Поховання на човнах у давніх слов'ян

У статті розповідається про ранньослов’янський обряд поховання на човнах. Наводяться данні археологічних розкопок на території України, середньовічні письмові джерела, елементи фольклору, що свідчать про наявність такого обряду.В статье рассказывается о древнеславянском обряде захоронения на лодках. Приводятся данные археологических раскопок на территории Украины, средневековые письменные источники, элементы фольклора, свидетельствующие о наличии такого обряда.In the article is told about the ancient-Slavonic ceremony of burial place on boats. Data of archaeological excavations on territories of Ukraine, medieval writing sources

Longitudinal Changes in Depression Among Patients at an Integrated Primary Care Clinic During the COVID-19 Pandemic

Introduction: The current study assessed trajectory of within subject change in depressive symptoms before and after the COVID-19 related lockdowns were implemented in the United States in 2019-2020.  Method: A General Estimating Equations model was conducted with electronic medical records data of 36,868 adult patients at a chain of federally funded integrated primary care clinics. Changes in Patient Health Questionnaire-2 (PHQ-2) scores were included in the model as the dependent variable.  Results:  April 2020 was the only month when PHQ-2 scores increased with 95% confidence. April and December 2020 had greater likelihood than April and December 2019 to show a mean increase in depressive symptoms.  Discussion: Depression rates increased substantially at the start of the pandemic (i.e., April 2020) and subsequently returned to pre-pandemic expectations. However, depression rates were less likely to decline in December 2019, which may be due to social distancing and cancellation of holiday gatherings

An Early Neolithic enclosure at the site of Vlaho, Pelagonia

[EN] Recent study of Vlaho in Pelagonia confirms that it is the earliest known Neolithic settlement in North Macedonia. Multidisciplinary research of the architecture and material reveals a complex enclosure site dating to the seventh millennium BC, with dozens of ditches, daub buildings, white painted pottery and domesticated plants and animals

Feeding habits of the golden jackal (Canis Aureus) on the basis of new examinations

The aim of our study based on field research was to evaluate the diet composition and feeding habits of the golden jackal (Canis aureus) living in the area of Vajszló (Ormánság region, SW Hungary). During the research period (from autumn 2010 to spring 2012) n=268 jackal scats (feces) were collected on a 13.6 km transect. On the basis of scat analysis we found that jackals consumed primarily small mammals (B%: percentage of biomass consumed, mean 68%), all of which the most dominant species was the common vole (a pest species). Small mammal consumption varied seasonally between 48% and 96%. The secondary food for the jackal was usually the wild boar (including piglets and inwards) with an annual 12%, or plants (16%). Wildlife management point of view is important that jackals consumed cervids mainly in winter (B%, 5.6%). Consumption of cervids during the reproductive period was only occasional (B%, 2.9%), and was not detected in the summer scat samples. Our examination confirms earlier results from Hungary, i.e. the jackal has opportunistic feeding strategy, its diet varies depending on the seasonal food availability, but small mammals are the primary foods in all seasons. The jackal prey mainly on small-sized, open-field living, terrestrial and wild living animals. These shows that the jackal characteristically hunts alone, but occasionally it hunts in pairs or groups. The research was supported by the Hungarian-Serbian bilateral programme entitled “Population density and feeding habits of the golden jackal (Canis aureus L. 1758) in different habitats in the Pannonian ecoregion” (project number: RS-14/09). Report was supported by the Ministry of Human Resources. (Research Faculty) (registration number: 7 629- 24/2013/TUDPOL)

Acoustic survey on golden jackal population in the area of sastya game management unit

The aim of our study was based on field research to estimate the population density of golden jackal (Canis aureus) -which is continuously spreading in Hungary - in the area of Sastya Hunting Club, Vajszló (Ormánság region, SW Hungary). The species has been living here for two decades, so based on earlier studies it has a stable population in this area. Acoustic monitoring method was used to estimate the density. Survey was executed in March and in November 2012, during two precipitation-free and windless nights. Size of the study area was 1570 hectares in spring and 2200 hectares in autumn. During the first field-work howling of 5 different jackal groups were detected (1 individual in 1 case, 2 individuals in 1 case, more than 2 individuals in 3 cases); 9 diffent groups were heard in the second survey (1 individual in 1 case, 2 individuals in 2 cases, more than 2 individuals in 6 cases). The estimated group density was 3,2 in spring and 4,1 in autumn by 1000 hectares. Our results are in accordance with earlier studies done in this region. The research was supported by the Hungarian-Serbian bilateral programme entitled “Population density and feeding habits of the golden jackal (Canis aureus L. 1758) in different habitats in the Pannonian ecoregion” (project number: RS-14/09). The publication was supported by the “Research Faculty Grant” of the Hungarian Ministry of Human Resources”

Albumin: antioxidant or pro-oxidant in patients on peritoneal dialysis?

Albumin (HSA) is a multifunctional serum protein. Free Cys34 thiol group makes HSA a major source of free thiols in the circulation. HSA is also a dominant carrier of exchangeable copper pool with a high affinity binding site for this redox-active ion, located at the N-terminus. Combination of these two properties highlights HSA as a powerful circulatory antioxidant. The presence of free thiol groups in HSA and its copper binding capacity have been shown to be interconnected and essential for the binding and sequestering of copper ions, thus preventing metal-catalysed production of reactive oxygen species. End stage kidney disease (ESRD) is a condition accompanied by oxidative stress. The aim of this study was to examine changes in the antioxidative capacity of HSA and Cu(II) binding affinity in patients on peritoneal dialysis (PD), and relate it to the Cys34 thiol group content and structural changes of this molecule. HSA molecules are modified in ESRD patients on PD, having lower content of bound copper ions and thiol groups, reduced copper binding affinity and overall antioxidant capacity. An increased content of advanced glycation end-products and altered conformation was detected in HSA from PD patients. Function of HSA as a sequestrator of free Cu(II) ions, is impaired. A significant portion of the high-affinity metal-binding site was unable to interact with Cu(II) ions, as shown by EPR. Similar results on copper binding were obtained in subgroups of patients with and without diabetes mellitus, suggesting that ESRD and constant exposure to high glucose concentration during dialysis influenced protein modification. Since the concentration of Cu(II) in the circulation of these patients is much higher than in healthy persons and that Cu(II) binding capacity of albumin from patients is significantly lower, the albumin may be considered to turn from antioxidant to pro-oxidant activity

Binding of enterolactone and enterodiol to human serum albumin: increase of cysteine-34 thiol group reactivity

The interaction of polyphenolic molecules with human serum albumin (HSA) could lead to changes in the reactivity of the HSA Cys34 thiol group (HSA-SH). The influences of enterolactone (EL) and enterodiol (ED) binding on HSA-SH reactivity in fatty acid (FA)-free HSA, and in HSA with bound stearic acid (S) in S/HSA molar ratios of 1 : 1 and 4 : 1, were investigated by the determination of the pseudo first order rate constants (k') for the thiol reaction with 5,5'-dithiobis-(2-nitrobenzoic acid). The binding affinities and binding sites of EL and ED were also determined, using fluorescence measurements of the intrinsic fluorescence of Trp214 and diazepam (binding site marker). EL and ED binding to HSA increased the reactivity of HSA-SH in all assayed HSA-enterolignan complexes by 9.1-33.1%. The strongest effects were obtained for FA-free HSA-enterolignan complexes. S modulated/reduced the effect of EL on HSA-SH reactivity, while its influence on the effect of ED was negligible. The binding of enterolignans to HSA was investigated: the binding constants were the highest for FA-free HSA (EL: 11.64 x 10(4) M-1 and ED: 5.59 x 10(4) M-1 at 37 degrees C) and the lowest for S/HSA 4 : 1-enterolignan complexes (EL: 2.43 x 10(4) M-1 and ED: 1.92 x 10(4) M-1). When the S/HSA ratio was increased, the binding affinities and number of binding sites for EL and ED were decreased. At the same time, a high correlation between binding constants and increased Cys34 reactivity was found (r = 0.974). Competitive experiments using diazepam indicated that the binding of ED and of EL was located in the hydrophobic pocket of site II in HSA. Overall, it is evident that stearic acid could modulate the enterolignan effects on HSA-SH reactivity as well as their binding to HSA. This finding could be important for pharmacokinetics and the expression of enterolignan antioxidant effects in vivo after an intake of lignan rich food

The Spider: behind the scene : the Spider Variations by Jasmina Mitrusic Deric

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