Gestión de colecciones del Museo del Hidalgo

SIAM. Series Iberoamericanas de Museología. Año 3, Vol.

The Noradrenergic System in Parkinson’s Disease

Nowadays it is well accepted that in Parkinson's disease (PD), the neurodegenerative process occurs in stages and that damage to other areas precedes the neuronal loss in the substantia nigra pars compacta, which is considered a pathophysiological hallmark of PD. This heterogeneous and progressive neurodegeneration may explain the diverse symptomatology of the disease, including motor and non-motor alterations. In PD, one of the first areas undergoing degeneration is the locus coeruleus (LC). This noradrenergic nucleus provides extensive innervation throughout the brain and plays a fundamental neuromodulator role, participating in stress responses, emotional memory, and control of motor, sensory, and autonomic functions. Early in the disease, LC neurons suffer modifications that can condition the effectiveness of pharmacological treatments, and importantly, can lead to the appearance of common non-motor symptomatology. The noradrenergic system also exerts anti-inflammatory and neuroprotective effect on the dopaminergic degeneration and noradrenergic damage can consequently condition the progress of the disease. From the pharmacological point of view, it is also important to understand how the noradrenergic system performs in PD, since noradrenergic medication is often used in these patients, and drug interactions can take place when combining them with the gold standard drug therapy in PD, L-3,4-dihydroxyphenylalanine (L-DOPA). This review provides an overview about the functional status of the noradrenergic system in PD and its contribution to the efficacy of pharmacological-based treatments. Based on preclinical and clinical publications, a special attention will be dedicated to the most prevalent non-motor symptoms of the disease.This study was supported by grants from the Basque Government (PIBA 2019-38, IT1345-19), UPV/EHU (PPGA19/15), and Spanish Government (SAF2016‐77758‐R [AEI/FEDER, UE]). EP-R has a fellowship from the Basque Country and SV-S from the UPV/EHU

The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes

The precise regulation of S-phase-specific genes is critical for cell proliferation. How the repressive chromatin configuration mediated by the retinoblastoma protein and repressor E2F factors changes at the G1/S transition to allow transcription activation is unclear. Here we show ChIP-on-chip studies that reveal that the chromatin remodeller CHD8 binds ∼2000 transcriptionally active promoters. The spectrum of CHD8 target genes was enriched in E2F-dependent genes. We found that CHD8 binds E2F-dependent promoters at the G1/S transition but not in quiescent cells. Consistently, CHD8 was required for G1/S-specific expression of these genes and for cell cycle re-entry on serum stimulation of quiescent cells. We also show that CHD8 interacts with E2F1 and, importantly, loading of E2F1 and E2F3, but not E2F4, onto S-specific promoters, requires CHD8. However, CHD8 recruiting is independent of these factors. Recruiting of MLL histone methyltransferase complexes to S-specific promoters was also severely impaired in the absence of CHD8. Furthermore, depletion of CHD8 abolished E2F1 overexpression-dependent S-phase stimulation of serum-starved cells, highlighting the essential role of CHD8 in E2F-dependent transcription activation

Genome-wide study of chromatin remodeling factor CHD8 role in transcription

1 página. Cold Spring Harbor Laboratory (CSHL) Meeting on Mechanisms of Eukaryotic Trasncription 2011. August 30 - september 3, 2011.CHD8 (Chromodomain-Helicase-DNA binding protein 8) is a member of the chromodomain helicase DNA-binding (CHD) subfamily of enzymes, which also belongs to the SNF2 family of ATP-dependent chromatin remodelers.Peer reviewe

Comportamiento de la vigilancia epidemiológica de la leptospirosis humana en Colombia, 2007-2011

Introduction: Leptospirosis is a reemerging zoonosis of worldwide distribution, caused by a spirochete of the genus Leptospira. In Colombia, the disease represents a major public health issue, and there has been an increased number of cases in humans and animals.Objective: To characterize epidemiologically cases of leptospirosis reported to the National Public Health Surveillance in Colombia, and to make an approach to determine the serogroups circulating in the country.Materials and methods: A retrospective observational study was designed using a process of monitoring records, which included cases reported by the software SIVIGILA and samples sent to the Microbiology Group of the National Laboratory Network (GM-RNL), for the period 2007-2011. We registered socio-demographic variables and analyzed 17 serogroups of Leptospira.Results: A total of 11,786 records were processed, with 4,621 confirmed cases of leptospirosis. The geographic places which reported the highest number of cases were: Valle del Cauca, Antioquia, Risaralda, Atlántico and Barranquilla, and those with the highest incidence were Guaviare, Risaralda, San Andres, Santa Marta and Barranquilla. The largest number of cases was from urban areas, and more commonly in men (77%), students (19.4%) and housewives (13.6%). A median age of 29 years (IQR 45-19) was observed. There was evidence of 17 serogroups circulating in the country, from which the three most frequent were Australis (24.89%), Hebdomadis (9.33%) and Sejroe (8.0%).Conclusions: In Colombia, the reported cases have improved as well as their final classification, allowing us to determine the Australis serogroup as the most widely circulating one. doi: http://dx.doi.org/10.7705/biomedica.v33i0.1608Introducción. La leptospirosis es una zoonosis reemergente de distribución mundial causada por una espiroqueta del género Leptospira. Durante los últimos años en Colombia aumentó el número de casos en humanos y animales.Objetivo. Caracterizar epidemiológicamente los casos de leptospirosis notificados al Sistema Nacional de Vigilancia en Salud Pública de Colombia y hacer una aproximación para conocer los serogrupos que circulan en el país.Materiales y métodos. Se diseñó un estudio observacional de corte retrospectivo, con registros del proceso de vigilancia de los casos reportados por el software Sivigila y muestras enviadas al Grupo de Microbiología de la Red Nacional de Laboratorios, durante el periodo 2007 a 2011. Se registraron variables de tipo sociodemográficas y se analizaron 17 serogrupos de Leptospira. En el análisis seutilizaron medidas de frecuencia, tendencia central y dispersión.Resultados. Se procesaron 11.786 registros, confirmándose 4.621 casos de leptospirosis. Las entidades territoriales con mayor registro fueron Valle del Cauca, Antioquia, Risaralda, Atlántico y Barranquilla; y las de incidencia más alta fueron Guaviare, Risaralda, San Andrés, Santa Marta y Barranquilla. El mayor número de casos reportados perteneció al área urbana, con mayor frecuencia de hombres (77 %), estudiantes (19,4 %) y amas de casas (13,6 %), con una mediana por edad de 29 años (rango intercuartílico: 45-19). Se evidenció la circulación de 17 serogrupos en el país; los más frecuentes fueron Australis (24,89 %), Hebdomadis (9,33 %) y Sejroe (8,0 %).Conclusión. En Colombia se ha mejorado la notificación y clasificación final de los casos, lo que ha permitido identificar al serogrupo Australis como el de mayor circulación. doi: http://dx.doi.org/10.7705/biomedica.v33i0.1608

Susceptibilidad inmunológica a las infecciones virales de vía aérea posterior a la pandemia de COVID-19

The immunological susceptibility to viral airway infections after the covid-19 pandemic has been related to the decrease in the spread of these viruses as a result of non-pharmaceutical interventions implemented during the pandemic. Social distancing, confinement, and the use of a mask made it possible to limit the respiratory transmission chain; decreasing SARS-COV-2 and concomitantly other respiratory viruses such as Influenza and Respiratory Syncytial Virus. However, this beneficial effect during the COVID-19 pandemic is currently responsible for a decrease in herd immunity against them. Low exposure to these respiratory viruses could culminate in more serious viral epidemics in the future as well as increased incidence of other respiratory viruses. The role of the immune system has an important implication in this immune susceptibility that occurred after the covid-19 pandemic. This system plays an essential role in the suppression of viruses because it is the first line of defense of the human body through the innate and adaptive immune system. The present review seeks to establish the relationship between immunological susceptibility to respiratory viruses and the COVID-19 pandemic; by identifying the factors associated with the increased incidence of respiratory viruses; as well as the response of the immune system to these viruses. In addition, to determine the etiological prevalence of the main viruses in the face of this susceptibility after the COVID-19 pandemic.La susceptibilidad inmunológica a las infecciones virales de vía aérea posterior a la pandemia covid-19 se ha relacionado a la disminución en la propagación de estos virus producto de las intervenciones no farmacéuticas implementadas durante la pandemia. El distanciamiento social, el confinamiento y el uso de mascarilla permitió limitar la cadena de transmisión respiratoria; disminuyendo el SARS-COV-2 y concomitantemente otros virus respiratorios como Influenza y Virus Respiratorio Sincicial. Sin embargo, este efecto beneficioso durante la pandemia COVID-19 es el responsable hoy en día de una disminución en la inmunidad colectiva contra ellos. La escasa exposición a estos virus respiratorios podría culminar en epidemias virales más graves futuramente así como un alza en la incidencia de otros virus respiratorios. El papel del sistema inmunológico tiene una implicación importante en esta susceptibilidad inmune sucedida posterior a la pandemia covid-19. Este sistema es la primera línea de defensa del cuerpo humano mediante el sistema inmune innato y adaptativo. La presente revisión, busca establecer la relación entre la susceptibilidad inmunológica a los virus respiratorios y la pandemia COVID-19; mediante la identificación de los factores asociados al alza de incidencia de virus respiratorios; así como la respuesta del sistema inmunológico ante estos virus. Además, de determinar la prevalencia etiológica de los principales virus  ante esta susceptibilidad posterior a la pandemia COVID-19

Modelos de desarrollo e inserción internacional: aportes para el análisis de la política exterior argentina desde la redemocratización: 1983-2011, actores y temas de agenda.

En este e-book titulado “Modelos de desarrollo e inserción internacional. Aportes para el análisis de la política exterior argentina desde la redemocratización (1983-2011). Actores y temas de agenda”se sistematizan parte de los resultados obtenidos a través del proyecto de investigación “Modelos de desarrollo e inserción internacional. Aportes para el análisis de la política exterior argentina desde la redemocratización (1983-2011)”, financiado por la Agencia Nacional de Promoción Científica y Tecnológica (ANCyT) bajo el código PICT-2011-0681.Fil: Busso, Anabella. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Actis, Esteban. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Ceppi, Natalia. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Fabani, Ornela. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Fernández Alonso, José. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Lorenzini, María Elena. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Novello, María Rocío. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Paredes Rodríguez, Rubén. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina.Fil: Simonoff, Alejandro. Universidad Nacional de La Plata; Argentina.Fil: Zelicovich, Julieta. Universidad Nacional de Rosario. Facultad de Ciencia Política y Relaciones Internacionales; Argentina

FICARAM-15 Cruise Report 20th March – 22nd May 2013 on board BIO Hespérides by the Group FICARAM

54 páginas, 19 figuras, 3 anexosThe FICARAM-15 is the fifteenth repetition of a section conducted in 1994. This section is part of the international program GOSHIP (http://www.go-ship.org/CruisePlans.html) to develop a globally coordinated network of sustained hydrographic sections as part of the global ocean/climate observing system. The objective of the FICARAM-15 cruise is to investigate the temporal evolution of the anthropogenic carbon and evaluate the CO2 absorption capacity of the South Atlantic region, the Equatorial zone, and the subtropical region of Azores-Gibraltar in the North Atlantic. This cruise is supported by the CATARINA project funded by the Ministry of Economy and Competitiveness (CTM2010-17141) and is part of the European Union FP7 project CARBOCHANGE (http://carbochange.b.uib.no/). The objective of FICARAM-15 cruise is framed in the CATARINA project conducted by the tasks I.2.1 (air-sea CO2 exchange) I.3 (ventilation of water masses), I.4.1 (zonal variability of N2O and CH4), I.4.2 (anthropogenic carbon storage), I.4.4 (saturation horizon of calcium carbonate along the section) and I.5.4 (evolution of the acidification rates). Another component of the FICARAM-15 cruise aims to examine the biological and biogeochemical mechanisms that hinder total dissolved organic carbon (DOC) remineralisation in marine systems, taking a multidisciplinary perspective and applying many different approaches. This is the global objective of the Spanish project DOREMI (CTM2012-34294) that joins this FICARAM-15 cruise.During the FICARAM cruise the physical oceanography group was responsible for collecting the following data sets: CTD and XBT data; vessel-mounted ADCP and lowered ADCP; continuous thermosalinograph. Physical oceanographers participated in the cruise financed through Project “Tipping Corners in the Meridional Overturning Circulation” (TIC-MOC), CTM2011-28867. The FICARAM-15 cruise was organized in two phases with a common sampling. LEG 1: From Punta Arenas (Chile) to Recife (Brazil): 62 stations. Chief Scientist: Aida F. Ríos, PI of CATARINA project LEG 2: From Recife (Brazil) to Cartagena (Spain): 46 stations Chief Scientist: Celia Marrasé, PI of DOREMI project This report contains the sampling of all the variables at each station along the FICARAM section, as well as the analysis of the biogeochemical variables and the preliminary results. The principal investigator of the DOREMI project produced another report with the common sampling section, showing the analysis and results of the experiments on dissolved organic matter carried out on board.This cruise is supported by the CATARINA project funded by the Ministry of Economy and Competitiveness (CTM2010-17141) and is part of the European Union FP7 project CARBOCHANGE (http://carbochange.b.uib.no/)Peer reviewe

Aproximación al significado léxico con primitivos y moléculas: trabajo experimental (I)

Documento de trabajo que recoge trece informes realizados por estudiantes del Grado de Lengua Española y sus Literaturas durante el curso 2017/18, que recoge los datos, su análisis y discusión de diversos trabajos experimentales en los que se intenta una aproximación al significado léxico de algunas palabras mediante primitivos y moléculas. Este trabajo se inserta en el Proyecto de Innovación "Piensapalabras" (2017/18, nº 125)