491 research outputs found
Monovalent counterion distributions at highly charged water interfaces: Proton-transfer and Poisson-Boltzmann theory
Surface sensitive synchrotron-X-ray scattering studies reveal the
distributions of monovalent ions next to highly charged interfaces. A lipid
phosphate (dihexadecyl hydrogen-phosphate) was spread as a monolayer at the
air-water interface, containing CsI at various concentrations. Using anomalous
reflectivity off and at the Cs resonance, we provide, for the first
time, spatial counterion distributions (Cs) next to the negatively charged
interface over a wide range of ionic concentrations. We argue that at low salt
concentrations and for pure water the enhanced concentration of hydroniums
HO at the interface leads to proton-transfer back to the phosphate
group by a high contact-potential, whereas high salt concentrations lower the
contact-potential resulting in proton-release and increased surface
charge-density. The experimental ionic distributions are in excellent agreement
with a renormalized-surface-charge Poisson-Boltzmann theory without fitting
parameters or additional assumptions
Binary separation in very thin nematic films: thickness and phase coexistence
The behavior as a function of temperature of very thin films (10 to 200 nm)
of pentylcyanobiphenyl (5CB) on silicon substrates is reported. In the vicinity
of the nematic/isotropic transition we observe a coexistence of two regions of
different thicknesses: thick regions are in the nematic state while thin ones
are in the isotropic state. Moreover, the transition temperature is shifted
downward following a 1/h^2 law (h is the film thickness). Microscope
observations and small angle X-ray scattering allowed us to draw a phase
diagram which is explained in terms of a binary first order phase transition
where thickness plays the role of an order parameter.Comment: 5 pages, 3 figures, submitted to PRL on the 26th of Apri
Post-traumatic stress disorder following childbirth: an update of current issues and recommendations for future research
Objective:
This paper aimed to report the current status of research in the field of post-traumatic stress disorder following childbirth (PTSD FC), and to update the findings of an earlier 2008 paper.
Background:
A group of international researchers, clinicians and service users met in 2006 to establish the state of clinical and academic knowledge relating to PTSD FC. A paper identified four key areas of research knowledge at that time.
Methods:
Fourteen clinicians and researchers met in Oxford, UK to update the previously published paper relating to PTSD FC. The first part of the meeting focused on updating the four key areas identified previously, and the second part on discussing new and emerging areas of research within the field.
Results:
A number of advances have been made in research within the area of PTSD FC. Prevalence is well established within mothers, several intervention studies have been published, and there is growing interest in new areas: staff and pathways; prevention and early intervention; impact on families and children; special populations; and post-traumatic growth.
Conclusion:
Despite progress, significant gaps remain within the PTSD FC knowledge base. Further research continues to be needed across all areas identified in 2006, and five areas were identified which can be seen as ‘new and emerging’. All of these new areas require further extensive research. Relatively little is still known about PTSD FC
Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination.
Abstract
OBJECTIVE:
We characterised the clinical course, treatment and outcomes in 59 patients with relapsing myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination.
METHODS:
We evaluated clinical phenotypes, annualised relapse rates (ARR) prior and on immunotherapy and Expanded Disability Status Scale (EDSS), in 218 demyelinating episodes from 33 paediatric and 26 adult patients.
RESULTS:
The most common initial presentation in the cohort was optic neuritis (ON) in 54% (bilateral (BON) 32%, unilateral (UON) 22%), followed by acute disseminated encephalomyelitis (ADEM) (20%), which occurred exclusively in children. ON was the dominant phenotype (UON 35%, BON 19%) of all clinical episodes. 109/226 (48%) MRIs had no brain lesions. Patients were steroid responsive, but 70% of episodes treated with oral prednisone relapsed, particularly at doses <10\u2009mg daily or within 2 months of cessation. Immunotherapy, including maintenance prednisone (P=0.0004), intravenous immunoglobulin, rituximab and mycophenolate, all reduced median ARRs on-treatment. Treatment failure rates were lower in patients on maintenance steroids (5%) compared with non-steroidal maintenance immunotherapy (38%) (P=0.016). 58% of patients experienced residual disability (average follow-up 61 months, visual loss in 24%). Patients with ON were less likely to have sustained disability defined by a final EDSS of 652 (OR 0.15, P=0.032), while those who had any myelitis were more likely to have sustained residual deficits (OR 3.56, P=0.077).
CONCLUSION:
Relapsing MOG antibody-associated demyelination is strongly associated with ON across all age groups and ADEM in children. Patients are highly responsive to steroids, but vulnerable to relapse on steroid reduction and cessation
X-ray standing wave and reflectometric characterization of multilayer structures
Microstructural characterization of synthetic periodic multilayers by x-ray
standing waves have been presented. It has been shown that the analysis of
multilayers by combined x-ray reflectometry (XRR) and x-ray standing wave (XSW)
techniques can overcome the deficiencies of the individual techniques in
microstructural analysis. While interface roughnesses are more accurately
determined by the XRR technique, layer composition is more accurately
determined by the XSW technique where an element is directly identified by its
characteristic emission. These aspects have been explained with an example of a
20 period Pt/C multilayer. The composition of the C-layers due to Pt
dissolution in the C-layers, PtC, has been determined by the XSW
technique. In the XSW analysis when the whole amount of Pt present in the
C-layers is assumed to be within the broadened interface, it l eads to larger
interface roughness values, inconsistent with those determined by the XRR
technique. Constraining the interface roughness values to those determined by
the XRR technique, requires an additional amount of dissolved Pt in the
C-layers to expl ain the Pt fluorescence yield excited by the standing wave
field. This analysis provides the average composition PtC of the
C-layers .Comment: 12 pages RevTex, 10 eps figures embedde
Determination of total x-ray absorption coefficient using non-resonant x-ray emission
An alternative measure of x-ray absorption spectroscopy (XAS) called inverse partial fluorescence yield (IPFY) has recently been developed that is both bulk sensitive and free of saturation effects. Here we show that the angle dependence of IPFY can provide a measure directly proportional to the total x-ray absorption coefficient, µ(E). In contrast, fluorescence yield (FY) and electron yield (EY) spectra are offset and/or distorted from µ(E) by an unknown and difficult to measure amount. Moreover, our measurement can determine µ(E) in absolute units with no free parameters by scaling to µ(E) at the non-resonant emission energy. We demonstrate this technique with measurements on NiO and NdGaO3. Determining µ(E) across edge-steps enables the use of XAS as a non-destructive measure of material composition. In NdGaO3, we also demonstrate the utility of IPFY for insulating samples, where neither EY or FY provide reliable spectra due to sample charging and self-absorption effects, respectively
Asymmetric magnetization reversal in exchange-biased hysteresis loops
This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics.Polarized neutron reflectometry is used to probe the in-plane projection of the net-magnetization vector M of polycrystalline Fe films exchange coupled to twinned (110) MnF2 or FeF2 antiferromagnetic (AF) layers. The magnetization reversal mechanism depends upon the orientation of the cooling field with respect to the twinned microstructure of the AF, and whether the applied field is increased to (or decreased from) a positive saturating field; i.e., the magnetization reversal is asymmetric. The reversal of the sample magnetization from one saturated state to the other occurs via either domain wall motion or magnetization rotation on opposite sides of the same hysteresis loop
A case study of a mother's intertwining experiences with incest and postpartum depression
The association between childhood sexual abuse (CSA) and major depression disorder (MDD) gives reason to suspect that many mothers with postpartum depression (PPD) have a history of CSA. However, few studies have investigated how CSA and PPD are related. In this case study we explore how the experience of incest intertwines with the experience of postpartum depression. We focus on participant subject “Nina,” who has experienced both. We interviewed her three times and we analysed the interviews with Giorgi's phenomenological descriptive method to arrive at a contextualised meaning structure. Nina's intruding fantasies of men who abuse her children merge with her recollections of her own incest experiences. She may succeed in forcing these fantasies out of her consciousness, but they still alter her perceptions, thoughts, and emotions. She feels overwhelmed and succumbs to sadness, while she also is drawn towards information about CSA, which in turn feeds her fantasies. The psychodynamic concepts of repetition compulsion, transference, and projection may provide some explanation of Nina's actions, thoughts, and emotions through her past experiences. With our phenomenological stance, we aim to acknowledge Nina's descriptions of her everyday life here and now. With reference to Husserl, Heidegger, Merleau-Ponty, and Minkowski, we show that Nina's past is not a dated memory; rather it determines the structure of her consciousness that constitutes her past as her true present and future. Incest dominates Nina's world, and her possibilities for action are restricted by this perceived world. Any suspension of action implies anguish, and she resolves this by incest-structured action that in turn feeds and colours her expectations. Thus anxiety and depression are intertwined in the structure of this experience
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