Aportes polínicos invernales en colmenas de Sierra Morena (Córdoba, España)

Se ha rcal~do un esaudio de aportes polfnkos invernales en colmc.nas de b SM:.rra (C6<doba, EspañJ). Adcmis de les p61cnes descrito; oon an1erioridad pan b tcmporad.l alla de recolecci6o, apartccn ellos tipoc poUnicas ca elcv.Jdas proporciones: Composirat, Oxalis pc;.oprat, PhiUyuo fJIIfUtlfolia, CoryfttSll\'ttfana. Elica arboru, cte. l...3.s ,¡gnirfcativas difc· rencias aparecidas tnlrc b.s colmenas CSiudladas en tuii.DlO a la participación de farniliM polínic: as.. apoyarian la tcoria de que el compDrt3mienro recolc:ctor de polen enApi: mtU1Tm: s.igue el modelo de. la •constancia individuar.Wintcr pcllimfcrous sourC from thc Sierra (Cérdoba, Spain) wcre Sludicd, Be· sides thc pollens previousJy dtSCribcd for thC higb harv<:SI sea.c;on, Lhe follow1ng WCIC found in ~ignifi cant proportions.: Composiroe, OxoiiJ pes-caproe, Phillytta anguJri{rHia, C01ylus D\-tllona, Erica arborta, etc. Thc signilic.3. nl differences betwec:n hivt:S ~lb rcspcctto ttlc ~n icipation of ttle pollinic fam.ilics, suppon ttlc "indhidual constanc}"' theory ia the pollen b;m.'CSicr bcha\oiGT of A pis melliftrQ

Experimental proof of faster-is-slower in systems of frictional particles flowing through constrictions

The "faster-is-slower" (FIS) effect was first predicted by computer simulations of the egress of pedestrians through a narrow exit D. Helbing, I. J. Farkas, and T. Vicsek, Nature (London) 407, 487 (2000)NATUAS0028-083610.1038/35035023]. FIS refers to the finding that, under certain conditions, an excess of the individuals'' vigor in the attempt to exit causes a decrease in the flow rate. In general, this effect is identified by the appearance of a minimum when plotting the total evacuation time of a crowd as a function of the pedestrian desired velocity. Here, we experimentally show that the FIS effect indeed occurs in three different systems of discrete particles flowing through a constriction: (a) humans evacuating a room, (b) a herd of sheep entering a barn, and (c) grains flowing out a 2D hopper over a vibrated incline. This finding suggests that FIS is a universal phenomenon for active matter passing through a narrowing

The road to deterministic matrices with the restricted isometry property

The restricted isometry property (RIP) is a well-known matrix condition that provides state-of-the-art reconstruction guarantees for compressed sensing. While random matrices are known to satisfy this property with high probability, deterministic constructions have found less success. In this paper, we consider various techniques for demonstrating RIP deterministically, some popular and some novel, and we evaluate their performance. In evaluating some techniques, we apply random matrix theory and inadvertently find a simple alternative proof that certain random matrices are RIP. Later, we propose a particular class of matrices as candidates for being RIP, namely, equiangular tight frames (ETFs). Using the known correspondence between real ETFs and strongly regular graphs, we investigate certain combinatorial implications of a real ETF being RIP. Specifically, we give probabilistic intuition for a new bound on the clique number of Paley graphs of prime order, and we conjecture that the corresponding ETFs are RIP in a manner similar to random matrices.Comment: 24 page

Convex Hull Abstraction in Specialisation of CLP Programs

We introduce an abstract domain consisting of atomic formulas constrained by linear arithmetic constraints (or convex hulls). This domain is used in an algorithm for specialization of constraint logic programs. The algorithm incorporates in a single phase both top-down goal directed propagation and bottom-up answer propagation, and uses a widening on the convex hull domain to ensure termination. We give examples to show the precision gained by this approach over other methods in the literature for specializing constraint logic programs. The specialization method can also be used for ordinary logic programs containing arithmetic, as well as constraint logic programs. Assignments, inequalities and equalities with arithmetic expressions can be interpreted as constraints during specialization, thus increasing the amount of specialization that can be achieved.We introduce an abstract domain consisting of atomic formulas constrained by linear arithmetic constraints (or convex hulls). This domain is used in an algorithm for specialization of constraint logic programs. The algorithm incorporates in a single phase both top-down goal directed propagation and bottom-up answer propagation, and uses a widening on the convex hull domain to ensure termination. We give examples to show the precision gained by this approach over other methods in the literature for specializing constraint logic programs. The specialization method can also be used for ordinary logic programs containing arithmetic, as well as constraint logic programs. Assignments, inequalities and equalities with arithmetic expressions can be interpreted as constraints during specialization, thus increasing the amount of specialization that can be achieved.</p

Famosa: Evaluation of a multigene panel in patients with suspected HBOC

Background: Objectives: Characterize 1) the frequency of mutations in patients with clinical criteria for HBOC using a 25-gene panel in a Spanish population (FAMOSA study). 2) The psychological impact of these tests and patient''s counseling preferences. Methods: Patients with breast or ovarian cancer who met the NCCN criteria for genetic testing with a) prior testing for BRCA genes with NO mutation identified; or b) recently diagnosed (<6 months) and not genetically tested, were enrolled for multiplex cancer testing (MyRisk 25-gene panel). Participants completed self-questionnaires regarding geneting counseling preferences and three psychological scales (MICRA, CWS, R-IES) at base-line, one week, three and twelve months after results disclosure. Results: From November 14 to February 15, 210 patients were included in the FAMOSA study (109 HBOC). 61 (56%) patients were previously tested for BRCA1/2 gene mutations with conventional techniques; median age: 44y (22-77); gender: 3 males / 106 females; cancer types: breast 95 (87%); ovary 14 (13%). Overall 22 pathogenic variants were identified in 21 patients (19, 3%): 10 BRCA1, 2 BRCA2, 2 PALB2, 3 MUYTH, 1 CDKN2A; 2 ATM, 1 BRAD1, 1 BRIP1. One patient had an unexpected mutation in CDKN2A gene (gluteus sarcoma age 20; bilateral breast ca; ages 45 and 50; father lung ca, age 70; brother melanoma, age 35). Three patients had a significant mutation of a recessive condition in MUYTH. Of 61 patients previously tested negative for HBOC, 1 had a pathogenic variant in BRCA1 and 17/ 19 patients with VUS were classified negative in BRCA genes with MyRisk.Patients are willing to be disclosed all available information from panel testing. Differences were observed among type of results at short and mid-term. Cancer worry was higher in moderate-penetrance carriers than high penetrance carriers. Longer follow up is ongoing. Conclusions: Panel testing in patients with HBOC yielded a 19, 3% mutation rate, increasing the yield of genetic mutations beyond BRCA. Patients are willing to be disclosed all available information from panel testing

Diversidad de grupos taxonómicos en pastizales de campos ganaderos de Patagonia Norte

Las variaciones en el clima y el pastoreo generan cambios en la estructura y en el funcionamiento de los ecosistemas, influyendo en la composición de las comunidades vegetales.Identificar las especies vegetales espontáneas en predios con manejo ganadero permite cuantificar y evaluar cambios en la biodiversidad de pastizales naturales, sometidos a uso antrópico. El objetivo de este trabajo fue identificar las especies vegetales ubicadas en diferentes unidades de paisaje en sistemas ganaderos extensivos de Patagonia Norte. Se evaluó la riqueza y la diversidad de familias para cada unidad o sitios de muestreoEstación Experimental Agropecuaria BarilocheFil: Peralta, Paola. Universidad Nacional de Río Negro. Escuela de Veterinaria y Producción Agroindustrial; ArgentinaFil: Torres, J.M. Universidad Nacional de Río Negro. Escuela de Veterinaria y Producción Agroindustrial; ArgentinaFil: Favere, Verónica Mariela. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Alto Valle. Agencia de Extensión Rural Valle Medio; ArgentinaFil: Starnone, Nazarena. Ministerio de Agricultura Ganadería y Pesca de la Provincia de Río negro; ArgentinaFil: Neira, D. Universidad Nacional de Rio Negro. Escuela de Veterinaria y Producción Agroindustrial; ArgentinaFil: Ibañez, Rocío. Universidad Nacional de Río Negro. Escuela de Veterinaria y Producción Agroindustrial; ArgentinaFil: Vallejo, Danila. Universidad Nacional de Río Negro. Escuela de Veterinaria y Producción Agroindustrial; ArgentinaFil: Easdale, Marcos Horacio. Instituto Nacional de Tecnología Agropecuaria (INTA). Estacion Experimental Agropecuaria Bariloche; ArgentinaFil: Klich, María Guadalupe. Universidad Nacional de Río Negro. Escuela de Veterinaria y Producción Agroindustrial; Argentin

A multiple stakeholder multicriteria decision analysis in diabetic macular edema management: the MULTIDEX‑EMD study

Background The clinical and economic management of retinal diseases has become more complex following the introduction of new intravitreal treatments. Multicriteria decision analysis (MCDA) ofers the potential to overcome the challenges associated with traditional decision-making tools. Objectives A MCDA to determine the most relevant criteria to decision-making in the management of diabetic macular edema (DME) based on the perspectives of multiple stakeholders in Spain was developed. This MCDA was termed the MULTIDEX-EMD study. Methods Nineteen stakeholders (7 physicians, 4 pharmacists, 5 health authorities and health management experts, 1 psychologist, and 2 patient representatives) participated in this three-phase project. In phase A, an advisory board defned all of the criteria that could infuence DME treatment decision-making. These criteria were then screened using a discrete choice experiment (DCE) (phase B). Next, a multinomial logit model was ftted by applying the backward elimination algorithm (relevant criteria: p value<0.05). Finally, the results were discussed in a deliberative process (phase C). Results Thirty-one criteria were initially defned (phase A) and grouped into 5 categories: efcacy/efectiveness, safety, organizational and economic impact, patient-reported outcomes, and other therapeutic features. The DCE results (phase B) showed that 10 criteria were relevant to the decision-making process for a 50- to 65-year-old DME patient: mean change in best corrected visual acuity (p value<0.001), percentage of patients with an improvement of ≥15 letters (p value<0.001), efect duration per administration (p value=0.008), retinal detachment (p value<0.001), endophthalmitis (p value=0.012), myocardial infarction (p value<0.001), intravitreal hemorrhage (p value=0.021), annual treatment cost per patient (p value=0.001), health-related quality of life (HRQoL) (p value=0.004), and disability level (p value=0.021). Conclusions From a multi-stakeholder perspective, the selection of an appropriate treatment for DME patients should guarantee patient safety and maximize the visual acuity improvement and treatment efect duration. It should also contribute to system sustainability by being afordable, it should have a positive impact on HRQoL, and it should prevent disability

Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.

The interaction of the tumor necrosis factor receptor (TNFR) family member CD27 on naive CD8 &lt;sup&gt;+&lt;/sup&gt; T (Tn) cells with homotrimeric CD70 on antigen-presenting cells (APCs) is necessary for T cell memory fate determination. Here, we examined CD27 signaling during Tn cell activation and differentiation. In conjunction with T cell receptor (TCR) stimulation, ligation of CD27 by a synthetic trimeric CD70 ligand triggered CD27 internalization and degradation, suggesting active regulation of this signaling axis. Internalized CD27 recruited the signaling adaptor TRAF2 and the phosphatase SHP-1, thereby modulating TCR and CD28 signals. CD27-mediated modulation of TCR signals promoted transcription factor circuits that induced memory rather than effector associated gene programs, which are induced by CD28 costimulation. CD27-costimulated chimeric antigen receptor (CAR)-engineered T cells exhibited improved tumor control compared with CD28-costimulated CAR-T cells. Thus, CD27 signaling during Tn cell activation promotes memory properties with relevance to T cell immunotherapy