Open-label, randomized, crossover comparative bioavailability study of cefixime from two tablet formulations after single oral administration

Background: Cefixime is an oral extended spectrum third generation cephalosporin, which has marked in vitro bactericidal activity against a wide variety of Gram-positive and Gram-negative organisms, effective in the treatment of community-acquired infections such as respiratory tract infection and urinary tract infection. The objective of this randomized, crossover study was to compare the bioequivalence (BE) of two tablets of test (Milixim® 200 mg, containing 200 mg of cefixime) with Reference formulation (Cefixime, 400 mg).Methods: A total of 12 healthy volunteers were randomly assigned to crossover, single-dose treatment regimens. Serial blood samples were collected, and plasma concentrations of cefixime were analyzed using the high-performance liquid chromatographic technique. Pharmacokinetic parameters and BE limits were calculated using non-compartmental methods.Results: The mean Cmax for the test and reference formulations were 4435.0298±149 and 4408.2150±1021 ng/mL, respectively. The mean area under the serum concentration curve (AUC)0-t were 38108.2614±8583.6535 and 38457.5791±8105.2529 ng/hr/mL The mean ratios (test: reference) for Cmax, AUC0-t, were 99.7% and 98.5%, respectively. There were no significant differences in pharmacokinetic parameters between groups. Overall, the 90% confidence interval for the intra-individual ratios of the log-transformed Cmax and AUC values of the two formulations were within the BE interval of 80-125%.Conclusion: The study has demonstrated the BE of milixim and reference formulation of cefixime

Efficiency of Paddy Farms in India: an Empirical Evidence of TBP Area of Karnataka state

The study on efficiency of paddy farms revealed that majority of the farmers were operating in medium efficiency level (70%) followed by low efficiency level (17%) and high efficiency level(13%) with respect to nitrogen. Similar trend was noticed in plant protection chemicals wherein farmers operating in medium efficiency level (74%) were higher than those of high (13%) and low efficiency levels (13%). The percentage excess of nitrogen usage over the frontier level ranged from 38.86% to 91.03% and plant protection chemicals from 42.53% to 70.54% with increase in nitrogen levels indicating inputs like nitrogen and plant protection chemicals were used indiscriminately in the study area in view of practice of their own method of cultivation. It is suggested that farmers should be trained about adoption of Integrated Nutrient Management (INM) and Integrated Pest Management (IPM) practices in paddy cultivation in TBP area. Key words: Integrated Nutrient Management, IPM, Paddy, Frontier, MVP, OC, Efficienc

Echelon analysis of the relationship between population and land cover pattern based on remote sensing data

With continuing proliferation of human influences on landscapes, there is mounting incentive to undertake quantification of relationships between spatial patterns of human populations and vegetation. In considering such quantification, it is apparent that investigations must be conducted at different scales and in a comparative manner across regions. At the broader scales it becomes necessary to utilize remote sensing of vegetation for comparative studies against map referenced census data. This paper explores such an approach for the urbanized area in the Tokyo vicinity. Vegetation is represented by the normalized difference vegetation index (NDVI) as determined from data acquired by the thematic mapper (TM) sensor of the Landsat satellite. Sparseness of vegetation is analyzed in relation to density of human residence, first by regression analysis involving stratified distance zones and then by the recent echelon approach for characterization of surfaces. Echelons reveal structural organization of surfaces in an objective and explicit manner. The virtual surface determined by census data collected on a grid is shown to have structural correspondence with the surface representing vegetation greenness as reflected in magnitude of NDVI values computed from red and infrared bands of image data

Genetic evaluation for understanding combining ability effects and Heterotic grouping in Maize (Zea mays L.)

Combining ability of the genotypes/lines is a major factor in planning the breeding programme and for development of Heterotic hybrids. In the present study, twenty maize inbred lines were crossed to three diverse testers CM-111, GPM-549 and GPM-581 and the resultant F1 hybrids were evaluated in an alpha lattice design. General combining ability of lines which is representation of additive gene action was found to be significant for all the quantitative traits. Specific combining ability which is indication of non-additive gene action was found to be significant for the traits number of kernel rows per cob, number of kernels per row, cob girth, cob length, test weight and grain yield. Lines VL-058725, VL-1018527 and VL-108723 produced heterotic hybrids in cross combination with any of the tester due to their high GCA effects. Whereas, the lines VL-0536, SNL-1574 and VL-109086 interacted positively with their testers thus producing heterotic hybrids with high positive SCA. GGE biplot analysis was helpful in visualizing the combining ability effects and identify heterotic pattern among theinbred lines. Heterotic grouping based on SCA and mean grain yield was able to classify thirteen of the twenty inbred lines into two distinct heterotic groups i.e., Heterotic group A and B consisting of six and seven lines respectively. Heterotic group A consisted of lines with high GCA whereas, heterotic group B with low GCA lines. SCA effect showed significant positive correlation with all the quantitative traits and played a prominent role in determining the performance of hybrids, thus indicating the importance of non-additive gene action in developingheterotic hybrids

Existence and Uniqueness Results for Difference Φ-Laplacian Boundary Value Problems

This paper is devoted to study the existence and uniqueness of solutions to nonlinear difference Φ-Laplacian boundary value problems with mixed and Dirichlet boundary conditions

COMPARATIVE PHYTOCHEMICAL EVALUATION OF ETHNOBOTANICALLY IMPORTANT MEDICINAL PARASITIC HERB: ALECTRA CHITRAKUTENSIS

Objective: Alectra chitrakutensis (M. A. Rau) R. Prasad & R. D. Dixit is a critically endangered and ethnobotanically very important plant. Official drug i.e. dried rhizome of the plant has been reported to be used for treatment of leprosy, tuberculosis, paralysis, oedematous swelling, fevers, intestinal worms and constipation. Besides having high medicinal properties, detail studies on chemical constituents present in the rhizome of this particular species have not been done so far. Thus, in present study efforts were made for evaluation of phytochemical as well as physicochemical analysis of the rhizome collected from six different places of the Chitrakoot region of Madhya Pradesh (M. P.) and Uttar Pradesh (U. P.).Methods: Phytochemical analysis of the rhizome was carried out as per standard protocol given in Ayurvedic Pharmacopoeia of India (API). Separation and qualitative phytochemical screening were done by using an advance technique of High-performance Thin Layer Chromatography (HPTLC).Results: The study revealed the presence of alkaloids, steroids, triterpenoids, flavonoids, glycosides, carbohydrates, starch, saponin, tannins, etc. in the rhizome of the plants, and the study confirmed the chemotaxonomic resemblance among all the collected plant materials.Conclusion: Comparative study of six rhizome samples of A. Chitrakutensis provides authenticity for establishing Pharmacopoeial standardization of drug and evidence of the study proves the chemotaxonomic similarities of official drug.Keywords: Alectra chitrakutensis, Endangered plant, Quality control, Physicochemical, Phytochemical analysis, HPTL

Effects of gamma rays on germination and growth in Jatropha curcas L.

The present investigation was carried out at the Forestry Research Farm, Navsari Agricultural University; Navsari to evaluate the gamma rays at 10 kR, 20 kR and 30 kR induced variability in Jatropha curcas L. on germination, growth and yield for seven Jatropha genotypes (Phule J-1, Urlikanchan, Hansraj, SKN Big, Chhatrapati, Hansot and MPJ-55). The significantly maximum germination percentage (66.96%), seedling survival (74.18%), seedling collar diameter (0.958cm), shoot length (49.442cm), number of leaves per seedling (7.757) and leaf area (37. 58)was observed in Chhatrapati genotype during nursery stage. While low rate of gamma rays treatment (10 kR) had stimulatory effect for germination percentage, seedling survival, seedling collar diameter, shoot length, number of leaves per seedling and leaf area. However, higher gamma rays doses (30 kR) drastically reduced all studied characters. The interaction effect of genotype and gamma rays were significant for number of leaves per seedling. Further, it was not significant in other traits like germination percentage, seedling survival, seedling collar diameter, shoot length and leaf area

Growth and yield of Vigna radiata L.) under Terminalia arjuna and Mitragyna parvifolia based agrisilvicultural system

The present investigation was carried out in an agrisilvicultural system with treatments involving silvicultural component of 20 years old Terminalia arjuna Bedd. (Arjun) and Mitragyna parvifolia Korth (Kalam) intercropped with agricultural component of four varieties of green gram (Vigna radiata L.) viz. Pusa Vishal, GM-3, GM-4 and K-851. All the varieties of green gram were compared for growth and yield parameters like plant height (cm), number of leaves, number of branches per plant, total grain yield per plant as well as per plot at harvestablestage under Arjuna and Kalam trees. All the varieties of green gram performed superior in terms of number of leaves, numbers of branches, grain yield (per plant and per plot basis) under open condition as compared to crops under Arjuna and Kalam. However, only the plant height was found to be highest under Arjun, followed by Kalam trees. Among all the varieties tested, K-851 variety showed superiority for number of leaves (12.31) and number of branches per plant (3.96) and grain yield (2.66 gm per plant and 0.80 kg per plot) as compared to other varieties (at P=0.05). Therefore, this variety is suggested to grow in south Gujarat condition. Further, comparatively lower yield of crop under tree cover could be due to shade effect, which can be managed by regular pruning of tree branches

EFFECT OF SHARPUNKHAMULACHURNA WITH TANDULODAK IN ASRUGDARA

Any abnormality in Rutuchakra (menstrual rhythm) leads excessive and irregular uterine bleeding which is known as “Asrugdara” in classical text. In routine practice of Striroga and Prasutitantra number of patients present with excessive and irregular bleeding vaginally. To study the effect of Sharpunkhamulachurna with Tandulodak in Asrugdara. Asrugdara gives rise to various systemic and psychological disorders which needs treatment. 30 patients were diagnosed with symptoms of Asrugdara attending OPD of our institute and fulfilling criteria are taken for the study. A special proforma was prepared with all points of history taking, physical signs and symptoms and lab. Investigations. The parameters were scored on the basis of standard methods of statistical analysis.In the study, Artavapraman shows 78.8% of relief, Rajastarvaavadhi shows 49.0% of relief, Daha shows 36.9% of relief, Adhoudarshula shows 59.2% of relief, interval between 2 cycle shows 0% of relief, consistency of bleeding shows 44.8% of relief, Varna shows 41.1% of relief and by wilcoxon test it is found that it is highly significant. So it can be concluded that efficacy of Sharpunkhamula churna is significant in Asrugdara on this symptom.Among the available treatment for Asrugdara, Sharpunkhamulachurna is beneficial in curing the vitiated Doshas. The treatment which includes Sharpunkhamulachurna which have been used based on their properties like Tikta and Kashayarasatmak which helps in Stambankarma, it is also Vatakaphaghna - all these objectives are fulfilled to the greater extent