Muscle Damage Biomarkers in Congestion Weeks in English Premier League Soccer Players: A Prospective Study for Two Consecutive Seasons

The current study was conducted to compare muscle damage biomarkers in single- vs. multi-match weeks in elite soccer players for two consecutive seasons. A secondary objective was to analyze the influence of playing position and exposure time on muscle damage in single- vs. multi-match weeks. This is a prospective cohort study performed in a professional elite soccer club in the English Premier League during the 2018-2019 and 2019-2020 seasons up until the lockdown due to the COVID-19 pandemic. Data were collected in the Medical Department Room of an English Premier League Club before and after the soccer game from a total of 29 elite soccer players (mean +/- S.D.; age = 27.59 +/- 3.83 years; height = 1.83 +/- 0.05 m; body mass = 80.16 +/- 7.45 kg) who were enrolled in the club during both seasons. The main outcome measurements were creatine kinase (CK), weight, lean mass, % fat DEXA, high speed running, total distance, density of total distance and high-speed running and wellbeing questionnaires. Significance was set at p < 0.05. Players who completed more than 60 min in the previous game had significantly increased pregame CK levels and fatigue in multi-match weeks. Midfielders had both significantly increased pregame CK and muscle soreness in multi-match weeks. Midfielders and players with an exposure time of at least 60 min showed higher pregame CK values that should play a key role for deciding substitutions.We thank all the Medical Department at Watford FC, specially Chris Mogekwu and all the Physiotherapy Department at Camilo Jose Cela University. Both helped us get the sample and with the kindly support for this research. The results of the study are presented clearly, honestly, and without fabrication, falsification, or inappropriate data manipulation, and statement that results of the present study do not constitute endorsement by IJERPH. Documen

Neumonía grave adquirida en la comunidad

Community-acquired pneumonia (CAP) is characterized by the concurrence of symptoms and signs of acute lower respiratory tract infection and pulmonary infiltrate on the chest x-ray or other imaging test. We present a clinical case of severe pneumonia and discuss some novel and controversial aspects of diagnosis and its treatment.La neumonía adquirida en la comunidad (NAC) se caracteriza por la concurrencia de síntomas y signos de infección aguda del tracto respiratorio inferior e infiltrado pulmonar por radiografía de tórax u otra prueba de imagen. Presentamos un caso clínico de neumonía grave y comentamos algunos aspectos novedosos y controvertidos del diagnóstico y su tratamiento.

The underestimated role of carrion in vertebrates' diet studies

Aim: Despite the increasing scientific evidence on the importance of carrion in the ecology and evolution of many vertebrates, scavenging is still barely considered in diet studies. Here, we draw attention to how scientific literature has underestimated the role of vertebrates as scavengers, identifying the ecological traits that characterize those species whose role as scavengers could have gone especially unnoticed. Location: Global. Time Period: 1938–2022. Major Taxa Studied: Terrestrial vertebrate scavengers. Methods: We analysed and compared (a) the largest database available on scavenging patterns by carrion-consuming vertebrates, (b) 908 diet studies about 156 scavenger species and (c) one of the most complete databases on bird and mammal diets (Elton Traits database). For each of these 156 species, we calculated their scavenging degree (i.e. proportion of carcases where the species is detected consuming carrion) as a proxy for carrion consumption, and related their ecological traits with the probability of being identified as scavengers in diet studies and in the Elton Traits database. Results: More than half of the species identified as scavengers at monitored carcasses were not assigned carrion as food source in their diet studies nor in the Elton Traits database. Using a subset of study sites, we found a direct relationship between a species' scavenging degree and its rate of carrion biomass removal. In addition, scavenger species, which were classified as non-predators and mammals had a lower probability of being identified as scavengers in diet studies and in the Elton Traits database, respectively. Main Conclusions: Our results clearly indicate an underestimation of the role of scavenging in vertebrate food webs. Given that detritus recycling is fundamental to ecosystem functioning, we encourage further recognition and investigation of the role of carrion as a food resource for vertebrates, especially for non-predator species and mammals with higher scavenging degree.JM was supported by a Basque Government predoctoral grant (PRE_2018_2_0112), ZMR, LNA and EA by contracts co-funded by the Generalitat Valenciana and the European Social Fund (ESF) (APOSTD/2019/016, ACIF/2019/056 and APOSTD/2021/028 respectively). MM, JMPG and ESG were funded by MCIN/AEI/10.13039/501100011033, by ‘European Union NextGenerationEU/PRTR’, ERDF ‘A way of making Europe’ and by ESF ‘Investing in your future’ (grant numbers RYC-2015-19231, IJC-2019-038968, TED2021-130890B-C21, PID2021-128952NB-I00 and RYC-2019-027216-I). ESG was also partially funded by the HORIZONMSCA-2021-SE-0 action number: 101086387, ‘REMARKABLE’ project. ZMR and DRG were also funded by the Junta de Andalucía (POSTDOC_21_00353 and PREDOC_00262). RPR was co-funded by the ESF and Plan Propio I+D+i UCLM

Trombosis de la arteria hepática. Reporte de un caso clínico y revisión de la literatura

A 60-year-old man who entered Internal Medicine ward due to acute abdominal pain, detected in abdominal CT with intravenous contrast thrombosis of the common hepatic artery, so anticoagulation is started. In the etiological study lupus anticoagulant is detected. During evolution, he requires the placement of a stent by the development of a saccular aneurysm, without presenting other complications.Hombre de 60 años que ingresa en Medicina Interna por dolor abdominal agudo, detectándose en TC abdominal con contraste intravenoso trombosis de la arteria hepática común, por lo que se inicia anticoagulación. En el estudio etiológico se detecta anticoagulante lúpico. Durante la evolución requiere la colocación de una endoprótesis vascular por desarrollo de un aneurisma sacular, sin presentar otras complicaciones

Conocimiento de la unidad de fisioterapia por parte de los médicos de un servicio de atención primaria rural

Objetivo Conocer si los médicos de un servicio de atención primaria rural utilizan los recursos de la fisioterapia y su grado de satisfacción. Material y métodos Estudio descriptivo observacional y transversal mediante encuesta anónima a los médicos del servicio de AP de Ribadavia en septiembre 2006. Analizadas variables sociodemográficas (edad, sexo, antigüedad en el puesto de trabajo, proximidad a la unidad de fisioterapia) y variables como conocimiento de la cartera de servicios, número de pacientes derivados mensualmente, patologías más frecuentes derivadas, influencia de medios de transporte para la derivación. Para el análisis univariante de los resultados se utilizaron índices estadísticos descriptivos y para el bivariante la prueba de chi-cuadrado. Resultados 18 respuestas de 20 encuestados, el 50% mujeres. Media de antigüedad en puesto de trabajo, 93,33 meses (IC 95%) (45,47- 141,20), media de edad, 48,60 (IC 95%) (46,98-50,21). El 33,3% trabaja en el mismo centro de salud de la unidad de fisioterapia. Un 11,1% deriva más de 10 pacientes, y un 55,6% deriva menos de 5 pacientes al mes. Patologías osteoarticulares degenerativas/inflamatorias (94,4%) son las más derivadas seguidas de traumáticas (44,4%). Un 38% nunca deriva patología respiratoria, un 33,3% nunca deriva incontinencias urinarias. El 83,3% cree que sus pacientes mejoran mucho, el 16,7% cree que regular. El 72, 2% considera que el transporte influye a la hora de derivar. Conclusiones Los médicos del servicio valoran positivamente la fisioterapia, pero desconocen todas las posibilidades que puede ofrecerles, ciñéndose, en su mayoría a derivar pacientes con patología osteoarticular. Un elevado porcentaje considera que la falta de medios de transporte influye en la derivación

Machine learning methods applied to combined Raman and LIBS spectra: Implications for mineral discrimination in planetary missions

Producción CientíficaThe combined analysis of geological targets by complementary spectroscopic techniques could enhance the characterization of the mineral phases found on Mars. This is indeed the case with the SuperCam instrument onboard the Perseverance rover. In this framework, the present study seeks to evaluate and compare multiple machine learning techniques for the characterization of carbonate minerals based on Raman-LIBS (Laser-Induced Breakdown Spectroscopy) spectroscopic data. To do so, a Ca-Mg prediction curve was created by mixing hydromagnesite and calcite at different concentration ratios. After their characterization by Raman and LIBS spectroscopy, different multivariable machine learning (Gaussian process regression, support vector machines, ensembles of trees, and artificial neural networks) were used to predict the concentration ratio of each sample from their respective datasets. The results obtained by separately analyzing Raman and LIBS data were then compared to those obtained by combining them. By comparing their performance, this work demonstrates that mineral discrimination based on Gaussian and ensemble methods optimized the combine of Raman-LIBS dataset outperformed those ensured by Raman and LIBS data alone. This demonstrated that the fusion of data combination and machine learning is a promising approach to optimize the analysis of spectroscopic data returned from Mars.Agencia Estatal de Investigación, grant (PID2022-142490OB-C32)Ministerio de Economía y Competitividad (MINECO),Grant/Award Number (RDE2018-102600-T

Application of chemometrics on Raman spectra from Mars: Recent advances and future perspectives

Producción CientíficaThe SuperCam and SHERLOC instruments onboard the NASA/Perseverancerover are returning the first Raman spectra to be ever collected from anotherplanet. Similarly, the RLS instrument onboard the ESA/Rosalind Franklinrover will collect Raman spectra from powdered rocks sampled from thesubsurface of Mars. To optimize the scientific exploitation of Raman spectrareturned from planetary exploration missions, tailored chemometric tools arebeing developed that take into account the analytical capability of the men-tioned Raman spectrometers. In this framework, the ERICA research groupis using laboratory simulators of SuperCam and RLS to perform representa-tive laboratory studies that will enhance the scientific outcome of bothMars2020 and ExoMars missions. On one hand, preliminary studies provedthe chemometric analysis of RLS datasets could be used to obtain a reliablesemi-quantitative estimation of the main mineral phases composing Martiangeological samples. On the other hand, it was proved the data fusion ofRaman and LIBS spectra gathered by SuperCam could be used to enhancethe discrimination of mineral phases from remote geological targets. Besidesdescribing the models developed by the ERICA group, this work presents anoverview of the complementary chemometric approaches so far tested in thisfield of study and propose further improvements to be addressed in thefuture.Ministerio de Economía y Competitividad, Beca/Concesión Número:PID2019-107442RBC31European Union’s Horizon 2020 research and innovation program. grant agreement no. 68730

Proteins and pathways in atrial fibrillation and atrial cardiomyopathy underlying cryptogenic stroke

Atrial fibrillation (AF) is one of the most prevalent causes of cryptogenic stroke. Also, apart from AF itself, structural and remodelling changes in the atria might be an underlying cause of cryptogenic stroke. We aimed to discover circulating proteins and reveal pathways altered in AF and atrial cardiomyopathy, measured by left atrial volume index (LAVI) and peak atrial longitudinal strain (PALS), in patients with cryptogenic stroke. An aptamer array (including 1310 proteins) was measured in the blood of 20 cryptogenic stroke patients monitored during 28 days with a Holter device as a case-control study of the Crypto-AF cohort. Protein levels were compared between patients with (n = 10) and without AF (n = 10) after stroke, and the best candidates were tested in 111 patients from the same cohort (44 patients with AF and 67 without AF). In addition, in the first 20 patients, proteins were explored according to PALS and LAVI values. Forty-six proteins were differentially expressed in AF cases. Of those, four proteins were tested in a larger sample size. Only DPP7, presenting lower levels in AF patients, was further validated. Fifty-seven proteins correlated with LAVI, and 270 correlated with PALS. NT-proBNP was common in all the discovery analyses performed. Interestingly, many proteins and pathways were altered in patients with low PALS. Multiple proteins and pathways related to AF and atrial cardiomyopathy have been revealed. The role of DPP7 as a biomarker for stroke aetiology should be further explored. Moreover, the present study may be considered hypothesis-generatin

Integración de recursos electrónicos en las bibliotecas del Consorcio de Bibliotecas Universitarias de Andaluzas (CBUA)

En los últimos años, el presupuesto en recursos electrónicos ha ido creciendo paulatinamente en las Bibliotecas Universitarias y como consecuencia las inversiones en este tipo de materiales han ido aumentando, convirtiéndose hoy día la Biblioteca Universitaria en una gran factoría virtual. El Consorcio de Bibliotecas Universitarias Andaluzas (CBUA) que asume entre sus políticas el desarrollo de proyectos para la mejora de la calidad de los servicios a través de la cooperación, consciente de esta situación, acomete el plan de dotar a las Bibliotecas del Consorcio de tecnologías centradas en el usuario, para hacer más accesibles las colecciones de recursos electrónicos y poder competir en la Europa del conocimiento con parámetros de calidad. Se presenta el proyecto que está llevando a cabo el Grupo de Trabajo de MAP y ERM del CBUA, de implementación y puesta en marcha de herramientas, para el acceso, integración y gestión de los recursos electrónicos en las Bibliotecas Universitarias Andaluzas, para un mejor uso de las colecciones digitales contratadas, que redundará en la calidad y mejora de los servicios prestados. Se enumeran las fases del proyecto, los objetivos operativos, las líneas de acción, las acciones realizadas, la documentación generada, la difusión y formación en las nuevas herramientas y la repercusión que está teniendo en las Bibliotecas del CBU