Evalutaion of embedded malingering indices in a non-litigating, relief seeking sample: a partial cross-validation using control, clinical, and derived groups

Researchers have recently noted college students fail validity measures and base rate data are needed for students meeting Slick et al.’s criteria (1999) for malingering. The association between meeting Slick Criteria and subsequent recommendations (i.e., to receive external gain) is unknown as is the diagnostic utility of embedded validity indices in this population. The authors utilized archival data from: 1) a university psychological clinic (n = 986) and 2) a university student control sample (n = 182). Measures included the Wechsler Adult Intelligence Scale-III, Wechsler Memory Scale-III, and Personality Assessment Inventory. Empirically supported embedded validity indices were utilized to retrospectively identify suspected malingering patients. Group performance, according to level of symptom credibility and level of incentive seeking, was evaluated through a series of multivariate mean comparisons. Data are presented for frequency of falling in the noncredible range on all validity indices. Diagnostic statistics for each index are presented according to hypothetical base rates. Examination of receiving psychological recommendations to obtain external incentive (i.e., academic accommodations, medications, etc.) is reported according to incentive and credibility level. University patients explicitly seeking external gain, particularly those meeting criteria for malingering, demonstrated lower performance on the measures and received a higher rate of recommendations for academic accommodations and/or medications than patients not seeking external incentive. Nevertheless, a number of diagnostic statistics indicated some embedded validity indices lack specificity for malingering in university samples. The current study supports classifying patients according to level of incentive seeking when evaluating neurocognitive performance and feigned or exaggerated deficits

KUALITAS SINYAL DAN KINERJA JARINGAN DATA ANTAR LORA GATEWAY RFM95

Tujuan penelitian ini menganalisis kualitas sinyal dan kinerja jaringan data antar LoRa gateway RFM95 dalam kondisi Line Of Sight. Posisi antar pemancar dan penerima saat pengukuran berada pada jarak 100 m, 200 m, 500 m dan 700 m menggunakan antenna gain 2 dB dan daya pancar 10 dbm. Perubahan Spreading Factor diterapkan untuk mendapatkan parameter-parameter yang mempengaruhi kinerja sistem LoRa yaitu antara lain RSSI terhadap jarak, SNR terhadap jarak, Packet Delivery Ratio terhadap jarak, Delay terhadap jarak, Delay terhadap panjang paket dan perbandingan perhitungan transmission delay terhadap hasil pengukuran delay. Hasil pengujian memberikan informasi bahwa RSSI menurun terhadap jarak sedangkan Spreading Factor tidak terlalu mempengaruhi RSSI. Parameter lainnya yaitu SNR dipengaruhi oleh jarak, kondisi noise pada kanal area pengukuran dan Spreading Factor. Packet Delivery Ratio menurun ketika jarak bertambah tetapi dengan menggunakan SF 9 menunjukan hasil yang lebih bagus dibandingkan dengan menggunakan SF 7, terlihat pada jarak 700m dengan SF 9 mempunyai PDR 76% sedangkan dengan SF 7 mempunyai PDR 44%. Delay dipengaruhi oleh panjang paket dan penggunaan SF9 menghasilkan delay yang lebih besar daripada SF 7 terlihat pada jarak 700m dengan SF9 menghasilkan delay 0.996678 s dan SF 7 menghasilkan delay 0.060945s&nbsp

Model Implementasi Strategi Sebagai Determinan Kinerja Perusahaan

Berbagai studi menunjukkan bahwa implementasi strategi jauh lebih penting daripada formulasi strategi. Namun demikian, masih sedikit penelitian mengenai kerangka implementasi strategi untuk meningkatkan kesuksesan organisasi. Penelitian ini mengembangkan model implementasi strategi yang berperan meningkatkan kualitas implementasi strategi Perusahaan. Studi menganalisis pengaruh kualitas implementasi strategi terhadap kesuksesan implementasi strategi dan kinerja Perusahaan. Survei dilaksanakan pada 62 Perusahaan Indonesia dari berbagai bidang industri. Data dianalisis secara statistik dengan Structural Equation Modeling (SEM). Penelitian menemukan pengaruh signifikan tujuh faktor tahapan implementasi dan sembilan faktor kapabilitas pendukung implementasi strategi terhadap kesuksesan implementasi strategi. Selanjutnya kesuksesan implementasi strategi memiliki pengaruh signifikan terhadap kinerja Perusahaan

2022: the year in cardiovascular disease - the year of upfront lipid lowering combination therapy

Recent data clearly show that we are extremely ineffective in the use of lipid-lowering therapy (LLT). Furthermore, the problem seems to be the most serious in the group of patients at very high and extremely high-risk – the patients who stand to benefit most from effective therapy

Postmarketing nutrivigilance safety profile: A line of dietary food supplements containing red yeast rice for dyslipidemia

Introduction: In the absence of a European standardized postmarketing food supplement surveillance system (nutrivigilance), some member states and companies have developed their own approaches to monitoring potential adverse reactions to secure a high level of product safety. This paper describes the use of a nutrivigilance system in monitoring the incidence of spontaneously reported suspected adverse reactions associated with food supplements containing red yeast rice (RYR). Material and methods: We report the data from a widely used product marketed under the trademark Armolipid/Armolipid Plus. Postmarketing information was collected in a voluntary nutrivigilance system established by the manufacturing company (Meda Pharma SpA, a Viatris Company, Monza, Italy). From 1st October 2004 to 31st December 2019, this system captured cases of suspected adverse reactions spontaneously reported by consumers, healthcare professionals, health authorities, regardless of causality. Results: The total number of case reports received mentioning the RYR food supplement product line was 542, in which 855 adverse events (AEs) were reported. The total reporting rate of AEs was estimated to be 0.037% of 2,287,449 exposed consumers. Of the 542 cases, 21 (0.0009% of exposed consumers) included suspected serious adverse events (SAEs). After careful investigation, 6 cases (0.0003% of consumers exposed) and 6 AEs were assessed by the manufacturer as serious and potentially related to exposure to the above-mentioned RYR-based nutraceutical. Conclusions: This nutrivigilance-derived data analysis clearly demonstrates a low prevalence of suspected adverse events associated with the red yeast rice product line. Consumer safety of food supplements could be generally improved by raising awareness of the importance of following the indications and warnings detailed in a food supplement's labeling

HLA-G 3'UTR Polymorphisms Impact the Prognosis of Stage II-III CRC Patients in Fluoropyrimidine-Based Treatment

An important hallmark of CRC is the evasion of immune surveillance. HLA-G is a negative regulator of host's immune response. Overexpression of HLA-G protein in primary tumour CRC tissues has already been associated to worse prognosis; however a definition of the role of immunogenetic host background is still lacking. Germline polymorphisms in the 3'UTR region of HLA-G influence the magnitude of the protein by modulating HLA-G mRNA stability. Soluble HLA-G has been associated to 3'UTR +2960 Ins/Ins and +3035 C/T (lower levels) and +3187 G/G (high levels) genotypes. HLA-G 3'UTR SNPs have never been explored in CRC outcome. The purpose of this study was to investigate if common HLA-G 3'UTR polymorphisms have an impact on DFS and OS of 253 stage II-III CRC patients, after primary surgery and ADJ-CT based on FL. The 3'UTR was sequenced and SNPs were analyzed for their association with survival by Kaplan-Meier and multivariate Cox models; results underwent internal validation using a resampling method (bootstrap analysis). In a multivariate analysis, we estimated an association with improved DFS in Ins allele (Ins/Del +Ins/Ins) carriers (HR 0.60, 95% CI 0.38-0.93, P = 0.023) and in patients with +3035 C/T genotype (HR 0.51, 95% CI 0.26-0.99, P = 0.045). The +3187 G/G mutated carriers (G/G vs A/A+A/G) were associated to a worst prognosis in both DFS (HR 2.46, 95% CI 1.19-5.05, P = 0.015) and OS (HR 2.71, 95% CI 1.16-6.63, P = 0.022). Our study shows a prognostic and independent role of 3 HLA-G 3'UTR SNPs, +2960 14-bp INDEL, +3035 C>T, and +3187 A>G

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Postmarketing nutrivigilance safety profile: a line of dietary food supplements containing red yeast rice for dyslipidemia

Introduction: In the absence of a European standardized postmarketing food supplement surveillance system (nutrivigilance), some member states and companies have developed their own approaches to monitoring potential adverse reactions to secure a high level of product safety. This paper describes the use of a nutrivigilance system in monitoring the incidence of spontaneously reported suspected adverse reactions associated with food supplements containing red yeast rice (RYR). Material and methods: We report the data from a widely used product marketed under the trademark Armolipid/Armolipid Plus. Postmarketing information was collected in a voluntary nutrivigilance system established by the manufacturing company (Meda Pharma SpA, a Viatris Company, Monza, Italy). From 1st October 2004 to 31st December 2019, this system captured cases of suspected adverse reactions spontaneously reported by consumers, healthcare professionals, health authorities, regardless of causality. Results: The total number of case reports received mentioning the RYR food supplement product line was 542, in which 855 adverse events (AEs) were reported. The total reporting rate of AEs was estimated to be 0.037% of 2,287,449 exposed consumers. Of the 542 cases, 21 (0.0009% of exposed consumers) included suspected serious adverse events (SAEs). After careful investigation, 6 cases (0.0003% of consumers exposed) and 6 AEs were assessed by the manufacturer as serious and potentially related to exposure to the above-mentioned RYR-based nutraceutical. Conclusions: This nutrivigilance-derived data analysis clearly demonstrates a low prevalence of suspected adverse events associated with the red yeast rice product line. Consumer safety of food supplements could be generally improved by raising awareness of the importance of following the indications and warnings detailed in a food supplement’s labeling