519 research outputs found
Superhydrophobic Paper from Nanostructured Fluorinated Cellulose Esters
The development of economically and ecologically viable strategies for sup erhydrophobization offers a vast variety of interesting applications in self-cleaning surfaces. Examples include packaging materials, textiles, outdoor clothing, and microfluidic devices. In this work, we produced superhydrophobic paper by spin-coating a dispersion of nanostructured fluorinated cellulose esters. Modification of cellulose nanocrystals was accomplished using 2H,2H,3H,3H-perfluorononanoyl chloride and 2H,2H,3H,3H-perfluoroundecanoyl chloride, which are well-known for their ability to reduce surface energy. A stable dispersion of nanospherical fluorinated cellulose ester was obtained by using the nanoprecipitation technique. The hydrophobized fluorinated cellulose esters were characterized by both solid- and liquid-state nuclear magnetic resonance, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and contact angle measurements. Further, we investigated the size, shape, and structure morphology of nanostructured fluorinated cellulose esters by dynamic light scattering, scanning electron microscopy, and X-ray diffraction measurements.Peer reviewe
Securing a Wireless Site Network to Create a BIM-allied Work-front
The Building Information Model (BIM) serves as a framework to align all the project-related data, providing interoperability to store and retrieve information interactively. Unfortunately, the construction site itself is excluded from this interaction as the large amount of data requires high data transfer rates and ruggedized hardware. However, advanced wireless communication technologies open radically new avenues to relay large amounts of data automatically and in near real-time. Construction could be a key beneficiary of these advancements. Wireless communication integrated with BIM, GPS and the Internet is able to provide the backbone necessary for creating intelligent systems, supporting the designer in his or her office as well as workers on the work-front. This paper presents a study that documents the development and testing of prototypes designed to facilitate information sharing at the field-level during construction. The main system constitutes an information hub, called the eCKiosk, connecting “senders and receivers” both on-site as well as off-site. The system design is discussed and some of the main modules are demonstrated. Since the electronic Kiosk depends on robust connections to the wireless devices distributed across the site, reliable connectivity is essential. For this reason, the discussion includes a study of the electronic signals behaviour in an ever-changing construction site. Measurements of the signal strengths during excavation and concrete work are presented and compared with theoretical calculations used to predict wave propagation. The results show how present models overestimate signal attenuation patterns on the construction site. This is important for designing a reliable and secure wireless site networks to link BIM to the work-front
Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic autoimmune disease caused by mutations in the AIRE gene. Although mainly an endocrine disease, a substantial fraction of patients have gastrointestinal manifestations. In this study, we have examined the role of anticommensal responses and their regulation. APECED patients had increased levels of Abs against Saccharomyces cerevisiae (p <0.0001) and against several species of commensal gut bacteria, but not against species predominantly associated with other locations. The anticommensal Ab levels did not correlate with gastrointestinal autoantibodies, neutralizing anti-IL-17 or -IL-22 Abs, or gastrointestinal symptoms, although scarcity of the available clinical data suggests that further study is required. However, the anti-S. cerevisiae Ab levels showed a significant inverse correlation with FOXP3 expression levels in regulatory T cells (Treg), previously shown to be dysfunctional in APECED. The correlation was strongest in the activated CD45RO(+) population (rho = 20.706; p <0.01). APECED patients also had decreased numbers of FOXP3(+) cells in gut biopsies. These results show that APECED patients develop early and sustained responses to gut microbial Ags in a pattern reminiscent of Crohn's disease. This abnormal immune recognition of gut commensals is linked to a systemic Treg defect, which is also reflected as a local decrease of gut-associated Treg. To our knowledge, these data are the first to show dysregulated responses to non-self commensal Ags in APECED and indicate that AIRE contributes to the regulation of gut homeostasis, at least indirectly. The data also raise the possibility of persistent microbial stimulation as a contributing factor in the pathogenesis of APECED.Peer reviewe
Integrated population models poorly estimate the demographic contribution of immigration
Estimating the contribution of demographic parameters to changes in population growth is essential for understanding why populations fluctuate. Integrated population models (IPMs) offer a possibility to estimate the contributions of additional demographic parameters, for which no data have been explicitly collected—typically immigration. Such parameters are often subsequently highlighted as important drivers of population growth. Yet, accuracy in estimating their temporal variation, and consequently their contribution to changes in population growth rate, has not been investigated.
To quantify the magnitude and cause of potential biases when estimating the contribution of immigration using IPMs, we simulated data (using northern wheatear Oenanthe oenanthe population estimates) from controlled scenarios to examine potential biases and how they depend on IPM parameterization, formulation of priors, the level of temporal variation in immigration and sample size. We also used empirical data on populations with known rates of immigration: Soay sheep Ovis aries and Mauritius kestrel Falco punctatus with zero immigration and grey wolf Canis lupus in Scandinavia with near-zero immigration.
IPMs strongly overestimated the contribution of immigration to changes in population growth in scenarios when immigration was simulated with zero temporal variation (proportion of variance attributed to immigration = 63% for the more constrained formulation and real sample size) and in the wild populations, where the true number of immigrants was zero or near-zero (kestrel 19.1%–98.2%, sheep 4.2%–36.1% and wolf 84.0%–99.2%). Although the estimation of the contribution of immigration in the simulation study became more accurate with increasing temporal variation and sample size, it was often not possible to distinguish between an accurate estimation from data with high temporal variation versus an overestimation from data with low temporal variation. Unrealistically, large sample sizes may be required to estimate the contribution of immigration well.
To minimize the risk of overestimating the contribution of immigration (or any additional parameter) in IPMs, we recommend to: (a) look for evidence of variation in immigration before investigating its contribution to population growth, (b) simulate and model data for comparison to the real data and (c) use explicit data on immigration when possible
Conceptual Design and Structural Optimization of NASA Environmentally Responsible Aviation (ERA) Hybrid Wing Body Aircraft
Simultaneously achieving the fuel consumption and noise reduction goals set forth by NASA's Environmentally Responsible Aviation (ERA) project requires innovative and unconventional aircraft concepts. In response, advanced hybrid wing body (HWB) aircraft concepts have been proposed and analyzed as a means of meeting these objectives. For the current study, several HWB concepts were analyzed using the Hybrid wing body Conceptual Design and structural optimization (HCDstruct) analysis code. HCDstruct is a medium-fidelity finite element based conceptual design and structural optimization tool developed to fill the critical analysis gap existing between lower order structural sizing approaches and detailed, often finite element based sizing methods for HWB aircraft concepts. Whereas prior versions of the tool used a half-model approach in building the representative finite element model, a full wing-tip-to-wing-tip modeling capability was recently added to HCDstruct, which alleviated the symmetry constraints at the model centerline in place of a free-flying model and allowed for more realistic center body, aft body, and wing loading and trim response. The latest version of HCDstruct was applied to two ERA reference cases, including the Boeing Open Rotor Engine Integration On an HWB (OREIO) concept and the Boeing ERA-0009H1 concept, and results agreed favorably with detailed Boeing design data and related Flight Optimization System (FLOPS) analyses. Following these benchmark cases, HCDstruct was used to size NASA's ERA HWB concepts and to perform a related scaling study
Rubber-Modified Glassy Amorphous Polymers Prepared via Chemically Induced Phase Separation. 4. Comparison of Properties of Semi- and Full-IPNs, and Copolymers of Acrylate−Aliphatic Epoxy Systems
Towards constraints on the SUSY seesaw from flavour-dependent leptogenesis
We systematically investigate constraints on the parameters of the
supersymmetric type-I seesaw mechanism from the requirement of successful
thermal leptogenesis in the presence of upper bounds on the reheat temperature
of the early Universe. To this end, we solve the
flavour-dependent Boltzmann equations in the MSSM, extended to include
reheating. With conservative bounds on , leading to mildly
constrained scenarios for thermal leptogenesis, compatibility with observation
can be obtained for extensive new regions of the parameter space, due to
flavour-dependent effects. On the other hand, focusing on (normal) hierarchical
light and heavy neutrinos, the hypothesis that there is no CP violation
associated with the right-handed neutrino sector, and that leptogenesis
exclusively arises from the CP-violating phases of the matrix,
is only marginally consistent. Taking into account stricter bounds on
further suggests that (additional) sources of CP violation must
arise from the right-handed neutrino sector, further implying stronger
constraints for the right-handed neutrino parameters.Comment: 42 pages, 12 figures; final version published in JCAP; numerical
results for the efficiency factor can be downloaded from
http://www.newphysics.eu/leptogenesis
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