontinent, the Bengal Bay clone (ST772). We generated whole-genome sequence data of 340 isolates from 14 countries, including the first isolates from Bangladesh and India, to reconstruct the evolutionary history and genomic epidemiology of the lineage. Our data show that the clone emerged on the Indian subcontinent in the early 1960s and disseminated rapidly in the 1990s. Short-term outbreaks in community and health care settings occurred following intercontinental transmission, typically associated with travel and family contacts on the subcontinent, but ongoing endemic transmission was uncommon. Acquisition of a multidrug resistance integrated plasmid was instrumental in the emergence of a single dominant and globally disseminated clade in the early 1990s. Phenotypic data on biofilm, growth, and toxicity point to antimicrobial resistance as the driving force in the evolution of ST772. The Bengal Bay clone therefore combines the multidrug resistance of traditional health care-associated clones with the epidemiological transmission of community-associated methicillin-resistant S. aureus (MRSA). Our study demonstrates the importance of whole-genome sequencing for tracking the evolution of emerging and resistant pathogens. It provides a critical framework for ongoing surveillance of the clone on the Indian subcontinent and elsewhere

Forecasting wind gusts in winter storms using a calibrated convection-permitting ensemble

Windstorms associated with low‐pressure systems from the North Atlantic are the most important natural hazards for central Europe. Although their predictability has generally improved over the last decades, forecasting wind gusts is still challenging, due to the multiple scales involved. One of the first ensemble prediction systems at convection‐permitting resolution, COSMO‐DE‐EPS, offers a novel 2.8‐km dataset over Germany for the 2011–2016 period. The high resolution allows representation of mesoscale features that are barely captured by global models, while the long period allows both investigation of rare storms and application of statistical post‐processing. Ensemble model output statistics based on a truncated logistic distribution substantially improve forecasts of wind gusts in the whole dataset. However, some winter storms exhibit uncharacteristic forecast errors that cannot be reduced by post‐processing. During the passage of the most severe storm, gusts related to a cold jet are predicted relatively well at the time of maximum intensity, whereas those related to a warm jet are poorly predicted at an early phase. Wind gusts are overestimated during two cases of frontal convection, which suggests that even higher resolution is needed to resolve fully the downward mixing of momentum and the stabilization resulting from convective dynamics. In contrast, extreme gusts are underestimated during a rare case involving a possible sting jet, but this arises from the representation of the synoptic rather than the mesoscale. The synoptic scale also controls the ensemble spread, which is inherited mostly from the initial and boundary conditions. This is unsurprising, but leads to high forecast uncertainty in the case of a small, fast‐moving cyclone crossing the model domain. These results illustrate how statistical post‐processing can help identify the limits of predictability across scales in convection‐permitting ensemble forecasts. They may guide the development of regime‐dependent statistical methods to improve forecasts of wind gusts in winter storms further

A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus

In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly global challenge. In addition to the long-known healthcare-associated clones, novel strains have also emerged outside of the hospital settings, in the community as well as in livestock. The emergence and spread of virulent clones expressing Panton-Valentine leukocidin (PVL) is an additional cause for concern. In order to provide an overview of pandemic, epidemic and sporadic strains, more than 3,000 clinical and veterinary isolates of MRSA mainly from Germany, the United Kingdom, Ireland, France, Malta, Abu Dhabi, Hong Kong, Australia, Trinidad & Tobago as well as some reference strains from the United States have been genotyped by DNA microarray analysis. This technique allowed the assignment of the MRSA isolates to 34 distinct lineages which can be clearly defined based on non-mobile genes. The results were in accordance with data from multilocus sequence typing. More than 100 different strains were distinguished based on affiliation to these lineages, SCCmec type and the presence or absence of PVL. These strains are described here mainly with regard to clinically relevant antimicrobial resistance- and virulence-associated markers, but also in relation to epidemiology and geographic distribution. The findings of the study show a high level of biodiversity among MRSA, especially among strains harbouring SCCmec IV and V elements. The data also indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements

A Field Guide to Pandemic, Epidemic and Sporadic Clones of Methicillin-Resistant Staphylococcus aureus

In recent years, methicillin-resistant Staphylococcus aureus (MRSA) have become a truly global challenge. In addition to the long-known healthcare-associated clones, novel strains have also emerged outside of the hospital settings, in the community as well as in livestock. The emergence and spread of virulent clones expressing Panton-Valentine leukocidin (PVL) is an additional cause for concern. In order to provide an overview of pandemic, epidemic and sporadic strains, more than 3,000 clinical and veterinary isolates of MRSA mainly from Germany, the United Kingdom, Ireland, France, Malta, Abu Dhabi, Hong Kong, Australia, Trinidad & Tobago as well as some reference strains from the United States have been genotyped by DNA microarray analysis. This technique allowed the assignment of the MRSA isolates to 34 distinct lineages which can be clearly defined based on non-mobile genes. The results were in accordance with data from multilocus sequence typing. More than 100 different strains were distinguished based on affiliation to these lineages, SCCmec type and the presence or absence of PVL. These strains are described here mainly with regard to clinically relevant antimicrobial resistance- and virulence-associated markers, but also in relation to epidemiology and geographic distribution. The findings of the study show a high level of biodiversity among MRSA, especially among strains harbouring SCCmec IV and V elements. The data also indicate a high rate of genetic recombination in MRSA involving SCC elements, bacteriophages or other mobile genetic elements and large-scale chromosomal replacements