Comparing pre- and post-pandemic greenhouse gas and noise emissions from road traffic in Rome (Italy): a multi-step approach

This study presents the results of a traffic simulation analysis and emissions (greenhouse gas and noise) assessment comparing pre-pandemic (2019) and post-pandemic (2022) periods. The estimation of road traffic demand is based on conventional data sources and floating car data; next, the traffic simulation procedure was performed providing road network traffic volumes, which are the input for the emission models. The diffusion of teleworking, e-commerce, as well as the digitization of many processes, services and activities, lead to a significant change in urban mobility. Results show a significant though still not complete resumption of commuters travel activity (−10% compared to pre-pandemic period) in the morning peak-hour. This translates into an 11% reduction of greenhouse gas emissions and a 0.1% increase in noise emissions

On Transport Monitoring and Forecasting during COVID-19 Pandemic in Rome

This paper presents the results of a study on the Rome mobility system aiming at estimating the impacts of the progressive lockdown, imposed by the government, due to the Covid-19 pandemic as well as to support decision makers in planning the transport system for the restart towards a post-Covid "new normal". The analysis of data obtained by the transport monitoring system has been fundamental for both investigating effects of the lockdown and feeding transport models to predict the impacts on future actions. At first, the paper focuses on the so-called transport analytics, by describing mobility trends for the multimodal transportation system of Rome. Then, the results of the simulated scenarios to design public transport services, able to ensure passengers social distancing required in the first post-Covid months, are presented and discussed

Management of anaphylaxis due to COVID-19 vaccines in the elderly

Older adults, especially men and/or those with diabetes, hypertension, and/or obesity, are prone to severe COVID-19. In some countries, older adults, particularly those residing in nursing homes, have been prioritized to receive COVID-19 vaccines due to high risk of death. In very rare instances, the COVID-19 vaccines can induce anaphylaxis, and the management of anaphylaxis in older people should be considered carefully. An ARIA-EAACI-EuGMS (Allergic Rhinitis and its Impact on Asthma, European Academy of Allergy and Clinical Immunology, and European Geriatric Medicine Society) Working Group has proposed some recommendations for older adults receiving the COVID-19 vaccines. Anaphylaxis to COVID-19 vaccines is extremely rare (from 1 per 100,000 to 5 per million injections). Symptoms are similar in younger and older adults but they tend to be more severe in the older patients. Adrenaline is the mainstay treatment and should be readily available. A flowchart is proposed to manage anaphylaxis in the older patients.Peer reviewe

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

The Adoption of Green Vehicles in Last Mile Logistics: A Systematic Review

Widespread adoption of green vehicles in urban logistics may contribute to the alleviation of problems such as environmental pollution, global warming, and oil dependency. However, the current adoption of green vehicles in the last mile logistics is relatively low despite many actions taken by public authorities to overcome the negative externalities of distributing goods in cities. This paper presents a comprehensive literature review on studies investigating the adoption of green vehicles in urban freight transportation, paying specific attention to e-commerce. To shed light on the adoption of green vehicles in city logistics, the paper conducts a systematic review of the empirical literature on the topic. The 159 articles reviewed were classified into the following: (a) Optimization and scheduling (67 papers); (b) policy (55 papers); (c) sustainability (37 papers). Among the 159 articles, a further selection of 17 papers dealing with e-commerce, i.e., studies that highlight the most relevant aspects related to the integration of green vehicles in e-commerce urban logistics, was performed. Our findings indicate that green vehicles are competitive in urban deliveries characterized by frequent stop-and-go movements and low consolidation levels while incentives are still necessary for their adoption. The use of autonomous vehicles results the most promising and challenging solution for last-mile logistics

Traffic Simulation-Based Approach for A Cradle-to-Grave Greenhouse Gases Emission Model

This paper presents a model to evaluate the life cycle greenhouse gases (GHG) emissions, expressed in terms of carbon dioxide equivalent (CO2eq), of a generic fleet composition as a function of the traffic simulation results. First we evaluated the complete life cycle of each category of the vehicles currently circulating; next, by defining a general linear equation, the traffic environmental performances of a real road network (city of Rome) were evaluated using a traffic simulation approach. Finally, the proposed methodology was applied to evaluate the GHG emission of a 100% penetration of battery electric vehicles (BEVs) and various electric and conventional vehicles composition scenarios. In terms of life cycle impacts, BEVs are the vehicles with the highest GHG emissions at the vehicle level (construction + maintenance + end-of-life processes) that are, on average, 20% higher than internal combustion engine vehicles, and 6.5% higher than hybrid electric vehicles (HEVs). Nevertheless, a 100% BEVs penetration scenario generates a reduction of the environmental impact at the mobility system level of about 65%

Sustainable Transportation for Events: A Systematic Review

Event business is constantly growing in frequency and size, attracting people from nearby areas and different countries as well. Transportation plays a key role in a successful event, especially for major ones, where the large number of participants requires ad hoc designing of event mobility and might include implementation of new infrastructures. In recent decades, environmental issues have emphasized event negative externalities, leading to the design of green events. This paper presents a comprehensive systematic literature review on studies investigating the sustainable practices related to event mobility. The methodology showcases a selection of 32 articles, which were classified according to their main contributions into five categories, for which gaps and trends were shown. Our findings indicate that there are not enough studies to draw conclusions about good practices that can be generalized to each kind of event. Additionally, strong limitations in the reviewed papers are the different contexts of the analysis and the lack of a validation through empirical data. The research presented in this paper adds a contribution to the sustainable event transportation literature reporting the most established models, methods, and interventions. In detail, the most promising interventions involve mass transit and demand-oriented services that rely on intelligent transportation systems and user information

A cost evaluation analysis for naval accessibility to Sardinia and Corsica

An analytical model for the evaluation of the naval transportation costs in Ro-Pax services is presented in order to compare the naval accessibility of two main Mediterranean islands with their mainland countries