Factores metabólicos predictivos de respuesta a tratamiento de la ¹⁸F-FDG PET/TC en el cáncer de cérvix localmente avanzado tratado con radioquimioterapia

El tratamiento con radioterapia y cisplatino concurrente es el estándar en pacientes con cáncer de cérvix localmente avanzado desde hace algo más de dos décadas. Sin embargo, el comportamiento de la enfermedad es heterogéneo con tasas de supervivencia y recaída que podrían mejorarse si se identificara la agresividad biológica de cada paciente y se intensificaran los tratamientos de manera individualizada. La 18F-FDG PET/TC permite estadificar de manera más precisa que los estudios convencionales y adaptar el tratamiento radioterápico. Además, con el desarrollo de la radiómica, se propone a los parámetros cuantitativos metabólicos como nuevos factores pronósticos que ayudan a estratificar a las pacientes. El objetivo principal de este trabajo es confirmar la hipótesis de que los parámetros SUVmax (máximo valor de captación estandarizada de 18F-FDG), MTV (volumen metabólico tumoral) y TLG (lesión glicolítica total) del tumor primario son factores predictivos de respuesta al tratamiento radioquimioterápico. Como objetivo secundario, se estudian los parámetros de textura metabólica, se establecen puntos de corte para cada parámetro que permitan predecir la supervivencia y se estudia la relación de los parámetros cuantitativos con factores pronósticos clásicos del cáncer de cérvix..

Análisis de la pesquería del voraz Pagellus bogaraveo (Brünnich, 1768) que se desarrolla en el estrecho de Gibraltar

El voraz Pagelllus bogaraveo es un recurso de gran interés en la provincia de Cádiz, siendo una especie objetivo de gran parte de las flotas que faenan en el Estrecho de Gibraltar y que utilizan para su pesquería un arte específico denominado voracera. En este trabajo se analizó el desarrollo de esta pesquería a través de los datos recogidos de las notas de ventas de varias lonjas que de la provincia de Cádiz, durante el periodo 2001-2016. Se observó que la pesquería evoluciona con una estacionalidad muy marcada a lo largo del año. El examen de los precios de mercado indicó una variabilidad respecto al calibre de los ejemplares siendo el tamaño 2 el que más valor alcanzó. Según lo analizado, esta especie se encuentra sobreexplotada. Cabe señalar que esta especie es hemafrodita proterándrica, lo que la hace muy sensible a la sobrepesca. Por ello, sería conveniente tomar medidas que pudiesen ayudar a la sostenibilidad de la población, como el aumento de la talla mínima de captura a 35 cm para mantener la proporción entre machos y hembras.The blackspot seabream or red seabream Pagellus bogaraveo commonly known as voraz is the target species to the artisanal fleet that operate in the Strait of Gibraltar, being a species of great interest to the province of Cadiz. The blackspot seabream is caught by a locally designed hook line known as “voracera”. This paper aims to analyze this fishery by going through the sales notes submitted by fishmarket operators to the Regional Government of Andalucía from 2001 through 2016. The balckspot seabream shows a notable seasonal pattern. First sale prices are notably affected by the fish length-grade being grade 2 the one with the highest value. Total catch variation through the analyzed period reveals that this fishery has been overerploited. It must be noted that the blackspot seabream is highly sensitive to overfishing because of its protandrous hermaphroditism, with late first maturity (4- 5years) as females and rather low productivity. Technical measures should be adopted to ensure the stock sustainability. Minimum landing size should be set to 35 cm to ensure a balance exploitation between younger fish (males) and older fish (females).El trabajo consta de 34 páginas, sin incluir los anexos

Construcción de Comunidad Mediante una Estrategia de Fortalecimiento Comunicacional para la OPS Red Nacional Jóvenes de Ambiente

En este documento se presenta la construcción de una estrategia para el fortalecimiento comunicacional para Red Nacional Jóvenes de Ambiente, nodo La Dorada, Caldas, organización que desarrolla procesos y proyectos con el fin de preservar el ambiente, mediante diversas iniciativas y metodologías, esta estrategia se diseña como parte del desarrollo del diplomado en Construcción de Redes Sociales de Comunicación que ha sido elegido como opción de grado, mediante el cual se ponen en práctica los conocimientos adquiridos durante la formación académica como comunicadora social en la UNAD. Para la elaboración de esta propuesta se realizó un acercamiento y análisis de la OPS mediante diversas metodologías que permitieron identificar las diversas dinámicas de comunicación tanto internas como externas, con el fin de analizar y realizar un diagnóstico acertado de estos procesos, identificando cuales son las fortalezas y debilidades de esta, para así lograr elaborar una estrategia de fortalecimiento comunicacional que se adapte a los procesos actuales de la organización, que permitan fortalecer estos factores, garantizando así actividades sigan promoviendo el desarrollo en la región mediante las acciones y proyectos que esta realiza, este documento se desarrolló teniendo en cuenta las guías de actividades y rubricas de evaluación que se plantearon para la elaboración del diplomado, dejando como resultado final este documento.This document presents the construction of a strategy for communication strengthening for Red Nacional Jovenes de Ambiente nodo La Dorada, Caldas, an organization that develops processes and projects in order to preserve the environment, through various initiatives and methodologies, this strategy is designed as part of the development of the diploma in Construction of Social Communication Networks that has been chosen as a degree option, through which the knowledge acquired during academic training as a social communicator at UNAD is put into practice. To prepare this proposal, an approach and analysis of the OPS was carried out using various methodologies that allowed the identification of the various dynamics of both internal and external communication, in order to analyze and carry out an accurate diagnosis of these processes, identifying what the strengths are. . and weaknesses of this, in order to develop a communication strengthening strategy that adapts to the current processes of the organization, which allows strengthening these factors, thus guaranteeing activities that continue to promote development in the region through the actions and projects that it carries out, This document was developed taking into account the activity guides and evaluation rubrics that were proposed for the development of the diploma, leaving this document as the final result

Lianas Significantly Reduce Aboveground and Belowground Carbon Storage: A Virtual Removal Experiment

Lianas are a quintessential tropical plant growth-form; they are speciose and abundant in tropical forests worldwide. Lianas compete intensely with trees, reducing nearly all aspects of tree performance. However, the negative effects of lianas on trees have never been combined and quantified for multiple tropical forests. Here, we present the first comprehensive standardized quantification of the effect of lianas on trees across tropical forests worldwide. We used data from 50 liana removal experiments and quantified the effect size of lianas on tree growth, biomass accretion, reproduction, mortality, leaf water potential, sap flow velocity, and leaf area index (LAI) across different forest types. Using a three-level mixed-effect meta-analysis, we found unequivocal evidence that lianas significantly reduce tree growth and biomass accretion in ecological, logging, and silvicultural studies. Lianas also significantly reduce tree reproduction, recruitment, and physiological performance. The relative detrimental effect of lianas on trees does not increase in drier forests, where lianas tend to be more abundant. Our results highlight the substantial liana-induced reduction in tree performance and biomass accumulation, and they provide quantitative data on the effects of lianas on trees that are essential for large-scale plant demographic and ecosystem models that predict forest change and carbon dynamics

Tourist information sources at different stages of the travel experience

Tourist destination managers must design effective communication strategies as part of their promotional tasks. In order to do so, destinations need to know what sources of information tourists actually use during the stages of a trip. Previous studies have partially addressed this issue but only used a limited list of sources analysed or only focused on three stages (pre-, during and post-). Our study considers a fourth stage –destination choice–, and also 27 sources of information were included in the questionnaires sent to our sample of analysis composed of 1,621 tourists from the four main countries visiting Spain: France, Germany, Italy and the United Kingdom. The results confirm the prevalence of Internet search engines for destination choice and trip preparation phases, but also point out to the importance of recommendations from friends and family in the destination choice stage, of maps and plans during the trip, and of Facebook in the post-trip stage. It is also shown that, among the official channels of the destinations, only the website stands out as one of the most consulted sources

Metal-organic framework MIL-101(Cr) based mixed matrix membranes for esterification of ethanol and acetic acid in a membrane reactor

Mixed matrix membranes (MMMs) based on the polyimide Matrimid® (PI) with metal-organic framework (MOF) MIL-101(Cr) as porous nanostructured filler were synthesized and applied as separation element in a membrane reactor to carry out the esterification of acetic acid with ethanol. The MMMs were characterized by techniques including X-ray diffraction, IR spectroscopy and scanning electron microscopy. In order to compare the performance of MIL-101(Cr)-PI MMMs in the membrane reactor, pure PI and HKUST-1-PI membranes were also used. MMMs provided a better reactor performance than the bare PI membrane because of the increase in permeability associated to the presence of MOF as filler. The PI membrane reactor barely achieved the same conversion as a fixed bed reactor, while the MIL- 101(Cr)-PI membrane showed a reactor performance similar to that of the HKUST-1-PI membrane with higher stability, as confirmed by membrane characterization after the reaction experiments

Recruitment of Staufen2 Enhances Dendritic Localization of an Intron-Containing CaMKIIα mRNA

Regulation of mRNA localization is a conserved cellular process observed in many types of cells and organisms. Asymmetrical mRNA distribution plays a particularly important role in the nervous system, where local translation of localized mRNA represents a key mechanism in synaptic plasticity. CaMKIIα is a very abundant mRNA detected in neurites, consistent with its crucial role at glutamatergic synapses. Here, we report the presence of CaMKIIα mRNA isoforms that contain intron i16 in dendrites, RNA granules, and synaptoneurosomes from primary neurons and brain. This subpopulation of unspliced mRNA preferentially localizes to distal dendrites in a synaptic-activity-dependent manner. Staufen2, a well-established marker of RNA transport in dendrites, interacts with intron i16 sequences and enhances its distal dendritic localization, pointing to the existence of intron-mediated mechanisms in the molecular pathways that modulate dendritic transport and localization of synaptic mRNAs.This work was funded by grants from the Ministry of Economy and Competitiveness of Spain (BFU2014-52591-R CG) and the European Union (FEDER) to C.G

Las narraciones de la vida cotidiana para abrir caminos hacia la escritura

El presente artículo presenta los avances de la investigación titulada “las narraciones de la vida cotidiana para abrir caminos hacia la escritura”, el propósito es fortalecer la producción escrita a través del uso de la narrativa de hechos cotidianos en la vida de los niños y niñas en la producción escrita de textos libres y diarios escolares. La metodológica está basada en un enfoque cualitativo, en la fase de planeación, el diagnóstico determinó que las y los estudiantes trascriben elementos explícitos de las lecturas, sin dar lugar a una producción textual relacionada con la interacción social y cultural del entorno en el que se desenvuelven.En la fase de acción, se hizo un manejo de los diarios escolares donde se evidenció un acercamiento a la escritura con énfasis en la percepción de los acontecimientos y significados que representa sus experiencias, haciendo de estos una narración rica en expresar sus intereses y la relación de las interacciones que traen consigo una carga de nuevas expectativas y posturas frente a la vida. En proceso se encuentra el desarrollo de seis (6) talleres con base en el texto libre desde su sentir personal, sin embargo se puede deducir que con el trabajo adelantado

POST RUPTIVOS: LA EXPERIENCIA DE HACER PROMOCIÓN DIGITAL DE LECTURA EN REDES SOCIALES

El artículo hace referencia a los componentes, procesos y resultados que se han obtenido en el proyecto de investigación “Post-ruptivos, laboratorio experimental de promoción digital de lectura”, cuya columna vertebral está constituida por el quehacer del semillero Post-ruptivos, integrado por jóvenes estudiantes del Politécnico Grancolobiano

Microglial and neurogenic alterations in hypothalamus due to acute stress

This study was supported by FEDER/Ministerio de Ciencia, Innovación y Universidades – Agencia Estatal de Investigación from Spain (PSI2017-83408-P to Pedraza C.), and Ministerio de Educación, Cultura y Deporte from Spain (FPU16/05308 to Nieto-Quero A).Microglial cells are an important glial population known to be involved in several biological processes such as stress response. These cells engage an activated state following a stress insult that may lead to nervous tissue damage, including new cell generation impairment. This has been widely studied in regions with notable neurogenesis such as de hippocampus, however, the effect in other regions with fewer yet relevant neurogenesis remains partially unknown. One of them is the hypothalamus, a key vegetative control center playing an important role in stress response. Moreover, most of the stress models studied concern neuroinflammatory and neurogenic changes due to a chronic stressor but not a single stress event. Given the repercussion of these processes alone, it would be interesting to elucidate the relationship between microglial response, hypothalamic neurogenesis, and acute stress. This project focuses on studying acute stressed C57BL/6J mice, both at the histological and molecular level. An intense stressor combining water immersion and movement restriction was performed. Using immunohistochemical and molecular analysis with Luminex, we could analyze microglial distribution and morphology, neurogenesis, and inflammatory environment in the hypothalamic parenchyma (paraventromedial, ventromedial and arcuate nucleus).Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech