80 research outputs found

    Comparison Project Management Practices in Industry Auto Parts

    Get PDF
    A indústria de autopeças em função do seu principal cliente, as montadoras de veículos, desenvolvem anualmente dezenas de projetos de variada complexidade e tamanho. A observação sobre estas empresas mostra que na maior parte do tempo são verificadas falhas típicas de projetos com problemas de gerenciamento, escopos mal elaborados, atrasos, problemas de comunicação, qualidade, fluxo de caixa e etc. Se observamos a indústria de autopeças e sua influência na indústria automobilística, observaremos a existência de técnicas estruturadas para gerenciamento de projetos de novos produtos, que obviamente visam garantir o adequado gerenciamento dos projetos e como consequência o cumprimento dos objetivos estabelecidos. Este relatório técnico visa comparar de forma simplificada duas praticas de gerenciamento de projetos, O APQP (“Advanced Product Quality Planning”) Planejamento avançado da qualidade) que é utilizado pela indústria de autopeças e automobilística e o PMBOK (“Project Management Body of Knowledge” – Guia de conhecimento em gerenciamento de projetos) o) elaborado pelo PMI e de ampla utilização no mercado. The auto parts, according to their main client, the assembly of vehicles, are dozens of projects each year that range in complexity and size. The observation of these companies shows that most of the time failures are observed with typical problems of project management, poorly developed scopes, delays, communication problems, quality, cash flow and so on. If you look at the auto parts and his influence in the auto industry, we could observe the existence of structured practices for managing projects of new products, which of course are to ensure the proper management of projects and consequently the achievement of goals set. This report aims to compare two practices in a simplified form of project management, The APQP which is used by the automotive industry and auto parts and prepared by the PMBOK in wide use in the market

    Comportamento do crescimento e desenvolvimento físico de crianças de escola pública e particular

    Get PDF
    The study contributes to the design of the profile somatomotor, the living habits and motor skills in children and adolescents, the establishment of polities on physical education and sports in Brazil. 251 children participated average of 10.58 ± 1.73 years. For the evaluation materials were used and recommended by the protocol PROESP-BR. The results mean BMI 18.05 ± 2.84 and 19.66 ± 4.06 kg/m2, flexibility 32.55 ± 11.26 cm and 36.86 ± 8.46 cm, abdominal strength 33.37 ± 8.67 and 38.55 ± 12.69 rep, medicineball pitch of 270.29 ± 58.27 and 236.35 ± 78.35 cm were significant for CR. While the race by 20 meters 4.08 ± 0.51 and 4.57 ± 0.57 Monday took a significant result for EVF. Tests of horizontal jump 135.77 ± 32.62 cm and 142.20 ± 27.79 cm and race, 9 minutes 1440.58 ± 283.06 and 1383.20 ± 258.50 m m were not significant between the groups. In analyzing the performance by gender and age, it appears that social factors do not overlap with the genetic loads, but are related to everyday experiences associated with the genotype.O estudo contribui para o delineamento do perfil somatomotor, dos hábitos de vida e aptidão motora em crianças e adolescentes, na constituição de políticas de educação física e esportes no Brasil. Participaram 251 crianças com idades médias de 10,58 ± 1,73 anos. Para a avaliação foram utilizados os materiais e protocolo recomendados pelo PROESP-BR. Os resultados médios de IMC 18,05±2,84 e 19,66±4,06 Kg/m2, flexibilidade 32,55±11,26cm e 36,86±8,46cm, resistência abdominal 33,37±8,67 e 38,55±12,69 rep, arremesso de medicineball 270,29±58,27 e 236,35±78,35 cm foram significativos para CR. Enquanto a corrida de 20 metros 4,08±0,51 e 4,57±0,57 seg teve resultado significativo para EVF. Os testes do salto horizontal 135,77±32,62cm e 142,20±27,79cm e corrida de 9 minutos 1440,58±283,06m e 1383,20±258,50m não foram significativos entre os grupos. Ao se analisar o desempenho por gênero e idade, conclui-se que fatores sociais não sobrepõem às cargas genéticas, e sim estão relacionados com experiências cotidianas associado ao genótipo

    The Brazilian Registry of Adult Patient Undergoing Cardiovascular Surgery, the BYPASS Project: Results of the First 1,722 Patients

    Get PDF
    Objective: To report the early results of the BYPASS project - the Brazilian registrY of adult Patient undergoing cArdiovaScular Surgery - a national, observational, prospective, and longitudinal follow-up registry, aiming to chart a profile of patients undergoing cardiovascular surgery in Brazil, assessing the data harvested from the initial 1,722 patients. Methods: Data collection involved institutions throughout the whole country, comprising 17 centers in 4 regions: Southeast (8), Northeast (5), South (3), and Center-West (1). The study population consists of patients over 18 years of age, and the types of operations recorded were: coronary artery bypass graft (CABG), mitral valve, aortic valve (either conventional or transcatheter), surgical correction of atrial fibrillation, cardiac transplantation, mechanical circulatory support and congenital heart diseases in adults. Results: 83.1% of patients came from the public health system (SUS), 9.6% from the supplemental (private insurance) healthcare systemsand 7.3% from private (out-of-pocket) clinic. Male patients comprised 66%, 30% were diabetics, 46% had dyslipidemia, 28% previously sustained a myocardial infarction, and 9.4% underwent prior cardiovascular surgery. Patients underwent coronary artery bypass surgery were 54.1% and 31.5% to valve surgery, either isolated or combined. The overall postoperative mortality up to the 7th postoperative day was 4%for CABG was 2.6%, and for valve operations, 4.4%. Conclusion: This first report outlines the consecution of the Brazilian surgical cardiac database, intended to serve primarily as a tool for providing information for clinical improvement and patient safety and constitute a basis for production of research protocols.Univ Fed Sao Paulo UNIFESP EPM, Hosp Sao Paulo, Sao Paulo, SP, BrazilHosp Caridade Sao Vicente Paulo, Jundiai, SP, BrazilInst Med Integral Prof Fernando Figueira IMIP, Recife, PE, BrazilHosp Base FUNFARME & FAMERP, Sao Jose Do Rio Preto, SP, BrazilIMC, Sao Jose Do Rio Preto, SP, BrazilIrmandade Santa Casa Sao Paulo INCT HPV, Fac Ciencias Med Santa Casa Sao Paulo, Sao Paulo, SP, BrazilFundacao Univ Cardiol, Inst Cardiol Rio Grande do Sul, Porto Alegre, RS, BrazilInst Coracao Natal, Natal, RN, BrazilInst Cardiol Dist Fed, Brasilia, DF, BrazilUniv Fed Maranhao HU UFMA, Univ Hosp, Sao Luis, MA, BrazilHosp Evangelico, Cachoeiro De Itapemirim, ES, BrazilHosp Coracao Sergipe, Aracaju, SE, BrazilHosp Nossa Senhora Salete, Inst Cirurgia Cardiovasc ICCV, Cascavel, PR, BrazilHosp Wilson Rosado, Mossoro, RN, BrazilHosp Bosque Saude, Sao Paulo, SP, BrazilHosp Univ Santa Maria, Santa Maria, RS, BrazilHosp Coracao HCor, Sao Paulo, SP, BrazilHosp Coracao IP HCor, Ins Pesquisa, Sao Paulo, SP, BrazilInst Coracao InCor, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP EPM, Hosp Sao Paulo, Sao Paulo, SP, BrazilWeb of Scienc

    Descrição das habilidades e práticas organizacionais para o desenvolvimento do programa de melhoria continua - um estudo de caso de uma indústria moageira de cacau / Description of organizational skills and practices for continuous improvement program development - a case study of a cocoa mill

    Get PDF
    A indústria moageira de cacau nacional enfrenta desafios relacionados a concorrência de moageiras instaladas em países do continente africano no que diz respeito ao custo de produção. Neste sentido, a Melhoria Contínua (MC) se apresenta como uma das alternativas viável na busca pela redução de custo e melhoria na eficiência produtiva. A MC se caracteriza por uma busca permanente e acumulativa, no longo prazo, de produtividade e qualidade dos processos, além da satisfação das partes interessadas na organização por meio do uso abordagens de melhoria e técnicas, tanto estatística como gerencial articulada na forma de habilidades Por isso posto, o objetivo deste trabalho se concentra em descrever as práticas de melhoria contínua adotadas pela empresa moageira de cacau selecionada como objeto de estudo de caso. A avaliação da adoção das práticas de melhoria será feita por meio de um estudo de caso único utilizando como instrumento de pesquisas, observações in loco e entrevistas semiestruturada com os gestores da qualidade responsáveis pela MC da empresa localizada no litoral sul do estado da Bahia, região cacaueira. Como resultado deste trabalho destaca-se que a ausência de um sistema integrado de melhoria contínua que impossibilita um melhor retorno, analise e continuidade dos projetos implantados. Nota-se também a necessidade de um amadurecimento e delimitação as responsabilidades dentro da organização para que as tentativas de mudança que resultem em fracasso deixem de procurar culpados. Ainda existe a necessidade de sensibilizar as pessoas da organização quanto à necessidade de treinamento do nível operacional além do fortalecimento de mecanismo para a retenção de conhecimento.

    Low-Level Laser Application in the Early Myocardial Infarction Stage Has No Beneficial Role in Heart Failure

    Get PDF
    Low-level laser therapy (LLLT) has been targeted as a promising approach that can mitigate post infarction cardiac remodeling. There is some interesting evidence showing that the beneficial role of the LLLT could persist long-term even after the end of the application, but it remains to be systematically evaluated. Therefore, the present study aimed to test the hypothesis that LLLT beneficial effects in the early post-infarction cardiac remodeling could remain in overt heart failure even with the disruption of irradiations. Female Wistar rats were subjected to the coronary occlusion to induce myocardial infarction or Sham operation. A single LLLT application was carried out after 60 s and 3 days post-coronary occlusion, respectively. Echocardiography was performed 3 days and at the end of the experiment (5 weeks) to evaluate cardiac function. After the last echocardiographic examination. LV hemodynamic evaluation was performed at baseline and on sudden afterload increases. Compared with the Sham group, infarcted rats showed increased systolic and diastolic internal diameter as well as a depressed shortening fraction of LV. The only benefit of the LLLT was a higher shortening fraction after 3 days of infarction. However, treated-LLLT rats show a lower shortening fraction in the 5th week of study when compared with Sham and non-irradiated rats. A worsening of cardiac function was confirmed in the hemodynamic analysis as evidenced by the higher LV end-diastolic pressure and lower +dP/dt and dP/dt with five weeks of study. Cardiac functional reserve was also impaired by infarction as evidenced by an attenuated response of stroke work index and cardiac output to a sudden afterload stress, without LLLT repercussions. No significant differences were found in the myocardial expression of Akti NEGF pathway. Collectively, these findings illustrate that LLLT improves LV systolic function in the early post-infarction cardiac remodeling. However, this beneficial effect may be dependent on the maintenance of phototherapy. Long-term studies with LLLT application are needed to establish whether these effects ultimately translate into improved cardiac remodeling.Conselho Nacional de Desenvolvimento Cientifico e TecnologicoFAPESPNove de Julho Univ, Lab Biophoton, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Lab Cardiac Physiol, Sao Paulo, SP, BrazilNove de Julho Univ, Program Med, Sao Paulo, BrazilUniv Sao Judas Tadeu, Brazil Phys Educ & Aging Sci Program, Translat Physiol Lab, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Cardiac Physiol, Sao Paulo, SP, BrazilCNPq: 4400851/2014-8FAPESP: 09-54225/8FAPESP: 15/11028-9Web of Scienc

    Revisão da literatura sobre as principais drogas vigentes para tratamento da obesidade no Brasil

    Get PDF
    Objetivo: fornecer atualizações sobre as drogas aprovadas no Brasil para o tratamento farmacológico da diabetes, bem como novas drogas promissoras para tal fim, visando ampliar, mas não esgotar, o conhecimento médico sobre tal assunto.  Metodologia: revisão narrativa de literatura desenvolvida com base numa pesquisa exploratória de cunho qualitativo concentrada no mês de março de 2023. Resultado: fundamentação teórica através de artigos e estudos atualizados ou anteriores considerados relevantes. Considerações finais: Diversos estudos mostram a eficácia dessas drogas na perda de peso ao comparar com o placebo. Contudo, deve-se respeitar a individualidade de cada paciente conforme o percentual de perda de peso, comorbidades, tolerância e adesão a posologia. A tirzepatida, embora ainda não aprovada no Brasil, vem se mostrando como uma droga segura e eficaz para o tratamento da obesidade em comparação com as outras drogas, com resultados satisfatórios. Além disso, sempre associar o tratamento farmacológico com a prática de atividade física e dieta com restrição calórica para obter melhores desfechos. São necessários novos ensaios clínicos, revisões sistemáticas e metanálise para levantar novas evidências de eficácia e segurança sobre o tema

    Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

    Get PDF
    BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin

    Physiological, biochemical, and ultrastructural characterization of selenium toxicity in cowpea plants

    Get PDF
    Selenium (Se) is considered a beneficial element for plants; however, in high concentrations, it causes negative effects on plant physiology and development. This study reports the first physiological, nutritional, and ultrastructural description of Se toxicity in cowpea growing under field conditions. Selenium was supplied as a foliar application of sodium selenite at varying concentrations (0, 50, 100, 200, 400, 800, 1200, and 1600 g ha−1). An increased yield was observed with the application of 50 g ha−1 Se. Application of concentrations higher than 50 g ha−1 caused leaf toxicity. Increased lipid peroxidation and hydrogen peroxide concentration and reduced total sugars, sucrose, and carotenoid concentration were observed at highest doses tested (1200 and 1600 g ha−1). Applications of more than 50 g ha−1 Se reduced the phloem diameter, caused chlorosis of the leaf blade with a coalescence of lesions, and caused pink salt deposits to appear. Lesions were observed mainly near the trichomes on the adaxial surface of the leaf blade. An analysis of the element distribution with microprobe X-ray fluorescence spectrometry (μ-XRF) revealed accumulation of Se, calcium (Ca), potassium (K), copper (Cu), and manganese (Mn) near the primary vein and in the necrotic brown areas of the leaf lesions. In contrast, Na was homogeneously distributed in the leaf tissue
    corecore