Nephrotic syndrome caused by Babesia spp. in a dog: A case repor

P?ginas. 91-99Un canino, macho, entero, de raza Weimaraner, de dos a?os de edad, es presentado a consulta por adelgazamiento progresivo y distensi?n abdominal en el transcurso de cuatro semanas. Al realizar examen cl?nico y las pruebas de laboratorio, se confirm? la presencia de s?ndrome nefr?tico y enfermedad renal cr?nica, posiblemente desencadenada por Babesia spp. El tratamiento se enfoc? en el control del hemopar?sito y manejo sintom?tico de las afecciones asociadas al s?ndrome. El presente documento expone un caso cl?nico de s?ndrome nefr?tico, su diagn?stico y tratamiento.ABSTRACT. A two-years-old canine intact male Weimaraner is presented to the veterinary clinic with a record of progressive weight loss and abdominal distension since 4 weeks ago. Clinical examination and laboratory tests confirmed the presence of nephrotic syndrome and chronic kidney disease, suspected to be caused by Babesia spp. The treatment was focused on the hemoparasites and reduction of ascites. In this report we discuss the nephrotic syndrome, its diagnosis and treatment

Despu?s del silencio una representaci?n audiovisual ficcional del bullying y la homofobia

252 p. Recurso Electr?nicoEn los ?ltimos a?os, el bullying se ha convertido en un tema medi?tico, pero su abordaje a menudo es superficial. Una de las principales razones por las cuales se presenta este fen?meno en las instituciones educativas es la homofobia, que tiene sus ra?ces en concepciones err?neas de la sociedad sobre la diversidad sexual. El bullying homof?bico es un problema colectivo y en algunos casos, invisible, donde los abusadores reprimen los derechos b?sicos de la v?ctima como: su libre expresi?n y el derecho de afrontar su sexualidad de la mejor manera posible. El cine de ficci?n, como espacio de representaci?n cultural y de reflexi?n social, se torna como un medio pertinente para abordar problem?ticas sociales desde un punto de vista m?s profundo. Es por ello que hemos decidido tomar este tema como eje de nuestra investigaci?n, para el cual se pretende desarrollar un cortometraje de ficci?n, llamado ?Despu?s Del Silencio?, una historia sobre lo que puede desencadenar la pr?ctica del bullying sobre la vida de un adolescente.In the last years, bullying has become a media issue. But its approach is often superficial. One of the mean reasons why this phenomenon happens in educational institutions is hompohobia, which is rooted in misconceptions about sexual diversity. Homophobic bullying is a collective problema and in some cases, invisible, where abusers repressed the basic rights of the victim as free expression and the right to confront their sexuality in the best way posible. Fiction films, as a space of cultural representation fiction cinema as a space of cultural representation and social reflection, becomes as relevant to address social problems from a deeper point of view means. That is why we decided to take this issue as the focus of our research, for which it aims to develop a short fiction film called " After the Silence?. A story about what can trigger the practice of bullying on the life of a teenager. Keywords: Bullying, Homophobia, Sexual diversity, film, audiovisual, media, communication, fiction

La relaci?n entre la CAG de derecho interno y las CAE de los CDI

Aquellas Cl?usulas Antielusivas Espec?ficas (?CAE?) de los Convenios para evitar la Doble Imposici?n (?CDI?), que tienen una estructura objetiva (?CAE propias?), establecen su alcance a trav?s de criterios espec?ficos (l?mites temporales, l?mites cuantitativos, exigencias verificables de manera formal como las caracter?sticas del receptor del pago, el accionariado del receptor del flujo, entre otros), no entran en conflicto con la Cl?usula Antielusiva General (?CAG?) de derecho interno. Un an?lisis distinto debe llevarse a cabo en relaci?n a las ?CAE impropias?, esto es, aquellas cl?usulas que, destinadas a un sector o tipo de renta espec?fico, comparten la naturaleza de la CAG en el sentido que se encuentran sustentadas en el criterio ?sustancia sobre forma? o ?realidad econ?mica?. S?lo en este caso la relaci?n se resuelve a trav?s del principio lex specialis derogat generali. Estas cl?usulas (CAE impropias) no implican ning?n tipo de regla de protecci?n al contribuyente, lo que nos parece grave, ya que su redacci?n utiliza terminolog?a vaga y ambigua (?principal prop?sito o uno de los principales prop?sitos?), y sin ninguna disposici?n de salvaguarda. Nuestro planteamiento sugiere criterios para proteger al contribuyente de la aplicaci?n de las referidas cl?usulas por parte de la autoridad tributaria

Improved personalized survival prediction of patients with diffuse large B-cell Lymphoma using gene expression profiling

BACKGROUND: Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this pathology, leading to the discovery of prognostic factors based on gene expression data, genomic rearrangements and mutational subgroups. Nevertheless, additional efforts are needed in order to enable survival predictions at the patient level. In this study we investigated new machine learning-based models of survival using transcriptomic and clinical data. METHODS: Gene expression profiling (GEP) of in 2 different publicly available retrospective DLBCL cohorts were analyzed. Cox regression and unsupervised clustering were performed in order to identify probes associated with overall survival on the largest cohort. Random forests were created to model survival using combinations of GEP data, COO classification and clinical information. Cross-validation was used to compare model results in the training set, and Harrel's concordance index (c-index) was used to assess model's predictability. Results were validated in an independent test set. RESULTS: Two hundred thirty-three and sixty-four patients were included in the training and test set, respectively. Initially we derived and validated a 4-gene expression clusterization that was independently associated with lower survival in 20% of patients. This pattern included the following genes: TNFRSF9, BIRC3, BCL2L1 and G3BP2. Thereafter, we applied machine-learning models to predict survival. A set of 102 genes was highly predictive of disease outcome, outperforming available clinical information and COO classification. The final best model integrated clinical information, COO classification, 4-gene-based clusterization and the expression levels of 50 individual genes (training set c-index, 0.8404, test set c-index, 0.7942). CONCLUSION: Our results indicate that DLBCL survival models based on the application of machine learning algorithms to gene expression and clinical data can largely outperform other important prognostic variables such as disease stage and COO. Head-to-head comparisons with other risk stratification models are needed to compare its usefulness

Una aplicaci?n de la teor?a del comportamiento planificado al segmento masculino latinoamericano de productos de cuidado personal

This research study identifies those factors which influence the consumption of care products in the Latinamerican male segment. That's why, an instrument based on the behavorial theory was applied to 600 men living in two countries of this regi?n and having different levels of development regarding the above mentioned category, Mexico -highly developed- and Peru -moderately developed-. The data obtained were analyzed using a model of structural equations. The results show that a subjective norm will stop men's consumption of these kinds of products. Similarly, the impact of this subjective norm will be lower in young men, allowing them to have a great aperture in the consumption of these care products.Este estudio busca identificar los factores que influyen en el consumo de productos de cuidado personal dentro del segmento masculino latinoamericano. Para ello, se aplic? un instrumento basado en la teor?a del comportamiento planificado a 600 hombres pertenecientes a dos pa?ses de la regi?n con diferentes niveles de desarrollo de la categor?a en cuesti?n: M?xico (alto desarrollo) y Per? (moderado desarrollo). Los datos obtenidos fueron analizados a partir de un modelo de ecuaciones estructurales. Los resultados sugieren que, en ambos pa?ses estudiados, la norma subjetiva inhibir?a el consumo de este tipo de productos entre los hombres. Asimismo, el impacto de la norma subjetiva ser?a menor en hombres j?venes, teniendo ellos mayor apertura al consumo de estos productos

Bases para la segmentaci?n del mercado homosexual en la ciudad de Lima: un enfoque para el sector de entretenimiento

The homosexual population is an important consumer market for different categories, being the entertainment the most significant. Academic and commercial researchers have addressed this market focusing on developed countries, and considering it a single and homogeneous segment. The following research proposes to set the bases for a segmentation of the homosexual population in Lima, Peru, in order to understand the motives of each identified consumer segment, within the entertainment category. The results allow to identify three segments in the studied population with different demographic, psychographic and behavioral characteristics regarding the consumption of entertainment, which gives rise to different needs and opportunities to satisfy them.La poblaci?n homosexual representa un importante mercado de consumo para diferentes categor?as, destacando entre ellas el entretenimiento. Investigaciones acad?micas y comerciales han abordado este mercado principalmente enfoc?ndose en pa?ses desarrollados, y consider?ndolo como un segmento ?nico y homog?neo. La presente investigaci?n propone sentar las bases para una segmentaci?n de la poblaci?n homosexual en Lima, capital de Per?, orientada a comprender las motivaciones de consumo de cada segmento identificado en el marco de la categor?a entretenimiento. A trav?s de los resultados obtenidos se identificaron tres segmentos en la poblaci?n estudiada con caracter?sticas demogr?ficas, psicogr?ficas y preferencias distintas en cuanto a actividades de entretenimiento, de lo cual se desprenden diferentes necesidades y oportunidades para satisfacerlas

Análisis de la productividad científica y visibilidad de las publicaciones sobre usabilidad (1971-2005)

Objetivo: Analizar los artículos sobre usabilidad publicados durante el periodo 1971-2005 desde el punto de vista bibliométrico. Material y Métodos: Para obtener los trabajos se interrogaron las bases de datos del CSIC, Social Science Citation Index, Science Citation Index, PsycInfo, MEDLINE e Inspec mediante estrategias de búsqueda diseñadas ad hoc para cada base de datos. Se calcularon los índices de aporte, aporte específico y solapamiento y los indicadores de evolución de la productividad científica, productividad de las instituciones de trabajo y de las revistas, y distribución de las revistas por área de conocimiento. Resultados: Se ha observado un crecimiento exponencial de los artículos publicados, más acusado en el último quinquenio. Las instituciones más productivas son fundamentalmente universitarias y estadounidenses y las revistas más productivas pertenecen al campo de la informática, ingeniería y psicología. Conclusiones: en la actualidad existe una incógnita sobre la consideración de la usabilidad como ciencia o disciplina científica, ya que no cuenta con un currículo formativo acorde, ni un perfil profesional determinado, ni un área específica de conocimiento en la que se pueda englobar.Aims: To analyse usability-related articles published in the period 1971-2005 from a bibliometric point of view. Methods: A search for articles was made in the CSIC databases, the Social Science Citation Index, Science Citation Index, PsycInfo, MEDLINE and Inspec databases, using ad hoc search strategies designed for each. Contribution, specific contribution and overlap indices were calculated, as were the indicators of change in scientific production, the productivity of institutions and journals, and the distribution of journals by area of knowledge. Results: An exponential increase in the number of published articles was recorded, with the highest increase seen over the last fi ve years. The most productive institutions were mostly US universities; the most productive journals were related to Computer Science, Engineering and Psychology. Conclusions: Currently there is controversy surrounding the idea of usability as a science or scientific discipline since it lacks an appropriate training curriculum, has no set professional profile, and it is unsure into what specific area of knowledge it falls.Bolaños Pizarro, Máxima, [email protected] ; Vidal Infer, Antonio, [email protected] ; Navarro Molina, Carolina, [email protected] ; Valderrama Zurian, Juan, [email protected] ; Gonzalez Alcaide, Gregorio, [email protected] ; Aleixandre Benavent, Rafael, [email protected]

Cyclophilins in Ischemic Heart Disease: Differences Between Acute and Chronic Coronary Artery Disease Patients

Background: Cyclophilins (Cyps) are a family of peptidyl-prolyl cis/trans isomerases consistently involved in cardiovascular diseases through the inflammation pathway. This study aims to investigate the serum levels of Cyps (CypA, CypB, CypC and CypD) in patients with coronary artery disease (CAD) and the correlation with clinical characteristics and inflammation parameters. Methods: We developed an observational prospective study with a total of 125 subjects: 40 patients with acute CAD, 40 patients with chronic CAD and 45 control volunteers, in whom serum levels of Cyps (CypA, CypB, CypC and CypD), interleukins and metalloproteinases were measured. Results: CypA levels increased significantly in CAD patients compared with control subjects, but no differences were noted between acute CAD (7.80 +/- 1.30 ng/mL) and chronic CAD (5.52 +/- 0.76 ng/mL) patients (P = 0.13). No differences in CypB and CypD levels were showed between CAD patients and controls and between acute CAD and chronic CAD patients. In relation with CypC, the levels in CAD patients were significantly higher compared to controls (32.42 +/- 3.71 pg/mL vs. 9.38 +/- 1.51 pg/mL, P 17.5 pg/mL cut-off point, and it was significantly associated with older age, hypertension, dyslipidemia and more extensive CAD in acute and chronic CAD groups. Conclusions: CypA and CypC levels are increased in CAD patients. High CypC serum levels could be a novel biomarker in CAD patients correlating with a more severe disease

Minimally Invasive Esophagectomy for Cancer: A Safe Procedure in Oncological Surgery

Introduction: Minimally invasive surgery (MIS) in the surgical management of esophageal cancer is now accepted as a valid technique. The aim of this study is to show our initial experience with this approach.Material and Methods: Observational study using data collected prospectively from a database, which includes 23 patients operated by MIS. Esophageal dissection was performed by videothoracoscopy, followed by laparotomy or laparoscopy. An Akiyama gastroplasty was made up, and pulled up through the posterior mediastinum and an side-to-side esophagogastric cervical anastomosis was then performed.Results: Most of the patients (19) were male and the average age was 63.3 years. Most tumors were located underneath the carina. 17 were adenocarcinomas and 6 squamous cell type. 19 patients received neoadjuvant therapy. The average operating time was 377.5 minutes and in 5 patients it was necessary to make a thoracotomy to finish the esophageal dissection. An average of 18 lymph node were removed and the most frequent pathological stage was the IIA. The morbidity was 47.8%, 5 patients with respiratory complications and 7 patients presenting a anastomosis leakage or fistula. 3 patients died postoperatively. The average follow-up was 23.5 months and the estimated 5-year overall survival was 61.8%.Conclusion:This study confirms previous reports about MIS which seems to be a valid technique if made by experienced teams. Our results support a satisfactory oncological outcome and a low rate of respiratory complications