Characterisation of a candidate dual AGN

We present Chandra and optical observations of a candidate dual AGN discovered serendipitously while searching for recoiling black holes via a cross-correlation between the serendipitous XMM source catalog (2XMMi) and SDSS-DR7 galaxies with a separation no larger than ten times the sum of their Petrosian radii. The system has a stellar mass ratio M$_{1}$/M$_{2}\approx 0.7$. One of the galaxies (Source 1) shows clear evidence for AGN activity in the form of hard X-ray emission and optical emission-line diagnostics typical of AGN ionisation. The nucleus of the other galaxy (Source 2) has a soft X-ray spectrum, bluer colours, and optical emission line ratios dominated by stellar photoionisation with a "composite" signature, which might indicate the presence of a weak AGN. When plotted on a diagram with X-ray luminosity vs [OIII] luminosity both nuclei fall within the locus defined by local Seyfert galaxies. From the optical spectrum we estimate the electron densities finding n$_{1} < 27$ e$^{-}$ cm$^{-3}$ and n$_{2} \approx 200$ e$^{-}$ cm$^{-3}$. From a 2D decomposition of the surface brightness distribution we infer that both galaxies host rotationally supported bulges (Sersic index $< 1$). While the active nature of Source 1 can be established with confidence, whether the nucleus of Source 2 is active remains a matter of debate. Evidence that a faint AGN might reside in its nucleus is, however, tantalising.Comment: 16 pages, 9 figures. Accepted for publication on MNRAS. Comments welcom

Cardiac damage biomarkers and heart rate variability following a 118-km mountain race: relationship with performance and recovery

This study aimed to assess the release of cardiac damage biomarkers jointly with cardiac autonomic modulation after a mountain ultramarathon. Such knowledge and the possible relationship of these markers with race time is of primary interest to establish possible recommendations upon athletes’ recovery and return to training following these competitions. Forty six athletes enrolled in the Penyagolosa Trails CSP115 race (118 km and a total positive elevation of 5439 m) took part in the study. N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive cardiac troponin T (hs-TNT) concentrations as well as linear and nonlinear heart rate variability (HRV) were evaluated before and after the race. NT-proBNP and hs-TNT significantly increased post-race; fifty percent of the finishers surpassed the Upper Reference Limit (URL) for hs-TNT while 87% exceeded the URL for NT-proBNP. Overall and vagally-mediated HRV were diminished and cardiac autonomic modulation became less complex and more predictable following the race. More pronounced vagal modulation decreases were associated with higher levels of postexertional NT-proBNP. Moreover, rise in hs-TNT and NT-proBNP was greater among faster runners, while pre-race overall and vagally-mediated HRV were correlated with finishing time. Participation in a 118-km ultratrail induces an acute release of cardiac damage biomarkers and a large alteration of cardiac autonomic modulation. Furthermore, faster runners were those who exhibited a greater rise in those cardiac damage biomarkers. In light of these findings, an appropriate recovery period after ultraendurance races appears prudent and particularly important among better performing athletes. At the same time, HRV analysis is shown as a promising tool to assess athletes’ readiness to perform at their maximum level in an ultraendurance race

El tratamiento normativo de los símbolos oficiales en el entorno europeo: el caso de España y sus países cercanos

The article seeks to justify the linkage of the protocol with the legal sciences and how within the official protocol there are different legal regulations that set the guidelines for action in their field. It will be analyzed how the countries closest to Spain, namely Germany, France, Italy and Portugal, legally regulate the official protocol and specifically in relation to the use of official symbols: shield, flag and anthem. In this way we will analyze if it is possible to establish some kind of general guideline on the existence or not of this type of regulations between them and what concrete aspects regarding the use of these symbols are established in each one of the cases. Finally we will show the degree of concreteness that exists in this legislation in Spain in relation to the one we have found in the other countries analyzed.El artículo pretende justificar la vinculación del protocolo con las ciencias jurídicas y cómo dentro del protocolo oficial existen diferentes regulaciones legales que marcan las pautas de actuación en su ámbito. Se analizará de qué forma los países del entorno más cercano a España, concretamente Alemania, Francia, Italia y Portugal, regulan legalmente el protocolo oficial y concretamente en relación al uso de los símbolos oficiales: escudo, bandera e himno. De esta forma analizaremos si es posible establecer algún tipo de pauta general sobre la existencia o no de este tipo de regulaciones entre ellos y qué aspectos concretos relativos al uso de estos símbolos se establecen en cada uno de los casos. Finalmente mostraremos el grado de concreción que existe en esta normativa en España respecto a la que hemos encontrado en los otros países analizados.The article seeks to justify the linkage of the protocol with the legal sciences and how within the official protocol there are different legal regulations that set the guidelines for action in their field. It will be analyzed how the countries closest to Spain, namely Germany, France, Italy and Portugal, legally regulate the official protocol and specifically in relation to the use of official symbols: shield, flag and anthem. In this way we will analyze if it is possible to establish some kind of general guideline on the existence or not of this type of regulations between them and what concrete aspects regarding the use of these symbols are established in each one of the cases. Finally we will show the degree of concreteness that exists in this legislation in Spain in relation to the one we have found in the other countries analyzed

Ask The Machine: Systematic detection of wind-type outflows in low-mass X-ray binaries

The systematic discovery of outflows in the optical spectra of low-mass X-ray binaries opened a new avenue for the study of the outburst evolution in these extreme systems. However, the efficient detection of such features in a continuously growing database requires the development of new analysis techniques with a particular focus on scalability, adaptability, and automatization. In this pilot study, we explore the use of machine learning algorithms to perform the identification of outflows in spectral line profiles observed in the optical range. We train and test the classifier on a simulated database, constructed through a combination of disc emission line profiles and outflow signatures, emulating typical observations of low-mass X-ray binaries. The final, trained classifier is applied to two sets of spectra taken during two bright outbursts that were particularly well covered, those of V404 Cyg (2015) and MAXI J1820+070 (2018). The resulting classification gained by this novel approach is overall consistent with that obtained through traditional techniques, while it simultaneously provides a number of key advantages over the latter, including the access to low velocity outflows. This study sets the foundations for future studies on large samples of spectra from low-mass X-ray binaries and other compact binaries.Comment: Accepted for publication in MNRAS. 13 pages, 6 figure

Investigation of wear mechanics and behaviour of NiCr metallic foam abradables

Current aero-engine sealing materials are reaching their operating limit, as manufacturers seek more efficient engines with longer service lives. Even when utilised in optimum conditions, current materials have inconsistencies in performance due to variabilities in their microstructure, which lead to undesirable responses and events. As such, a new generation of sealing materials is required. Metallic foams are one such material, given the opportunities that exist to both engineer material properties, and achieve relatively consistent microstructures when compared to the current class of thermally sprayed abradable materials. In this study, the abradability of a nickel (70%)–chromium (30%) (NiCr) alloy foam is investigated, with the role of cell size and filler material considered. Tests are performed on a representative high-speed test rig, where a flat blade is used to simulate an aero-engine incursion event. A series of in situ measurement techniques, such as force, temperature and stroboscopic wear measurements are used to characterise the incursion, with DIC (Digital Image Correlation) techniques also employed to investigate breakdown of the foam. Unfilled foams were shown to lead to high blade wear, with the inclusion of filler materials leading to load transfer and collapse of the foam away from the incursion site, along with improved fracture. Both load transfer and ligament collapse mechanisms were found to promote more favourable rub mechanics at all incursion rates tested

Glucocorticoid Resistance: Interference between the Glucocorticoid Receptor and the MAPK Signalling Pathways

Endogenous glucocorticoids (GCs) are steroid hormones that signal in virtually all cell types to modulate tissue homeostasis throughout life. Also, synthetic GC derivatives (pharmacological GCs) constitute the first-line treatment in many chronic inflammatory conditions with unquestionable therapeutic benefits despite the associated adverse effects. GC actions are principally mediated through the GC receptor (GR), a ligand-dependent transcription factor. Despite the ubiquitous expression of GR, imbalances in GC signalling affect tissues differently, and with variable degrees of severity through mechanisms that are not completely deciphered. Congenital or acquired GC hypersensitivity or resistance syndromes can impact responsiveness to endogenous or pharmacological GCs, causing disease or inadequate therapeutic outcomes, respectively. Acquired GC resistance is defined as loss of efficacy or desensitization over time, and arises as a consequence of chronic inflammation, affecting around 30% of GC-treated patients. It represents an important limitation in the management of chronic inflammatory diseases and cancer, and can be due to impairment of multiple mechanisms along the GC signalling pathway. Among them, activation of the mitogen-activated protein kinases (MAPKs) and/or alterations in expression of their regulators, the dual-specific phosphatases (DUSPs), have been identified as common mechanisms of GC resistance. While many of the anti-inflammatory actions of GCs rely on GR-mediated inhibition of MAPKs and/or induction of DUSPs, the GC anti-inflammatory capacity is decreased or lost in conditions of excessive MAPK activation, contributing to disease susceptibility in tissue- and disease- specific manners. Here, we discuss potential strategies to modulate GC responsiveness, with the dual goal of overcoming GC resistance and minimizing the onset and severity of unwanted adverse effects while maintaining therapeutic potential

Immediate and 24-h post-marathon cardiac troponin T is associated with relative exercise intensity

Purpose We aimed at exploring whether cardiopulmonary ftness, echocardiographic measures and relative exercise intensity were associated with high-sensitivity cardiac troponin T (hs-TNT) rise and normalization following a marathon. Methods Nighty-eight participants (83 men, 15 women; 38.72±3.63 years) were subjected to echocardiographic assessment and a cardiopulmonary exercise test (CPET) before the race. hs-TNT was measured before, immediately after and at 24, 48, 96, 144 and 192 h post-race. Speed and mean heart rate (HR) during the race were relativized to CPET values: peak speed (%VVMAX), peak HR (HR%MAX), speed and HR at the second ventilatory threshold (HR%VT2 and %VVT2). Results Hs-TNT increased from pre- to post-race (5.74±5.29 vs. 50.4±57.04 ng/L; p<0.001), seeing values above the Upper Reference Limit (URL) in 95% of the participants. At 24 h post-race, 39% of the runners still exceeded the URL (High hs-TNT group). hs-TNT rise was correlated with marathon speed %VVT2 (r=0.22; p=0.042), mean HR%VT2 (r=0.30; p=0.007), and mean HR%MAX (r=0.32; p=0.004). Moreover, the High hs-TNT group performed the marathon at a higher Speed %VVT2 (88.21±6.53 vs. 83.49±6.54%; p=0.002) and Speed %VVMAX (72±4.25 vs. 69.40±5.53%; p=0.009). hsTNT showed no signifcant associations with cardiopulmonary ftness and echocardiographic measures, except for a slight correlation with left ventricular end systolic diameter (r=0.26; p=0.018). Conclusion Post-race hs-TNT was above the URL in barely all runners. Magnitude of hs-TNT rise was correlated with exercise mean HR; whereas, its normalization kept relationship with marathon relative speed

Somatic and germline analysis of a familial Rothmund-Thomson syndrome in two siblings with osteosarcoma

Rothmund–Thomson syndrome (RTS) is characterized by a rash that begins in the first few months of life and eventually develops into poikiloderma. Associated symptoms are alterations in the teeth, sparse hair, thin eyebrows, lack of eyelashes, low stature, bone abnormalities, hematological illnesses, gastrointestinal disease, malnutrition, cataracts, and predisposition to cancer, principally to bone tumors and skin cancer. Diagnostic certitude is provided by a genetic study involving detection of pathogenic variants of the RECQL4 gene. We hereby present a familiar case of RTS in two siblings from a Portuguese family, both diagnosed with osteosarcoma. Genomic analysis (203 genes) of both tumors as well as germline analysis of the RECQL4 gene, thus confirming the syndrome in the family, have been performed. The relevance of clinical recognition of the hallmarks of the disease and thus early diagnosis with early intervention is highlighted

Characterization of a candidate dual AGN

We present Chandra and optical observations of a candidate dual active galactic nucleus (AGN) discovered serendipitously while searching for recoiling black holes via a cross-correlation between the serendipitous XMM source catalogue (2XMMi) and SDSS-DR7 galaxies with a separation no larger than 10 times the sum of their Petrosian radii. The system has a stellar mass ratio M_1/M_2 ≈ 0.7. One of the galaxies (Source 1) shows clear evidence for AGN activity in the form of hard X-ray emission and optical emission-line diagnostics typical of AGN ionization. The nucleus of the other galaxy (Source 2) has a soft X-ray spectrum, bluer colours, and optical emission-line ratios dominated by stellar photoionization with a ‘composite’ signature, which might indicate the presence of a weak AGN. When plotted on a diagram with X-ray luminosity versus [OIII] luminosity, both nuclei fall within the locus defined by local Seyfert galaxies. From the optical spectrum, we estimate the electron densities finding n_1 < 27 e− cm^(−3) and n_2 ≈ 200 e− cm^(−3). From a 2D decomposition of the surface brightness distribution, we infer that both galaxies host rotationally supported bulges (Sérsic index <1). While the active nature of Source 1 can be established with confidence, whether the nucleus of Source 2 is active remains a matter of debate. Evidence that a faint AGN might reside in its nucleus is, however, tantalizing