8 research outputs found
The absence of macrophage Nrf2 promotes early atherogenesis
- Author
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Farm Risk Map: A contextual tool for risk identification and sustainable management on farms
- Author
- B Boulding
- B Kotey
- B Ăhlmer
- C Carnaghan
- CJM Ondersteijn
- DJ Pannell
- E Kasanen
- E Noe
- E O'Donnell
- E Taylor
- G Lien
- G Martin
- H Marvin
- Ilkka Kauranen
- J Baarda
- J LeppÀlÀ
- J LeppÀlÀ
- J Roughton
- J van der Ploeg
- Jarkko LeppÀlÀ
- JB Hardaker
- JB Hardaker
- JM Juran
- K Olson
- K Partanen
- KJ Donham
- L DeRoo
- L Evans
- M Boehlje
- M Leitch
- MA Lyles
- Mervi Murtonen
- P Granqvist
- P Jokipii
- P Lowe
- R Rautiainen
- RBM Huirne
- RD Kay
- S Jeffrey
- S-O Tergan
- T Uusitalo
- TEA Mattila
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
RVD induction and autologous stem cell transplantation followed by lenalidomide maintenance in newly diagnosed multiple myeloma:a phase 2 study of the Finnish Myeloma Group
- Author
- Anttila P. (Pekka)
- Bazia P. (Piotr)
- Heiskanen J. (Jouni)
- Huotari V. (Virva)
- Ilveskero S. (Sorella)
- Jantunen E. (Esa)
- Kakko S. (Sakari)
- Kananen K. (Kristiina)
- Launonen K. (Kirsi)
- Lievonen J. (Juha)
- Lundan T. (Tuija)
- Luoma S. (Sini)
- MĂ€ntymaa P. (Pentti)
- Ollikainen H. (Hanna)
- Partanen A. (Anu)
- Pelliniemi T.-T. (Tarja-Terttu)
- Putkonen M. (Mervi)
- RÀsÀnen A. (Anu)
- Sankelo M. (Marja)
- Selander T. (Tuomas)
- Siitonen T. (Timo)
- Sikiö A. (Anu)
- Silvennoinen R. (Raija)
- Suominen M. (Merja)
- SĂ€ily M. (Marjaana)
- TerÀvÀ V. (Venla)
- Tienhaara A. (Anri)
- Publication venue
- Springer Nature
- Publication date
- 01/01/2019
- Field of study
Abstract
Autologous stem cell transplantation (ASCT) combined with novel agents is the standard treatment for transplant-eligible, newly diagnosed myeloma (NDMM) patients. Lenalidomide is approved for maintenance after ASCT until progression, although the optimal duration of maintenance is unknown. In this trial, 80 patients with NDMM received three cycles of lenalidomide, bortezomib, and dexamethasone followed by ASCT and lenalidomide maintenance until progression or toxicity. The primary endpoint was the proportion of flow-negative patients. Molecular response was assessed if patients were flow-negative or in stringent complete response (sCR). By intention to treat, the overall response rate was 89%. Neither median progression-free survival nor overall survival (OS) has been reached. The OS at 3 years was 83%. Flow-negativity was reached in 53% and PCR-negativity in 28% of the patients. With a median follow-up of 27 months, 29 (36%) patients are still on lenalidomide and 66% of them have sustained flow-negativity. Lenalidomide maintenance phase was reached in 8/16 high-risk patients but seven of them have progressed after a median of only 6 months. In low- or standard-risk patients, the outcome was promising, but high-risk patients need more effective treatment approach. Flow-negativity with the conventional flow was an independent predictor for longer PFS
The absence of macrophage Nrf2 promotes early atherogenesis
- Author
- Anna-Kaisa Ruotsalainen
- Anna-Liisa Levonen
- Barajas
- Bea
- Chan
- Chen
- Cheng
- Collins
- Curtiss
- Dai
- Emilia Kansanen
- Fledderus
- Freigang
- Glass
- Harada
- Heidi M. Laitinen
- Hoeksema
- Hosoya
- Ishibashi
- Ishii
- Itoh
- Janne HeikkilÀ
- Jari P. Lappalainen
- Johnson
- JyrkkÀnen
- Kadl
- Kisucka
- Kong
- Kuhn
- Langer
- Levonen
- Maruyama
- Masayuki Yamamoto
- Matias Inkala
- Matti Jauhiainen
- Mervi E. Partanen
- Miller
- Moellering
- Moore
- Orozco
- Park
- Petri I. MĂ€kinen
- Qiao
- Seppo YlÀ-Herttuala
- Sohvi Hörkkö
- Sugamura
- Sussan
- Suvi E. Heinonen
- Tero Vatanen
- Thimmulappa
- Yancey
- YlÀ-Herttuala
- Zakkar
- Zanotti
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Nascent body ego: Metapsychological and neurophysiological aspects
- Author
- Akhtar S.
- Bland BH
- Blass EM
- Boyer LB
- Campos RG
- Chugani HT
- Chugani HT
- Fifer WP
- Freud S.
- Freud S.
- Freud S.
- Freud S.
- Freud S.
- Freud S.
- Futagi Y.
- Grossman WI
- Hoffer W.
- HĂ€gglund TâB
- Isakower O.
- Johannes Lehtonen
- Juhani Partanen
- Kandel E.
- Kari Launiala
- Kendler KS
- Lehtonen J.
- Lehtonen J.
- Lehtonen J.
- Lehtonen J.
- Lehtonen J.
- Lehtonen J.
- Lehtonen J.
- Lehtonen J.
- Lewin B.
- Lewin B.
- Liu D.
- Magoun HW
- Maija Purhonen
- Mancia M.
- Maulsby RL
- Mehler J.
- Mervi Kononen
- Minna ValkonenâKorhonen
- Moruzzi G.
- Pacella BL
- Paul K.
- Purhonen M.
- Quinodoz JM
- Rycroft C.
- Saarinen PI
- Scher MS
- Schore AN
- Seppo Saarikoski
- Soltis J.
- Stroganova TA
- Volkan VD
- von Wright GH
- Watt DF
- Yamaguchi Y.
- Zanardo V.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- A David Smith
- Aaltonen L.
- Aaltonen V.
- Aarno Palotie
- Aarsland D.
- Aavikko M.
- Abalos M. S.
- Abdelnour C.
- Abner E.
- Abraham R.
- Ad Adarmes-GĂłmez
- Adam Boxer
- Adam Ziemann
- Adams H.
- Adams P. M.
- Adarmes-GĂłmez A.
- Adarmes-GĂłmez A. D.
- Adriana Gamboa
- Adrienne L Cupples
- Adrienne Tin
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Agustina Legaz
- Ahmad S.
- Aimee Pierce
- Aino Salminen
- Airi Jussila
- Aisha Khaleeq
- Aki Havulinna
- Akinyemi R. O.
- Al-Chalabi A.
- Alan B Stevens
- Alan Lerner
- AlarcĂłn-MartĂn E.
- Albert M. S.
- Alberto Benussi
- Albin R. L.
- Alcolea D.
- Aldo Saenz
- Alegret M.
- Alessandra Chesi
- Alessandro Vacca
- Alexander Teumer
- Alexis Brice
- Ali M.
- Alisa Manning
- Alison E Fohner
- Allan I Levey
- Allen M.
- Allende I. R.
- Alonso M. D.
- Alonso M. D.
- Alvarez I.
- Alvarez L.
- Alvin Thomas
- Alyssa Aguirre
- Amanda Cano
- Amanda Elliott
- Amanda G Smith
- Amanda J Myers
- Amer-Ferrer G.
- Amin N.
- Ammar Al-Chalabi
- Amouyel P.
- Amy Gerrish
- Amy Williams
- Ana MauleĂłn
- Ana Pancho
- Anastasia Shcherban
- Anastasiou A.
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- Anders Malarstig
- Andrade V.
- Andrea Ganna
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- Andrew J Saykin
- Andrew McQuillin
- Andrew N McDavid
- Andrew P Lieberman
- Andrew Peterson
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- Victoria Fernandez-Hernandez
- Victoria Perez
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- Will S Bush
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- William W Seeley
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- Xia T. -H.
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- Xinli Hu
- Xiongwei Zhu
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- Xu F.
- Xuan Liu
- Yanbing Wang
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Yasaman Saba
- Yash Patel
- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C. P.
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- Zulaica M.
- Zulma Sevillano
- Ălvarez V.
- Ă sa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele
FinnGen provides genetic insights from a well-phenotyped isolated population
- Author
- Aalto-Setala Katriina
- Aavikko Mervi
- Alasoo Kaur
- Arvas Mikko
- Auro Kirsi
- Biswas Shameek
- Bizaki-Vallaskangas Argyro
- Carpen Olli
- Chen Chia-Yen
- Dada Oluwaseun A.
- Daly Mark J.
- Ding Zhihao
- Donner Kati M.
- Ehm Margaret G.
- Eklund Kari
- Elnahas Abdelrahman G.
- Esko Tonu
- Farkkila Martti
- FinnGen
- Finucane Hilary
- Foley Christopher N.
- Fox Caroline
- Ganna Andrea
- Ghazal Awaisa
- Gracia-Tabuenca Javier
- Graham Robert R.
- Green Eric M.
- Hakanen Antti
- Hautalahti Marco
- Havulinna Aki S.
- Hedman Asa K.
- Heyne Henrike O.
- Hiekkalinna Tero
- Hiltunen Mikko
- Hinttala Reetta
- Hovatta Iiris
- Hu Xinli
- Huertas-Vazquez Adriana
- Huilaja Laura
- Hunkapiller Julie
- Jacob Howard
- Jalanko Anu
- Jensen Jan-Nygaard
- Joensuu Heikki
- John Sally
- Julkunen Valtteri
- Jung Marc
- Junttila Juhani
- Kaarniranta Kai
- Kahonen Mika
- Kajanne Risto
- Kallio Lila
- Kalviainen Reetta
- Kanai Masahiro
- Kaprio Jaakko
- Karjalainen Juha
- Kaunisto Mari A.
- Kerimov Nurlan
- Kettunen Johannes
- Kiiskinen Tuomo
- Kilpelainen Elina
- Kilpi Terhi
- Klinger Katherine
- Koskelainen Sami
- Kosma Veli-Matti
- Kristiansson Kati
- Kuopio Teijo
- Kurki Mitja, I
- Kurra Venla
- Lahtela Elisa
- Laiho Paivi
- Laisk Triin
- Laitinen Tarja
- Laivuori Hannele
- Laukkanen Jari
- Lawless Nathan
- Lehisto Arto A.
- Lemmela Susanna
- Liu Aoxing
- Llorens Vincent
- Longerich Simonne
- Loukola Anu
- Magi Reedik
- Makela Johanna
- Makela Tomi P.
- Makitie Antti
- Malarstig Anders
- Mannermaa Arto
- Maranville Joseph
- Mars Nina
- Matakidou Athena
- Mattsson Hannele
- McCarthy Mark
- Meretoja Tuomo
- Metspalu Andres
- Milani Lili
- Mozaffari Sahar, V
- Nelis Mari
- Niemi Mari E. K.
- Niemi Marianna
- Niiranen Teemu
- Okafo George
- Ollila Hanna M.
- Paajanen Teemu
- Palomaki Antti
- Palotie Aarno
- Palotie Tuula
- Palta Priit
- Parn Kalle
- Parolo Pietro Della Briotta
- Partanen Jukka
- Paul Dirk S.
- Pelkonen Margit
- Pendergrass Rion K.
- Perola Markus
- Petrovski Slave
- Pitkaranta Anne
- Platt Adam
- Plenge Robert
- Pulford David
- Punkka Eero
- Pussinen Pirkko
- Raghavan Neha
- Rahimov Fedik
- Rajpal Deepak
- Ramo Joel
- Reeve Mary P.
- Reigo Anu
- Reis Kadri
- Renaud Nicole A.
- Riley-Gillis Bridget
- Ripatti Samuli
- Rodosthenous Rodosthenis
- Rueger Sina
- Runz Heiko
- Ruotsalainen Sanni
- Saarentaus Elmo
- Salminen Aino
- Salminen Eveliina
- Salomaa Veikko
- Schleutker Johanna
- Serpi Raisa
- Shen Huei-yi
- Siegel Richard
- Siirtola Harri
- Silander Kaisa
- Siltanen Sanna
- Sipila Timo P.
- Soini Sirpa
- Soininen Hilkka
- Sul Jae Hoon
- Sun Benjamin
- Tachmazidou Ioanna
- Tasanen Kaisa
- Tienari Pentti
- Toppila-Salmi Sanna
- Tukiainen Taru
- Tuomi Tiinamaija
- Turunen Joni A.
- Ulirsch Jacob C.
- Vaura Felix
- Veerapen Kumar
- Virolainen Petri
- Waring Jeffrey
- Waterworth Dawn
- Yang Robert
- Zhou Wei
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
New insights into the genetic etiology of Alzheimerâs disease and related dementias
- Author
- Aaltonen Lauri
- Aaltonen Vesa
- Aarsland Dag
- Aavikko Mervi
- Abalos Mariana Sanchez
- Abdelnour Carla
- Abner Erin
- Abraham Richard
- Adams Hieab
- Adams Perrie M.
- Adarmes-GĂłmez Ad
- Adarmes-GĂłmez Astrid D.
- Aguilera Nuria
- Aguilera Nuria
- Aguirre Alyssa
- Ahmad Shahzad
- Akinyemi Rufus O.
- Al-Chalabi Ammar
- AlarcĂłn-MartĂn Emilio
- Albert Marilyn S.
- Albin Roger L.
- Alcolea Daniel
- Alegret Montserrat
- Ali Muhammad
- Allen Mariet
- Allende Irene Rosas
- Alonso MarĂa Dolores
- Alonso MarĂa Dolores
- Alvarez Ignacio
- Alvarez Lisa
- Amer-Ferrer Guillermo
- Amin Najaf
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera Martirio
- Antikainen Riitta
- Antonell Anna
- Anttonen Vuokko
- AntĂșnez Carmen
- Aparicio Hugo J.
- Apostolova Liana G.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola
- Armstrong Nicola J.
- Arnold Steven E.
- Arosio Beatrice
- Arvas Mikko
- Assogna Francesca
- Asthana Sanjay
- Athanasiu Lavinia
- Atwood Craig S.
- Auge Franck
- Auranen Annika
- Auvinen PĂ€ivi
- Awaisa Ghazal
- Ayres Gayle
- Bacha Juan Ignacio
- Bahadori Maryam
- Bahrami Shahram
- Bailly Henri
- Baldwin Clinton T.
- Banaj Nerisa
- Baquero Miquel
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Barral Sandra
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Becker James T.
- Becker Tim
- Beecham Gary W.
- Beekly Duane
- Behrens Tim
- Beiser Alexa
- Belezhanska Diyana
- Bellenguez CĂ©line
- Below Jennifer E.
- Below Jennifer E.
- Ben-Shlomo Yoav
- Benchek Penelope
- Benchek Penelope
- Benitez Bruno A.
- Bennett David
- Benussi Alberto
- Benussi Luisa
- Bergh Sverre
- Bernardo-Harrington Mateus
- Berr Claudine
- Bertelson John
- Besse CĂ©line
- Bessi Valentina
- Betts Jo
- Bhangale Tushar
- Biessels Geert Jan
- Binetti Giuliano
- Bing Nan
- Bird Thomas D.
- Bis Joshua C.
- Biswas Shameek
- Bizarro Alessandra
- Bjerke Maria
- Blacker Deborah
- Blesa Rafael
- Blomster Timo
- Boada MercĂš
- Boecker Henning
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- BossĂč Paola
- Bowen James D.
- Bowers Natalie
- Boxer Adam
- Brauer Matt
- Brayne Carol
- Brein Georg
- Bresner Catherine
- Bressler Jan
- Breteler Monique
- Brewer James
- Brice Alexis
- Brodaty Henry
- Broeckhoven Christine Van
- Bronson Paola
- Brookes KJ
- Brown Kristelle
- Brown Kristelle S.
- Brusco Luis Ignacio
- BrÄthen Geir
- Buendia Mar
- Buiza-Rueda Dolores
- Bullido MarĂa J.
- Burguera Juan Andrés
- Burholt Vanessa
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Bush William S.
- Buxbaum Joseph D.
- Bûrger Katharina
- Cairns Nigel J.
- Calero Miguel
- Caliskan Minal
- Call Katherine
- Call Kathy
- campion Dominique
- Campos-Martin Rafael
- Cano Amanda
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Christopher S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carpén Olli
- Carracedo Ăngel
- Carrasquillo Minerva M.
- Carrillo F.
- Carrillo FĂĄtima
- Carrion-Claro M.
- CarriĂłn-Claro Mario
- Casajeros MarĂa JosĂ©
- Castaño Eduardo M.
- Cañabate Pilar
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Challis Ben
- Chang Diana
- Chapuis Julien
- Charbonnier Camille
- Chasman Daniel
- Chasse Scott
- Chatelain Clement
- Chauhan Ganesh
- Chen Chia-Yen
- Chen Hao
- Chen Hubert
- Chen Hung-Hsin
- Chen Xing
- Chene GeneviĂšve
- Chesi Alessandra
- Chesselet Marie-Francoise
- Chhibber Aparna
- Chillotti Caterina
- Chin Nathaniel A.
- Chipi Elena
- Choy David
- Chu Audrey
- Chui Helena C.
- Chung Jaeyoon
- Chung Jaeyoon
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A. H. R.
- Clarimon Jordi
- Clark Christopher
- Clarke Robert
- Close David
- Collinge John
- Comic Hata
- Conti Elisa
- Cores Valeria
- Corma-GĂłmez AnaĂŻs
- Costa Marcos R.
- Costantini Emanuele
- Cox Simon
- Craft Suzanne
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Crohns Marika
- Cruchaga Carlos
- Cuccaro Michael L.
- Cuccaro Michael L.
- Cuesta Carolina
- Cullum Munro
- Cummings Beryl
- Cupples Adrienne L.
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daly Mark
- Damotte Vincent
- Daniele Antonio
- Darby Eveleen
- Dardiotis Efthimios
- Dartigues Jean-François
- Davies Chloe
- Davies Gail
- Davis Barbara
- Davis Justin Wade
- de Deyn Peter Paul
- De Jager Philip L.
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D.
- Debette Stéphanie
- DeCarli Charles
- DeCarli Charles S.
- Deckert JĂŒrgen
- del Ser Teodoro
- Deleuze Jean-François
- della Briotta Parola Pietro
- della Briotta Parolo Pietro
- Deloukas Panagiotis
- Deloukas Pangiotis
- Denning Nicola
- Deramecourt Vincent
- Deramerourt Vincent
- DeStefano Anita
- DeToledo John
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen MĂłnica
- Diogo Dorothee
- Djurovic Srdjan
- Dombroski Beth A.
- Dongen Jasper Van
- Donner Kati
- Doody Rachelle S.
- Dowzell Kimberley
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Duperron Marie-Gabrielle
- Dupuis Josée
- Duron Emmanuelle
- DĂŒzel Emrah
- Eaton Susan
- Ehm Meg
- Eicher John
- Eiriksdottir Gudny
- Eklund Kari
- Elenius Klaus
- Elliott Amanda
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner NilĂŒfer
- Escott-Price Valentina
- Escuela R.
- Escuela RocĂo
- Esmaeeli Sahar
- Espinosa Ana
- Espinosa Miguel Angel Labrador
- Etchepareborda Ignacio
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- Faber Kelley M.
- Fabrizio Tagliavini
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- Fallon Kenneth B.
- Fan Frank
- Fardo David W.
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- Farotti Lucia
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- Fenoglio Chiara
- Fernandez-Hernandez Victoria
- FernĂĄndez-Fuertes Marta
- Ferrarese Carlo
- Ferrari Raffaele
- Ferreira Catarina B.
- Ferri Evelyn
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
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- Fitzpatrick Annette
- Fladby Tormod
- FlieĂbach Klaus
- Fohner Alison E.
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M.
- Forsell Charlotte
- Fortea Juan
- Fostinelli Silvia
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- Fox Nick
- Fox Nick C.
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- Frank-GarcĂa Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frosch Matthew P.
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- Fulton-Howard Brian
- Fulton-Howard Brian
- FÀrkkilÀ Martti
- Gailhajenet Anna
- Galasko Douglas R.
- Galeano Pablo
- Galimberti Daniela
- Gamboa Adriana
- Ganguli Mary
- Ganna Andrea
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Garcia-Tabuenca Javier
- GarcĂa-Alberca Jose Maria
- GarcĂa-GonzĂĄlez Pablo
- Garrote-Espina L.
- Garrote-Espina Lorena
- Gearing Marla
- Geerlings Mirjam
- Georgantas Bob
- George-Hyslop Peter St
- Germani Sandra
- Gerrish Amy
- Geschwind Daniel H.
- Ghanbari Mohsen
- Ghetti Bernardino
- Ghidoni Roberta
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- Giedraitis Vilmantas
- Giegling Ina
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- Gill Michael
- Giorgio Giaccone
- Glatt Stephen J.
- Goate Alison M.
- Goldhardt Oliver
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- Gordillo Jorge Esparza
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- Grabe Hans
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- Green Robert C.
- Greenberg Steven
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- GrĂŒnblatt Edna
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
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- Guitart Marina
- Gurling Hugh
- Gursoy Ulvi
- Gwilliam Rhian
- GĂłmez-Garre P.
- GĂłmez-Garre Pilar
- Haapasalo Annakaisa
- Habes Mohamad
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Haines Jonathan L.
- Hakonarson Hakon
- Hall James
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hannula-Jouppi Katariina
- Hanon Olivier
- Harari Oscar
- Hardy John
- Harju Jarmo
- Harju Terttu
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Harvima Ilkka
- Harwood Janet
- Hausner Lucrezia
- Haut Jacob
- Hautala Nina
- Havulinna Aki
- Head Elizabeth
- Heap Graham
- Heckbert Susan R.
- Hedman Ă sa
- Heikkinen Sami
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Henderson Victor W.
- Hendolin Minna
- Heneka Michael T.
- Hernandez Michelle
- HernĂĄndez Isabel
- Herold Christine
- Heron Samuel
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- van Rooij Jeroen
- van Swieten John
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- Vargas Liliana
- Vassar Robert
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- Vicente Maria Pilar
- Vidal Jean-SĂ©bastien
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- Vinters Harry V.
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- Vivancos Liliana
- Vogelgsang Jonathan
- Vojinovic Dina
- Vonsattel Jean-Paul
- Voutilainen Markku
- Vyhnalek Martin
- Wadhawan Samir
- Wagner Michael
- Wallon David
- Wang Clarence
- Wang Li-San
- Wang Ruiqi
- Wang Yanbing
- Warden Donald
- Waring Jeff
- Waring Jeffrey
- Warner Nick
- Warren Jason D.
- Waterworth Dawn
- Weber Heike
- Weinhold Leonie
- Weinstein Galit
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- Whelan Christopher
- Whitehead Patrice L.
- Wichmann H-Erich
- Wigmore Eleonor
- Wijsman Ellen M.
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Amy
- Williams Benjamin
- Williams Dylan
- Williams Julie
- Williamson Jennifer
- Wilms Henrik
- Wiltfang Jens
- Windle Gill
- Wingo Thomas S.
- Wisniewski Thomas
- Wittfeld Katharina
- Woltjer Randall L.
- Wong Regis
- Woods Bob
- Woon Martin
- Wright Clinton B.
- Wu Chuang-Kuo
- Wu Ying
- Xia Tai-he
- Xu Ethan
- Xu Fanli
- Yanek Lisa
- Yang Qiong
- Yang Yunju
- Yannakoulia Mary
- Yaqub Amber
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zare Habil
- Zhang Xiaoling
- Zhang Yuanchao
- Zhao Yi
- Zhao Yi
- Zhou Wei
- Zhu Congcong
- Zhu Xiongwei
- Ziemann Adam
- Zoia Chiara Paola
- Zompo Maria Del
- Zulaica Miren
- Ălvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimerâs disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/âproxyâ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE Δ4 allele