Critical comments on EEG sensor space dynamical connectivity analysis

any different analysis techniques have been developed and applied to EEG recordings that allow one to investigate how different brain areas interact. One particular class of methods, based on the linear parametric representation of multiple interacting time series, is widely used to study causal connectivity in the brain. However, the results obtained by these methods should be interpreted with great care. The goal of this paper is to show, both theoretically and using simulations, that results obtained by applying causal connectivity measures on the sensor (scalp) time series do not allow interpretation in terms of interacting brain sources. This is because (1) the channel locations cannot be seen as an approximation of a source's anatomical location and (2) spurious connectivity can occur between sensors. Although many measures of causal connectivity derived from EEG sensor time series are affected by the latter, here we will focus on the well-known time domain index of Granger causality (GC) and on the frequency domain directed transfer function (DTF). Using the state-space framework and designing two simulation studies we show that mixing effects caused by volume conduction can lead to spurious connections, detected either by time domain GC or by DTF. Therefore, GC/DTF causal connectivity measures should be computed at the source level, or derived within analysis frameworks that model the effects of volume conduction. Since mixing effects can also occur in the source space, it is advised to combine source space analysis with connectivity measures that are robust to mixing

Plataforma neurotecnológica aplicada al estudio y entrenamiento de la actividad cognitiva del ajedrecista

RESUMEN El ajedrez es un juego que demanda una continua actividad atencional en la solución de problemas. El entrenamiento adecuado de la atención en el ajedrecista mediante el empleo de técnicas psicológicas permite una mayor regulación de la precisión perceptiva, capacidad para integrar y procesar estímulos simultáneamente, fiabilidad de la respuesta, tiempo de reacción y concentración. En correspondencia con estos particulares la investigación tiene como objetivo diseñar una plataforma neurotecnológica que permita el estudio y entrenamiento de la actividad cognitiva de los ajedrecistas. El sistema neurotecnológico presentado es pertinente para el entrenamiento de los ajedrecistas en los marcos de los sistemas de entrenamientos contemporáneos. Su instrumentación permite la regulación del componente cognitivo, incrementa la tolerancia a la interferencia atencional, la concentración, el control espacial del tablero de ajedrez, la resistencia atencional y la velocidad de procesamiento de la información en la solución de problemas ajedrecísticos. ABSTRACT Chess is a game that demands a continuous attention activity in the solution of problems. The adequate training of the attention in the chess player through the use of psychological techniques allows a greater regulation of the perceptive precision, ability to integrate and process stimuli simultaneously, reliability of the response, reaction time and concentration. In correspondence with these individuals, the research aims to design a neurotechnological platform that allows the study and training of the cognitive activity of chess players. The neurotechnological system presented is relevant for the training of chess players in the frames of contemporary training systems. Its instrumentation allows the regulation of the cognitive component, it increases the tolerance to the attentional interference, the concentration, the spatial control of the chessboard, the attentional resistance and the speed of information processing in the solution of chess problems

TERASENSE: THz device technology laboratory: final summary

The use of THz frequencies, particularly W and G band allows reaching higher resolution and deeper penetration in emerging applications like imaging, sensing, etc. The development of those new applications lays on reliable technologies, background of expertise and know-how. The CDS2008-00068 TERASENSE CONSOLIDER project has given the opportunity to extent upwards in frequency the previous background of the microwaves research group partners. This article summarizes the developments of the TERASENSE work package “THz Device Technology Laboratory”.This work was supported by the Spanish Ministerio de Ciencia e Innovación through the CONSOLIDER-INGENIO 2010 program reference CSD2008-00068 TERASENSE

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Musical expertise and foreign speech perception

The aim of this experiment was to investigate the influence of musical expertise on the automatic perception of foreign syllables and harmonic sounds. Participants were Cuban students with high level of expertise in music or in visual arts and with the same level of general education and socio-economic background. We used a multi-feature Mismatch Negativity (MMN) design with sequences of either syllables in Mandarin Chinese or harmonic sounds, both comprising deviants in pitch contour, duration and Voice Onset Time (VOT) or equivalent that were either far from (Large deviants) or close to (Small deviants) the standard. For both Mandarin syllables and harmonic sounds, results were clear-cut in showing larger MMNs to pitch contour deviants in musicians than in visual artists. Results were less clear for duration and VOT deviants, possibly because of the specific characteristics of the stimuli. Results are interpreted as reflecting similar processing of pitch contour in speech and non-speech sounds. The implications of these results for understanding the influence of intense musical training from childhood to adulthood and of genetic predispositions for music on foreign language perception is discussed

Desarrollo humano y justicia

El desarrollo humano y la justicia, así como las maneras de su realización, han acompañado conflictivamente la historia de la civilización humana. Sin embargo el tema alcanza una especial significación desde la Segunda Guerra , gracias al crecimiento económico y la desigualdad inéditas. Algunos de los más destacados científicos de las ciencias sociales y humanas enfrentaron el desafío desde sus disciplinas a comienzos del siglo XX. Importantes fueron los planteamientos desde la educación y la sicología, pero también desde la política y el derecho. Pero a partir de la década de los treinta, las tesis de la vertiente técnica de la economía impusieron el prejuicio de un modelo de hombre oeconomicus, egoísta y, por ello, supuestamente libre y racional, como referente para explicar y medir la mejor sociedad posible. Por ello, a pesar del ambiente propicio en algunos planteamientos de las demás ciencias sociales, éstos se vieron relativizados por los planteamientos de la economía que mostraba su eficacia

Desarrollo humano y justicia

El desarrollo humano y la justicia, así como las maneras de su realización, han acompañado conflictivamente la historia de la civilización humana. Sin embargo el tema alcanza una especial significación desde la Segunda Guerra , gracias al crecimiento económico y la desigualdad inéditas. Algunos de los más destacados científicos de las ciencias sociales y humanas enfrentaron el desafío desde sus disciplinas a comienzos del siglo XX. Importantes fueron los planteamientos desde la educación y la sicología, pero también desde la política y el derecho. Pero a partir de la década de los treinta, las tesis de la vertiente técnica de la economía impusieron el prejuicio de un modelo de hombre oeconomicus, egoísta y, por ello, supuestamente libre y racional, como referente para explicar y medir la mejor sociedad posible. Por ello, a pesar del ambiente propicio en algunos planteamientos de las demás ciencias sociales, éstos se vieron relativizados por los planteamientos de la economía que mostraba su eficacia

100 Cartas para Paulo Freire de quienes pretendemos Enseñar

Realizar un texto colectivo como “100 Cartas para Paule Freire de quienes pretendemos Enseñar”, es un desafío al reunir el aprehender desde el sentido profesional de la educación y con el espíritu de transformación, desde la educación como un espacio endógeno de revolución y exógeno a las comunidades y sociedades, en busca de un sentido de identidad. Hoy desde una crítica decolonial, antirracista, feminista y ecologica en la construcción de un sentido real que busque enfrentar el sistema hegemónico y destructivo que se ha impuesto con explotación, sangre y libertades de nuestro pueblo