Determinación de la actividad antibacteriana "in vitro" del extracto etanólico de la hoja de Erythroxylum novogranatense var truxillense (coca) frente a bacterias orales cariogénicas

El objetivo de la investigación fue determinar la actividad antimicrobiana del extracto de la hoja de Erythroxylum novogranatense var. truxillense frente a bacterias relacionadas directamente con caries dental, a saber Streptococus mutans y Lactobacillus casei. Mediante la técnica de maceración alcohólica, filtrado y evaporación a 40 ˚C del la solución alcohólica, se obtuvo los principios activos totales del Erythroxylum novogranatense var. truxillense. Se utilizó 20 µl de agua destilada y alcohol de 96˚, como control negativo y positivo respectivamente. Al realizar las pruebas de sensibilidad se obtuvieron los siguientes resultados: Los diámetros de los halos de inhibición para S. mutans tuvieron una media de 34.4mm±2.12mm, y para el caso de L. casei, 33.7mm±3.40mm. Y con respecto a la medida de los halos de inhibición del control negativo y positivo se obtuvo una medida de 00 mm en todos los cultivos para el agua destilada y de 11.4mm±2.12mm en el caso del alcohol a 96°. Encontrándose que éstos difieren en forma estadísticamente significativa al 95% de confianza. Palabras claves: coca, efecto antimicrobiano, Erythroxylum novogranatense var. truxillense, extracto alcohólico, bacterias cariogénicas, Streptococcus mutans, Lactobacillus casei.The aim of the investigation was to determine the antimicrobial activity of the Erythroxylum novogranatense var. truxillense extract against teeth caries bacteria related, which are Streptococus mutans and Lactobacillus casei. Through an alcoholic oxidation technique, filtered and vapored at 40 ˚C, it was obtained the main actives components of Erythroxylum novogranatense var. truxillense. Sterilized water was used as negative control, and 96˚ alcohol as the positive one. The disk diffusion method was performed to test antimicrobial activity. The following results were obtained during the performance of the sensibility tests: For S. mutans there was an average inhibiting halo of 34.4mm±2.12mm, and 33.7mm±3.40mm for L. casei. For control inhibition halos (positive and negative) there was an 00 mm in distilled water and 11.4mm±2.12mm for 96° alcohol. This research was made with a 95% of statistics confidence and significant differences were found. Key words: Coca, antimicrobial effect, Erythroxylum novogranatense var. truxillens, Streptococcus mutans, Lactobacillus casei.Tesi

Ciencia Odontológica 2.0

Libro que muestra avances de la Investigación Odontológica en MéxicoEs para los integrantes de la Red de Investigación en Estomatología (RIE) una enorme alegría presentar el segundo de una serie de 6 libros sobre casos clínicos, revisiones de la literatura e investigaciones. La RIE está integrada por cuerpos académicos de la UAEH, UAEM, UAC y UdeG

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Cancer caregivers quality of life

Les aidants naturels sont un élément de plus en plus important dans l'appui et la gestion des soins des patients atteints de cancer. Cependant cela n'est pas sans conséquence pour l'aidant naturel. Notre thèse vise donc d'une part à évaluer la qualité de vie (QdV) des aidants en oncologie et d'autre part à s'interroger sur ses pistes d'amélioration.Ces objectifs nous ont conduit à valider un instrument de QdV fiable et spécifique aux aidants: le Caregiver Oncology Quality of Life Questionnaire (CarGOQoL). Nous avons étudié la stabilité de ce questionnaire dans différents sous-groupes, examiné la relation entre la QdV de l'aidant et celle du patient en prenant en compte le phénomène de response shift, et réalisé des études visant à évaluer l'impact de la maladie et de son traitement dans la QdV des aidants en Oncologie dans différents contextes et sous-groupes. Les principales propriétés de fiabilité et de validité du CarGOQoL sont satisfaisantes. Grâce aux indices d'adéquation, nous pouvons affirmer que le CarGOQoL est stable. Les résultats de nos études montrent une association positive entre la QdV des patients et des aidants et l'influence du bien-être psychologique du patient sur celui de l'aidant. Les études spécifiques des aidants en oncologie nous montrent la pertinence de la mesure de la QdV des aidants au moyen du CarGOQoL.En conclusion, nos résultats suggèrent que le cancer impacte sur la QdV des aidants. Le maintien de la QdV des aidants naturels est un facteur important dans leur volonté de fournir de l'aide. Les professionnels de santé doivent mettre en place des dispositifs pour soutenir les aidants parfois demandeurs de répit afin de maintenir leur QdV.Family caregivers are an important element in the support and care management of patients with cancer. However this is not without consequences for the caregiver who is affected by the disease and the treatment of his beloved one. Therefore, this thesis aims firstly to assess the quality of life (QoL) of caregivers in oncology and secondly to question possible suggestions for its improvement. These goals have led us to validate a reliable and specific QoL instrument for caregivers: the Caregiver Oncology Quality of Life Questionnaire (CarGOQoL). We studied the stability of this questionnaire in different sub-groups, we examined the relationship between QoL of the caregiver and the patient, taking into account the phenomenon of response shift. and we carried out studies to assess the impact of the disease and its treatment in the QoL of caregivers in oncology in different contexts and sub-groups.The main properties of reliability and validity of CarGOQoL are satisfactory. Moreover, using the suitability indices, we can say that the CarGOQoL is stable. The results of our studies show a positive association between the QoL of patients and caregivers. In addition, the influence of psychological well-being of the patient on the caregivers' one was reported. The two specific studies of caregivers in oncology showed us the relevance of measuring the QoL of caregivers through the CarGOQoL. In conclusion, our results suggest that cancer impacts on the QoL of caregivers. Maintaining the QoL of caregivers is an important factor in their willingness to provide assistance. Health professionals must put in place interventions to support caregivers in order to maintain their QoL

Using the random forest method to detect a response shift in the quality of life of multiple sclerosis patients: a cohort study

International audienc