Cyber-pi: Intelligent cyberthreat detection and supervised response

Integration of cyber incident management systems comes with a series of challenges on the organisational, technical and human dimension. In this paper we introduce Cyber-pi, a reference architecture for integrated cyber threat detection and response. This architecture is used to facilitate the study of the human aspects and showcases the interplay between the human and automated operator; these two dimensions are represented by the SIEM interface and the self-healing component of Cyber-pi respectively

Interoperability Challenges in the Cybersecurity Information Sharing Ecosystem

Threat intelligence helps businesses and organisations make the right decisions in their fight against cyber threats, and strategically design their digital defences for an optimised and up-to-date security situation. Combined with advanced security analysis, threat intelligence helps reduce the time between the detection of an attack and its containment. This is achieved by continuously providing information, accompanied by data, on existing and emerging cyber threats and vulnerabilities affecting corporate networks. This paper addresses challenges that organisations are bound to face when they decide to invest in effective and interoperable cybersecurity information sharing and categorises them in a layered model. Based on this, it provides an evaluation of existing sources that share cybersecurity information. The aim of this research is to help organisations improve their cyber threat information exchange capabilities, to enhance their security posture and be more prepared against emerging threats

The next generation internet initiative

Digital transformation is pushing all market sectors to level up their digital capabilities to better serve customers and improve the user experience. The European Commission launched in 2016 the Next Generation Internet (NGI) initiative as part of the DSM strategy. NGI includes a number of different – but always interrelated – emerging technologies in the following focus areas: artificial intelligence and autonomous machines, blockchains and distributed ledgers, big data, Internet of Things, 5G, cybersecurity and privacy technologies, cloud and edge computing, and open data. As for cooperation in the field of Information and Communications Technology, Europe and the United States should seek a joint framework to expand efforts in new emerging technologies, while preserving common principles around a comprehensive EU–US digital economy dialogue. The NGI Initiative is an important opportunity to radically rethink the way the Internet works today, and more human-focused narratives are needed more than ever

An energy efficient modulation scheme for body-centric nano-communications in the THz band

In body-centric communications, energy efficiency is the most critical parameter, while the maximum achievable data rate is not of primary concern. In this paper we present a novel modulation scheme, which can be efficiently used in body-centric terahertz (THz) nanonetworks. This scheme is a combination of the time-spread On-Off keying (TS-OOK) and the pulse position modulation (PPM). The new modulation scheme presents lower energy consumption levels at a small cost to the achievable data rate. Furthermore, another important aspect is that, due to the nature of noise in THz communications, the proposed modulation is affected in a much smaller way by the noise. Finally, we present analytical and simulation results in order to compare the new scheme with TS-OOK

Acute Heart Failure in a Healthy Young Patient after Severe Carbon Monoxide Poisoning

Introduction: Carbon monoxide (CO) poisoning may cause severe cellular hypoxia. Materials and methods: A 28-year-old male presented reduced levels of consciousness and dyspnoea after CO exposure. Clinical examination revealed tachypnoea, bilateral rales, dilated jugular veins and confusion. Troponin I, lactate and carboxyhaemoglobin levels were increased. Thoracic X-ray depicted pulmonary oedema and an echocardiogram, severe heart failure (HF; EF<25%). He was intubated due to clinical deterioration. Results: He remained intubated for 5 days with excellent improvement of left ventricular function (EF>55%). He was discharged 1 week later with full recovery. Discussion: Acute HF is a rare serious complication of CO poisoning, even in healthy young individuals

An energy efficient modulation scheme for body-centric terahertz (THz) nanonetworks

In body-centric communications, energy efficiency is a critical performance metric, while the achievable data rate is not of primary concern. In this paper we present a novel modulation scheme, which can be efficiently used in body-centric terahertz (THz) nanonetworks. The proposed scheme is a combination of the time-spread On-Off keying (TS–OOK) and the pulse position modulation (PPM) and presents lower energy consumption, compared to other existing methods as TS–OOK, at a minor cost to the data rate. Furthermore, another important aspect is that the proposed modulation scheme can be effectively used to mitigate the impact of the specific kind of noise in THz body-centric communications, thus leading to better error performance. Finally, we present analytical and simulation results in order to compare the new scheme with the existing TS–OOK

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe