Repurposing resources as open content: studying the experiences of new providers

Much educational content sits within institutional systems protected from global access, this proprietary approach restricts opportunities for informal learning and the exchange of materials between cultures. One response to reducing this particular digital divide is to open up access to existing courses by providing them as free to use Open Educational Resources (OERs). This is being addressed through work on OpenLearn (the open content initiative from The Open University developed with support from the William and Flora Hewlett Foundation) and POCKET (The Project on Open Content for Knowledge Exposition and Teaching, supported by JISC under the repositories and preservation programme). The approach is evaluative considering transfer of lessons from work on the reworking of distance learning materials (within the OpenLearn initiative) to the reworking of material from campus-based universities (supported by the POCKET project). Analysis will include the role of supporting artifacts (guidelines, examples, tools) and the process support required (shared aims, workshops, structure). Evaluation tools that are being applied include logging of experience, stake holder interviews, and analytics data. We are building on existing evaluation of the OpenLearn initiative that has revealed models for learner use of open educational resources and studied the reuse of released open resources. Results include the need for a range of reworkable formats, support and time pressures on voluntary use – these results are supported by case study information and overall usage statistics. Further data that will be available from POCKET by September 2008 will include reflections from participants, workshop outcomes and initial stakeholder interviews, full evaluation of POCKET will be complete by April 2009. This paper will have examined our understanding of the process by which content can be transformed from existing learning materials to freely available open educational resources. Conclusions at this stage will focus on the process of adoption and transfer from OpenLearn and the effectiveness of the evaluation and project approach. Comparison will be made with the advantages and disadvantages of the self supported approach adopted initially in OpenLearn and suggestions given for structures that enable collaboration in producing open educational resources

Early neoproterozoic marine redox conditions recorded in black shale from the little Dal Group, Northwest Territories, Canada

Black shale in the Little Dal Group (ca. <817 Ma), Mackenzie Mountains Supergroup (779 Ma), was deposited during the early Neoproterozoic, and is one of the few known black shale deposits from this crucial time in Earth’s evolutionary history. Relative iron enrichment (FeT/Al) and conventional iron speciation (DOP), along with enrichment in molybdenum, total sulphur, and total organic carbon, were studied. Iron systematics (FeT/Al >0.5 and DOP <0.80) indicate ferruginous, anoxic, and possibly oxic bottom-water conditions over the time of deposition of the entire black shale unit. The enrichment factors of several of the authigenic redox-sensitive trace elements (U, Mo, V) are strongly correlated, and appear to be related to both the FeT and the organic carbon content of the black shale. Molybdenum enrichment (<10 ppm) is limited, which is in very good agreement with data from Mesoproterozoic black shales, but is much lower than Mo enrichments in Paleozoic black shales (typically >100 ppm). Several black muddy siltstones yielded similar results, but authigenic iron was greatly overwhelmed by siliciclastic sedimentation. These new data support the theory that ocean bottom-waters returned from sulphidic to ferruginous prior to development of oxygenated conditions in the Ediacaran open ocean. This study documents a predominantly open-marine basin that was characterised by ferruginous conditions, similar to Archean and early Paleoproterozoic conditions, with brief intervals when oxic conditions developed.Master'

Scanning electrochemical microscopy as a local probe of oxygen permeability in cartilage

The use of scanning electrochemical microscopy, a high-resolution chemical imaging technique, to probe the distribution and mobility of solutes in articular cartilage is described. In this application, a mobile ultramicroelectrode is positioned close (not, vert, similar1 μm) to the cartilage sample surface, which has been equilibrated in a bathing solution containing the solute of interest. The solute is electrolyzed at a diffusion-limited rate, and the current response measured as the ultramicroelectrode is scanned across the sample surface. The topography of the samples was determined using Ru(CN)64−, a solute to which the cartilage matrix was impermeable. This revealed a number of pit-like depressions corresponding to the distribution of chondrocytes, which were also observed by atomic force and light microscopy. Subsequent imaging of the same area of the cartilage sample for the diffusion-limited reduction of oxygen indicated enhanced, but heterogeneous, permeability of oxygen across the cartilage surface. In particular, areas of high permeability were observed in the cellular and pericellular regions. This is the first time that inhomogeneities in the permeability of cartilage toward simple solutes, such as oxygen, have been observed on a micrometer scale

Effect of within-session breaks in play on responsible gambling behaviour during sustained monetary losses

Rapid, continuous gambling formats are associated with higher risks for gambling-related harm in terms of excessive monetary and time expenditure. The current study investigated the effect on gambling response latency and persistence, of a new form of within-game intervention that required players to actively engage in response inhibition via monitoring for stop signals. Seventy-four experienced electronic gaming machine gamblers, with a mean age of 35.28 years, were recruited to participate in a rapid, continuous gambling task where real money could be won and lost. Participants were randomly allocated to either the control condition where no intervention was presented, or either a condition with a passive three minute break in play or a condition with a three minute intervention that required participants to engage in response inhibition. Although there was no main effect for experimental condition on gambling persistence, both interventions were effective in elevating response latency during a period of sustained losses. It was concluded that within-game interventions that create an enforced break in play are effective in increasing response latency between bets during periods of sustained losses. Furthermore, within-game interventions that require active involvement appear to be more effective in increasing response latency than standard, passive breaks in play

Correction: Exome Sequencing in an Admixed Isolated Population IndicatesNFXL1 Variants Confer a Risk for Specific Language Impairment

Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding of underlying genetic mechanisms has proved challenging. In this study, we use molecular genetic techniques to investigate an admixed isolated founder population from the Robinson Crusoe Island (Chile), who are affected by a high incidence of SLI, increasing the power to discover contributory genetic factors. We utilize exome sequencing in selected individuals from this population to identify eight coding variants that are of putative significance. We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 × 10–4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. We conclude that coding variants within NFXL1 confer an increased risk of SLI within a complex genetic model

Waste and its Disguises: Technologies of (Un)knowing

The introduction to this special issue starts with a brief thematisation of the key theoretical interventions in the anthropology of waste in order to situate our own contribution. We follow this by discussing, and adding to the recent anthropology and sociology of ignorance and not knowing, before turning to the intersections between waste and ignorance, thinking through how we and other scholars have theorised ways of deflecting attention away from wastes, whether they are lands, material or human bodies. We broadly categorise these technologies of deflection and unknowing into ‘spatial’, ‘temporal’, ‘epistemological’, ‘calculative’ and ‘rhetorical’. Specific techniques within these categories serve to eclipse other ways of knowing (i.e. the sensory, affective aspects of waste (e)valuation) and often depoliticise decisions concerning wastes, places, materials, people and their livelihoods

“Introduction”

Una introduzzione al primo libro sulle editoriales cartoneras in America Latina

Additional file 3: Figure S3. of A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication

Validation of exosome recovery. VAMT exosomes (2 × 109) were added into 6- well plates containing 2 ml of serum free basal mTeSR1 medium and incubated for 48 h. After 48 h, medium was collected and subjected to exosome isolation for NTA. Almost all of the 2 × 109 exosomes added were recovered without a significant loss, with a recovery efficiency of >95%. The exosome samples were run 5 times and averaged. SD is shown as the error bar. (TIFF 1107 kb

Additional file 4: Figure S4. of A transwell assay that excludes exosomes for assessment of tunneling nanotube-mediated intercellular communication

Uptake of exosomes crossing the transwell membrane is significantly decreased by heparin treatment of recipient cells. PKH26 (Red) labelled VAMT exosomes were added to MSTO cells pre-treated with (b) or without (a) 10 μg/mL heparin. Exosome uptake was analyzed after 24 h of culture. DIC and DIC + fluorescent merged images of control and heparin-treated cells are shown. (TIFF 2404 kb

Exome Sequencing in an Admixed Isolated Population Indicates NFXL1 Variants Confer a Risk for Specific Language Impairment

Children affected by Specific Language Impairment (SLI) fail to acquire age appropriate language skills despite adequate intelligence and opportunity. SLI is highly heritable, but the understanding of underlying genetic mechanisms has proved challenging. In this study, we use molecular genetic techniques to investigate an admixed isolated founder population from the Robinson Crusoe Island (Chile), who are affected by a high incidence of SLI, increasing the power to discover contributory genetic factors. We utilize exome sequencing in selected individuals from this population to identify eight coding variants that are of putative significance. We then apply association analyses across the wider population to highlight a single rare coding variant (rs144169475, Minor Allele Frequency of 4.1% in admixed South American populations) in the NFXL1 gene that confers a nonsynonymous change (N150K) and is significantly associated with language impairment in the Robinson Crusoe population (p = 2.04 × 10–4, 8 variants tested). Subsequent sequencing of NFXL1 in 117 UK SLI cases identified four individuals with heterozygous variants predicted to be of functional consequence. We conclude that coding variants within NFXL1 confer an increased risk of SLI within a complex genetic model