Evoluzione dello stato nutrituzionale del mais in sistema biologico e convenzionale

Si tratta di una serie di soluzioni tecniche che mirano a ridurre gli impatti negativi dell’ agricoltura sull’ ambiente, i quali si possono manifestare in misura diversa a seconda delle attività svolte e del comparto ambientale interessato. Particolare attenzione è rivolta alla prevenzione del degrado della qualità delle risorse irriproducibili, come l’ acqua ed il suolo mettendo in evidenza ai rischi di inquinamento ad esso connessi. Attualmente l’ azoto rappresenta uno degli inquinanti che desta maggior preoccupazioni. L’ intensificazione degli apporti di tale nutriente, sotto forma di concimi naturali o fertilizzanti chimici, ha comportato numerose conseguenze, ad esempio: - perdita di fertilità dal terreno, dovuto principalmente alla volatilizzazione dell’ ammoniaca; - eutrofizzazione delle acque, soprattutto per quei sistemi acquosi caratterizzati da una scarsa profondità e medio- alte temperature; - formazione di derivati azotati che spesso risultano dannosi non solo per l’ ambiente ma anche per l’ uomo stesso, come per esempio le nitrosammine, composti altamente cancerogeni; - intensificazione del fenomeno di acidificazione delle piogge; - incremento dell’ assottigliamento dello strato d’ ozono e del fenomeno effetto serra.openAGR-40

Visualising accessibility: an interactive tool and two applications to empirical case studies of urban development and public engagement

While a substantial body of literature exists on the theoretical definitions and measures of accessibility, the extent to which such measures are applied into practice to assess project alternatives is less frequent (Geurs and Van Wee, 2004). Recent studies affirm that one of the main barriers to the usability of accessibility measure is the lack of visualisation quality and mapping tool for accessibility representation (te Brömmelstroet et al, 2014), while visualisation tools are commonly recognised as the most effective methodology to facilitate knowledge sharing, particularly in those processes involving public stakeholders and non-experts with different expertise. Starting form this consideration, this paper presents an application of the Interactive Visualisation Tool, named InViTo (Pensa and Masala, 2014a; 2014b; Pensa, et al., 2014; Pensa, Masala and Lami, 2013; Pensa, Masala and Marina, 2013) able to generate maps of the level of perceived accessibility (i.e. “desirability”) of different urban areas. Desirability is here computed as the perceived level of access to different urban items as transport supply (metro and rail stations, public transport stops, parking) and urban activities such as hospitals, schools, museums. In this respect, the concept of desirability encompasses a measure of accessibility to several urban facilities, and the perception that residents of the study area have of such facilities. The InViTo tool allows to build up maps of desirability interactively, by making selection of the chosen items and by giving differential weights to each items. This makes the tools powerful and very useful particularly when discussing and showing analysis results to stakeholders, who could have the opportunity to see in real time the results of different scenario alternatives and assumptions. © AET 2014 and contributors 2 In the paper two applications are presented. The first one to the empirical case study of Rome, presents the steps to undertake in order to apply the tool: from data gathering, maps coding, and results representation. The second application aims at exploring the potential usability of the tool in engaging public stakeholders into the assessment of different urban development options. Furthermore, the results of a workshop held in Turin, in which public and private stakeholders were interactively involved, are discussed. The paper is organised as follows. In section 2, an overview of the InViTo tool is given with a focus on its applicability formeasuring accessibility. In section 3 the results of the two InViTo applications are discussed. Conclusions are drawn in section 4, with an outlook to undergoing research issues

Knowledge management behaviors in venture capital crossroads: a comparison between IVC and CVC ambidexterity

PurposeInstitutional venture capitalists (IVCs) and corporate venture capitalists (CVCs) deploy analogous activities but adopt different approaches to financing innovation and value creation for venture-backed firms. Thus, this paper aims to investigate their potential ambidexterity as a result of knowledge management (KM) strategies and processes.Design/methodology/approachAfter a focused literature review showing evidence of KM behaviors as a source of potential ambidexterity for IVCs and CVCs, descriptive, inferential and discriminant analyses on the 15 most active IVCs and CVCs in the world in 2019 are presented. Correlations between numbers of deals, prevailing entrepreneurial intensity and potential ambidexterity are investigated.FindingsSpecific differences are analyzed from a KM perspective, revealing that the number/percentage of operations per round can result as a misleading criterion of knowledge accumulation. Finally, a theoretical model for ambidexterity for venture capitalists is developed.Originality/valueThe study shows that IVCs act with greater investment capacity because of their organizational structure and purpose and focus on financial goals; moreover, they are ambidextrous, although their exploration may more frequently entail exploitation than "real" exploration. CVCs tend to invest in sectors related to their core business, coherent with their strategic purpose and more oriented with KM strategies for accumulating intellectual capital

Combined NMDA Inhibitor Use in a Patient With Multisubstance-induced Psychotic Disorder

This document is an Accepted Manuscript reprinted from Journal of Addiction Medicine, Vol. 12 (3): 247-251, May 2018, with permission of Kluwer Law International. Under embargo until 1 May 2019. The Version of Record is available online at DOI: https://doi.org/10.1097/ADM.0000000000000390: Novel psychoactive substance use is a major social concern. Their use may elicit or uncover unpredictably as yet undescribed clinical pictures. We aimed to illustrate a multisubstance use case indistinguishable from paranoid schizophrenia, so to alert clinicians on possibly misdiagnosing substance-induced psychotic disorders. CASE REPORT: We describe a case of a 32-year-old man who started at 18 years with cannabinoids and ketamine, and is currently using N-methyl-D-aspartate (NMDA) antagonists. At age 23, he developed social withdrawal after being assaulted by a stranger, but did not consult psychiatrists until age 26; during this period, he was using internet-purchased methoxetamine and ketamine, and was persecutory, irritable, suspicious, and insomniac and discontinued all received medical prescriptions. He added dextromethorphan to his list of used substances. At age 31, while using phencyclidine, and, for the first time, methoxphenidine, he developed a religious delusion, involving God calling him to reach Him, and the near-death experiences ensured by NMDA antagonists backed his purpose. He received Diagnostic and Statistical Manual of Mental Disorders, 5th Edition diagnosis of multisubstance-induced psychotic disorder and was hospitalized 8 times, 6 of which after visiting the emergency room due to the development of extreme anguish, verbal and physical aggression, and paranoia. He reportedly used methoxphenidine, methoxyphencyclidine, ethylnorketamine, norketamine, and deschlorketamine, to achieve near-death experiences, and eventually to reach God in heavens. CONCLUSIONS: This case points to the need for better control of drugs sold on the internet. It also illustrates that people using NMDA antagonists may present clinical pictures indistinguishable from those of major psychoses and are likely to be misdiagnosed.Peer reviewe

Visualising accessibility: an interactive tool and two applications to empirical case studies of urban development and public engagement

While a substantial body of literature exists on the theoretical definitions and measures of accessibility, the extent to which such measures are applied into practice to assess project alternatives is less frequent (Geurs and Van Wee, 2004). Recent studies affirm that one of the main barriers to the usability of accessibility measure is the lack of visualisation quality and mapping tool for accessibility representation (te Br\"ommelstroet et al, 2014), while visualisation tools are commonly recognised as the most effective methodology to facilitate knowledge sharing, particularly in those processes involving public stakeholders and non-experts with different expertise. Starting form this consideration, this paper presents an application of the Interactive Visualisation Tool, named InViTo (Pensa and Masala, 2014a; 2014b; Pensa, et al., 2014; Pensa, Masala and Lami, 2013; Pensa, Masala and Marina, 2013) able to generate maps of the level of perceived accessibility (i.e. \textquotedblleftdesirability\textquotedblright) of different urban areas. Desirability is here computed as the perceived level of access to different urban items as transport supply (metro and rail stations, public transport stops, parking) and urban activities such as hospitals, schools, museums. In this respect, the concept of desirability encompasses a measure of accessibility to several urban facilities, and the perception that residents of the study area have of such facilities. The InViTo tool allows to build up maps of desirability interactively, by making selection of the chosen items and by giving differential weights to each items. This makes the tools powerful and very useful particularly when discussing and showing analysis results to stakeholders, who could have the opportunity to see in real time the results of different scenario alternatives and assumptions. \textcopyright AET 2014 and contributors 2 In the paper two applications are presented. The first one to the empirical case study of Rome, presents the steps to undertake in order to apply the tool: from data gathering, maps coding, and results representation. The second application aims at exploring the potential usability of the tool in engaging public stakeholders into the assessment of different urban development options. Furthermore, the results of a workshop held in Turin, in which public and private stakeholders were interactively involved, are discussed. The paper is organised as follows. In section 2, an overview of the InViTo tool is given with a focus on its applicability formeasuring accessibility. In section 3 the results of the two InViTo applications are discussed. Conclusions are drawn in section 4, with an outlook to undergoing research issues

Geopolymer-zeolite composites for CO2 adsorption

Geopolymer-zeolite composites were produced mixing different geopolymer matrices with a synthetic commercial Na13X zeolite, to combine the functional microporosity of the zeolite with the mesoporosity of the geopolymer matrix, with the further possibility to consolidate the zeolite powder. The new materials were designed and produced in forms of monoliths to be used as adsorbents for low temperature CO2 capture applications. A potassium or sodium silicate activating solution was used to produce the metakaolin-based geopolymer matrices, then mixed with the synthetic zeolite used as a filler. As geopolymers can be regarded as the amorphous counterpart or precursor of crystalline zeolites, it is important to underline the chemical affinity between these two constituents. As a matter of fact, the morphological characterization evidenced the presence of geopolymer nanoprecipitates covering zeolite particles for the K-based composite, while in the Na-based composite the formation of a NaA zeolite phase was evidenced (Fig. 1). Please click Additional Files below to see the full abstract

Geopolymers adsorbents: Production and use

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Comparing Alzheimer’s and Parkinson’s diseases networks using graph communities structure

Background: Recent advances in large datasets analysis offer new insights to modern biology allowing system-level investigation of pathologies. Here we describe a novel computational method that exploits the ever-growing amount of "omics" data to shed light on Alzheimer's and Parkinson's diseases. Neurological disorders exhibit a huge number of molecular alterations due to a complex interplay between genetic and environmental factors. Classical reductionist approaches are focused on a few elements, providing a narrow overview of the etiopathogenic complexity of multifactorial diseases. On the other hand, high-throughput technologies allow the evaluation of many components of biological systems and their behaviors. Analysis of Parkinson's Disease (PD) and Alzheimer's Disease (AD) from a network perspective can highlight proteins or pathways common but differently represented that can be discriminating between the two pathological conditions, thus highlight similarities and differences. Results: In this work we propose a strategy that exploits network community structure identified with a state-of-the-art network community discovery algorithm called InfoMap, which takes advantage of information theory principles. We used two similarity measurements to quantify functional and topological similarities between the two pathologies. We built a Similarity Matrix to highlight similar communities and we analyzed statistically significant GO terms found in clustered areas of the matrix and in network communities. Our strategy allowed us to identify common known and unknown processes including DNA repair, RNA metabolism and glucose metabolism not detected with simple GO enrichment analysis. In particular, we were able to capture the connection between mitochondrial dysfunction and metabolism (glucose and glutamate/glutamine). Conclusions: This approach allows the identification of communities present in both pathologies which highlight common biological processes. Conversely, the identification of communities without any counterpart can be used to investigate processes that are characteristic of only one of the two pathologies. In general, the same strategy can be applied to compare any pair of biological networks

State of the art in interstitial pneumonia with autoimmune features: a systematic review on retrospective studies and suggestions for further advances

The term interstitial pneumonia with autoimmune features (IPAF) has been proposed to define patients with interstitial lung disease (ILD) associated with autoimmune signs not classifiable for connective tissue diseases (CTDs). This new definition overcomes previous nomenclatures and provides a uniform structure for prospective studies through specific classification criteria.This work evaluates the characteristics of IPAF patients reported in the literature, to highlight potential limits through a comparative analysis and to suggest better performing classification criteria.Four retrospective studies on the IPAF population have been considered. The study subjects differed in age, sex, smoking habit, ILD pattern and outcomes. Another important difference lies in the diverse items considered in the classification criteria. The retrospective design of the studies and the absence from some of them of a rheumatologist clearly involved in the diagnosis may have influenced the data, but current IPAF criteria seem to include a rather heterogeneous population. To overcome these discrepancies, this review suggests a limitation in the use of single items and the exclusion of extremely specific CTD criteria. This should avoid the definition of IPAF for those diseases at different stages or at early onset. The investigation of a functional or morphological cut-off of pulmonary involvement would be useful

How should ecohazard of micropollutants in wastewater be gauged? Using bioassays to profile alternative tertiary treatments

The research on emerging pollutants in wastewater has become a worldwide issue of increasing environmental concern, especially considering the growing interest in wastewater reuse. However, the latter implies additional post-treatment after the conventional activated sludge processes, in order to produce a safer effluent. Our work aimed at determining the efficiency of reducing the toxicity associated with organic micropollutants (OMPs) in secondary wastewater effluents, using 3 different post-treatment technologies (granular activated carbon (GAC), sand biofiltration and UV irradiation): in particular, target chemical analysis of the OMPs most commonly founded in wastewater was coupled with effect-based assays (estrogenicity and mutagenicity). While chemical analysis assessed satisfactory performances for all 3 technologies in the abatement of selected OMPs, biological assays evidenced another perspective: both GAC and sand biofilters were significantly able to make the estrogenic load plummet; however, the UV system was ineffective in estrogenicity abatement, and its effluent exhibited also a slight mutagenicity, likely due to photo-transformation by-products. These results indicate that a synergistic combination of chemical analysis and biological assays can drive to a proper gauging of post-treatment technologies, taking into account not only the removal of OMPs, but also their overall toxicityThis work was conceived within a Short Term Scientific Mission (STSM) of the Water2020 Cost Action ES1202: Conceiving Wastewater Treatment in 2020 | Energetic, environmental and economic challenges. Authors from Universidade de Santiago de Compostela belong to the Galician Competitive Research Group GRC 2013-032 and to the CRETUS Strategic Partnership (AGRUP2015/02). All these programmes are co-funded by FEDER (UE)S