273 research outputs found
Impact of cooperative learning on physical education in basic psychological needs
El Aprendizaje Cooperativo (AC) se perfila como una herramienta que centra a los estudiantes en el foco principal del proceso de enseñanza y aprendizaje en el área de Educación Física (EF). El objetivo de la presente investigación fue analizar el impacto del AC en la satisfacción de las Necesidades Psicológicas Básicas (BPNES) frente a un modelo de enseñanza tradicional en estudiantes de Educación Secundaria Obligatoria (ESO). Para el análisis, se tomó una muestra total formada por 185 participantes, en el que se empleó un método cuantitativo con un diseño cuasi-experimental. Se desarrollaron seis sesiones a través retos cooperativos. Se utilizó como instrumento la Escala de Medición de las BPNES adaptada a la EF. Los resultados mostraron una mejora estadísticamente significativa en la autonomía, competencia y relaciones sociales en el grupo experimental. Una metodología activa basada en el aprendizaje cooperativo en las clases de EF mejora la satisfacción de las BPNES.Cooperative Learning (AC) is emerging as a tool that places students at the centre of the teaching and learning process in the area of Physical Education (PE). The objective of the present investigation was to analyse the impact of AC on the satisfaction of Basic Psychological Needs (BPNES) against a traditional teaching model in students of Compulsory Secondary Education (ESO). For the analysis, a total sample consisting of 185 participants was taken, and a quantitative method with a quasi-experimental design was used. Participants experienced six sessions through cooperative challenges. The BPNES Measurement Scale adapted to PE was used as an instrument. The results showed a statistically significant improvement in autonomy, competence and social relations in the experimental group. An active methodology based on cooperative learning in PE classes improves the satisfaction of BPNES
Computationally Guided Design of a Readily Assembled Phosphite- Thioether Ligand for a Broad Range of Pd-Catalyzed Asymmetric Allylic Substitutions
A modular
approach employing indene as common starting material,
has enabled the straightforward preparation in three reaction steps
of P-thioether ligands for the Pd-catalyzed asymmetric allylic substitution.
The analysis of a starting library of P-thioether ligands based on
rational design and theoretical calculations has led to the discovery
of an optimized anthracenethiol derivative with excellent behavior
in the reaction of choice. Improving most approaches reported to date,
this ligand presents a broad substrate and nucleophile scope. Excellent
enantioselectivities have been achieved for a range of linear and
cyclic allylic substrates using a large number of C-, N-, and O-nucleophiles
(40 compounds in total). The species responsible for the catalytic
activity have been further investigated by NMR in order to clearly
establish the origin of the enantioselectivity. The resulting products
have been derivatized by means of ring-closing metathesis or Pauson–Khand
reactions to further prove the synthetic versatility of the methodology
for preparing enantiopure complex structures
A survey of UK medical schools' arrangements for early patient contact
Background: Many U.K. medical schools have patient contact in the first two years of the undergraduate course. Aim: To compare the purposes and organization of early patient contact in UK medical schools and to relate these arrangements to the schools' curricular objectives. Methods: A telephone survey of lead educators in UK medicals schools. Categories of contact were plotted against phases of the course to discern patterns of organisation. Results: The quantity of contact varies considerably (four to 65 days). There is a pattern, with learning objectives around the social context of health and illness preceding skills based work and integrated clinical knowledge for practice coming later. Schools fall into three categories: close adherence to the preclinical/clinical split, with limited early contact acting as an introduction to social aspects of health; provision of substantial patient contact to maximize the integration of knowledge and skills; and transitional, with limited clinical goals. General practice provides between one third and one half of early patient contact. Conclusions: Arrangements meet the objectives set by each school and reflect differing educational philosophies. Change is toward more early contact. There appears to be no national guidance which supports a minimum quantity of patient contact or specific educational purpose in the early years of U.K. basic medical training
Effect of temperature on geopolymer and Portland cement composites modified with Micro-encapsulated Phase Change materials
publishedVersio
The effect of microencapsulated phase change materials on the rheology of geopolymer and Portland cement mortars
The effect of microencapsulated phase‐change materials (MPCM) on the rheological properties of pre‐set geopolymer and Portland cement mortars was examined. Microcapsules with hydrophilic and hydrophobic shells were compared. The shear rate dependency of the viscosities fitted well to a double Carreau model. The zero shear viscosities are higher for geopolymer mortar, illustrating poorer workability. The time evolution of the viscosities was explored at shear rates of 1 and 10 s−1. New empirical equations were developed to quantify the time‐dependent viscosity changes. The highest shear rate disrupted the buildup of the mortar structures much more than the lower shear rate. Microcapsules with a hydrophobic shell affect the rheological properties much less than the microcapsules with a hydrophilic shell, due to the higher water adsorption onto the hydrophilic microcapsules. Shear forces was found to break down the initial structures within geopolymer mortars more easily than for Portland cement mortars, while the geopolymer reaction products are able to withstand shear forces better than Portland cement hydration products. Initially, the viscosity of geopolymer mortars increases relatively slowly during due to formation of geopolymer precursors; at longer times, there is a steeper viscosity rise caused by the development of a 3D‐geopolymer network. Disruption of agglomerates causes the viscosities of portland cement mortars to decrease during the first few minutes, after which the hydration process (increasing viscosities) competes with shear‐induced disruption of the structures (decreasing viscosities), resulting in a complex viscosity behavior.publishedVersio
Relationship between Structure, Entropy and Diffusivity in Water and Water-like Liquids
Anomalous behaviour of the excess entropy () and the associated scaling
relationship with diffusivity are compared in liquids with very different
underlying interactions but similar water-like anomalies: water (SPC/E and
TIP3P models), tetrahedral ionic melts (SiO and BeF) and a fluid with
core-softened, two-scale ramp (2SRP) interactions. We demonstrate the presence
of an excess entropy anomaly in the two water models. Using length and energy
scales appropriate for onset of anomalous behaviour, the density range of the
excess entropy anomaly is shown to be much narrower in water than in ionic
melts or the 2SRP fluid. While the reduced diffusivities () conform to the
excess entropy scaling relation, for all the systems
(Y. Rosenfeld, Phys. Rev. A {\bf 1977}, {\it 15}, 2545), the exponential
scaling parameter, , shows a small isochore-dependence in the case of
water. Replacing by pair correlation-based approximants accentuates the
isochore-dependence of the diffusivity scaling. Isochores with similar
diffusivity scaling parameters are shown to have the temperature dependence of
the corresponding entropic contribution. The relationship between diffusivity,
excess entropy and pair correlation approximants to the excess entropy are very
similar in all the tetrahedral liquids.Comment: 24 pages, 4 figures, to be published in Journal of Physical Chemistry
Analytical and numerical analyses of the micromechanics of soft fibrous connective tissues
State of the art research and treatment of biological tissues require
accurate and efficient methods for describing their mechanical properties.
Indeed, micromechanics motivated approaches provide a systematic method for
elevating relevant data from the microscopic level to the macroscopic one. In
this work the mechanical responses of hyperelastic tissues with one and two
families of collagen fibers are analyzed by application of a new variational
estimate accounting for their histology and the behaviors of their
constituents. The resulting, close form expressions, are used to determine the
overall response of the wall of a healthy human coronary artery. To demonstrate
the accuracy of the proposed method these predictions are compared with
corresponding 3-D finite element simulations of a periodic unit cell of the
tissue with two families of fibers. Throughout, the analytical predictions for
the highly nonlinear and anisotropic tissue are in agreement with the numerical
simulations
The Role of Native Language and the Fundamental Design of the Auditory System in Detecting Rhythm Changes
Accepted December 13, 2018Purpose: We investigated whether rhythm discrimination
is mainly driven by the native language of the listener or
by the fundamental design of the human auditory system
and universal cognitive mechanisms shared by all people
irrespective of rhythmic patterns in their native language.
Method: In multiple experiments, we asked participants to
listen to 2 continuous acoustic sequences and to determine
whether their rhythms were the same or different (AX
discrimination). Participants were native speakers of
4 languages with different rhythmic properties (Spanish,
French, English, and German) to understand whether the
predominant rhythmic patterns of a native language affect
sensitivity, bias, and reaction time in detecting rhythmic
changes in linguistic (Experiment 2) and in nonlinguistic
(Experiments 1 and 2) acoustic sequences. We examined
sensitivity and bias measures, as well as reaction times.
We also computed Bayes factors in order to assess the
effect of native language.
Results: All listeners performed better (i.e., responded
faster and manifested higher sensitivity and accuracy)
when detecting the presence or absence of a rhythm
change when the 1st stimulus in an AX test pair exhibited
regular rhythm (i.e., a syllable-timed rhythmic pattern)
than when the 1st stimulus exhibited irregular rhythm (i.e.,
stress-timed rhythmic pattern). This result pattern was
observed both on linguistic and nonlinguistic stimuli
and was not modulated by the native language of the
participant.
Conclusion: We conclude that rhythm change detection is
a fundamental function of a processing system that relies
on general auditory mechanisms and is not modulated by
linguistic experience.The authors acknowledge support from Spanish Ministry of Economy and Competitiveness Grant PSI2017-82563-P (awarded to A. G. S.), the “Severo Ochoa” Programme for Centres/Units of Excellence in R&D Grant SEV-2015-490 (BCBL), and the Basque Foundation for Science Grant IKERBASQUE (awarded to A. G. S. and M. O.). D. M. G. was supported by Grant PIA/Basal FB0003 from the Chilean Research Council. L. P. was supported by the Spanish Ministry of Economy and Competitiveness via Juan de la Cierva fellowship
Pasireotide in the Personalized Treatment of Acromegaly
The delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some months to be fully evaluated. Considering this, acromegaly treatment should benefit from personalized medicine therapeutic approach by using biomarkers identifying drug response. Pasireotide has been positioned mostly as a compound to be used in first-generation SRLs resistant patients and after surgical failure, but sufficient data are now available to indicate it is a first line therapy for patients with certain characteristics. Pasireotide has been proved to be useful in patients in which hyperintensity T2 MRI signal is shown and in those depicting low SST2 and high expression of SST5, low or mutated AIP condition and sparsely granulated immunohistochemical pattern. This combination of clinical and pathological characteristics is unique for certain patients and seems to cluster in the same cases, strongly suggesting an etiopathogenic link. Thus, in this paper we propose to include this clinico-pathologic phenotype in the therapeutic algorithm, which would allow us to use as first line medical treatment those compounds with the highest potential for achieving the fastest control of GH hypersecretion as well as a positive effect upon tumor shrinkage, therefore accelerating the implementation of precision medicine for acromegaly. Moreover, we suggest the development, validation and clinical use of a pasireotide acute test, able to identify patients responsive to pasireotide LAR as the acute octreotide test is able to do for SRLs
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