Desviación forzada de la mirada hacia abajo y adentro en un caso de hemorragia de la región periacueductal

Se describe un caso de una paciente con un síndrome incompleto de Koerber-Elschnig, compuesto por imposibilidad de la mirada hacia arriba permaneciendo los ojos hacia abajo y adentro, nistagmus retractor y de convergencia motivado por una hemorragia muy reducida ubicada en la región rostrodorsal inter-rúbrica que afecta al haz retroflejo y respeta la comisura posterior y zona pretectal, demostrándose con ello en el hombre la importancia del haz retroflejo en el control de la mirada hacia arriba

Assessing antimicrobial potential of agroindustrial byproducts' extracts produced through solid state fermentation in marine fish

[Excerpt] Sustainability is definitely the 21st century word. The future global food provision is dependent on fish and on sustainable expansion of aquaculture production. For that, alternative nutritional strategies for aquaculture disease management are required, reducing the use of synthetic drugs. Agroindustrial byproducts(brewery, winery and olive oil industry) constitute a circular and ecofriendly potential source of add-value bioactive compounds. Solid state fermentation(SSF) is a biotechnological low cost process that may be applied to these byproducts to effectively increase bioavailability of their bioactive compounds and so their antimicrobial potential against fish pathogens. The aim of this study was to evaluate antibacterial properties of agroindustry(beer, wine and oil processing industries) byproducts' extracts produced through SSF with Aspergillus ibericus. [...]SPO3(ref.POCI-01-0145-FEDER-030377;FCT) & InovFeed(ref. MAR-02.01.01-FEAMP0111;Mar2020)info:eu-repo/semantics/publishedVersio

Negative and positive feedback from a supernova remnant with SHREC: a detailed study of the shocked gas in IC443

Interstellar matter and star formatio

Negative and positive feedback from a supernova remnant with SHREC: a detailed study of the shocked gas in IC443

Supernova remnants (SNRs) contribute to regulate the star formation efficiency and evolution of galaxies. As they expand into the interstellar medium (ISM), they transfer vast amounts of energy and momentum that displace, compress, and heat the surrounding material. Despite the extensive work in galaxy evolution models, it remains to be observationally validated to what extent the molecular ISM is affected by the interaction with SNRs. We use the first results of the ESO-ARO Public Spectroscopic Survey SHREC to investigate the shock interaction between the SNR IC443 and the nearby molecular clump G. We use high-sensitivity SiO(2-1) and H13CO+(1-0) maps obtained by SHREC together with SiO(1-0) observations obtained with the 40-m telescope at the Yebes Observatory. We find that the bulk of the SiO emission is arising from the ongoing shock interaction between IC443 and clump G. The shocked gas shows a well-ordered kinematic structure, with velocities blue-shifted with respect to the central velocity of the SNR, similar to what observed towards other SNR-cloud interaction sites. The shock compression enhances the molecular gas density, n(H2), up to >105 cm-3, a factor of >10 higher than the ambient gas density and similar to values required to ignite star formation. Finally, we estimate that up to 50 per cent of the momentum injected by IC443 is transferred to the interacting molecular material. Therefore, the molecular ISM may represent an important momentum carrier in sites of SNR-cloud interactions

Interim 2017/18 influenza seasonal vaccine effectiveness: Combined results from five European studies

Between September 2017 and February 2018, influenza A(H1N1)pdm09, A(H3N2) and B viruses (mainly B/Yamagata, not included in 2017/18 trivalent vaccines) co-circulated in Europe. Interim results from five European studies indicate that, in all age groups, 2017/18 influenza vaccine effectiveness was 25 to 52% against any influenza, 55 to 68% against influenza A(H1N1)pdm09, -42 to 7% against influenza A(H3N2) and 36 to 54% against influenza B. 2017/18 influenza vaccine should be promoted where influenza still circulates

Diminishing benefits of urban living for children and adolescents’ growth and development

Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified

Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment

Background High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four cardiometabolic risk factors for all countries and regions from 1980 to 2010. Methods We used data for exposure to risk factors by country, age group, and sex from pooled analyses of populationbased health surveys. We obtained relative risks for the eff ects of risk factors on cause-specifi c mortality from metaanalyses of large prospective studies. We calculated the population attributable fractions for- each risk factor alone, and for the combination of all risk factors, accounting for multicausality and for mediation of the eff ects of BMI by the other three risks. We calculated attributable deaths by multiplying the cause-specifi c population attributable fractions by the number of disease-specifi c deaths. We obtained cause-specifi c mortality from the Global Burden of Diseases, Injuries, and Risk Factors 2010 Study. We propagated the uncertainties of all the inputs to the fi nal estimates. Findings In 2010, high blood pressure was the leading risk factor for deaths due to cardiovascular diseases, chronic kidney disease, and diabetes in every region, causing more than 40% of worldwide deaths from these diseases; high BMI and glucose were each responsible for about 15% of deaths, and high cholesterol for more than 10%. After accounting for multicausality, 63% (10\ub78 million deaths, 95% CI 10\ub71\u201311\ub75) of deaths from these diseases in 2010 were attributable to the combined eff ect of these four metabolic risk factors, compared with 67% (7\ub71 million deaths, 6\ub76\u20137\ub76) in 1980. The mortality burden of high BMI and glucose nearly doubled from 1980 to 2010. At the country level, age-standardised death rates from these diseases attributable to the combined eff ects of these four risk factors surpassed 925 deaths per 100 000 for men in Belarus, Kazakhstan, and Mongolia, but were less than 130 deaths per 100 000 for women and less than 200 for men in some high-income countries including Australia, Canada, France, Japan, the Netherlands, Singapore, South Korea, and Spain. Interpretation The salient features of the cardiometabolic disease and risk factor epidemic at the beginning of the 21st century are high blood pressure and an increasing eff ect of obesity and diabetes. The mortality burden of cardiometabolic risk factors has shifted from high-income to low-income and middle-income countries. Lowering cardiometabolic risks through dietary, behavioural, and pharmacological interventions should be a part of the globalresponse to non-communicable diseases