Tracking Damage in Carbon Fibre Components using Infrared Imaging

This work demonstrates a non-contact technique that uses infrared imaging for tracking damage within carbon fibre composites under cyclic loading. The technique has been successfully applied to a range of coupon geometries, including 45-degree slot and hole in the plate specimens. The approach provides a methodology to monitor damage within composites components as it develops in the form of delaminations and surface cracking

Using binary stars to bound the mass of the graviton

Interacting white dwarf binary star systems, including helium cataclysmic variable (HeCV) systems, are expected to be strong sources of gravitational radiation, and should be detectable by proposed space-based laser interferometer gravitational wave observatories such as LISA. Several HeCV star systems are presently known and can be studied optically, which will allow electromagnetic and gravitational wave observations to be correlated. Comparisons of the phases of a gravitational wave signal and the orbital light curve from an interacting binary white dwarf star system can be used to bound the mass of the graviton. Observations of typical HeCV systems by LISA could potentially yield an upper bound on the inverse mass of the graviton as strong as $h/m_{g} = \lambda_{g} > 1 \times 10^{15}$ km ($m_{g} < 1 \times 10^{-24}$ eV), more than two orders of magnitude better than present solar system derived bounds.Comment: 21 pages plus 4 figures; ReVTe

White dwarfs as test objects of Lorentz violations

In the present work the thermodynamical properties of bosonic and fermionic gases are analyzed under the condition that a modified dispersion relation is present. This last condition implies a breakdown of Lorentz symmetry. The implications upon the condensation temperature will be studied, as well, as upon other thermodynamical variables such as specific heat, entropy, etc. Moreover, it will be argued that those cases entailing a violation of time reversal symmetry of the motion equations could lead to problems with the concept of entropy. Concerning the fermionic case it will be shown that Fermi temperature suffers a modification due to the breakdown of Lorentz symmetry. The results will be applied to white dwarfs and the consequences upon the Chandrasekhar mass--radius relation will be shown. The possibility of resorting to white dwarfs for the testing of modified dispersion relations is also addressed. It will be shown that the comparison of the current observations against the predictions of our model allows us to discard some values of one of the parameters appearing in the modifications of the dispersion relation.Comment: Accepted in Classical and Quantum Gravitatio

A comparability study of 5 commercial KRAS tests

<p>Abstract</p> <p>Background</p> <p>Activating mutations in the <it>KRAS </it>gene occur frequently in human tumors, including colorectal carcinomas; most mutations occur in codons 12 and 13. Mutations in <it>KRAS </it>have been associated with poor response to anti-epidermal growth factor receptor antibodies. Therefore, an accurate and readily available analysis of <it>KRAS </it>mutational status is needed. The aim of this study was to evaluate concordance between <it>KRAS </it>assays performed by 6 different laboratories.</p> <p>Methods</p> <p>Forty formalin-fixed paraffin-embedded colorectal cancer tumor samples were obtained. Sample sections were submitted for <it>KRAS </it>mutation analysis to 5 independent commercial laboratories (Agencourt, Gentris, Genzyme, HistoGeneX, and Invitek) and to the Amgen DNA Sequencing Laboratory for direct polymerase chain reaction sequencing. The assay used by Invitek is no longer commercially available and has been replaced by an alternative technique. Results from the commercial services were compared with those from Amgen direct sequencing by κ statistics.</p> <p>Results</p> <p><it>KRAS </it>mutations were observed in codon 12 and/or 13 in 20 of 40 (50%) samples in Amgen direct sequencing assays. Results from HistoGeneX (κ = 0.95), Genzyme (κ = 0.94), and Agencourt (κ = 0.94) were in almost perfect agreement with these results, and the results from Gentris were in substantial agreement with the results from Amgen (κ = 0.75). The Invitek allele-specific assay demonstrated slight agreement (κ = 0.13).</p> <p>Conclusions</p> <p>This study provides data on the comparability of <it>KRAS </it>mutational analyses. The results suggest that most (but not all) commercial services provide analysis that is accurate and comparable with direct sequencing.</p

Cocreating with Young Fathers: Producing Community-Informed Training Videos to Foster more Inclusive Support Environments

Our contribution draws upon a collaborative project called ‘Diverse Dads’, which ran between October 2020 and April 2021, during the 2020–2021 COVID-19 pandemic. The team comprised members of the North East Young Dads and Lads (NEYDL) Project, advisors from support organisations that champion inclusivity, and the Following Young Fathers Further (FYFF) research team. ‘Diverse Dads’ sought to identify and address gaps in service provision for young minoritised dads in the North East, and to promote cross-sector conversations concerning inclusive support for young dads from diverse communities. With support provided remotely by the FYFF team, peer research was undertaken by three young men from NEYDL. Our work highlights how methods of coproduction and cocreation were achieved during the pandemic. NEYDL is also embarking on an ambitious new digital service journey with partners DigiDAD, producing digital outputs that are made by and for young fathers. Working collaboratively, the peer research team and DigiDAD produced a set of videos designed to support training for professionals in mainstream, family, and statutory services. Showcasing one of these creative outputs, our contribution will discuss the continued value of coproduction and cocreation with young people and using creative, digital methods to support productive discussions between young fathers, professionals, and researchers

Joint Elastic Side-Scattering Lidar and Raman Lidar Measurements of Aerosol Optical Properties in South East Colorado

We describe an experiment, located in south-east Colorado, USA, that measured aerosol optical depth profiles using two Lidar techniques. Two independent detectors measured scattered light from a vertical UV laser beam. One detector, located at the laser site, measured light via the inelastic Raman backscattering process. This is a common method used in atmospheric science for measuring aerosol optical depth profiles. The other detector, located approximately 40km distant, viewed the laser beam from the side. This detector featured a 3.5m2 mirror and measured elastically scattered light in a bistatic Lidar configuration following the method used at the Pierre Auger cosmic ray observatory. The goal of this experiment was to assess and improve methods to measure atmospheric clarity, specifically aerosol optical depth profiles, for cosmic ray UV fluorescence detectors that use the atmosphere as a giant calorimeter. The experiment collected data from September 2010 to July 2011 under varying conditions of aerosol loading. We describe the instruments and techniques and compare the aerosol optical depth profiles measured by the Raman and bistatic Lidar detectors.Comment: 34 pages, 16 figure

Interactions between visual and semantic processing during object recognition revealed by modulatory effects of age of acquisition

The age of acquisition (AoA) of objects and their names is a powerful determinant of processing speed in adulthood, with early-acquired objects being recognized and named faster than late-acquired objects. Previous research using fMRI (Ellis et al., 2006. Traces of vocabulary acquisition in the brain: evidence from covert object naming. NeuroImage 33, 958–968) found that AoA modulated the strength of BOLD responses in both occipital and left anterior temporal cortex during object naming. We used magnetoencephalography (MEG) to explore in more detail the nature of the influence of AoA on activity in those two regions. Covert object naming recruited a network within the left hemisphere that is familiar from previous research, including visual, left occipito-temporal, anterior temporal and inferior frontal regions. Region of interest (ROI) analyses found that occipital cortex generated a rapid evoked response (~ 75–200 ms at 0–40 Hz) that peaked at 95 ms but was not modulated by AoA. That response was followed by a complex of later occipital responses that extended from ~ 300 to 850 ms and were stronger to early- than late-acquired items from ~ 325 to 675 ms at 10–20 Hz in the induced rather than the evoked component. Left anterior temporal cortex showed an evoked response that occurred significantly later than the first occipital response (~ 100–400 ms at 0–10 Hz with a peak at 191 ms) and was stronger to early- than late-acquired items from ~ 100 to 300 ms at 2–12 Hz. A later anterior temporal response from ~ 550 to 1050 ms at 5–20 Hz was not modulated by AoA. The results indicate that the initial analysis of object forms in visual cortex is not influenced by AoA. A fastforward sweep of activation from occipital and left anterior temporal cortex then results in stronger activation of semantic representations for early- than late-acquired objects. Top-down re-activation of occipital cortex by semantic representations is then greater for early than late acquired objects resulting in delayed modulation of the visual response

A search for radio emission from Galactic supersoft X-ray sources

We have made a deep search for radio emission from all the northern hemisphere supersoft X-ray sources using the VLA and MERLIN telescopes, at 5 and 8.4 GHz. Three previously undetected sources: T Pyx, V1974 Cygni and RX J0019.8+2156 were imaged in quiescence using the VLA in order to search for any persistent emission. No radio emission was detected in any of the VLA fields down to a typical 1 sigma RMS noise of 20 uJy/beam, however, 17 new point sources were detected in the fields with 5 GHz fluxes between 100 and 1500 uJy giving an average 100 uJy-source density of around 200 per square degree, comparable to what was found in the MERLIN HDF survey. The persistent source AG Draconis was observed by MERLIN to provide a confirmation of previous VLA observations and to investigate the source at a higher resolution. The core is resolved at the milliarcsec scale into two components which have a combined flux of around 1 mJy. It is possible that we are detecting nebulosity which is becoming resolved out by the higher MERLIN resolution. We have investigated possible causes of radio emission from a wind environment, both directly from the secondary star, and also as a consequence of the high X-ray luminosity from the white dwarf. There is an order of magnitude discrepancy between observed and modelled values which can be explained by the uncertainty in fundamental quantities within these systems.Comment: Accepted for publication in MNRAS, 7 pages, 1 figur