The Portrait of Dorian Gray: A corpus-based analysis of translated verb + noun (object) collocations in Peninsular and Colombian Spanish

This is an accepted manuscript of an article published by Springer in In: Corpas Pastor G., Mitkov R. (eds) Computational and Corpus-Based Phraseology. EUROPHRAS 2019 on 18/09/2019, available online: https://doi.org/10.1007/978-3-030-30135-4_30 The accepted version of the publication may differ from the final published version.Corpus-based Translation Studies have promoted research on the features of translated language, by focusing on the process and product of translation, from a descriptive perspective. Some of these features have been proposed by Toury [31] under the term of laws of translation, namely the law of growing standardisation and the law of interference. The law of standardisation appears to be particularly at play in diatopy, and more specifically in the case of transnational languages (e.g. English, Spanish, French, German). In fact, some studies have revealed the tendency to standardise the diatopic varieties of Spanish in translated language [8, 9, 11, 12]. This paper focuses on verb + noun (object) collocations of Spanish translations of The Portrait of Dorian Gray by Oscar Wilde. Two different varieties have been chosen (Peninsular and Colombian Spanish). Our main aim is to establish whether the Colombian Spanish translation actually matches the variety spoken in Colombia or it is closer to general or standard Spanish. For this purpose, the techniques used to translate this type of collocations in both Spanish translations will be analysed. Furthermore, the diatopic distribution of these collocations will be studied by means of large corpora.Published versio

Linkage mapping of the Phg-1 and Co-14 genes for resistance to angular leaf spot and anthracnose in the common bean cultivar AND 277

The Andean common bean AND 277 has the Co-14 and the Phg-1 alleles that confer resistance to 21 and eight races, respectively, of the anthracnose (ANT) and angular leaf spot (ALS) pathogens. Because of its broad resistance spectrum, Co-14 is one of the main genes used in ANT resistance breeding. Additionally, Phg-1 is used for resistance to ALS. In this study, we elucidate the inheritance of the resistance of AND 277 to both pathogens using F2 populations from the AND 277 × Rudá and AND 277 × Ouro Negro crosses and F2:3 families from the AND 277 × Ouro Negro cross. Rudá and Ouro Negro are susceptible to all of the above races of both pathogens. Co-segregation analysis revealed that a single dominant gene in AND 277 confers resistance to races 65, 73, and 2047 of the ANT and to race 63-23 of the ALS pathogens. Co-14 and Phg-1 are tightly linked (0.0 cM) on linkage group Pv01. Through synteny mapping between common bean and soybean we also identified two new molecular markers, CV542014450 and TGA1.1570, tagging the Co-14 and Phg-1 loci. These markers are linked at 0.7 and 1.3 cM, respectively, from the Co-14/Phg-1 locus in coupling phase. The analysis of allele segregation in the BAT 93/Jalo EEP558 and California Dark Red Kidney/Yolano recombinant populations revealed that CV542014450 and TGA1.1570 segregated in the expected 1:1 ratio. Due to the physical linkage in cis configuration, Co-14 and Phg-1 are inherited together and can be monitored indirectly with the CV542014450 and TGA1.1570 markers. These results illustrate the rapid discovery of new markers through synteny mapping. These markers will reduce the time and costs associated with the pyramiding of these two disease resistance genes

Piezometric evolution in the aquifer of Aspe (Alicante)

El aprovechamiento de las aguas subterráneas de pequeños acuíferos ha jugado un papel fundamental en el desarrollo local, no siempre bien conocido y valorado. El acuífero de Aspe, en la provincia de Alicante, es un ejemplo en que este aprovechamiento ha estado relacionado históricamente con el crecimiento y desarrollo de la localidad de Aspe. La fuerte presión a la que se vio sometido durante buena parte del s. XX le llevó a una situación de sobreexplotación, de la cual apenas hay información. El abandono de muchas captaciones y la transformación del uso del territorio han permitido un cambio de su situación en las últimas décadas. El principal objetivo del presente trabajo ha sido actualizar el estado de conocimiento que se tiene de él y establecer su situación hidrodinámica. El seguimiento piezométrico ha permitido establecer una sectorización en función del comportamiento de los niveles piezométricos. Así, los sectores de las Fuentes y Tolomó han mostrado un ascenso progresivo, el cual no se corresponde con el comportamiento observado en los sectores de Alcaná y La Ofra. Estas diferencias de comportamiento apuntan a posibles desconexiones piezométricas entre sectores del acuífero.The use of groundwater in small aquifers has played a key role in local development, not always well known and valued. The aquifer of Aspe, in the province of Alicante, is an example in which this exploitation has been historically related to the growth and development of the town of Aspe. The strong pressure to which it was subjected during the twentieth century led to a situation of overexploitation, of which there is scarcely information. The abandonment of many wells and the transformation of land use have allowed a change of its situation in the last decades. The main objective of the present work has been to update the state of knowledge about it and establish its hydrodynamic situation. The piezometric monitoring has allowed to establish a sectorization according to the behaviors of the levels. Thus, the sectors of the Fuentes and Tolomó have shown a progressive piezometric level rise, which does not correspond to the behavior observed in the sectors of Alcaná and La Ofra. These differences in behavior point to possible piezometric disconnections between sectors of the aquifer.Este trabajo se ha realizado dentro del marco del proyecto ALTERACLIM (CGL2015-69773-C2-1) financiado por el Ministerio de Economía, Industria y Competitividad

Epidemiology of infections by HIV, Syphilis, Gonorrhea and Lymphogranuloma Venereum in Barcelona City: a population-based incidence study

Background The aim of this study was to determine the evolution of HIV infection, gonorrhea, syphilis and lymphogranuloma venereum (LGV), and their epidemiological characteristics in Barcelona city. Methods Population-based incidence study of all newly occurring diagnoses of HIV infection, syphilis, gonorrhea and LGV detected in Barcelona between January 2007 and December 2011. A descriptive analysis was performed. The annual incidence rates per 100,000 inhabitants were calculated by sex, sexual conduct and educational level. To estimate global sex-specific rates we used the Barcelona city census; for the calculation of rates by sexual conduct and educational level we used estimates of the Barcelona Health Interview Survey. Trends were analysed using the chi-squared test for linear trend. Results HIV. 66.8 % of the HIV cases were men who had sex with men (MSM). The incidence rates in MSM over the study period were from 692.67/100,000 to 909.88/100,000 inh. Syphilis. 74.2 % of the syphilis cases were MSM. The incidence rates in MSM were from 224.9/100,000 to 891.97/100,000 inh. and the MSM with a university education ranged from 196.3/100,000 to 1020.8/100,000. Gonorrhea. 45.5 % of the gonorrhea cases were MSM. The incidence rates in MSM were from 164.24/100,000 to 404.79/100,000 inh. and the MSM with university education ranged from 176.7/100,000 to 530.1/100,000 inh.. Lymphogranuloma venereum (LGV). 95.3 % of the LGV cases are MSM. The incidence rates in MSM were from 24.99/100,000 to 282.99/100,000 inh. and the MSM with university education ranged from 9.3/100,000 to 265/100,000 inh. Conclusion An increase in cases of STI was observed. These STI mainly affected MSM with a university education. Continuing to monitor changes in the epidemiology of STI, and identifying the most affected groups should permit redesigning preventive programs, with the goal of finding the most efficient way to reach these population groups

Modulation of the substrate specificity of the kinase PDK1 by distinct conformations of the full-length protein

The activation of at least 23 different mammalian kinases requires the phosphorylation of their hydrophobic motifs by the kinase PDK1. A linker connects the phosphoinositide-binding PH domain to the catalytic domain, which contains a docking site for substrates called the PIF pocket. Here, we used a chemical biology approach to show that PDK1 existed in equilibrium between at least three distinct conformations with differing substrate specificities. The inositol polyphosphate derivative HYG8 bound to the PH domain and disrupted PDK1 dimerization by stabilizing a monomeric conformation in which the PH domain associated with the catalytic domain and the PIF pocket was accessible. In the absence of lipids, HYG8 potently inhibited the phosphorylation of Akt (also termed PKB) but did not affect the intrinsic activity of PDK1 or the phosphorylation of SGK, which requires docking to the PIF pocket. In contrast, the small molecule valsartan bound to the PIF pocket and stabilized a second distinct monomeric conformation. Our study reveals dynamic conformations of full-length PDK1 in which the location of the linker and the PH domain relative to the catalytic domain determines the selective phosphorylation of PDK1 substrates. The study further suggests new approaches for the design of drugs to selectively modulate signaling downstream of PDK1

La facultad va a la escuela del barrio : Las Ciencias Naturales entre la universidad y la escuela primaria

Docentes, estudiantes e investigadores de distintas Unidades Académicas de la Universidad Nacional de La Plata, nos acercamos a las Escuelas Públicas Estatales con la intención de enriquecer, contribuir y mejorar a la enseñanza de las Ciencias Naturales, en el marco del proyecto de Extensión "La Facultad va a La Escuela del Barrio". A partir del compromiso de los directivos de las distintas instituciones realizamos un trabajo conjunto, dinámico y horizontal con los docentes, basado en la metodología taller, según sus intereses y la currícula escolar. Esta forma de trabajo no se reduce a una capacitación puntual o a una muestra llamativa de materiales y experimentos sino que, recupera y valora el saber particular de los maestros respecto a la "vida" en el aula y aporta nuestros conocimientos y metodologías, propias de una formación científico-profesional. A partir de esta "ida y vuelta" aportamos herramientas y estrategias permitiendo a los docentes llevar a cabo propuestas didácticas basadas en el trabajo de laboratorio y, a su vez, enriquecemos nuestra formación como profesionales críticos comprometidos con la sociedad.Trabajos del área Ciencias NaturalesDepartamento de Ciencias Exactas y Naturale

Search for WZ resonances in the fully leptonic channel using pp collisions at s=8 TeV with the ATLAS detector

A search for resonant WZ production in the ℓνℓ'ℓ' (ℓ,ℓ'=e,μ) decay channel using 20.3 fb-1 of s=8TeV pp collision data collected by the ATLAS experiment at LHC is presented. No significant deviation from the Standard Model prediction is observed and upper limits on the production cross sections of WZ resonances from an extended gauge model W' and from a simplified model of heavy vector triplets are derived. A corresponding observed (expected) lower mass limit of 1.52 (1.49) TeV is derived for the W' at the 95% confidence level.Peer Reviewe

Assessing the role of the TREM2 p.R47H variant as a risk factor for Alzheimer's disease and frontotemporal dementia

4 páginas, 1 figura, a tabla. Los autores pertenecen a The dementia genetic Spanish consortium (DEGESCO).A non-synonymous genetic rare variant, rs75932628-T (p.R47H), in the TREM2 gene has recently been reported to be a strong genetic risk factor for Alzheimer's disease (AD). Also, rare recessive mutations have been associated with frontotemporal dementia (FTD). We aimed to investigate the role of p.R47H variant in AD and FTD through a multi-center study comprising 3,172 AD and 682 FTD patients and 2,169 healthy controls from Spain. We found that 0.6% of AD cases carried this variant compared to 0.1% of controls (odds ratio [OR]=4.12, 95% confidence interval [CI]: 1.21-14.00, P=0.014). A meta-analysis comprising 32,598 subjects from four previous studies demonstrated the large effect of the p.R47H variant in AD risk (OR=4.11, 95% CI: 2.99-5.68, P=5.27x10-18). We did not find an association between p.R47H and age of onset of AD or family history of dementia. Finally, none of the FTD patients harbored this genetic variant. These data strongly support the important role of p.R47H in AD risk and suggest that this rare genetic variant is not related to FTD.This study was supported by grants from Instituto de Salud Carlos III (PI12/01311 and 12/00013), grants from the Ministry of Science (SAF2010-15558, SAF2009-10434), Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, Spain), Consolider (CSD2010-00045), and the Department of Health of the Government of Navarra (refs. 13085 and 3/2008). CR held during the period 2009-2013 a “Torres Quevedo” fellowship from the Spanish Ministry of Science and Technology, co-financed by the European Social Fund. Fundació ACE researchers are indebted to Trinitat Port-Carbó and her family who are supporting Fundació ACE scientific programs.Peer reviewe

Genomic Characterization of Host Factors Related to SARS-CoV-2 Infection in People with Dementia and Control Populations: The GR@ACE/DEGESCO Study

Emerging studies have suggested several chromosomal regions as potential host genetic factors involved in the susceptibility to SARS-CoV-2 infection and disease outcome. We nested a COVID-19 genome-wide association study using the GR@ACE/DEGESCO study, searching for susceptibility factors associated with COVID-19 disease. To this end, we compared 221 COVID-19 confirmed cases with 17,035 individuals in whom the COVID-19 disease status was unknown. Then, we performed a meta-analysis with the publicly available data from the COVID-19 Host Genetics Initiative. Because the APOE locus has been suggested as a potential modifier of COVID-19 disease, we added sensitivity analyses stratifying by dementia status or by disease severity. We confirmed the existence of the 3p21.31 region (LZTFL1, SLC6A20) implicated in the susceptibility to SARS-CoV-2 infection and TYK2 gene might be involved in COVID-19 severity. Nevertheless, no statistically significant association was observed in the COVID-19 fatal outcome or in the stratified analyses (dementia-only and non-dementia strata) for the APOE locus not supporting its involvement in SARS-CoV-2 pathobiology or COVID-19 prognosis

La Universidad contribuye a revalorizar la Ciencia en la Escuela Primaria.

A partir de la crisis económica del año 2002, un grupo de docentes, estudiantes e investigadores de distintas Unidades Académicas de la UNLP, nos acercamos a las Escuelas Públicas y Estatales con la intención de contribuir y fomentar la enseñanza de las Ciencias Naturales a través de la experimentación, en el marco del proyecto de Extensión "La Facultad va a la Escuela del Barrio". Un objetivo del proyecto es crear vínculos dinámicos y horizontales con Escuelas Primarias de la provincia de Buenos Aires. La estrategia de intervención se centra en la realización, con los docentes, de talleres basados en la currícula escolar e incluye tanto una planificación como una evaluación conjunta, dando un rol activo a los docentes en todas las instancias. Los talleres constituyen un dispositivo analizador, no sólo de conocimientos teóricos, sino también de las prácticas áulicas. Se parte de los conocimientos previos de las maestras, se busca problematizar e hipotetizar diferentes fenómenos naturales y, a partir de los resultados de una secuencia de experiencias, arribar a las conclusiones, discutiendo, además, su implementación en el aula. La planificación conjunta permite la incorporación del trabajo realizado al proceso de enseñanza-aprendizaje en forma natural. La intervención no se reduce a unos pocos encuentros y a un grupo definido de personas sino que apuesta a que el docente se apropie de metodologías científicas y revalorice el conocimiento científico como significativo, principalmente en instituciones cuya comunidad se encuentra inmersa en una dura realidad socio-económica. La interacción dentro del ámbito escolar nos interioriza de la realidad institucional, lo cuál no sólo permite analizar las variables institucionales para definir la estrategia de articulación sino que enriquece nuestra formación docente-profesional. La constitución interdisciplinaria del grupo (ver que pertenecemos a distintas facultades y/o carreras) permite garantizar respuestas a las inquietudes de las maestras, las cuales suelen abarcar diferentes temas, consecuencia de que su conocimiento proviene de múltiples recortes disciplinares. El Proyecto realiza una autoevaluación continua, analizando la pertinencia de la estrategia de intervención y los resultados obtenidos. Al finalizar el ciclo lectivo realizamos una evaluación conjunta con cada colegio. De ambas evaluaciones rescatamos los siguientes indicadores: el impacto positivo que conlleva la implementación en el aula; la adquisición de equipamiento de laboratorio por parte de las escuelas; la creación de nuevos talleres surgidos de las inquietudes de las docentes; el efecto multiplicador hacia otras instituciones, todo ello consecuencia de la movilidad docente y/o del interés de las sedes de inspección y nuestra incorporación al Proyecto Institucional.