Increasing the efficiency of medical research with dynamic research summaries for researchers and consumers

Literature reviews are usually the first step in conducting medical research projects.They often lead to the creation of a useful research question. However, this initialstep in medical research contains inefficiencies, which if removed, could speedup the research process and thereby enhance development of innovative healthrelated products. In addition, existing research article databases offer informationwhich is inaccessible to most lay consumers. This article proposes an alternativeapproach for allowing researchers to assess the state of research in a particulararea called “dynamic research summaries.” These summaries would offer a regularlyupdated narrative of existing research in any given area. They could increasethe speed at which researchers of all levels review literature and develop usefulresearch questions. In addition, this article proposes translating this information into a consumer friendly form that enhances the ability of non-expert consumers to review existing research relevant to their illness or a loved one’s illness. This consumer friendly version could also be translated into other languages, such as Spanish in the US, to increase accessibility for minority groups that speak other languages more proficiently. Finally, the article discusses the potential of either the public or private sector leading efforts to develop dynamic research summaries for experts and consumers

For Asians only? The perils of ancestry-based drug prescribing

The article discusses various aspects of ancestry-based drug prescribing and contemporary medical ethics in the U.S. Ancestry has been used by researchers to identify a subgroup of people most likely to have a certain allele linked to an adverse drug response. Also discussed are carbamazepine labeling, the U.S. Food and Drug Administration\u27s (FDA) Alert on drug prescribing based on allele testing and the ethics of genetically categorizing people

The ISCIP Analyst, Volume XIII, Issue 2

This repository item contains a single issue of The ISCIP Analyst, an analytical review journal published from 1996 to 2010 by the Boston University Institute for the Study of Conflict, Ideology, and Policy

The role of the gut microbiome in sustainable teleost aquaculture

As the most diverse vertebrate group and a major component of a growing global aquaculture industry, teleosts continue to attract significant scientific attention. The growth in global aquaculture, driven by declines in wild stocks, has provided additional empirical demand, and thus opportunities, to explore teleost diversity. Among key developments is the recent growth in microbiome exploration, facilitated by advances in high-throughput sequencing technologies. Here, we consider studies on teleost gut microbiomes in the context of sustainable aquaculture, which we have discussed in four themes: diet, immunity, artificial selection and closed-loop systems. We demonstrate the influence aquaculture has had on gut microbiome research, while also providing a road map for the main deterministic forces that influence the gut microbiome, with topical applications to aquaculture. Functional significance is considered within an aquaculture context with reference to impacts on nutrition and immunity. Finally, we identify key knowledge gaps, both methodological and conceptual, and propose promising applications of gut microbiome manipulation to aquaculture, and future priorities in microbiome research. These include insect-based feeds, vaccination, mechanism of pro- and prebiotics, artificial selection on the hologenome, in-water bacteriophages in recirculating aquaculture systems (RAS), physiochemical properties of water and dysbiosis as a biomarker

Many bioinformatics programming tasks can be automated with ChatGPT

Computer programming is a fundamental tool for life scientists, allowing them to carry out many essential research tasks. However, despite a variety of educational efforts, learning to write code can be a challenging endeavor for both researchers and students in life science disciplines. Recent advances in artificial intelligence have made it possible to translate human-language prompts to functional code, raising questions about whether these technologies can aid (or replace) life scientists' efforts to write code. Using 184 programming exercises from an introductory-bioinformatics course, we evaluated the extent to which one such model -- OpenAI's ChatGPT -- can successfully complete basic- to moderate-level programming tasks. On its first attempt, ChatGPT solved 139 (75.5%) of the exercises. For the remaining exercises, we provided natural-language feedback to the model, prompting it to try different approaches. Within 7 or fewer attempts, ChatGPT solved 179 (97.3%) of the exercises. These findings have important implications for life-sciences research and education. For many programming tasks, researchers no longer need to write code from scratch. Instead, machine-learning models may produce usable solutions. Instructors may need to adapt their pedagogical approaches and assessment techniques to account for these new capabilities that are available to the general public.Comment: 13 pages, 4 figures, to be submitted for publicatio

Physiological responses of Brassica napus to fulvic acid under water stress: Chlorophyll a fluorescence and antioxidant enzyme activity

AbstractThe ameliorative effect of fulvic acid (0, 300, and 600mgL−1) on photosystem II and antioxidant enzyme activity of the rapeseed (Brassica napus L.) plant under water stress (60, 100, and 140mm evaporation from class A pan) was studied using split plots in a randomized complete block design with three replications. Results indicated that application of fulvic acid (FA) improved the maximum quantum efficiency of PSII (Fv/Fm) and performance index (PI) of plants under both well-watered and limited-water conditions. The time span from Fo to Fm and the energy necessary for the closure of all reaction centers was significantly increased, but the size of the plastoquinone pool was reduced with increasing water stress levels. Plants treated with FA had higher peroxidase and catalase activities under all irrigation conditions. Activities of ascorbate peroxidase and superoxide dismutase in plants increased with increasing water stress. Malondialdehyde increased under severe water stress, but application of FA significantly decreased lipid peroxidation. Production of reactive oxygen species (ROS) is a common phenomenon in plants under stress. Under this condition, the balance between the production of ROS and the quenching activity of antioxidants is upset, often resulting in oxidative damage. In this study, application of FA significantly increased fluorescence of chlorophyll a, inhibiting ROS production and enhancing antioxidant enzymes activity that destroyed ROS. Thus, ROS in plant cells was reduced under water stress by application of FA and consequently lipid peroxidation was reduced

The Stellar Population of h and chi Persei: Cluster Properties, Membership, and the Intrinsic Colors and Temperatures of Stars

(Abridged) From photometric observations of $\sim$ 47,000 stars and spectroscopy of $\sim$ 11,000 stars, we describe the first extensive study of the stellar population of the famous Double Cluster, h and $\chi$ Persei, down to subsolar masses. Both clusters have E(B-V) $\sim$ 0.52--0.55 and dM = 11.8--11.85; the halo population, while more poorly constrained, likely has identical properties. As determined from the main sequence turnoff, the luminosity of M supergiants, and pre-main sequence isochrones, ages for h Persei, $\chi$ Persei and the halo population all converge on $\approx$ 14 Myr. From these data, we establish the first spectroscopic and photometric membership lists of cluster stars down to early/mid M dwarfs. At minimum, there are $\sim$ 5,000 members within 10' of the cluster centers, while the entire h and $\chi$ Persei region has at least $\sim$ 13,000 and as many as 20,000 members. The Double Cluster contains $\approx$ 8,400 M$_{\odot}$ of stars within 10' of the cluster centers. We estimate a total mass of at least 20,000 M$_{\odot}$. We conclude our study by outlining outstanding questions regarding the properties of h and $\chi$ Persei. From comparing recent work, we compile a list of intrinsic colors and derive a new effective temperature scale for O--M dwarfs, giants, and supergiants.Comment: 88 pages, many figures, Accepted for publication in The Astrophysical Journal Supplements. Contact lead author for version with high-resolution figure

Biomimetic chitosan-mediated synthesis in heterogeneous phase of bulk and mesoporous silica nanoparticles

Both bulk and mesoporous silica nanoparticles can be obtained in the form of granular aggregates using chitosan flakes as additive under very soft biomimetic reaction conditions.Puchol Estors, Victoria, [email protected] ; El Haskouri, Jamal, [email protected] ; Latorre Saborit, Julio, [email protected] ; Beltran Porter, Aurelio, [email protected] ; Beltran Porter, Daniel, [email protected] ; Amoros del Toro, Pedro Jose, [email protected]